The Department of Biomedicine

BBB Seminar: Inger Sandlie

Engineering the recognition molecules of the adaptive immune system

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Inger Sandlie, Department of Molecular Biosciences, University of Oslo

Our field of interest is the study of the structure and function of antibodies and T cell receptors, the specific detecting molecules of the adaptive immune system. The purpose of our work is to engineer soluble T cell receptors, antibodies and antibody-derived molecules to be used in therapy and as research reagents. Our main focus is on the stability and on the affinity engineering of binding molecules. Most projects involve close collaboration with research groups within the Centre for Immune Regulation at the University of Oslo and the Oslo University Hospital. Some projects also bridge research on protein engineering with its medical application, such as the development of subunit vaccine reagents.

Host: Aurora Martinez, Department of Biomedicine