The Department of Biomedicine

BBB Seminar: Rein Aasland

The CW domain: a novel histone recognition module in chromatin regulators

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Rein Aasland
Department of Molecular Biology, University of Bergen

Post-translational modifications of the N-terminal histone tails, including lysine acetylation and methylation, have key roles in regulation of chromatin and gene expression. A number of protein modules has been identified that recognize differentially modified histone tails. This provides the respective proteins with the capacity to sense such modifications. We have identified the CW domain as a new histone recognition module in chromatin regulators. CW domains in different proteins recognise different methylated states of lysine 4 on histone H3 (H3K4me). Structural comparison of two CW domains has allowed us to propose how different CW domains can distinguish between different methylated histone tails. The role of CW domains in chromatin regulators will be discussed in light of data with the histone methyltransferase ASHH2 from Arabidopsis, a CW protein.

Host: Jaakko Saraste, Department of Biomedicine