BBB seminar: Douglas A. Lauffenburger
Douglas A. Lauffenburger
Department of Biological Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
Appreciation is increasing for the relevance of tumor cell-extrinsic mechanisms to drug resistance observed in a wide range of cancer types. These mechanisms can involve complex cell-cell interactions in tissue microenvironments, raising new challenges with respect to elucidation and understanding – but at the same time also raising new opportunities for address using therapeutic combinations aimed at diverse cell targets. In this seminar, I will present efforts by our laboratory in partnership with various collaborators focused on these challenges and opportunities, demonstrating value of multi-variate systems analysis approaches that closely integrate experiment and computational modeling.
Chairperson: James Lorens, Department of Biomedicine