CCBIO seminar: Jianfeng Chen
Regulation of immune cell trafficking by extracellular microenvironment
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Immune surveillance and host defence depend on the precisely regulated tissue-specific trafficking of lymphocytes. α4 integrins (α4β7 and α4β1) are heterodimeric lymphocyte homing receptors that mediate lymphocyte adhesion and migration by interacting with their ligands. The dynamic regulation of integrin-ligand binding by extracellular stimuli is essential to integrin-mediated lymphocyte trafficking. One research interest in my lab is the regulation of integrin adhesion and signaling by different extracellular microenvironmental factors. My talk will focus on two of our most recent findings: the switch of integrin ligand specificity by different chemokines, and the regulation of integrin-mediated lymphocyte adhesion and migration by febrile temperature.
Chairperson: Donald Gullberg, CCBIO