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Centre for Cancer Biomarkers CCBIO

Vision and research areas

CCBIO aims to discover, validate and translate functional cancer biomarkers to improve our understanding of tumor mechanisms, promote early diagnosis of aggressive tumor phenotypes, and support cost-effective and responsible treatment of cancer.

CCBIO is focusing on tumor microenvironment interactions in primary and metastatic lesions, and how tissue context can educate and define aggressive tumor features and predict cancer behavior. The center is studying how crosstalk between tumor cells and components in the tumor microenvironment reflects cancer complexity and heterogeneity and determine cancer prognosis, beyond what is given by description of genetic alterations in tumor cells.

CCBIO concentrates on the following overlapping and integrated programs:

1. Mechanisms of Tumor-Microenvironment Interactions (Basic Studies)

2. Exploration and Validation of Cancer Biomarkers (Biomarker Discovery)

3. Clinical Applications and Early Trials (Clinical Studies)

4. Ethics, Economics and Priorities (Societal Studies)

Biomedical project areas are supplemented with integrated ethics and economics projects, focused on how to prioritize and fund expensive cancer treatment in the era of expanding and costly personalized medicine. Collaboration partners, both national and international, have been included to support these programs.

Research teams in these programs

For the second term (2018 - 2023), the organization of CCBIO has been modified to reflect the current research activities. We now have four teams and corresponding project areas, as can be seen in this link. On top of this, the four programs are supported by resources on bioinformatics and processing of big data, and Rolf Reed is strategic advisor. Increased collaboration within CCBIO, between the different teams and investigators, has taken place over the years. CCBIO is supported by an International Faculty of top scientists in different fields.