The Department of Biomedicine
BBB seminar

BBB seminar: Antonino Cattaneo

An intrabody platform for conformational-selective and post-translational-specific interference in neurodegeneration

Main content

Antonino Cattaneo
Scuola Normale Superior, Pisa, Italy

After pioneering the concept and the development of intracellular expression of antibodies domains (intrabodies) in mammalian cells, we developed a platform for the conformational-selective and post-translational-specific interference towards target proteins in neurons. I will describe the application of the platform to Alzheimer’s neurodegeneration, by the specific targeting of Abeta oligomers in the endoplasmic reticulum. This molecularly- and subcellularly-precise approach allows to target the early, cell-autonomous phase of neurodegeneration, in the subcellular compartment where the first damage by misfolded proteins is done. I will discuss current approaches and the potential of the intrabody platform for a new generation of therapies for neurodegenerative diseases and for physiological studies.

Chairperson: Clive Bramham, Department of Biomedicine