BBB seminar: Fitz-Roy Curry
Investigations of vascular permeability: From molecular mechanisms to functional vascular exchange
Department of Physiology and Membrane Biology, School of Medicine, University of California at Davis, CA, USA
The presentation will update research previously reviewed in Cardiovascular Research (2010, 87:218-29). I will discuss novel mechanisms that have been discovered by investigating the control of vascular permeability at the cellular microvessel, and whole organ levels. Key ideas include (1) the ways experimental conditions determine the reliability of permeability measurements, (2) the tonic regulation of the stability of inter-endothelial cell junctions and the endothelial glycocalyx, and (3) phenotype plasticity of endothelium based upon measurements of acute and chronic responses of the endothelial barrier to injury. Some of the new studies planned during my stay in Bergen this fall will be described.
Chairperson: Rolf K. Reed, Dept. of Biomedicine