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BBB seminar: Trond Vidar Hansen

Biosynthesis, bioactions and biomedical applications of the protectins

Trond Vidar Hansen
Section of Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo

Endogenous w-3 polyunsaturated fatty acids (PUFAs) are enzymatically converted during inflammation-resolution processes to novel products named specialized pro-resolving mediators (SPMs). The SPMs promote clearance of bacteria and apoptotic cells, down-regulate proinflammatory mediator production and stimulate the resolution of inflammation. Clinical trial development programs with SPMs are ongoing and SPMs have received attention as leads towards drug discovery.

The LIPCHEM group has conducted studies on natural occurring oxygenated PUFAs,1 their activation of BK channels (voltage-gated potassium channels conducting large amounts of K+ across the cell membrane),2 as well as studies on novel SPMs.3,4 Results from biosynthetic studies, bioactions and biomedical applications using SPMs of the protectin family will be presented.

References:

1. Alborn HT, Hansen TV, Jones TH, Bennett DC, Tumlinson JH, Schmelz EA, Teal PE. Disulfooxy fatty acids from the American bird grasshopper Schistocerca americana, elicitors of plant volatiles. Proc Natl Acad Sci USA 2007, 104:12976

2. Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T. Atomic determinants of BK channel activation by polyunsaturated fatty acids. Proc Natl Acad Sci USA 2016, 113:13905

3. Gobbetti T, Dalli J, Colas RA, Federici Canova D, Aursnes M, Bonnet D, Alric L, Vergnolle N, Deraison C, Hansen TV, Serhan CN, Perretti M. Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. Proc Natl Acad Sci USA 2017, 114:3963

4. Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K, Aronica E, Porcu L, Pistorius K, Colas RA, Hansen TV, Perretti M, Kaminski RM, Dalli J, Vezzani A. n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain 2018, 141:3130

Chairperson: Nils Halberg, Department of Biomedicine