CCBIO seminar: Gwendalyn Randolph
The lymphatic vasculature in immunity and inflammatory disease
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
The lymphatic vasculature regulates the tissue microenvironment by controlling the passage of fluid, macromolecules, and immune cells to draining lymph nodes. We have come to recognize that the activities of the lymphatic vasculature in turn tune immune responses, including anti-tumor immunity and regulation of the pre-metastatic niche. In this seminar, I will present data that highlights the immunological roles of a specialized part of the lymphatic vasculature called collecting lymphatics. Although collecting vessels have not previously been linked to the immune response, the seminar will connect regulation of the permeability within collecting vessels to the regulation of chronic inflammation and immunity.
Chairperson: Helge Wiig, Department of Biomedicine