Centre for Cancer Biomarkers CCBIO
Completed doctoral degrees

CCBIO dissertations

Dissertations affiliated to the Centre of Cancer Biomarkers.

Doctorates of the Faculty of Medicine and Dentistry sitting in their robes at the doctorate promotion.
Ole Henrik Kongsvik

Main content


Ana Beatriz Mateus D'Avó Luís February 12.
Title: "Essays on Economic Incentives and Implications of Biomarker Tests"
Supervisors: Professor Tommy Staahl Gabrielsen and Associate Professor Julie Riise.
See press release.


Martin Pilskog January 23.
Title: "Predictive biomarkers for response to treatment with sunitinib in renal cancer patients"
Supervisors: Professor Oddbjørn Straume, Professor Christian Beisland and Professor Lars A. Akslen.
See press release.

Jahedul Alam January 31.
Title: "Novel Insights into Integrin α11 Expression and Function"
Supervisors: Professor Donald Gullberg, Professor Rolf K. Reed and Professor James Lorens.
See press release.

Hilde Renate Engerud February 7.
Title: "Molecular markers to predict prognosis and guide therapy in endometrial cancer"
Supervisors: Professor Camilla Krakstad and Professor Jone Trovik.
See press release.

Caroline Benedicte Nitter Engen February 14.
Title: "Exploring the boundaries of precision haemato-oncology - The case of FLT3 length mutated acute myeloid leukaemia"
Supervisors: Professor Bjørn Tore Gjertsen, Professor Emmet McCormack and Professor Øystein Bruserud.
See press release.

Tone Hoel Lende March 6.
Title: "Proliferation in operable breast cancer. Aspects of prognostication and relevance of carbohydrate metabolism"
Supervisors: Professor Håvard Søiland, Professor Emiel AM Janssen, Professor Emeritus Jan PA Baak and Professor Lars A. Akslen.
See press release.

Tormod Karlsen Bjånes March 6.
Title: "Drug delivery in pancreatic cancer"
Supervisors:  Bettina Riedel, Jan Schjøtt and Emmet McCormack.
See press release.

Harsh Nitin Dongre April 30.
Title: "Biomarkers and preclinical models for more precise diagnosis and personalized treatment of oral and vulva carcinomas - Study on human samples and experimental models"
Supervisors: Professor Daniela Elena Costea, Professor Line Bjørge and Professor Anne Christine Johannessen.
See press release.

Yaping Hua May 4.
Title: "Discovery and characterization of novel STAT3 and androgen receptor inhibitors in prostate cancer cells"
Supervisors: Professor Karl-Henning Kalland and Professor Xisong Ke.
See press release.

Hanna Elisabeth Dillekås June 4.
Title: "Importance of physical trauma on recurrence of breast cancer. Can tissue trauma synchronize growth of dormant micrometastases?"
Supervisors: Professor Oddbjørn Straume, Associate Professor Svein Arthur Jensen and Professor Olav Mella.
See press release.

Eduarda Guerreiro June 12.
Title: "Isolation and characterization of extracellular vesicles – Molecular couriers from cancer cell lines, and saliva and tear fluid from patients with primary Sjögren’s syndrome." (UiO/UiB)
Supervisors: Associate Professor Tine Merete Søland and Professor Daniela Costea.
See press release.

Ragnhild Haugse June 17.
Title: "Endothelial cell signaling and sonoporation"
Supervisors: Associate Professor Spiros Kotopoulis, Professor Emmet McCormack and PhD Anika Langer.
See press release.

Nazar Gafar Abdulrahman Mohamed June 19.
Title: "Biomarker Identification in Oral Squamous Cell Carcinoma. Study on Cohorts of Patients from Sudan"
Supervisors: Professor Daniela Elena Costea, Professor Anne Christine Johannessen, Professor Ahmed Sulaiman and PhD Elisabeth Sivy Nginamau.
See press release.

Sissel Dyrstad August 21.
Title: “A study on metabolic rewiring in cancer cell plasticity”
Supervisors: Professor Karl Johan Tronstad, Researcher Gro Vatne Røsland and Professor Jim Lorens
See press release.

Ehsan Hajjar December 17.
Title: “Next generation leukemia diagnostics and therapy through p53 isoforms”
Supervisors: Professor Bjørn Tore Gjertsen, Senior Researcher Vibeke Andresen and Advisor Sigrun Margrethe Hjelle
See press release.

Mikyung Kelly Seo
Title: "Economic evaluations of companion cancer biomarkers for targeted therapies”
Supervisors: Professor John Cairns and Dr. Alec Miners at the London School of Hygiene and Tropical Medicine (LSHTM). 


Katharina Bischof February 8th.
Title: "Rethinking Gynecological High-Grade Serous Carcinoma. Portraying the p53 isoform landscape and development of a new preclinical tool for optical imaging in xenograft models"
Supervisors: Professor Line Bjørge, Professor Emmet McCormack, Professor Bjørn Tore Gjertsen and Researcher Stian Knappskog
See press release.

Maria Lie Lotsberg April 29th.
Title: "The role of AXL and the microenvironment in cancer cell plasticity and therapy responses. A study in non-small cell lung cancer models".
Supervisors: Professor James B. Lorens, Professor Lars A. Akslen and Researcher Agnete S.T. Engelsen
See press release.

Maria Ryssdal Kraby (NTNU).
Title: "Tumor Vasculature in Subtypes of Breast Cancer.”
Supervisors: Professor Anna Bofin, Associate Professor Signe Opdahl, Professor Lars A. Akslen and Researcher Hege Russnes.
See press release.

Sahba Shafiee June 20th.
Title: "Translational Development of Preclinical Models and Therapies in Myelodysplastic Syndromes (MDS)"
Supervisors: Professor Emmet McCormack, Associate Professor Astrid Olsnes Kittang and Professor Bjørn Tore Gjertsen
See press release.

Kjersti Tefre Davidsen June 21st.
Title: "The Receptor Tyrosine Kinase Axl in Tumour Phenotyptic Plasticity and Acquired Resistance to Cancer Targeted- and Immunotherapy"
Supervisors: Professor James Lorens and Professor Oddbjørn Straume
See press release.

Sameer Bhargava Nov 1st (Cancer Registry of Norway & UIO)
Title: “Mammographic screening among immigrant women in Norway; disparities in attendance and selected screening outcomes.”
Supervisors: Professor Solveig Hofvind, Associate Professor Kåre Moen and Professor Lars A. Akslen.
See press release.

Sigmund Ytre-Hauge December 11th.
Title: "Advanced imaging biomarkers in endometrial cancer"
Supervisors: Professor Ingfrid S. Haldorsen, Professor Jone Trovik and Professor Helga B. Salvesen (†)
See press release.

Katrin Kleinmanns December 13th.
Title: "Rethinking High-Grade Serous Ovarian Carcinoma: Development of New Preclinical Animal Models for Evaluation of Image-guided Surgery and Immunotherapy."
Supervisors: Professor Emmet McCormack and Professor Line Bjørge.
See press release.


Tina Fonnes November 30th.
Title: “Preclinical models and molecular biomarkers - tools to improve treatment in endometrial carcinoma”
Supervisors: Professor Camilla Krakstad, Professor Emmet McCormack and Professor Bjørn Tore Gjertsen.
See press release.

Lawrence Fred Sembajwe August 24th.
Title: "EXT Proteins: Role in Heparan Sulfate Assembly and in Tumor Biology"
Supervisors: Professor Marion Kusche-Gullberg, Professor Donald Gullberg and Professor Helge Wiig.
See press release.

Israa Abdulrhman Ahmed June 26th.
Title: "Identification of prognostic biomarkers for oral squamous cell carcinoma. Study on human samples and experimental models"
Supervisors: Professor Daniela Elena Costea, Professor Anne Christine Johannessen and Associate Professor Dipak Sapkota.
See press release.

Waqas Azeem June 1st.
Title: "Regulatory patterns in prostate cell differentiation – investigation of transcription factors AR, GATA2 and NKX3-1".
Supervisors: Professor Karl-Henning Kalland and Xisong Ke.
See press release.

Emilia Hugdahl April 20th.
Title: "Prognostic and molecular markers in primary and metastatic cutaneous melanoma".
Supervisors: Professor Lars A. Akslen and PhD Rita Grude Ladstein.
See press release.

Maria Ramnefjell April 10th.
Title: “Prognostic biomarkers and clinico-pathologic characteristics in non-small cell lung cancer. A study with special focus on tumor-vascular interactions”.
Supervisors: Professor Lars A. Akslen and Associate Professor Lars Helgeland.
See press release.

Henriette Christie Ertsås April 6th.
Title: “The effects of ageing on microenvironment-contextual epithelial cell signalling”.
Supervisors: Professor James B. Lorens and Professor Rein Aasland.
See press release.

Stein-Erik Gullaksen March 23rd.
Title: “Single cell signalling and immune profiles in chronic myeloid leukaemia”.
Supervisors: Professor Bjørn Tore Gjertsen, Associate Professor Jorunn Kirkeleit and Professor Emmet Mc Cormack.
See press release.

Tor Audun Klingen February 20th.
Title:"Vascular invasion by tumor cells, and other prognostic factors in a population-based breast cancer study".
Supervisors: Professor Lars A. Akslen and Associate Professor Elisabeth Wik.
See press release.


Jan Roger Olsen January 27th.
Title:"Context dependent transcription factor regulation in normal and malignant cell differentiation".
Supervisors: Professor Karl-Henning KallandXisong Ke and Anne Margrete Øyan.
See press release.

Maria Omsland February 3rd.
Title: "Investigation of the intercellular structure tunneling nanotube (TNT) in leukemia".
Supervisors:  Dr. Vibeke Andresen and Professor Bjørn Tore Gjertsen.
See press release.

Pugazendhi Murugan Erusappan May 5th.
Title: “Molecular Aspects of Integrin α11 Function”
Supervisors: Professors Donald Gullberg and Helge Wiig.
See press release.

Karen Klepsland Mauland June 9th.
Title: "Context-related biomarkers in endometrial cancer – a study with focus on obesity and genomic alterations".
Supervisors: Dr. Henrica MJ Werner, Professor Helga B. Salvesen, Dr. Erling André Høivik and Professor Jone Trovik.
See press release.

Anna Berg June 22nd.
Title: "Molecular alterations and diagnostic imaging in premalignant and malignant endometrial lesions for improved diagnosis and treatment".
Supervisors: Professor Ingfrid Haldorsen, Professor Camilla Krakstad and Dr. Henrica MJ Werner.  
See press release.

Inga Reigstad June 22nd.
Title: "Investigation of different aspects of the tumor microenvironment as determinants of tumor development and progression".
Supervisors: Professors Linda Stuhr and Rolf K. Reed.  
See press release.

Sura Aziz June 27th.
Title: "Biological and clinico-pathologic markers in breast cancer. With focus on histologic features, markers of proliferation and angiogenesis".
Supervisors: Professor Lars A. Akslen and Associate Professor Elisabeth Wik.
See press release.

Stefan Hinz September 8th.
Title: “Mechanisms of AXL mediated cell plasticity and drug resistance”.
Supervisors: Professor James B. Lorens nd PhD Gro Gausdal.
See press release.

Marit Valla October 12th.
Title: "Molecular subtypes of breast cancer: incidence and prognosis". 
Supervisors: Professor Anna M. Bofin, NTNU, Researcher Signe Opdahl, also NTNU, and Professor Lars A. Akslen, CCBIO. This was a collaboration project between CCBIO and NTNU.

Kristi Krüger November 8th.
Title: “Markers of angiogenesis and the basal-like phenotype of breast cancer”. 
Supervisors: Professor Lars A. Akslen and MD PhD Elisabeth Wik.
See press release.

Mari Kyllesø Halle November 10th.
Title: “Molecular alterations suggesting new treatment strategies in uterine carcinomas”. 
Supervisors: Professors Camilla Krakstad and Jone Trovik.
See press release.

Gry Sandvik Haaland November 17th.
Title: “Investigations of the cancer therapeutic and protective effects of warfarin-mediated inhibition of the receptor tyrosine kinase AXL”.
Supervisors: Professor James Lorens and MD PhD Oddbjørn Straume.  
See press release.




André Sulen December 9th.
Title:"Leukocyte p38 and p53 proteins after environmental exposure; variation, associations and applicability".
Supervisors: Professor Bjørn Tore Gjertsen, Jörg Aβmus and Bjørg Eli Hollund.
See press release.

Cornelia Schuster November 22nd.
Title: "Investigation of predictive markers in patients with metastatic melanoma treated with bevacizumab".
Supervisors: Dr. Oddbjørn Straume and Professor Lars A. Akslen
See press release.

Elise Aasebø November 4th.
Title: “Mass spectrometry-based proteome quantification in leukemic cells from acute myeloid leukemia patients”.
Supervisors: Professor Frode S. Berven, Professor Frode Selheim, Dr. Marc Vaudel and Bjørn Tore Gjertsen.
See press release.

Lavina Ahmed November 2nd.
Title:"Axl as a Biomarker in Breast and Lung Cancer".
Supervisors: Professor Lars A. Akslen, Dr. David Micklem and Dr. Hawa Nalwoga. 
See press release.

Gøril Knutsvik October 31st.
Title: "Biomarkers in breast cancer, with special focus on tumor cell proliferation".
Supervisors: Professor Lars A. Akslen and Associate Professor Ingunn M. Stefansson.
See press release.

Ingvild Løberg Tangen October 7th.
Title: "Hormone signaling related factors as biomarkers in endometrial cancer"
Supervisors: Associate Professor Camilla Krakstad and Professor Helga Salvesen.
See press release.

Hengshuo Liu September 16th.
Title: “Expression and mechanosensitivity of integrin alpha 11 in the tumour microenvironment”.
Supervisors: Professor Donald Gullberg and Professor Rolf K. Reed.
See press release.

Fanny Pélissier May 9th.
Title: “The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor”.
Supervisors: Professor James B. Lorens and Dr. Mark LaBarge. 
See press release.

Himalaya Parajuli April 29th.
Title: "Integrin Role of integrin α11 in oral carcinogenesis. In vitro and in vivo studies ".
Supervisors: Professors Daniela Elena Costea, Anne Christine Johannessen and Donald Gullberg
See press release.

Jenny Hild Aase Husby 5 February 2016.
Title: ”Functional imaging to promote individualized and targeted therapy in endometrial cancer”.  
Supervisors: Professors Ingfrid S. Haldorsen and Helga B. Salvesen.
See press release.



Lene Elisabeth Myhren 16 October 2015.

Title: ”Cell death induction by free and encapsulated cancer drug candidates”.
Supervisors: Stein Ove Døskeland, Lars Herfindal and Bjørn Tore Gjertsen.
Press release.


Katarzyna Wnuk-Lipinska 7 April 2015.
Title: “The role of Axl signaling in phenotypic plasticity in normal and neoplastic epithelial cells”.
Supervisors: Professor James B.Lorens and David Micklem.
Press release.


Ida Wiig Sørensen 12 February 2015.
Title: «Molecular Characterisation of Integrin a 11 Function».
Main supervisor: Professor Donald Gullberg. Co-supervisor: Professor Marion Kusche-Gullberg.
Press release.




Crina Elena Tiron 20 June 2014.
Title: “The Role of the Axl Receptor Tyrosine Kinase in Breast Cancer”.
Main supervisor: Professor James B. Lorens.
Press release.


Tariq Al-Hadi Osman 4 June 2014.
Title: “Cancer stem cell-related markers in normal and neoplastic oral mucosa; a study on human samples and experimental models”.
Main supervisor: Professor Daniela Elena Costea. Co-supervisor: Anne Christine Johannessen.
Press release.


Øystein Helland 23 May 2015.
Title:  "Ovarian Cancer: A clinical challenge requiring basic answers. Development of an orthotopic ovarian xenograft model accessible to surgical intervention and exploring the role of Treg in evasion of immune destruction".
Main supervisor: Professor Line Bjørge. Co-supervisors: Professors Bjørn Tore Gjertsen and Emmet McCormack.
Press release. 


Henrica Maria Johanna Werner 20 May 2014.
Title: "Clinical and molecular markers in endometrial cancer. Studying prognostic and predictive biomarkers that can help to individualise therapeutic decisions".
Main supervisor: Professor Helga Salvesen. Co-supervisor: PhD Candidate Jone Trovik.
Press release.


Amani Hamza A. Osman 20 February 2014.
Title: "Characterization of the tumor stroma and stem cell niche in oral squamous cell carcinoma".
Main supervisor: Professor Anne Christine Johannessen. Co-supervisor: Professor Daniela Elena Costea.
Press release.


Åshild Lunde 7 February 2014.
Title: ″Tensions in Practice, Knowledge and Regulation: Genetic Counseling in Norway″.
Main supervisor: Professor Roger Strand. Co-supervisor: professor Karin Nordin.
Press release.




Hanne Eknes Puntervoll 11 December 2013.
Title: "Molecular studies of sporadic and hereditary cutaneous malignant melanoma”.
Main supervisors (50/50): Professors Anders Molven and Lars A. Akslen.
Press release.


Hanne Haslene-Hox 11 October 2013.
Title: “The microenvironment in human ovarian carcinoma - characterization through proteomic analysis of tissue interstitial fluid”.
Main supervisor: Professor Helge Wiig. Co-supervisors: Professor Helga Salvesen and Professor Olav Tenstad.
Press release.


Elisabeth Wik 30 September 2013.
Title:  “Endometrial carcinoma: a step closer to individualized therapy? Exploring transcriptional alterations in relation to prognostic biomarkers”.
Main supervisor: Professor Helga Salvesen. Co-supervisor: Professor Lars A.Akslen.
Press release.


Even Birkeland 20 September 2013.
Title: “Mutations and gene amplifications in endometrial carcinomas. Clinical characteristics and potential targets for therapy related to KRAS, MYC, ATAD2, PIK3CA and FGFR2 alterations”.
Main supervisor: Professor Helga Salvesen. Co-supervisor: Associate Professor Camilla Krakstad.
Press release.


Jørn Skavland 30 August 2013.
Title:  "Risk stratification and therapy response monitoring by phosphoprotein profiles in acute myeloid leukaemia".
Main supervisor: Professor Bjørn Tore Gjertsen. Co-supervisor: Professor Øystein Bruserud.
Press release.