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The Department of Biomedicine

BBB Seminar: Kevin Knower

Epigenetic markers of oestrogen production in the breast

Kevin Knower
Cancer Drug Discovery Laboratory, Prince Henry's Institute of Medical Research, Clayton, VIC, Australia 

Oestrogen promotes breast cancer progression in two-thirds of post-menopausal patients. Our laboratory has previously shown that oestrogen formation is affected by epigenetics, a heritable process reversed by drugs. In this presentation I will demonstrate how oestrogen production is stimulated by epigenetic changes, and how these alterations increase breast cancer risk and progression. Our work aims to identify novel therapeutic targets, and lead to better forms of breast cancer treatment with fewer side effects. 

 Host: Marit Bakke , Department of Biomedicine