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Asbjørn Svardal's picture

Asbjørn Svardal

Professor
  • E-mailAsbjorn.Svardal@uib.no
  • Phone+47 55 97 46 81
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • 2020. Rosuvastatin alters the genetic composition of the human gut microbiome. Scientific Reports. 1-9.
  • 2020. Increased fatty acid oxidation and mitochondrial proliferation in liver are associated with increased plasma kynurenine metabolites and nicotinamide levels in normolipidemic and carnitine-depleted rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1-8.
  • 2019. Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study. American Journal of Clinical Nutrition. 1239-1250.
  • 2019. The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection. The Journal of Heart and Lung Transplantation. 1097-1103.
  • 2019. Short-term activation of peroxisome proliferator-activated receptors α and γ induces tissue-specific effects on lipid metabolism and fatty acid composition in male Wistar rats. PPAR Research. 1-12.
  • 2019. Hyperoxia and lack of ascorbic acid deplete tetrahydrobiopterin without affecting NO generation in endothelial cells. Undersea & Hyperbaric Medicine. 509-519.
  • 2019. Decrease of tetrahydrobiopterin and NO generation in endothelial cells exposed to simulated diving. Undersea & Hyperbaric Medicine. 159-169.
  • 2019. Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome. Clinical Endocrinology. 810-815.
  • 2018. Serum carnitine metabolites and incident type 2 diabetes mellitus in patients with suspected stable angina pectoris. Journal of Clinical Endocrinology and Metabolism. 1033-1041.
  • 2018. Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice. Nutrition & Metabolism. 1-13.
  • 2018. A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis. PLOS ONE. 1-16.
  • 2017. Serum acylcarnitines and risk of cardiovascular death and acute myocardial infarction in patients with stable angina pectoris. Journal of the American Heart Association. 1-28.
  • 2017. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. Journal of Lipid Research. 1362-1373.
  • 2017. HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation. BMC Infectious Diseases. 1-8.
  • 2016. The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis. Atherosclerosis. 64-69.
  • 2016. Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice. Lipids in Health and Disease. 16 pages.
  • 2016. Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. Scientific Reports.
  • 2016. Microbiota-Dependent Marker TMAO Is Elevated in Silent Ischemia but Is Not Associated with First-Time Myocardial Infarction in HIV Infection. Journal of Acquired Immune Deficiency Syndromes. 130-136.
  • 2016. Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery. Metabolic Syndrome and Related Disorders. 197-201.
  • 2016. Low levels of short- and medium-chain acylcarnitines in HIV-infected patients. European Journal of Clinical Investigation. 408-417.
  • 2016. Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterology journal. 532-541.
  • 2015. Preanalytical stability of gemcitabine and its metabolite 2', 2'-difluoro-2'-deoxyuridine in whole blood-assessed by liquid chromatography tandem mass spectrometry. Journal of Pharmaceutical Sciences. 4427-4432.
  • 2015. Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure. Journal of Internal Medicine. 717-726.
  • 2015. Liquid chromatography/tandem mass spectrometry method for simultaneous quantification of eight endogenous nucleotides and the intracellular gemcitabine metabolite dFdCTP in human peripheral blood mononuclear cells. Journal of chromatography. B. 212-220.
  • 2015. Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study. Lipids in Health and Disease. 12 pages.
  • 2015. A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats. Mar. Drugs. Marine Drugs. 5706-5721.
  • 2014. Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults. Lipids in Health and Disease.
  • 2014. Hypolipidemic effect of dietary water-soluble protein extract from chicken: impact on genes regulating hepatic lipid and bile acid metabolism. European Journal of Nutrition. 193-204.
  • 2014. Hypolipidemic effect of dietary water-soluble protein extract from chicken: impact on genes regulating hepatic lipid and bile acid metabolism. European Journal of Nutrition. 193-204.
  • 2013. The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine. PLOS ONE. 9 pages.
  • 2013. Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α. European Journal of Nutrition. 1315-1325.
  • 2013. Hyperoxia but not ambient pressure decreases tetrahydrobiopterin level without affecting the enzymatic capability of nitric oxide synthase in human endothelial cells. European Journal of Applied Physiology. 1695-1704.
  • 2013. Fish Oil and the Pan-PPAR Agonist Tetradecylthioacetic Acid Affect the Amino Acid and Carnitine Metabolism in Rats. PLOS ONE. 9 pages.
  • 2013. Disturbed carnitine regulation in chronic heart failure - Increased plasma levels of palmitoyl-carnitine are associated with poor prognosis. International Journal of Cardiology. 1892-1899.
  • 2013. A salmon peptide diet alleviates experimental colitis as compared with fish oil. Journal of Nutritional Science (JNS). 1-8.
  • 2013. A fish protein hydrolysate alters fatty acid composition in liver and adipose tissue and increases plasma carnitine levels in a mouse model of chronic inflammation. Lipids in Health and Disease. 11 pages.
  • 2012. Stress and expression of cyclooxygenases (cox1, cox2a, cox2b) and intestinal eicosanoids, in Atlantic salmon. Fish Physiology & Biochemistry. 951-962.
  • 2012. Simultaneous quantification of tetrahydrobiopterin, dihydrobiopterin, and biopterin by liquid chromatography coupled electrospray tandem mass spectrometry. Analytical Biochemistry. 163-170.
  • 2012. Seasonal trends in adenylate nucleotide content in eggs of recruit and repeat spawning Atlantic cod (Gadus morhua L.) and implications for egg quality and buoyancy. Journal of Sea Research. 63-73.
  • 2012. Free carnitine and acylcarnitines in obese patients with polycystic ovary syndrome and effects of pioglitazone treatment. Fertility and Sterility. 1620-1626,e1.
  • 2012. Differential effects on nitric oxide synthase, heat shock proteins and glutathione in human endothelial cells exposed to heat stress and simulated diving. European Journal of Applied Physiology. 2717-2725.
  • 2012. Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats. Scandinavian Journal of Gastroenterology. 49-58.
  • 2012. Dietary supplementation of herring roe and milt enhances fatty acid catabolism in female mice transgenic for hTNFa. European Journal of Nutrition. 741-753.
  • 2011. Tetradecylthioacetic acid increases hepatic mitochondrial beta-oxidation and alters fatty acid composition in a mouse model of chronic inflammation. Lipids. 679-689.
  • 2011. Low-dose exposure to alkylphenols adversely affects the sexual development of Atlantic cod (Gadus morhua): Acceleration of the onset of puberty and delayed seasonal gonad development in mature female cod. Aquatic Toxicology. 136-150.
  • 2010. The combined impact of plant-derived dietary ingredients and acute stress on the intestinal arachidonic acid cascade in Atlantic salmon ( Salmo salar). British Journal of Nutrition. 851-861.
  • 2010. Simulated diving after heat stress potentiates the induction of heat shock protein 70 and elevates glutathione in human endothelial cells. Cell stress & chaperones (Print). 405-414.
  • 2010. Development of Atlantic cod (Gadus morhua) exposed to produced water during early life stages: Effects on embryos, larvae, and juvenile fish. Marine Environmental Research. 383-394.
  • 2009. Simulated diving after heat stress potentiates the induction of heat shock protein 70 and elevates glutathione in human endothelial cells. Cell stress & chaperones (Print).
  • 2009. Liquid chromatography-tandem mass spectrometry analysis of folate and folate catabolites in human serum. Clinical Chemistry. 1147-1154.
  • 2009. Analytical Recovery of Folate Degradation Products Formed in Human Serum and Plasma at Room Temperature. Journal of Nutrition. 1415-1418.
  • 2008. Measurement of folate in fresh and archival serum samples as p-aminobenzoylglutamate equivalents. Clinical Chemistry. 665-672.
  • 2007. Quantitative profiling of folate and one-carbon metabolism in large-scale epidemiological studies by mass spectrometry. Clinical Chemistry and Laboratory Medicine. 1737-1745.
  • 2007. Effects of alkylphenols on the reproductive system of Atlantic cod (Gadus morhua). Aquatic Toxicology. 207-218.
  • 2007. Effects of alkylphenols on glycerophospholipids and cholesterol in liver and brain from female Atlantic cod (Gadus morhua). Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 420-430.
  • 2006. Glutathione in blood cells decreases without DNA breaks after a simulated saturation dive to 250 msw. Aviation, Space and Environmental Medicine. 597-604.
  • 2005. Gas chromatography–mass spectrometry analysis of alkylphenols in cod (Gadus morhua) tissues as pentafluorobenzoate derivatives. Journal of Chromatography A. 255-268.
  • 2005. FLOW REDUCTION, SESTON DEPLETION, MEAT CONTENT AND DISTRIBUTION OF DIARRHETIC SHELLFISH TOXINS IN A LONG-LINE BLUE MUSSEL (MYTILUS EDULIS) FARM. Journal of Shellfish Research. 15-23.
  • 2004. Gas chromatography–mass spectrometry analysis of alkylphenols in produced water from offshore oil installations as pentafluorobenzoate derivatives. Journal of Chromatography A. 131-141.
  • 2004. Effects of alkylphenols on redox status in first spawning Atlantic cod (Gadus morhua). Aquatic Toxicology. 95-105.
  • 2004. Effects of alkylphenols on CYP1A and CYP3A expression in first spawning Atlantic cod (Gadus morhua). Aquatic Toxicology. 303-313.
  • 2002. Human TNF- alfa in transgenic mice induces differential changes in redox status and glutathione-regulating enzymes. The FASEB Journal. 1450-1452.
  • 2002. Additive toxicity of limonene and 50% oxygen and the role of glutathione in detoxification in human lung cells. Toxicology. 75-88.
  • 2000. The Effect of Glutathione Modulation on the Concentration of Homocysteine in Plasma of Rats. Pharmacology and Toxicology. 103-107.
  • 2000. Correlation between Plasma Total Homocysteine and Copper in Patients with Peripheral Vascular Disease. Clinical Chemistry. 385-391.
  • 1999. Glutathione modulation changes the penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine into the gastric mucosa of rats. Digestive Diseases and Sciences. 2063-2075.
  • 1999. Glutathione in the cellular defense of human lung cells exposed to hyperoxia and high pressure. Undersea & Hyperbaric Medicine. 75-85.
  • 1998. Toxicity of hyperoxia and high pressure on C3H/10T1/2 cells and effects on cellular glutathione. Undersea & Hyperbaric Medicine. 33-41.
  • 1998. Influence of treatment with aminoglutethimide on plasma and red-blood-cell gluthatione status in breast cancer patients. Cancer Chemotherapy and Pharmacology. 46-52.
  • 1997. Redox status of plasma homocysteine and related aminothiols in smoking and nonsmoking young adults. Clinical Chemistry. 1997-1999.
  • 1997. Glutathione and N-acetylcysteine reduce gastric mucosal blood flow in rats. Digestive Diseases and Sciences. 1765-1774.
  • 1995. Redox status and proteinbinding of plasma homocysteine and other aminothiols in patients with early peripheral vascular disease. Arteriosclerosis, Thrombosis and Vascular Biology. 232-240.
  • 1995. Increased levels of oxidized glutathione in CD4+ lymphocytes associated with disturbed intracellular redox balance in human immunodeficiency virus type 1 infection. Blood. 258-267.
  • 1995. Fully automated assay for cobalamin-dependent methylmalonyl CoA mutase. Clinical Chemistry. 1164-1170.
  • 1995. Decreased levels of total and reduced glutathione in CD4+ lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor system: possible immunopathogenic role of oxidative stress. Blood. 1383-1391.
  • 1994. Redox status and proteinbinding of plasma homocysteine and other aminothiols in patients with hyperhomocysteinemia due to cobalamin deficiency. American Journal of Clinical Nutrition. 631-635.
  • 1993. Separation and detection of tissue CoASH and longchain acyl-CoA by reversed-phase high-performance liquid chromatography after precolumn derivatization. Journal of Chromatography A. 251-256.
  • 1993. Redox status and protein-binding of plasma homocysteine and other aminothiols in patients with hyperhomocysteinemia due to cobalamin deficiency. American Journal of Clinical Nutrition.
  • 1993. Redox status and Protein-binding of aminothiols during the transient hyperhomocysteinemia that follows homocysteine administration. Clinical Chemistry. 980-985.
  • 1993. Modulation of phosphatidylcholine biosynthesis by peroxisomal proliferating fatty acid analogs. Lipids. 795-801.
  • 1993. Hyperhomocysteinemia in patients operated for lower extremity ischemia below the age of 50. Effect of smoking and extent of disease. European Journal of Surgery. 393-396.
  • 1993. Homocysteine and Other Tiols as Components of the Metabolic Derangement in Patients with Homocystinuria. Metabolism: Clinical and Experimental. 1481-1485.
  • 1993. Allupurinol does not affect the concentration of endogenous glutathione in liver cells in rats after 60 min of normothermic liver ischemia. European Journal of Surgery. 355-359.
  • 1992. Dynamic relation between reduced, oxidized and protein-bound homocysteine and other thiols components in plasma during methionine loading in healthy men. Clinical Chemistry. 1316-1321.
  • 1992. Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma. Analytical Biochemistry. 218-229.
  • 1992. DNA cell cycle distribution and glutathione (GSH) content according to circadian stage in bone marrow of cancer patients. British Journal of Cancer. 39-45.
  • 1991. Modulation of glutathione content and the effect on methionine auxotrophy and cellular distribution of homocysteine and cysteine in mouse cell lines. Carcinogenesis. 241-247.
  • 1991. Glutathione content in human bone marrow and circadian stage relation to DNA synthesis. Journal of the National Cancer Institute. 1092-1098.
  • 1991. Bestemmelse av homocystein og metylmalonsyre ved kobalaminmangel. Tidsskrift for Den norske legeforening. 450-455.
  • 1990. The change in liver glutathion concentration in salmon (Salmo salar) and char (Salvelinus alpinus) during and after medication with furazolidone. Bulletin of European Association of Fish Pathology. 35-36.
  • 1990. Growth state dependent increase of glutathione by homocysteine and other thiols, and homocysteine formation in glutathione depleted mouse cell lines. Biochemical Pharmacology. 421-429.
  • 1990. Glutathione content in human bone marrow and circadian stage relation to DNA synthesis. Journal of the National Cancer Institute. 1092-1098.
  • 1990. Fatty acid metabolism in livers of rats treated with hypolipidemic sulphur substituted fatty acid analogues. Role of long-chain acyl-CoA and requirement for stimulated fatty acid oxidation in peroxisomes. Biochimica et Biophysica Acta. 211-221.
  • 1990. Determination of reduced, oxidized, and protein-bound glutathione in human plasma with precolumn derivatization with monobromobimane and liquid chromatography. Analytical Biochemistry. 338-346.
  • 1990. Cysteamine increases homocysteine export and glutathione content by independent mechanisms in C3H/10T1/2 cells. Molecular Pharmacology. 327-332.
  • 1989. Fully automated fluorescence assay for determining total homocysteine in plasma. Clinical Chemistry. 1921-1927.
  • 1989. Differential effects on growth, homocysteine, and related compounds of two inhibitors of S-adenosylhomocysteine catabolism, 3-deazaadenosine, and 3-deazaaristeromycin, in C3H/10T1/2 cells. Cancer Research. 324-330.
  • 1989. Changes in peroxisomes and mitochondria in liver of ethionine exposed rats: a biochemical and morphological investigation. Carcinogenesis. 987-994.
  • 1988. Growth support and toxicity of homocysteine and its effects on methionine metabolism in non-transformed and chemically transformed C3H/10T1/2 cells. Carcinogenesis. 9-16.
  • 1988. Ethionine-induced alterations of enzymes involved in lipid metabolism and their possible relationship to induction of fatty liver. Biochimica et Biophysica Acta. 349-358.
  • 1988. Effect of methotrexate on long-chain fatty acid metabolism in liver of rats fed a standard or a defined, choline-deficient diet. Biochimica et Biophysica Acta. 70-80.
  • 1988. Effect of methotrexate on homocysteine and other sulfur compounds in tissues of rats fed a normal or a defined, choline-deficient diet. Cancer Chemotherapy and Pharmacology. 313-318.
  • 1988. Effect of choline-deficiency and methotrexate administration on peroxisomal beta-oxidation, palmitoyl-CoA hydrolase activity and the glutathione content in rat liver. Carcinogenesis. 619-624.
  • 1988. Differential metabolic response of rat liver, kidney and spleen to ethionine exposure. S-adenosylamino acids, homocysteine and reduced glutathione in tissues. Carcinogenesis. 227-232.
  • 1987. Compartmentalization of S-adenosylhomocysteine in rat liver. Determination and characterization of the in vivo protein binding. Journal of Biological Chemistry. 15413-15417.
  • 1986. Disposition of homocysteine in rat hepatocytes and in nontransformed and malignant mouse embryo fibroblasts following exposure to inhibitors of S-adenosylhomocysteine catabolism. Cancer Research. 5095-5100.
  • 1986. Disposition of homocysteine and S-3-deazaadenosylhomocysteine in cells exposed to 3-deazaadenosine. Molecular Pharmacology. 154-158.
  • 1986. Determination of in vivo protein binding of homocysteine and its relation to free homocysteine in the liver and other tissues of the rat. Journal of Biological Chemistry. 3156-3163.
  • 1985. The aromatization of cyclohexanecarboxylic acid to hippuric acid: substrate specificity and species differences. Molecular and Cellular Biochemistry. 171-179.
  • 1985. The aromatization of cyclohexanecarboxyl-CoA to hippuric acid by guinea pig liver mitochondria: submitochondrial localization. Molecular and Cellular Biochemistry. 181-188.
  • 1984. Intracellular localization and some properties of the system in guinea pig liver responsible for the aromatization of cyclohexanecarboxylic acid to hippuric acid. Molecular and Cellular Biochemistry. 107-115.
  • 1982. Gas chromatographic—mass spectrometric determination of aromatization of cyclohexanecarylic acid in guinea pig liver. Journal of chromatography. B. 301-306.
  • 1981. Variation in microsomal subfractions obtained from normal animal tissues and transformed cells following cell disruption by nitrogen cavitation. Molecular and Cellular Biochemistry. 177-183.
  • 1981. Ultrastructure and polysome content of the microsomal subfractions of mouse plasmacytoma cells. Molecular and Cellular Biochemistry. 165-175.
  • 1981. Disposition of 2-(14C) flavone in the rat. Acta pharmaceutica Suecica. 55-62.
  • 1980. The effect of "shearing" forces during ultracentrifugation on the membrane-bound polysomes associated with light rough microsomes of MPC-11 cells. Molecular Biology Reports. 105-110.
  • 1980. Correlation of the effect of feeding upon the cell cycle distribution profiles of MPC-11 cells with the relative apperance of (3H)-choline labeled material in microsomal subfractions and other cell fractions. Molecular and Cellular Biochemistry. 159-171.
  • 1980. Aspects of the role of the endoplasmic reticulum in protein synthesis. Sub-cellular biochemistry. 117-170.
  • 1978. The isolation of microsomal subfractions of mouse plasmacytoma cells: The effect of salt concentration during nitrogen cavitation. Analytical Biochemistry. 332-336.
  • 1978. Differences in the incorporation of (3H)-glucosamine into nascent polypeptide chains on free polysomes and two fractions of membrane-bound polysomes in mouse myeloma cells. Molecular Biology Reports. 223-228.
Report
  • 1999. Alkylerte fenolers hormonelle innvirkning på torsk - generasjonseffekter. Vekst, overlevelse og kjønnsdifferensiering. 15. 15. .
Academic lecture
  • 2018. Using metabolic profiling to explore molecular effects of replacing saturated fat with polyunsaturated fat- a randomized controlled dietary intervention study.
  • 2018. Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat- a randomized controlled dietary intervention study.
  • 2007. A novel serum folate assay measuring intact and degraded folate species as para-aminobenzoylglutamate equivalents in fresh and stored samples.
  • 2002. Miljøeffekter av oljevirksomheten til havs, spesielt om alkylerte fenolers hormonelle innvirkning på torsk.
Doctoral dissertation
  • 2019. Tetrahydrobiopterin and nitric oxide synthesis after exposure to hyperoxia and simulated diving. An experimental study in human endothelial cells and healthy humans.
Academic chapter/article/Conference paper
  • 2007. Methods for folate measurement: Current status, caveats and future development. 9 pages.
  • 2007. Methods for folate measurement. Current status, caveats and future development. 10 pages.
  • 1987. Pertubation of homocysteine metabolism by pharmacological agents in experimental and clinical use. 10 pages.
  • 1986. Disposition of endogenous S-adenosyl-homocysteine and homocysteine following exposure to nucleoside analogues and methotrexate. 12 pages.
  • 1982. Differences among microsomal subfractions in normal and transformed cells obtained after cell disruption by nitrogen cavitation. 6 pages.
Poster
  • 2018. Using metabolic profiling to explore molecular effects of replacing saturated fat with polyunsaturated fat- a randomized controlled dietary intervention study.
  • 2015. P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.
  • 2015. MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS.
  • 2014. Stability of gemcitabine and metabolite in blood samples from pancreatic cancer patients.
  • 2014. Serum acylcarnitines and risk of acute myocardial infarction and cardiovascular death in patients with stable angina pectoris.
  • 2011. Serum acyl-carnitines and body mass index.
  • 2004. Determination of folate species and folate-related compounds in serum by liquid chromatography tandem mass spectroscopy.
Academic literature review
  • 2007. Review: Quantitative profiling of folate and one-carbon metabolism in large-scale epidemiological studies by mass spectrometry. 1737-1745.

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