Neuroscience Research Group
Our main interest is to elucidate the molecular control of synaptic
plasticity (experience-dependent changes in synaptic strength and
structure) in the healthy adult brain as well as during disease.
Dysregulation of synaptic plasticity is recognized to be involved in the
disease process of both neurological and neuropsychiatric disease.
We are using a multidisciplinary approach that combines
electrophysiological studies in live rats, mice and brain slices with
molecular, biochemical and imaging techniques including time-lapse
multiphoton microscopy to study proteins that play a key regulatory role
in synaptic plasticity. Arc (activity-regulated cytoskeleton-associated
protein) is one of these proteins and we are focusing our research on
characterizing the protein in detail addressing questions such as
regulation of activity, modifications, interaction network and genetic
contribution to disease.