Combining indoor residual spraying and long-lasting insecticidal nets for preventing malaria
This research aims to improve malaria control by evaluating the combined effect of indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) on malaria incidence in Ethiopia.
The proposal aims to assess whether the combined use of mosquito nets and indoor residual spraying (IRS) increases protection against malaria. The proposal is to conduct a two-armed cluster randomised controlled trial in Ethiopia to measure malaria incide nce and transmission, insecticide resistance, and to assess whether mosquito nets result in an age shift in malaria morbidity before and after trials. We shall also measure the entomological inoculation rates (EIR).
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We will use a cluster randomised cont rolled study design in the Adami Tullu area in the Ethiopian Rift Valley. The village will be the unit for randomisation. The intervention will consist of villages (clusters) receiving both IRS and long-lasting insecticidal nets (LLINs) while the control communities will use LLINs only. The cost-effectiveness study will be performed prospectively alongside the trial.
Our proposal addresses the core areas of the call by targeting malaria, a disease that contributes substantially to ill health and death i n children and adults in sub-Saharan Africa. More than just an intervention development programme by conducting epidemiological studies of malaria in Ethiopia, the research addresses important topics for the delivery of Millennium Development Goals (MDG 4 and 6).