• E-mailAgnete.Engelsen@uib.no
  • Phone+47 975 15 414
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen

Immunforsvarets frontliner

A field report from Engelsen's research stay at the French Research Institute Gustave Roussy (Paris, France) in the norwegian journal Forskerforum explains how we aim to engage the immune system in the eradication of cancers. (Article by Kjerstin Gjengedal). 

On a quest to cure cancer

'The premature death from cancer of a close friend and colleague, made Agnete Engelsen even more determined to find a way to cure this devastating disease.'

The PhD interview/ cancer research. Article in the UiB Magazine by Jens Helleland Ådnanes. 

Great excitement at the Research fair in Bergen

Excited children and adults crowded the Research Fair when researchers at the Center for Cancer Biomarkers (CCBIO) displayed living cancer cells in the microscope and performed a play about the cancer cell Greedy Frieda.

Read more about the research communication in the newspaper Studvest


CCBIO901 PhD course, Junior Scientist Symposium

MED1BIOMED, Mandatory MD course, Biomedisinske Tema

BMED331 Master course, Tumor biology

Academic article
  • Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit; Helwa, Reham; Tan, Tuan Zea; Lotsberg, Maria Lie; Pettersen, Ina Katrine Nitschke; Berg, Anna; Kindt, Charlotte; Hoel, Fredrik; Jacobsen, Kristine; Arason, Ari Jon; Engelsen, Agnete; Ditzel, Henrik J.; Lønning, Per Eystein; Krakstad, Camilla; Thiery, Jean Paul; Lorens, James; Knappskog, Stian; Tronstad, Karl Johan. 2019. Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC. Cancer & Metabolism.
  • Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn; Engelsen, Agnete; Bindesbøll, Christian; Sarowar, Shahin; Bahador, Marzieh; Bifulco, Ersilia; Goplen, Dorota; Waha, Andreas; Lie, Stein Atle; Gjertsen, Bjørn Tore; Selheim, Frode; Enger, Per Øyvind; Simonsen, Anne; Enger, Martha Chekenya. 2019. Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. British Journal of Cancer. 545-555.
  • Terry, Stéphane; Abdou, Abderemane; Svendsen, Agnete; Buart, Stéphanie; Dessen, Philippe; Corgnac, Stéphanie; Collares, Davi; Meurice, Guillaume; Gausdal, Gro; Baud, Véronique; Saintigny, Pierre; Lorens, James; Thiery, Jean Paul; Mami-Chouaib, Fathia; Chouaib, Salem. 2019. AXL targeting overcomes human lung cancer cell resistance to NK- And CTL-mediated cytotoxicity. Cancer immunology research. 1789-1802.
  • Jokela, Tiina; Svendsen, Agnete; Rybicka, Agata; Pelissier, Fanny; Garbe, James C.; Miyano, Masaru; Tiron, Crina Elena; Ferariu, Dan; Akslen, Lars A.; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. 2018. Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. Frontiers in Cell and Developmental Biology.
  • Chouaieb, Elyes; Terry, Stéphane; Corgnac, Stephanie; Svendsen, Agnete. 2018. Cancer Immunotherapy 2017 (Paris, France). Progress and challenges. Bulletin du Cancer. 537-541.
  • Bozickovic, Olivera; Skartveit, Linn; Svendsen, Agnete; Helland, Thomas; Jonsdottir, Kristin; Flågeng, Marianne Hauglid; Fenne, Ingvild Sveinsgjerd; Janssen, Emiel; Lorens, James; Bjørkhaug, Lise; Sagen, Jørn V.; Mellgren, Gunnar. 2018. A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology. 57-70.
  • Sletta, Kristine Yttersian; Tveitarås, Maria Kathrine; Lu, Ning; Svendsen, Agnete; Reed, Rolf K.; Garmann-Johnsen, Annette; Stuhr, Linda Elin Birkhaug. 2017. Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts. PLOS ONE. 1-19.
  • Torsvik, Anja; Stieber, Daniel; Enger, Per Øyvind; Golebiewska, Anna; Molven, Anders; Svendsen, Agnete; Westermark, Bengt; Niclou, Simone P; Olsen, Thale Kristin; Enger, Martha Chekenya; Bjerkvig, Rolf. 2014. U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells . Cancer Medicine. 812-824.
  • Gras Navarro, Andrea; Kmiecik, Justyna; Leiss, Lina Wik; Zelkowski, Mateusz; Engelsen, Agnete; Bruserud, Øystein; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha. 2014. NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. Journal of Immunology. 6192-6206.
  • Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike ; Skaftnesmo, Kai Ove; Planaguma, Jesus; Reed, Rolf K.; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Brekke, Cecilie; Chekenya, Martha. 2011. Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. PLOS ONE. 14 pages.
  • Svendsen, Agnete; Verhoeff, Joost JC; Immervoll, Heike ; Brøgger, Jan C; Kmiecik, Justyna; Poli, Aurélie; Netland, Inger Anne; Prestegarden, Lars; Planaguma, Jesus; Torsvik, Anja; Kjersem, Anneli Bohne; Sakariassen, Per Øystein; Heggdal, Jan Ingemann; van Furth, Wouter R; Bjerkvig, Rolf; Lund-Johansen, Morten; Enger, Per Øyvind; Felsberg, Joerg; Brons, Nicolas H.C.; Tronstad, Karl Johan; Waha, Andreas; Chekenya, Martha. 2011. Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathologica. 495-510.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Sleire, Linda; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Yan, Tao; Askland, Lasse Haugen; Persson, Andreas; Sakariassen, Per Øystein; Enger, Per Øyvind. 2010. Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Research. 4274-4279.
  • Røsland, Gro Vatne; Svendsen, Agnete; Torsvik, Anja; Sobala, Ewa; McCormack, Emmet Martin; Immervoll, Heike ; Mysliwietz, Josef; Tonn, Jörg Christian ; Goldbrunner, Roland; Lønning, Per Eystein; Bjerkvig, Rolf; Schichor, Christian. 2009. Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Research. 5331-5339.
  • Chekenya, Martha; Krakstad, Camilla; Svendsen, Agnete; Netland, Inger Anne; Staalesen, Vidar; Tysnes, Berit Bølge; Selheim, Frode; Wang, Jian; Sakariassen, Per Øystein; Sandal, Tone; Lønning, Per Eystein; Flatmark, Torgeir; Enger, Per Øyvind; Bjerkvig, Rolf; Sioud, M; Stallcup, William B. 2008. The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. Oncogene. 5182-5194.
  • Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg; Immervoll, Heike; Bøe, Stig Ove; Svendsen, Agnete; Prestegarden, Lars; Røsland, Gro Vatne; Thorsen, Frits Alan; Stuhr, Linda Elin Birkhaug; Molven, Anders; Bjerkvig, Rolf; Enger, Per Øyvind. 2008. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 761-768.
  • Niclou, Simone P; Danzeisen, Claude; Eikesdal, Hans Petter; Wiig, Helge; Brons, Nicolaas HC; Poli, Aurélie MF; Svendsen, Agnete; Torsvik, Anja; Enger, Per Øyvind; Terzis, Jorge A; Bjerkvig, Rolf. 2008. A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. The FASEB Journal. 3120-3128.
  • Thorsen, Frits Alan; Afione, Sandra; Huszthy, Peter Csaba; Tysnes, Berit Bølge; Svendsen, Agnete; Bjerkvig, Rolf; Kotin, Robert M.; Lønning, Per Eystein; Hoover, Frank. 2006. Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. Journal of Gene Medicine. 1131-1140.
Reader opinion piece
  • Torsvik, Anja; Røsland, Gro Vatne; Svendsen, Agnete; Molven, Anders; Immervoll, Heike ; McCormack, Emmet Martin; Lønning, Per Eystein; Primon, Monica; Sobala, Ewa; Tonn, Jörg Christian ; Goldbrunner, Roland; Schichor, Christian; Mysliwietz, Josef; Lah, Tamara; Motaln, Helena; Knappskog, Stian; Bjerkvig, Rolf. 2010. Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter. Cancer Research. 6393-6396.
Masters thesis
  • Rayford, Austin James. 2019. The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis.
Doctoral dissertation
  • Engelsen, Agnete Svendsen Tenfjord. 2013. Intratumoural Heterogeneity of Glioblastoma. Implications of Immature Phenotypes on Tumour Growth and Resistance to Treatment.
Academic chapter/article/Conference paper
  • Lotsberg, Maria Lie; Chen, Sandy; Dhakal, Sushil; Lorens, James; Baguley, Bruce; Chouaib, Salem; Svendsen, Agnete. 2020. Autophagy mediated danger signaling regulates tumor immunosurveillance and may potentiate the effects of anti-cancer immunotherapy through increased adjuvanticity. 22 pages.
  • Davidsen, Kjersti; Haaland, Gry Sandvik; Lie, Maria Kolnes; Lorens, James; Svendsen, Agnete. 2017. The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance. 28 pages.
  • Chekenya, Martha; Netland, Inger Anne; Verhoeff, Joost JC; Svendsen, Agnete; Brøgger, Jan; Immervoll, Heike ; Planaguma, Jesus; Kjersem, Anneli Bohne; Sakariassen, Per Øystein; Bjerkvig, Rolf; Heggedal, JI; Enger, Per Øyvind; Tronstad, Karl Johan; van Furth, Wouter R. 2010. NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. Neuro-Oncology. 8-8.
  • Wang, Jian; Tsinkalovsky, Oleg; Svendsen, Agnete; Prestegarden, Lars; Bjerkvig, Rolf; Enger, Per Øyvind. 2009. Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. Neuro-Oncology. 221-222.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Askland, L; Persson, A; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Hovland, Randi; Enger, Per Øyvind. 2009. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. Neuro-Oncology. 917-917.
  • Prestegarden, Lars; Svendsen, Agnete; Wang, Jian; Lasse, A; Andreas, P; Oystein, SP; Skaftnesmo, KO; Randi, H; Enger, Per Øyvind. 2008. CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. Neuro-Oncology. 778-778.
Academic literature review
  • Ferreira, Bibiana I.; Lie, Maria Kolnes; Svendsen, Agnete; Machado, Susana; Link, Wolfgang; Lorens, James. 2017. Adaptive mechanisms of resistance to anti-neoplastic agents. 53-66.

More information in national current research information system (CRIStin)

Research groups