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Mechanism of tissue and tumor fibrosis (MOTIF)
2018 Conference

SF Fibrosis Conference, 2018

The role of the fibrotic stroma - barrier or support?

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SF Fibrosis conference 2018
Photo:
Elisabeth Hove
1/13
Donald Gullberg at the SF conference 2018
Photo:
Elisabeth Hove
2/13
Christhopher McCulloch at the SF conference 2018
Photo:
Donald Gullberg
3/13
Boris Hinz
Photo:
Donald Gullberg
4/13
Dean Sheppard
Photo:
Donald Gullberg
5/13
Roya Navab at the SF conference 2018
Photo:
Donald Gullberg
6/13
Valerie Weaver
Photo:
Donald Gullberg
7/13
Zena Werb
Photo:
Donald Gullberg
8/13
Tammy Chang at the SF conference 2018
Photo:
Donald Gullberg
9/13
Ori Malle at the SF conference 2018
Photo:
Donald Gullberg
10/13
Eduard Gorina at the SF conference 2018
Photo:
Donald Gullberg
11/13
Donald Gullberg at the SF conference 2018
Photo:
Elisabeth Hove
12/13
San Fransisco from Marin Headlands
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San Fransisco from Marin Headlands
13/13
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SIU Fibrosis conference, June 7-8, 2018

San Francisco

Venue: Aldea conference centre, UCSF

Organizers: Donald Gullberg and Valerie Weaver

June 7thSession 1a. Cell-ECM interactions - Chair: C.McCulloch (UoT)Notes
8.30 – 9.10am1. Donald Gullberg, University of Bergen
Integrin α11β1 - a fibroblast protein with a role in fibrosis
 
9.15 – 9.55am2. Andrew Leask, University of Western Ontario
Fibroblast-specific expression of CCN2 is required for activation of cancer asssociated-fibroblasts, angiogenesis and metastasis in a murine mode of melanoma
External
10.00-10.20amCoffee 
 Session 1b. Cell-ECM interactions - Chair: D.Gullberg (UiB, UCSF) 
10.20-11.00am3. Christopher McCulloch, University of Toronto
Role of Flightless in Remodeling of the Fibrotic Stroma
 
11.05-11.45am4. Boris Hinz, University of Toronto
Macrophage-Myofibroblast (Mis-) Communication
External
11.50-12.305. Dean Sheppard, UCSF
Targeting TGFbeta-activing integrins to treat tissue fibrosis and cancer
 
12.35-1.00pmLunch 
 Session 2a. Tumor stroma associated fibrosis - Chair: V.Weaver (UCSF) 
1.00-1.40pm6. Roya Navab, University of Toronto
Desmoplasia is associated with poor prognosis and carcinoma-associated fibroblasts heterogeneity in non-small cell lung cancer
 
1.45-2.25pm7. Valerie Weaver, UCSF
Tumor stiffness and hypoxia
 
2.30-3.05pm8. Neil Bhowmick, Cedars Sinail Medical Centre, LA
The role of glutamine in fibroblastic activation and tumor progression
External
3.10-3.25pmCoffee 
 Session 2b. Tumor stroma associated fibrosis - Chair: D. Sheppard (UCSF) 
3.25-4.05pm9. Zena Werb, UCSF
Tissue fibrosis and hypoxia in aggressive, basal-like breast cancers
 
4.10-4.50pm10. Tushar Desai, Stanford
Mapping Wnt signaling niches at cellular resolution in intact lung during IPF progression
External
4.55-5.30pmBusiness meeting SIU - Upcoming student exchanges 
7.00 pmDinner for speakers and some other invited guests 
June 8thSession 3a. Mechanisms of fibrosis - Chair: B. Hinz (UoT) 
8.30 - 9.10am11. Ari Molofsky, UCSF
Mesenchymal - immune crosstalk at lymphocyte tissue niches
 
9.15 - 9.55am12. Yang Chen, MD Anderson Cancer Centre, Houston
Fibrosis and Cancer Metastasis
External
10.00-10.20amCoffee 
 Session 3b. Mechanisms of fibrosis - Chair: R. Navab (UoT) 
10.20-10.50am13. Tien Peng, UCSF
Stromal diversity and plasticity in the maintenance of organ function andfibrotic repair
 
10.55-11.30am14.Tammy Chang, UCSF
The Role of Focal Adhesion Kinase in Hepatic Fibrogenesis
 
11.35-12.1015. Ori Maller, UCSF
A reciprocal interplay between tissue fibrosis and tumor immunity in breast cancer
 
12.15-1.00pmLunch 
 Session 4. Emerging anti-fibrotic therapies - Chair: S. Porter (Fibrogen) 
1.00-1.40pm16. Bernard Coulie, Pliant Therapeutics    
Developing target engagement and inhibition tools to de-risk the clinical development of a dual selective αvβ6/αvβ1 integrin inhibitor in IPF and otherfibrotic diseases
 
1.45-2.25pm17. Eduard Gorina, Fibrogen
Pamrevlumab vs placebo in patients with IPF. Results of a Phase 2 Clinical Trial
 
2.30-3.10pm18. Kenneth E. Lipson, Fibrogen
Activity and mechanism of pamrevlumab (anti-CTGF) in a mouse radiation-induced lung fibrosis model
 
3.15-3.35pmCoffee

Financed: SIU