Centre for Cancer Biomarkers CCBIO

CCBIO Seminars

CCBIO has a monthly research seminar where invited guests and international speakers or the principal and associate investigators focus on current research topics and updates. The CCBIO seminar has been well visited and received.

Collage of photos from the CCBIO seminars.
Eli Vidhammer/Jørgen Barth/Oleg Tsinkalovsky

Seminars in 2018

01.02.18, Helge Wiig

Professor Helge Wiig, Department of Biomedicine, Faculty of Medicine, University of Bergen.
Time: 14:30
Chairperson: Lars A. Akslen
Title: "Lessons from a black box –The extracellular microenvironment and lymphatics in malignant tissue"

22.02.18, Ole Frithjof Norheim

Professor Ole Frithjof Norheim, physician and professor in medical ethics at the Department of Global Public Health and Primary Care, University of Bergen, and adjunct professor at the Department of Global Health and Population, Harvard TH Chan School of Public Health. Norheim is also a CCBIO associate investigator.
Time: 14:30
Chairperson: Roger Strand
Title: "Can biomarkers improve priority setting for new, expensive cancer drugs?"

22.03.18, Aaron Meyer

Assistant Professor Aaron Meyer, Department of Bioengineering, University of California at Los Angeles (UCLA).
Time: 14:30
Chairperson: Jim Lorens
Title: "Engineering more precise and potent TAM-targeted therapies"

26.04.18, Ian Mackenzie

Professor Ian Mackenzie from the Centre for Cell Biology and Cutaneous Research, the Blizard Institute, Queen Mary University of London.
Time: 14:30
Chairperson: Anne Christine Johannessen
Title: "Stem cell plasticity in head and neck cancers

31.05.18, Aurora Martinez.

Professor Aurora Martinez from the Department of Biomedicine, Faculty of Medicine, University of Bergen.
Time: 14:30
Chairperson: Camilla Krakstad
Title: "Pharmacological chaperoning: a potential treatment for genetic diseases, including some cancer syndromes."

07.06.18, Arvid Lundervold.

Professor Arvid Lundervold from the Department of Biomedicine, Faculty of Medicine, University of Bergen.
Time: 14:30
Chairperson: Lars A. Akslen.
Title: "Computational imaging and machine learning in biomedicine"

30.08.18, Edna Cukierman

Edna Cukierman from the Department of Cancer Biology, Fox Chase Cancer Center, Philadelphia, PA, USA
Topic will on tumor/stroma interactions. Title and abstract will be announced closer to the seminar date. 
Time: 14:30
Chairperson: Donald Gullberg.
Title: “Oncogenic synapses; stromal regulators of pancreatic cancer, metabolic support and innate immunosuppression”.  

19.09.18, Bruce Zetter, Merle Jacob, Lars A. Akslen and Roger Strand

CCBIO Special Seminar. Statements and reflection around the concept of excellence in research, incl. Harvard experiences. The seminar is organized as part of the CCBIO/Harvard INTPART partnership.
Time: 13.00
Title: "What is Scientfic Excellence?"

20.09.18, Michael Rogers and Bruce Zetter

CCBIO Special Seminar. The seminar is organized as part of the CCBIO/Harvard INTPART partnership.
Time: 09.00-12.00
Michael Rogers: "Validation of Anthrax Toxin Receptor 2 (Antxr2/CMG2) as a Target for Small Molecule Antiangiogenic Therapy."
Bruce Zetter: "Drug discovery for treating metastatic cancers."
Read more here.

27.09.18, Staffan Strömblad

Staffan Strömblad from the Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
Time: 14:30
Chairperson: Donald Gullberg.
Title: "Novel cell-matrix adhesion structures"

03.10.18, Marsha Moses, Roland Jonsson, Roopali Roy, Anne Blanchard

CCBIO Special Seminar. The seminar is organized as part of the CCBIO/Harvard INTPART partnership.
Time: 13.00-16.00
Title "The Importance of Mentoring for Career Development". The seminar will consist of short presentations, panel discussion and interactions with the audience.
Note that location is not Aud. 4 at BBB this time, but B302 at Haukeland Univ. Hospital, Sentralblokka (main building), 3rd floor.


Professor Arne Östman, Karolinska Institutet, Sweden, and also CCBIO international affiliated researcher.
Title and abstract will be announced closer to the seminar date.
Time: 14:30
Chairperson: Lars A. Akslen.

29.11.18, Frédéric Amant

Frédéric Amant from the Center for Gynecologic Oncology, Netherlands Cancer Institute and Academic Medical Center, Amsterdam, The Netherlands. Professor Amant is also one of CCBIO's international affiliated researchers.
Title and abstract will be announced closer to the seminar date. 
Time: 13:30 (Note: one hour earlier than usual)
Chairperson: Lars A. Akslen.


Tentative speaker: Cedric Zeltz, topic on fibroblast heterogeneity.
Time: 14:30
Chairperson: Donald Gullberg.


Seminars in 2017

The seminar dates and speakers for 2017 are:

26.01.17, Norman J. Maitland

Norman J. Maitland, Department of Biology, University of York, UK.
Time: 14:30
Chairperson: Karl-Henning Kalland
Title: Modelling of cell fate and differentiation using tissue-derived human prostate epithelial cells

23.02.17, Øystein Bruserud

Øystein Bruserud, the Leukaemia Research Group, Department of Clinical Science, University of Bergen, Norway.
Time: 14:30
Chairperson: Bjørn Tore Gjertsen
Title: Classification and prognostication of acute myeloid leukemia – the past, the present and the future

16.03.17, Klas Wiman

Klas Wiman, the Department of Oncology-Pathology, Karolinska Institute, Sweden.
Chairperson: Bjørn Tore Gjertsen
Title: Targeting missense and nonsense mutant p53 in cancer – from molecular biology to the clinic

27.04.17, Robert Lafyatis - CANCELLED

Robert Lafyatis, Division of Rheumatology and Clinical Immunology,University of Pittsburgh Medical Center, USA.
Chairperson: Donald Gullberg
Title: Understanding cellular heterogeneity and fibrosis in systemic sclerosis skin using single cell RNAseq: SFRP2/DPP4 and FMO1/LSP1 define two major fibroblast populations in normal skin

11.05.17, Ulf Landegren

Ulf Landegren, Department of Immunology, Genetics and Pathology, Uppsala University, Sweden.
Chairperson: Rolf Kåre Reed
Title: Molecular tools for high performance analyses of proteins and nucleic acids

15.06.17, Kalle Sipila

Kalle Sipila, Centre for Stem Cells and Regenerative Medicine, King's College London, UK
Chairperson: Donald Gullberg
Title: Integrative genomic and functional analysis of human primary oral SCC cells

28.09.17, Nuno M. Coelho 

Nuno M. Coelho, Matrix Dynamics Group, University of Toronto
Chairperson: Donald Gullberg
Title: DDR1 expression, collagen-dependent activation and signalling in cancer and tissue fibrosis

26.10.17, Jan Jacob Schuringa

Jan Jacob SchuringaDepartment of Experimental Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, The Netherlands
Chairperson: Bjørn Tore Gjertsen
Title: Towards identification and targeting of leukemic stem cells and (epi)genetically distinct subclones using humanized niche xenograft mouse models

03.11.17, CCBIO Special Seminar, Rameen Beroukhim

Rameen Beroukhim, Department of Medical Oncology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Chairperson: Lars A. Akslen
Title: Structural variations in the cancer genome

23.11.17, Satu Mustjoki

Satu Mustjoki, Hematology Research Unit Helsinki, Department of Clinical Chemistry and Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Finland
Chairperson: Bjørn Tore Gjertsen
Title: Immunogenicity in hematological malignancies and immunological effects of targeted therapy

12.12.17, CCBIO Special Seminar, Randolph Watnick

Randolph Watnick, the Department of Surgery, Harvard Medical School and the Vascular Biology Program at Boston Children’s Hospital, USA.
Chairperson: Lars A. Akslen
Title: A novel mechanism governing tumor initiation and cancer stem cell function.


Seminars in 2016

28.01.2016, Jean-Christophe Bourdon

Jean-Christophe Bourdon, Division of Cancer Research, Jacqui Wood Cancer Centre, University of Dundee, United Kingdom. 
Time: 14:30
Host: Bjørn Tore Gjertsen
Title: A decade of research on p53 sumarised.


25.02.2016, Olivier De Wever

Olivier De Wever, Laboratory of Experimental Cancer Research, Ghent University, Belgium.
Time: 14:30
Host: Donald Gullberg
Title: Communication in the tumor environment: diagnostic and therapeutic opportunities.


17.03.2016, Lutz P. Müller

Lutz P. Müller, MD; Clinic for Internal Medicine IV - Hematology / Oncology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Time: 14:30
Host: Donald Gullberg
Title: Growth promotion of colorectal cancer by mesenchymal stromal cells – when and how?


28.04.2016, Krister Wennerberg

Krister Wennerberg, Institute for Molecular Medicine Finland, University of Helsinki, Finland.
Time: 14:30
Host: Bjørn Tore Gjertsen
Title: Targeting cancers using individual systems medicine


26.05.2016 CCBIO Special Seminar

Speaker: Anne Blanchard and invited speakers
Time: 14:30
Host: Roger Strand
Title: Pharma and public cancer biomarker research in the transition from a blockbuster model to personalised medicine


16.06.2016, Gwendalyn J. Randolph

Gwendalyn J. Randolph, Division of Immunology, School of Medicine, Washington University in St. Lois, USA.
Time: 14:30
Host: Rolf K. Reed
Title: The Lymphatic vasculature in immunity and inflammatory disease


25.08.2016, Jonathan M. Irish

Jonathan M. Irish, Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA
Time: 14:30, Auditorium 2.
Host: James Lorens
Title: Decoding human tumor microenvironments and healthy tissues using high dimensional single cell mass cytometry 


29.09.2016, Herbert Schiller

Herbert Schiller, Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Neuherberg, Germany
Time: 14:30, Auditorium 4.
Host: Donald Gullberg
Title: Multi-dimensional proteomics of the extracellular matrix in regeneration and fibrosis



27.10.16 is cancelled, new date will be announced.
Time: 14.30, Auditorium 2
Hosts: Jan Håvik and Donald Gullberg


10.11.2016, CCBIO/OCC Network Meeting

A joint R&D Network titled "Personalized Cancer Therapy: Repurposing and in vitro drug screens

Time: 10:30-17.00, aud. 4 till lunchbreak, aud. 2 after lunchbreak, BB-building.


01.12.2016, Jean-Paul Thiery

Jean-Paul Thiery, Centre for Cancer Biomarkers CCBIO, The University of Bergen, Yong Loo Lin School of Medicine National University of Singapore, University Paris Denis Diderot, Paris, France and Comprehensive Cancer Center Institut Gustave Roussy, Villejuif, France.
Title: "Epithelial cell plasticity in carcinoma: Harnessing mechanisms controlling biomechanics and progression of malignancy for the design of new therapeutic strategies"

Time: 14.30, Auditorium 4
Host: James B. Lorens


15.12.2016, Kenneth Hugdahl

Kenneth Hugdahl, Department of Biological and Medical Psychology, University of Bergen.
Excellence in science: Experience with ERC Advanced Grants
Time: 14:30, Auditorium 4.
Host: Lars Akslen

Seminars in 2015


22.01.2015, John Cairns

John Cairns, Centre for Cancer Biomarkers (CCBIO), Department of Economics, University of Bergen, and Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, United Kingdom.
Time: 14:30
Host: Roger Stand

Title: "Assessing the cost-effectiveness of bevacizumab in the treatment of metastatic melanoma"


19.02.2015, Anne Christine Johannessen

Anne Christine Johannessen, Centre for Cancer Biomarkers (CCBIO), Department of Clinical Medicine, University of Bergen.
Time: 14:30.
Host: Roger Stand

Title: "Oral cancer – ongoing research with special focus on tumour microenvironment"


26.03.2015, Hani Gabra

Hani Gabra, Department of Surgery and Cancer, Imperial College London, UK.
Time: 14:30.
Host: Helga Salvesen

Title: "OPCML, a tumour suppressor and novel systems regulator of tyrosine kinase signalling in ovarian and other cancers"


08.04.2015, Rik Thompson and John Haley

CCBIO special seminar with keynote speakers:

Rik Thompson, Queensland University of Technology, Brisbane Australia. See more introduction here to Rik Thompson.

John D. Haley, Stony Brook School of Medicine New York, SBU Cancer Center and SBU Proteomics Center.

Title: "Tumor plasticity and drug resistance
Host: James Lorens.
Time: 14:00-16.00.


30.04.2015, Lorena Arranz

Lorena Arranz, Stem Cell Aging and Cancer Research Group, Department of Medical Biology, UiT The Arctic University of Norway, Tromsø

Title: Neuroglial dysregulation of the haematopoietic stem cell niche in myeloid leukaemias
Time: 14:30.
Host: Bjørn Tore Gjertsen


28.05.2015, Neil C. Henderson

Neil C. Henderson, MRC Centre for Inflammation Research, University of Edinburgh, UK.

Title: Targeting of pericytes and tissue myofibroblasts during organ fibrogenesis
Time: 14:30.
Host: Donald Gullberg


11.06.2015, Robert S. Kerbel

A combined CCBIO and BBB seminar

Robert S. Kerbel, Biological Sciences Platform, Sunnybrook Research Institute, Toronto, and Department of Medical Biophysics, University of Toronto, Canada

Title: Antiangiogenic therapeutics in oncology: Overview, update, and future directions
Time: 14:30
Host: Oleg Tsinkalovsky


27.08.2015, Roya Navab

Speaker: Roya Navab, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Title: Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer
Time: 14:30.
Host: Donald Gullberg


24.09.2015, Bruce Baguley

Speaker: Bruce Baguley, the Auckland Cancer Society Research Centre, The University of Auckland, New Zealand.

Title: The importance of being... a receptor tyrosine kinase.
Time: 14:30.
Host: Jim Lorens


15.10.2015, Matthew G. Krebs

Combined BBB and CCBIO Seminar.

Speaker: Matthew G. Krebs, Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, UK.

Title: Circulating biomarkers in early phase drug development for lung cancer.
Time: 14:30.
Host: Bjørn Tore Gjertsen


22.10.2015, Eric Sahai

Speaker: Eric Sahai, the Francis Crick Institute, London.

Title: The role of CAFs in therapy failure. Intravital imaging reveals how stroma dictates heterogeneous responses to targeted therapy.
Time: 14:30. (NB: In Auditorium 1 at BBB this time.)
Host: Donald Gullberg


26.11.2015, Patrick Schöffski

Speaker: Patrick Schöffski, the Laboratory of Experimental Oncology, the Department of Oncology, KU Leuven, Belgium.

Title: “Modelling mesenchymal malignancies: development of patient-derived xenografts of soft tissue sarcomas and gastrointestinal stromal tumours and in vivo-drug testing with direct implications for clinical research (bedside to bench and back)
Time: 14:30.
Host: Bjørn Tore Gjertsen


17.12.2015, Jarle Breivik

Speaker: Jarle Breivik, Dept. of Behavioural Sciences in Medicine, Faculty of Medicine, University of Oslo

Title: "Cancer and aging: Facing realities and an uncertain future".
Time: 14:30.
Host: Lars A. Akslen




Seminars in 2014

30.01.2014, Karl-Henning Kalland,

Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen:
Heterogeneity and reprogramming plasticity of cancer cells – therapeutic possibilities.


20.02.2014: Roger Strand,

Centre for Cancer Biomarkers (CCBIO) and Centre for the Study of the Sciences and the Humanities (SVT), University of Bergen:
Crossing the Styx


20.03.2014, Cédric Gaggioli,

Institute for Research on Cancer and Aging (IRCAN), Nice, France:
Production of LIF cytokine by cancer cells and fibroblasts contributes to the establishment of a pro-invasive tumor microenvironment.


24.04.2014, Angela Nieto,

Instituto de Neurociencias Consejo Superior de Investigaciones Científicas (CSIC)–Universidad Miguel Hernández (UMH), San Juan de Alicante, Spain:
Epithelial plasticity in development and disease


22.05.2014, Emmet McCormack,

Department of Clinical Science, University of Bergen:
Pharmacological inhibition of the SIRT1 deacetylase with the small molecule inhibitor Tenovin-6 enhances ablation of FLT3-ITD+ LSC in combination with TKI treatment.


28.08.2014, Inge Jonassen

Centre for Cancer Biomarkers and Computational Biology Unit, Department of Informatics, University of Bergen:

Towards characterizing tumour microenvironments – experimental and computational approaches.


02.10.2014, Zena Werb

Department of Anatomy, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA:

New insights into mechanisms underlying breast cancer metastasis


30.10.2014, Boris Hinz

Laboratory of Tissue Repair and Regeneration, University of Toronto, Canada

Myofibroblasts can have it all: matrix mechanics, integrins, and pro-fibrotic growth factor activation


27.11.2014, Bjørn Tore Gjertsen

Department of Clinical Science, University of Bergen

Oncogene-addicted cancer: chronic myelogen leukemia as a model of a tyrosine kinase driven malignancy


18.12.2014, Arne Östman

Department of Oncology-Pathology, Karolinska Institutet,
Stockholm, Sweden

Impact of PDGFR-regulated fibroblasts and pericytes on tumor progression, prognosis and drug response


Seminars in 2013

29.8.2013: Lars A. Akslen.

Director of CCBIO.

CCBIO: Current concepts and challenges in cancer research.

26.9.2013: Helga B. Salvesen.

Co-Director of CCBIO.

Individualized therapy based on molecular alterations in gynecologic cancer.

31.10.2013: Oddbjørn Straume.

CCBIO. Angiogenic biomarkers in malignant melanoma.

25.11.2013: Sonja Loges.

University Hospital Hamburg-Eppendorf, University Comprehensive Cancer. Center II, Medical Clinic & Institute of Tumor Biology. CCBIO Special Lecture:
Role of Gas6 - Axl axis in malignant interaction with the host.

28.11.2013: Bjørn Tore Gjertsen.

CCBIO. Phosphoprotein signaling in acute myeloid leukemia.



1About the “CCBIO Seminars”
The “CCBIO Seminars” form a seminar series covering the full spectrum of research areas within CCBIOs research focus. The seminars are held by invited local, national and international speakers suggested by colleagues at the CCBIO and their research collaborators. Please note that the series is also part of the master/PhD program at the Department of Biomeicine (see Section 6).

2. Place, time, transport
The seminars are held at BBB, Jonas Lies vei 91, 3rd floor, in auditorium 4. The auditorium is up the stairs on the right hand side after passing the reception at the BBB main entrance or is straight on when coming via the pedestrian bridge from Haukeland Hospital. Usually, the seminars take place every Thursday at 14:30. This fits tightly with the schedule of the campus bus, arriving at Haukeland Hospital at 14:30 and well wait for attendants if they make their way directly to the auditorium.

3. Call for proposal for speakers
Please get in touch with any member of the Scientific Committee (see Section 7) to suggest a guest speaker of your choice to open slots in the seminar schedule. Your suggestion is welcome any time but the best possible way to be successful would be to plan good time in advance. Please include the following information: affiliation, CV or publication list and webpage of the speaker and a short motivation. The Committee will select the speakers among those suggested, using the following criteria: scientific excellence, topic of general interest, topic diversity. Travel and accommodation costs for the selected speakers will be covered within certain limitations.

4. Please inform us about your guests
If a renowned scientist within a relevant field is going to visit your lab, for example as an “opponent” on the occasion of a thesis defence or for the purpose of research collaboration, and would be willing to give a seminar during his/her stay, please let us know. Take contact with Professor Donald Gullberg or Rolf Reed (see Section 7) as soon as possible.

5. Checklist for hosts
You should agree to act as host for the guest speaker you invite. This involves the following responsibilities:

  • Arranging transport and accommodation for the guest (for budget frame work and reimbursement procedure, please click here).
  • Arranging a social program for the guest during his/her stay.
  • Asking the speaker to submit an abstract and writing a short biography of the speaker describing his/her background, current research interests, merits (both preferably max. ½ an A4 page).
  • Sending abstract, biography and the webpage of the speaker to Geir Olav Løken latest two weeks before the seminar.
  • Asking the speaker to give a general introduction at the beginning of the talk and preferentially place his/her work/results into a broader perspective at the end. Further, informing him/her that the lecture should not greatly exceed 45 minutes.
  • Setting up the computer/overhead presentation in the auditorium together with the speaker in due time before the start of the seminar. In case you would like assistance, please contact Torstein Ravnskog at least one day in advance.
  • Chairing the seminar which includes introducing the speaker and leading the discussion.

6. Master/PhD programme (BMED380)
During the fall 2013, the CCBIO seminars series is part of the master/PhD program and is open to all students at the UiB interested in biomedical and biosciences research. Registration to the course can be done at StudentWeb. Attendance is monitored by you signing a name list laid out during the seminars. To obtain a 5-point credit, attendance at a minimum of 25 lectures over two semesters is required and short written reviews of two selected lectures have to be submitted (one review for each semester).

7. The Committee
The CCBIO seminars committee consist of CCBIOs Director Lars Akslen and the Professors Rolf Reed and Donald Gullberg. CCBIOs Administrative Leader is the contact person for  suggestions for speakers and other practicalities.http://www.youtube.com/watch?v=PRlkzdqMaFE


CCBIO Special Seminars

Whenever CCBIO’s PIs have separate symposia with interesting lecturers, senior researchers visiting outside of the annual symposium and the CCBIOseminars, or the opportunity arises to invite an especially interesting lecturer, CCBIO encourages them to arrange talks under the umbrella of the CCBIOSpecial Seminars. In this way, the special seminars are integrated into CCBIOs seminar series, while at the same time making them stand out. Thespecial seminars have been very well visited with 100 to 140 participants.