- E-mailAlf.Larsen@uib.no
- Phone+47 51 51 80 00
- Visitor AddressHaukeland universitetssykehus, Laboratoriebygget5009 Bergen
- Postal AddressPostboks 78045020 Bergen
Academic article
- (2022). Reassured on a background of vulnerability - people with microvascular angina 12 months after high-intensity physical exercise program. International Journal of Qualitative Studies on Health and Well-being. 12 pages.
- (2022). QRS fragmentation is associated with increased risk of ventricular arrhythmias in high-risk patients; Data from the SMASH 1 Study. Annals of Noninvasive Electrocardiology. 10 pages.
- (2022). Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study. BMJ Open. 13 pages.
- (2022). Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial. BMC Cardiovascular Disorders. 10 pages.
- (2022). Guideline-Recommended Time Less Than 90 Minutes From ECG to Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Is Associated with Major Survival Benefits, Especially in Octogenarians: A Contemporary Report in 11 226 Patients from NORIC. Journal of the American Heart Association (JAHA). 12 pages.
- (2022). Adding stress biomarkers to high-sensitivity cardiac troponin for rapid non-ST-elevation myocardial infarction rule-out protocols. European Heart Journal: Acute Cardiovascular Care. 201-212.
- (2021). Rationale and design of the PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial: a randomized, placebo-controlled, multicenter trial. Cardio-Oncology. 11 pages.
- (2021). Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study. The Lancet. 985-995.
- (2021). Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction. ESC Heart Failure. 2183-2192.
- (2021). Burden of treatment in patients with chronic heart failure – A cross-sectional study. Heart & Lung. 369-374.
- (2021). Blood Lactate AUC Is a Sensitive Test for Evaluating the Effect of Exercise Training on Functional Work Capacity in Patients with Chronic Heart Failure. Rehabilitation Research and Practice. 1-6.
- (2020). Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. Annals of Noninvasive Electrocardiology.
- (2020). Rethinking rehabilitation after percutaneous coronary intervention: a protocol of a multicentre cohort study on continuity of care, health literacy, adherence and costs at all care levels (the CONCARDPCI). BMJ Open. e031995.
- (2020). Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size. European Heart Journal: Acute Cardiovascular Care. 302-312.
- (2020). Increased functional capacity after 12 weeks of exercise training does not transform into improved skeletal muscle metabolism or ultrastructure in heart failure patients on modern optimal medical therapy. European Journal of Preventive Cardiology (EJPC). 1-7.
- (2020). Exploration of plasma lipids in mild cognitive impairment due to Alzheimer's disease . Journal of Alzheimer's Disease. 1117-1127.
- (2020). Effects of purified anthocyanins in people at risk for dementia: Study protocol for a phase II randomized controlled trial. Frontiers in Neurology. 1-10.
- (2020). Cardiac arrest as a reportable condition: A cohort study of the first 6 years of the Norwegian out-of-hospital cardiac arrest registry. BMJ Open. 1-7.
- (2019). Plasma tumour necrosis factor correlates with mRNA expression of tumour necrosis factor and mitochondrial transcription factors in skeletal muscle in patients with chronic heart failure treated with cardiac resynchronization therapy: potential role in myopathy. European Journal of Preventive Cardiology (EJPC). 1-5.
- (2019). Effects of interval training on inflammatory biomarkers in patients with ischemic heart failure. Scandinavian Cardiovascular Journal. 213-219.
- (2019). Effects of anthocyanin supplementation on serum lipids, glucose, markers of inflammation and cognition in adults with increased risk of dementia - A pilot study. Frontiers in Genetics. 1-11.
- (2019). Baseline and Exercise Predictors of VO2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF. Medicine & Science in Sports & Exercise. 810-819.
- (2019). BEtablocker Treatment After acute Myocardial Infarction in revascularized patients without reduced left ventricular ejection fraction (BETAMI): Rationale and design of a prospective, randomized, open, blinded end-point study. American Heart Journal. 37-46.
- (2019). Automatic estimation of coronary blood flow velocity step 1 for developing a tool to diagnose patients with micro-vascular angina pectoris. Frontiers in Cardiovascular Medicine. 1-11.
- (2018). The significance of ST-elevation in aVL in anterolateral myocardial infarction: An assessment by cardiac magnetic resonance imaging. Annals of Noninvasive Electrocardiology. 1-7.
- (2018). Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction. Journal of Electrocardiology. 195-202.
- (2018). Correlation of anteroseptal ST elevation with myocardial infarction territories through cardiovascular magnetic resonance imaging. Journal of Electrocardiology. 563-568.
- (2017). Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: A randomized clinical trial. Journal of the American Medical Association (JAMA). 341-350.
- (2017). Intracoronary autologous bone marrow cell transfer after myocardial infarction: The BOOST-2 randomised placebo-controlled clinical trial. European Heart Journal. 2936-2943.
- (2017). Impact of an exercise training program on cardiac neuronal function in heart failure patients on optimal medical therapy: A randomized Iodine-123 metaiodobenzylguanidine scintigraphy study. Journal of Nuclear Cardiology. 1-8.
- (2017). High-Intensity Interval Training in Patients with Heart Failure with Reduced Ejection Fraction. Circulation. 839-849.
- (2017). Appropriateness of anteroseptal myocardial infarction nomenclature evaluated by late gadolinium enhancement cardiovascular magnetic resonance imaging. Journal of Electrocardiology. 218-223.
- (2017). Administration of the Mitochondrial Permeability Transition Pore Inhibitor, TRO40303, prior to Primary Percutaneous Coronary Intervention, Does Not Affect the Levels of Pro-Inflammatory Cytokines or Acute-Phase Proteins. Cardiology. 122-132.
- (2016). Time-differentiated target temperature management after out-of-hospital cardiac arrest: A multicentre, randomised, parallel-group, assessor-blinded clinical trial (the TTH48 trial): Study protocol for a randomised controlled trial. Trials. 9 pages.
- (2016). Effects of aerobic interval training on measures of anxiety, depression and quality of life in patients with ischaemic heart failure and an implantable cardioverter defibrillator: A prospective non-randomized trial. Journal of Rehabilitation Medicine. 300-306.
- (2016). Effect of Vascular Risk Factors on the Progression of Mild Alzheimer's Disease and Lewy Body Dementia. Journal of Alzheimer's Disease. 575-584.
- (2016). Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease . New England Journal of Medicine. 1242-1252.
- (2016). Confronting one's vulnerability - patients with chest pain participating in a high-intensity exercise programme. Journal of Clinical Nursing (JCN). 2006-2015.
- (2016). A statistical analysis protocol for the time-differentiated target temperature management after out-of-hospital cardiac arrest (TTH48) clinical trial. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 1-8.
- (2015). The Localization and Characterization of Ischemic Scars in relation to the Infarct Related Coronary Artery Assessed by Cardiac Magnetic Resonance and a Novel Automatic Postprocessing Method. Cardiology Research and Practice. 9 pages.
- (2015). Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results. European Heart Journal. 112-119.
- (2015). Aerobic interval training in patients with heart failure and an implantable cardioverter defibrillator: a controlled study evaluating feasibility and effect. European Journal of Preventive Cardiology (EJPC). 296-303.
- (2014). Perceptions of healthcare professionals' support, shock anxiety and device acceptance among implantable cardioverter defibrillator recipients. Journal of Advanced Nursing. 2061-2071.
- (2014). Perceived support from healthcare professionals, shock anxiety and post-traumatic stress in implantable cardioverter defibrillator recipients. Journal of Clinical Nursing (JCN). 450-460.
- (2014). Comparison of Outcomes in Patients with ST-Segment Elevation Myocardial Infarction Discharged on Versus Not on Statin Therapy (from the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction Trial). American Journal of Cardiology. 1273-1279.
- (2013). Long-term prognosis of patients presenting with ST-segment elevation myocardial infarction with no significant coronary artery disease (from The HORIZONS-AMI Trial). American Journal of Cardiology. 643-648.
- (2013). Factors predicting the use of therapeutic hypothermia and survival in unconscious out-of-hospital cardiac arrest patients admitted to the ICU. Critical Care. 10 pages.
- (2013). Cardiac resynchronization therapy improves minute ventilation/carbon dioxide production slope and skeletal muscle capillary density without reversal of skeletal muscle pathology or inflammation. Europace. 857-864.
- (2012). Shock anxiety among implantable cardioverter defibrillator recipients with recent tachyarrhythmia. Pacing and Clinical Electrophysiology. 1369-1376.
- (2012). Rationale and Design of the 'MITOCARE' Study: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRO40303 for the Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction. Cardiology. 201-207.
- (2012). Increased confidence to engage in physical exertion: older ICD recipients' experiences of participating in an exercise training programme. European Journal of Cardiovascular Nursing. 261-268.
- (2011). Response of growth differentiation factor-15 to percutaneous coronary intervention and regular exercise training. Scandinavian Cardiovascular Journal. 27-32.
- (2011). Inflammatory response to percutaneous coronary intervention in stable coronary artery disease. Journal of Thrombosis and Thrombolysis. 92-98.
- (2011). High intensity interval training reduces systemic inflammation in post-PCI patients. European Journal of Cardiovascular Prevention & Rehabilitation. 850-857.
- (2011). Endothelial dysfunction predicts clinical restenosis after percutaneous coronary intervention. Scandinavian Cardiovascular Journal. 139-145.
- (2010). Variations in population-based levels of C-reactive protein, cardiovascular morbidity and all-cause mortalitystar, open: An analysis of the relationship between C-reactive protein, Troponin-T, cardiovascular morbidity and death rates in an unselected population in Southwest Norway. International Journal of Cardiology. 247-249.
- (2010). The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication. Thrombosis Journal.
- (2010). Reversible fetal renal failure after maternal treatment with Candesartan: A case report. Reproductive Toxicology. 381-382.
- (2010). Coronary blood flow and perfusion pressure during coronary angiography in patients with ongoing mechanical chest compression: a report on 6 cases. Resuscitation. 493-497.
- (2010). A history of late and very late stent thrombosis is not associated with increased activation of the contact system, a case control study. Thrombosis Journal. 6.
- (2009). Microvascular obstruction is a major determinant of infarct healing and subsequent left ventricular remodelling following primary percutaneous coronary intervention. European Heart Journal. 1978-1985.
- (2009). High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation: A randomized controlled trial evaluating the relationship to endothelial function and inflammation. American Heart Journal. 734-741.
- (2009). B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart failure. International Journal of Cardiology. 358-362.
- (2009). B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart failure. International Journal of Cardiology. 358-362.
- (2008). Effect of exercise training on chromogranin A and relationship to N-ANP and inflammatory cytokines in patients with chronic heart failure. International Journal of Cardiology. 117-120.
- (2008). Effect of exercise training on chromogranin A and relationship to N-ANP and inflammatory cytokines in patients with chronic heart failure. International Journal of Cardiology. 117-120.
- (2008). Change to a primary PCI program increases number of patients offered reperfusion therapy and significantly reduces mortality. A real life experience evaluating the initiation of a primary PCI service at a single center without on site heart surgery in Western Norway. International Journal of Cardiology. 208-213.
- (2007). Trening etter perkutan koronar intervensjon en undervurdert behandlingsmulighet. Tidsskrift for Den norske legeforening. 1365-1367.
- (2007). Cardiac arrest with continuous mechanical chest compression during percutaneous coronary intervention A report on the use of the LUCAS device. Resuscitation. 454-459.
- (2007). Anomalies of the coronary arteries originating from the right sinus of Valsalva (1) Single coronary artery originating from the right sinus associated with fusion of the left and the non coronary cusp and atrophy of the left coronary ostium (2)Three separate coronary arteries originating from the right sinus of Valsalva. International Journal of Cardiology. e86-e89.
- (2006). The effect of altering haemodynamics on the plasma concentrations of natriuretic peptides in heart failure. European Journal of Heart Failure. 628-633.
- (2006). The effect of altering haemodynamics on the plasma concentrations of natriuretic peptides in heart failure. European Journal of Heart Failure. 628-633.
- (2006). Nonemergent coronary angioplasty without on-site surgical backup: A randomized study evaluating outcomes in low-risk patients. American Heart Journal. 888-895.
- (2006). Late complications following the deployment of drug eluting stents. International Journal of Cardiology. 398-401.
- (2006). Large and small vessel vasoconstriction following coronary artery stenting - Effect of intra coronary nitroglycerine and relation to LDL cholesterol. International Journal of Cardiology. 61-65.
- (2005). Persistent left superior vena cava. Use of an innominate vein between left and right superior caval veins for the placement of a right ventricular lead during ICD/CRT implantation. European Heart Journal. 2178.
- (2005). Exercise training in congestive heart failure. A review of the current status. Minerva Cardioangiologica : a Journal on Cardiovascular Pathophysiology, Clinical Medicine and Therapy. 275-286.
- (2005). Characteristics and outcomes of patients with acute myocardial infarction and angiographically normal coronary arteries. American Journal of Cardiology. 261-263.
- (2004). Effect of exercise training in patients with heart failure: a pilot study on autonomous balance assessed by heart rate variability. Journal of Cardiovascular Risk. 162-167.
- (2004). Effect of exercise training in patients with heart failure: a pilot study on autonomic balance assessed by heart rate variability. Journal of Cardiovascular Risk. 162-167.
- (2003). Prognostic usefulness of an increase of N-terminal proatrial natriuretic peptide during exercise in patients with chronic heart failure. American Journal of Cardiology. 91-94.
- (1996). Pro-atrial natriuretisk faktor i plasma er prediktiv for klinisk status hos hjertesviktpasienter. Tidsskrift for Den norske legeforening. 1562-1566.
Lecture
- (2017). SEGMENTATION OF CORONARY ARTERIES FROM X-RAY ANGIOGRAPHY SEQUENCES DURING CONTRAST FLUID PROPAGATION BY IMAGE REGISTRATION.
Academic lecture
- (2022). Informing patients about potential adverse drug reactions after percutaneous coronary intervention reduces the occurrence of self-reported adverse drug reactions.
- (2016). A computer model for non-invasive heart diagnostics.
- (2014). Making sense of participating in an exercise training programme for chest pain patients with unexplained chest pain.
Editorial
- (2020). The pulse; from adagio to prestissimo; the prognostic importance of heart rate increase and its associations with cardiovascular risk factors. European Journal of Preventive Cardiology (EJPC). 520-525.
- (2018). The muscle hypothesis in heart failure revised: ‘The multisite training approach’. European Journal of Preventive Cardiology (EJPC). 1252-1256.
- (2017). Strength and aerobic exercise training in coronary artery disease; it's not `either-or? European Journal of Preventive Cardiology (EJPC). 1686-1691.
- (2012). Clinical and biomarker profile of trauma-induced secondary cardiac injury (Br J Surg 2012; 99: 789-797). British Journal of Surgery. 797-798.
Reader opinion piece
- (2016). Ut samme dag etter perkutan koronar intervensjon. Tidsskrift for Den norske legeforening. 384-385.
- (2012). Symptoms of anxiety and depression after percutaneous coronary intervention are associated with decreased heart rate variability, impaired endothelial function and increased inflammation. International Journal of Cardiology. 173-176.
- (2010). High-intensity interval exercise training improves heart rate variability in patients following percutaneous coronary intervention for angina pectoris. International Journal of Cardiology. 312-314.
Letter to the editor
- (2008). B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart failure. International Journal of Cardiology.
- (2004). Can sedentary patients with heart failure achieve the beneficial effect of exercise training without moving? European Heart Journal. 104-106.
- (2004). BNP in acute coronary syndromes: the heart expresses its suffering. European Heart Journal. 1284-1286.
Doctoral dissertation
- (2016). Exercise training in patients with heart failure and an implantable cardioverter defibrillator. Review of existing data, shock anxiety, feasibility and effects of an aerobic interval training intervention.
- (2004). Exercise training in congestive heart failure: evaluation of test protocols and effect on neurohormones, cytokines, heart rate variability and skeletal muscle histology.
Interview
- (2018). Vil bruke oljeteknologi - på hjertepasienter.
Academic chapter/article/Conference paper
- (2017). SEGMENTATION OF CORONARY ARTERIES FROM X-RAY ANGIOGRAPHY SEQUENCES DURING CONTRAST FLUID PROPAGATION BY IMAGE REGISTRATION.
Abstract
- (2021). Perceptions of efficacy and safety of generic medicines in patients after percutaneous coronary intervention. European Heart Journal.
- (2021). Communication of Potential Adverse Drug Reactions in Patients Undergoing Percutaneous Coronary Intervention. Circulation.
- (2020). Estimation of cardiac output from test-bolus during coronary computed tomography angiography: a personalized mathematical model. European Heart Journal. 3454-3454.
- (2019). Patients’ Perceptions of Generic Drugs After Percutaneous Coronary Intervention: A Multicentre Cohort Study. Circulation.
- (2012). Shock anxiety in ICD recipients: what is the impact of recent tachyarrhythmia - irrespective of shock exposure? European Journal of Cardiovascular Nursing. S10-S10.
- (2009). High Intensity Interval Training Reduces Late Luminal Loss Following Percutaneous Coronary Intervention With Stent Implantation. Journal of the American College of Cardiology. A258-A258.
- (2006). Calprotectin and S100A12 correlate with disease activity in rheumatoid arthritis, and S100A12 is associated with concomitant cardiovascular disease. Scandinavian Journal of Rheumatology. 40-40.
Poster
- (2019). Patients discharged on the same day following elective PCI report equal satisfaction using health related quality of life instruments as compared to usual care: results from a randomized trial. EHJ 2019; 40: Suppl. 1, P6527, ehz746.1117.
- (2018). Circulation. 2018;138:A12525. No Effect of Glycoprotein Platelet Inhibitors Administered During Primary PCI in Patients Included in the Norwegian Coronary Stent Trial.
- (2013). The relationship between perceived support from healthcare professionals, shock anxiety and device acceptance in implantable cardioverter defibrillator recipients.
- (2013). Perceived support from health care professionals, shock anxiety and posttraumatic stress in implantable cardioverter defibrillator recipients.
- (2012). Shock Anxiety among Implantable Cardioverter Defibrillator Recipients with Recent Tachyarrhythmia.
- (2012). Increased confidence to engage in physical exertion; older recipients’ experiences of participating in an exercise training programme.
- (2010). Patients admitted with ST-segment elevation myocardial Infarction and a normal or near normal coronary angiogram have a favorable prognosis: Analysis from HORIZONS-AMI trial. J Am Coll Cardiol 2010;55;A187.E1746 doi:10.1016/S0735-1097(10)61747-0.
- (2009). A history of late stent thrombosis is not associated with increased activation of the contact phase system. Journal of Thrombosis and Haemostasis 2009; Volume 7, Supplement 2: Abstract PP-MO-433.
- (2006). Primary PCI vs thrombolysis:An analysis of differences in outcome in a single centre without on site heart surgery in South-West Norway. Eur Heart J 2006, 27(Abstract Suppl), 315.
- (2006). Non-emergent coronary angioplasty without on-site surgical back-up: A randomized study evaluating outcomes in low-risk patients. Eur Heart J 2006, 27(Abstract Suppl), 517.
Errata
- (2021). Corrigendum: Effects of Anthocyanin Supplementation on Serum Lipids, Glucose, Markers of Inflammation and Cognition in Adults With Increased Risk of Dementia – A Pilot Study (Front. Genet., (2019), 10, (536), 10.3389/fgene.2019.00536). Frontiers in Genetics.
Academic literature review
- (2022). Myocardial Microvascular Physiology in Acute and Chronic Coronary Syndromes, Aortic Stenosis, and Heart Failure. Journal of Interventional Cardiology.
- (2021). Aortic calcification; from innocent bystander to independent predictor; the delicate balance in biology; da aaaCapo: Editorial accompanying 'Abdominal aortic calcification - from ancient friend to modern foe'. European Journal of Preventive Cardiology (EJPC). E20-E24.
- (2013). Is it safe to use TNF-α blockers for systemic inflammatory disease in patients with heart failure? Importance of dosage and receptor specificity. International Journal of Cardiology. 1719-1723.
- (2012). Exercise training and cardiac rehabilitation in patients with implantable cardioverter defibrillators: a review of current literature focusing on safety, effects of exercise training, and the psychological impact of programme participation. European Journal of Preventive Cardiology (EJPC). 804-812.
Article in business/trade/industry journal
- (2016). Kan pasienten skrives ut samme dag etter elektiv Percutan Koronar Intervensjon? Hjerteposten : fagtidsskrift for NSFs landsgruppe av kardiologiske sykepleiere.
- (2014). Kardial resynkroniseringsterapi ved hjertesvikt – norske retningslinjer. Tidsskrift for Den norske legeforening. E1-17.
More information in national current research information system (CRIStin)