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The Department of Biomedicine

BBB Seminar: Amanda Swain

Transcriptional regulation of early gonad and adrenal development

Amanda Swain, Section of Gene Function and Regulation, Institute of Cancer Research, London, UK

The mammalian adrenal and gonad are derived from the same primordia. We have been interested in understanding the process of the differentiation of these two tissues during embryonic development. We have identified the transcription co-factor Cited2 as being important in this early process and in-depth analysis shows that it works as a dosage modifier of Sf-1, an orphan nuclear hormone receptor that is essential for the formation of both the gonad and adrenal. Our work highlights the importance of transcription factor dosage in organogenesis.


Host: Marit Bakke (marit.bakke@biomed.uib.no), Department of Biomedicine