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Jeffrey Pollard

Professor Pollard pioneered studies on the role of macrophages in development and tumor progression. His lab was the first to demonstrate that tumor associated macrophages (TAMs) promote tumor progression and malignancy. His work has focused upon mechanisms behind these pro-tumoral actions of TAMs with a particular emphasis on metastatic disease. For these studies he was awarded the American Cancer Society Medal of Honor in basic sciences for his work in tumor immunology in 2010.

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Professor Pollard graduated with a firstclass special honors degree in Zoology from Sheffield University followed by a PhD at Imperial Cancer Research Fund (now CRUK) in London. He spent a post-doctoral period at Ontario Cancer Institute in Toronto and thereafter took a faculty position at King’s College University of London. In 1988, he joined the Albert Einstein College of Medicine in New York where he worked for 24 years. At the Albert Einstein College of Medicine, Professor Pollard was the Louis Goldstein Swann Chair in Women’s Health, Deputy Director of the NCI funded Cancer Center, and Director of the NIH funded Center for the Study of Reproductive Biology and Women’s Health. He joined the University of Edinburgh in 2012 as Director of the Medical Research Council Centre for Reproductive Health. In Edinburgh, he is Professor of Resilience Biology in the College of Medicine and Veterinary Medicine.

Professor Pollard is a Fellow of the Royal Society of Edinburgh, Fellow of the Royal Society of Biology, Fellow of the Academy of Medical Sciences, and a Fellow of the American Association for the Advancement of Sciences. He has published over 285 papers and edited several books/journal issues. He has an H-index of 110.

Professor Pollard pioneered studies on the role of macrophages in development and tumor progression. His lab was the first to demonstrate that tumor associated macrophages (TAMs) promote tumor progression and malignancy. His work has focused upon mechanisms behind these pro-tumoral actions of TAMs with a particular emphasis on metastatic disease. For these studies he was awarded the American Cancer Society Medal of Honor in basic sciences for his work in tumor immunology in 2010.

Current studies emphasize translation of mouse studies to humans, in breast, ovarian, endometrial and brain cancer. Scientifically the focus is on understanding the immunosuppressive role of macrophages towards cytotoxic T and NK cells, particularly in the context of human cancers. Studies include spatial mapping of the tumor microenvironment and its immune components to predict clinical outcomes and to develop novel therapeutics. His lab has developed new computational and imaging methods to achieve this aim. His lab also studies functions of TAMs using induced pluripotent stem cell derived human macrophages and genetic analysis in mouse models of cancer.

In 2020, Professor Pollard founded an immuno-oncology company “Macomics” dedicated to translating basic science to clinical efficacy in cancer. Professor Pollard’s lab is also the UK representative on the COST pan-European network Mye-info bank on myeloid cell biology to harmonize large data sets through integrating biobanks with genomic, proteomic and transcriptomic data by computational biology.

Professor Pollard intends to develop collaborations with members of CCBIO through advising on their programs in anti-macrophage therapies particularly through anti-CSF1R therapeutics. In addition, he has developed many methods for analysis of macrophage phenotypes within tumor tissue with the intent on using these to stratify patients for therapy. The CCBIO archives will be an invaluable resource for these studies as well as the clinical translational studies performed at CCBIO. He will collaborate broadly, and from the outset with Professors Bjørn Tore Gjertsen, Lars A. Akslen and Line Bjørge.