The Department of Biomedicine

BBB Seminar: Marco Conti

Role of PDE4 in shaping the ß-adrenergic signals

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Marco Conti
Department of Gynecology, Obstetrics, and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco (UCSF), CA, USA

This presentation will focus on the hypothesis that different cyclic nucleotide phosphodiesterases (PDEs) control the cAMP signals generated by occupancy of the β1- and β2-adrenergic receptors and contribute to the specificity of different adrenergic biological responses in the heart. Data will be presented to demonstrate that two PDE4 isoenzymes control β1/β2 adrenergic signaling in two distinct subcellular compartments in a simplified model of mouse embryonic fibroblasts, and in neonatal cardiac myocytes. In defining the macromolecular complexes involving different PDE4s, we will describe the properties, dynamics, and functional consequences of a macromolecular complex involving a PDE4 and the β1-adrenergic receptor. Finally, genetic models will be used to assess the role of these PDEs in cardiac function.

Host: Stein Ove Døskeland, Department of Biomedicine