The Department of Biomedicine

BBB seminar: Jonathan Wisor

Measuring and mitigating the impact of oxidative stress in the sleep deprived brain

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Jonathan Wisor
Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA

Sleep is a restorative process for the brain, one that counters the negative effects of being awake on brain metabolism. I will summarize data from my laboratory and others that demonstrate the occurrence of oxidative stress in the brain and its reversal by sleep. I will show evidence that oxidative stress compromises neuronal functioning and triggers sleepiness and sleep onset. I will propose possible pharmacological treatments to mitigate against the effect of oxidative stress on the sleep-deprived brain.

Chairperson: Janne Grønli, Department of Biological and Medical Psychology