Agnete S. T. Engelsen
- E-mailAgnete.Engelsen@uib.no
- Visitor AddressHaukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst5009 Bergen
- Postal AddressPostboks 78045020 Bergen
Immunforsvarets frontliner
A field report from Engelsen's research stay at the French Research Institute Gustave Roussy (Paris, France) in the norwegian journal Forskerforum explains how we aim to engage the immune system in the eradication of cancers. (Article by Kjerstin Gjengedal).
On a quest to cure cancer
'The premature death from cancer of a close friend and colleague, made Agnete Engelsen even more determined to find a way to cure this devastating disease.'
The PhD interview/ cancer research. Article in the UiB Magazine by Jens Helleland Ådnanes.
Read more about my opportunity to participate in the High-Impact Cancer Research (HICR): Cancer, Biology and Therapeutics Program at Harvard Medical School -a truly inspirational postgraduate medical education program!
Translational Cancer Research requires a wide range of standaard and advanced methodologies. Read more about the excitement and international participation at the first fully web-based version of CCBIO 905 Methods in Cancer Biomarker Research. This course is part of The CCBIO Research School for Cancer Studies.
Great excitement at the Research fair in Bergen
Excited children and adults crowded the Research Fair when researchers at the Center for Cancer Biomarkers (CCBIO) displayed living cancer cells in the microscope and performed a play about the cancer cell Greedy Frieda.
Read more about the research communication in the newspaper Studvest
Online teaching/ courses: Read more about the first fully web-based version of CCBIO905: Methods in Cancer Biomarker Research
Academic responsibility:
CCBIO901 Junior Scientist Symposium, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
MED1BIOMED Biomedisinske Tema, Mandatory MD course, Department of Biomedicine, UiB
CCBIO905 Methods in Cancer Biomarker Research, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
HUCEL 320 Cell culture and cellular techniques: Flow Cytometry, Master course, Department of Biomedicine, UiB
Individual lectures:
BMED331 Tumor biology, Master course, Department of Biomedicine, UiB
MED1BIOMED Biomedisinske Tema, Mandatory MD course, Department of Biomedicine, UiB
CCBIO905 Methods in Cancer Biomarker Research, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
BZL 256 Embryology, Department of Zoology, UiB
MED1BAS, FARM 260/NUTR, ODONT, Histology Mandatory preclinical MD lab courses, Department of Biomedicine, UiB
- (2022). Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models. Frontiers in Oncology. 1-24.
- (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. Frontiers in Cellular and Infection Microbiology. 1-23.
- (2022). Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition. Frontiers in Immunology. 24 pages.
- (2022). Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway. Frontiers in Cell and Developmental Biology. 1-23.
- (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. Physiological Reports.
- (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. Cancers. 24 pages.
- (2020). AXL is a driver of stemness in normal mammary gland and breast cancer. iScience. 1-40.
- (2020). AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. Journal of Thoracic Oncology. 973-999.
- (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC. Cancer & Metabolism.
- (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. British Journal of Cancer. 545-555.
- (2019). AXL targeting overcomes human lung cancer cell resistance to NK- And CTL-mediated cytotoxicity. Cancer immunology research. 1789-1802.
- (2018). Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. Frontiers in Cell and Developmental Biology.
- (2018). Cancer Immunotherapy 2017 (Paris, France). Progress and challenges. Bulletin du Cancer. 537-541.
- (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology. 57-70.
- (2017). Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts. PLOS ONE. 1-19.
- (2014). U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells . Cancer Medicine. 812-824.
- (2014). NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. Journal of Immunology. 6192-6206.
- (2011). Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. PLOS ONE. 14 pages.
- (2011). Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathologica. 495-510.
- (2010). Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Research. 4274-4279.
- (2009). Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Research. 5331-5339.
- (2008). The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. Oncogene. 5182-5194.
- (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 761-768.
- (2008). A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. The FASEB Journal. 3120-3128.
- (2006). Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. Journal of Gene Medicine. 1131-1140.
- (2010). Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter. Cancer Research. 6393-6396.
- (2023). Predictive Biomarkers Beyond Next Generation Sequencing: Functional Testing of Homologous Recombination Repair Deficiency Status in Patient-Derived Tissue Cultures.
- (2023). Disrupting the metabolic homeostasis of lung cancer to increase the efficacy of immune checkpoint inhibition.
- (2021). Human organotypic airway and lung organoids for the study of SARS-CoV-2 infectivity and cytopathology.
- (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment.
- (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment.
- (2019). The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis.
- (2013). Intratumoural Heterogeneity of Glioblastoma. Implications of Immature Phenotypes on Tumour Growth and Resistance to Treatment.
- (2020). Autophagy mediated danger signaling regulates tumor immunosurveillance and may potentiate the effects of anti-cancer immunotherapy through increased adjuvanticity. 22 pages.
- (2017). The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance. 28 pages.
- (2010). NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. Neuro-Oncology. 8-8.
- (2009). Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. Neuro-Oncology. 221-222.
- (2009). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. Neuro-Oncology. 917-917.
- (2008). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. Neuro-Oncology. 778-778.
- (2021). Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival. Cancers.
- (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) . Autophagy. 1-382.
- (2020). Hypoxia-driven intratumor heterogeneity and immune evasion. Cancer Letters. 1-10.
- (2020). Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade. Cancer Drug Resistance. 22 pages.
- (2017). Adaptive mechanisms of resistance to anti-neoplastic agents. MedChemComm. 53-66.
More information in national current research information system (CRIStin)