BBB seminar: Jonathan Wisor
Measuring and mitigating the impact of oxidative stress in the sleep deprived brain
Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
Sleep is a restorative process for the brain, one that counters the negative effects of being awake on brain metabolism. I will summarize data from my laboratory and others that demonstrate the occurrence of oxidative stress in the brain and its reversal by sleep. I will show evidence that oxidative stress compromises neuronal functioning and triggers sleepiness and sleep onset. I will propose possible pharmacological treatments to mitigate against the effect of oxidative stress on the sleep-deprived brain.
Chairperson: Janne Grønli, Department of Biological and Medical Psychology