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The Department of Biomedicine

BBB seminar: Siver Andreas Mostue

Choline-derived metabolites as NMR-visible biomarkers in breast cancer

Siver Andreas Mostue
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim

Aberrant metabolism is recognized as a hallmark of cancer. Several metabolic systems are affected. One of the least known abnormalities is the upregulation of turnover in choline phospholipid metabolism. Increased production and breakdown of phosphatidylcholine is seen in a wide range of cancers, and cancer cells display a metabolic phenotype with high levels of phosphocholine and glycerophosphocholine. Due to the chemical structure of choline-containing compounds, they can be studied using nuclear magnetic resonance (NMR) with relative ease. In this lecture, I will present research on NMR-based metabolic phenotyping in breast cancer, and discuss the potential value of targeting enzymes within choline phospholipid metabolism for therapeutic purposes.
 

Chairperson: Linda Elin Birkhaug Stuhr, Department of Biomedicine