Language of instruction
This course will provide broad understanding of aspects of cancer genome biology and their investigation by next generation sequencing (NGS) technologies. Methods for analysing DNA variation and structure and RNA expression patterns will be covered, as well as nuclear and chromatin structure. Also ethical, legal aspects, and hereditary predisposition will be taught.
Upon completing this course the candidate should have:
- What kinds of mutations may predispose for, contribute to, or appear during cancer development
- How these variants can be detected by NGS methods and be analysed bioinformatically
- How to employ these methods to stratify patients both diagnostically and therapeutically
- The different implications of the same aberrations depending on tissue type
- Ethical and legal regulations regarding genetic analyses of patient samples
- Can formulate problems, plan and carry out NGS analyses on samples from cancer patients.
- Be able to assess the expediency and application of different NGS methods in cancer diagnostics and research
- To know the contact points for NGS analysis and data storage and analysis in the Bergen area
- Be able to communicate relevant literature and methods concerning cancer genomics
- Be able to evaluate how knowledge about genome aberrations can help in understanding tumor biological mechanisms and as a guide to improved diagnosis, targeted treatment and follow up of cancer patients.
Once per year (spring)
3 ECTS (50-60 hours student work time)
Course registration and deadlines
Registration through this link.
Master's degree or equivalent education level is required, with the exception of students on the Medical Student Research Programme.
Recommended previous knowledge
Medical or health related educational background or PhD project related to medical / health related research. Basic knowledge of cancer and cell biology is required.
Part of training component
Recommended as part of the training component for all candidates affiliated with the Research School for Cancer Studies (RSCS)
Form of assessment
To pass the course, the candidate must:
- participate during at least 90% of the course
- participate actively in the group
- complete a multiple choice exam (you have 24 hours to complete the exam)
pass / fail
Who may participate
The course is primarily intended for PhD candidates who are affiliated with the Centre for Cancer Biomarkers (CCBIO), but is also open to other students, PhD candidates and students at the Medical Student Research Program.
3 full days with lectures and seminars
Group discussions with individual presentations
Reading curriculum (see mandatory reading)
Kjetil Utvik Harkestad
The literature curriculum can be found through this link .