The Department of Biomedicine

BBB seminar: Jorge Lira Ruas

The PGC-1alpha coactivator system: Regulators of skeletal muscle function and beyond

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Jorge Lira Ruas
Karolinska Institutet, Department of Physiology and Pharmacology, Molecular and Cellular Exercise Physiology Group, Stockholm, Sweden

Over the last decade, members of the PGC-1alpha (peroxisome proliferator-activated receptor gamma (PPAR-gamma) coactivator-1alpha) family of transcriptional coactivators have emerged as critical regulators of skeletal muscle plasticity. We have recently identified novel PGC-1alpha splice variants involved in the control of muscle mass and function, with significant impact on mouse models of muscle atrophy and cancer cachexia. Focus will be given to a new role for PGC-1alpha proteins in psychiatric disease.

Chairperson: Marit Bakke, Department of Biomedicine