BBB seminar: Jorge Lira Ruas
The PGC-1alpha coactivator system: Regulators of skeletal muscle function and beyond
Jorge Lira Ruas
Karolinska Institutet, Department of Physiology and Pharmacology, Molecular and Cellular Exercise Physiology Group, Stockholm, Sweden
Over the last decade, members of the PGC-1alpha (peroxisome proliferator-activated receptor gamma (PPAR-gamma) coactivator-1alpha) family of transcriptional coactivators have emerged as critical regulators of skeletal muscle plasticity. We have recently identified novel PGC-1alpha splice variants involved in the control of muscle mass and function, with significant impact on mouse models of muscle atrophy and cancer cachexia. Focus will be given to a new role for PGC-1alpha proteins in psychiatric disease.
Chairperson: Marit Bakke, Department of Biomedicine