BBB seminar: Christopher Proud
Signalling through mTORC1 and the control of protein synthesis
School of Biological Sciences, University of Southampton, UK
Signalling through mTORC1 (mammalian target of rapamycin complex 1) regulates many cellular functions, including growth, proliferation and gene expression. mTORC1 signalling is activated by hormones, growth factors and nutrients. It plays an important role in several human diseases such as tissue hypertrophy, restenosis, tuberous sclerosis and several cancers. The best understood effects of mTORC1 signalling are on protein synthesis, where it regulates several components of the translational machinery. I will discuss the roles of the two major mTORC1-regulated steps in translation in controlling overall protein synthesis and the translation of specific mRNAs, and our current understanding of the control of the involved components by mTORC1. These components are the eIF4E-binding proteins, which repress translation initiation, and elongation factor eEF2 kinase, which regulates translation elongation.
Host: Beate Stern <beate .email@example.com>, Department of Biomedicine