Astrid Guldbrandsen's picture

Astrid Guldbrandsen

Postdoctoral fellow

Mass spectrometry based proteomics for multiple sclerosis (MS) biomarker research using cerebrospinal fluid (CSF).

Focus on data sharing and organization through the interactive database CSF Proteome Resource, available at probe.uib.no/csf-pr

Experience with methods for glycoprotein and glycopeptide enrichment/separation and with data analysis from such experiments.

Journal articles
  • Kroksveen, Ann Cathrine; Guldbrandsen, Astrid; Vaudel, Marc; Lereim, Ragnhild Reehorst; Barsnes, Harald; Myhr, Kjell-Morten; Torkildsen, Øivind; Berven, Frode. 2017. In-depth cerebrospinal fluid quantitative proteome and deglycoproteome analysis: presenting a comprehensive picture of pathways and processes affected by multiple sclerosis. Journal of Proteome Research. 16: 179-194. doi: 10.1021/acs.jproteome.6b00659
  • Guldbrandsen, Astrid; Farag, Yehia Mohamed Mokhtar; Kroksveen, Ann Cathrine; Oveland, Eystein; Lereim, Ragnhild Reehorst; Opsahl, Jill Anette; Myhr, Kjell-Morten; Berven, Frode; Barsnes, Harald. 2016. CSF-PR 2.0: an interactive literature guide to quantitative cerebrospinal fluid mass spectrometry data from neurodegenerative disorders. Molecular & Cellular Proteomics. 16: 300-309. doi: 10.1074/mcp.O116.064477
  • Opsahl, Jill Anette; Vaudel, Marc; Guldbrandsen, Astrid; Aasebø, Elise; Van Pesch, Vincent; Franciotta, Diego; Myhr, Kjell-Morten; Barsnes, Harald; Berle, Magnus Foldal; Torkildsen, Øivind; Kroksveen, Ann Cathrine; Berven, Frode. 2016. Label-free analysis of human cerebrospinal fluid addressing various normalization strategies and revealing protein groups affected by multiple sclerosis. Proteomics. 16: 1154-1165. doi: 10.1002/pmic.201500284
  • Kroksveen, Ann Cathrine; Opsahl, Jill Anette; Guldbrandsen, Astrid; Myhr, Kjell-Morten; Oveland, Eystein; Torkildsen, Øivind; Berven, Frode. 2015. Cerebrospinal fluid proteomics in multiple sclerosis. Biochimica et Biophysica Acta - Proteins and Proteomics. 1854: 746-756. doi: 10.1016/j.bbapap.2014.12.013
  • Guldbrandsen, Astrid; Vethne, Heidrun; Farag, Yehia Mohamed Mokhtar; Oveland, Eystein; Garberg, Hilde Kristin; Berle, Magnus Foldal; Myhr, Kjell-Morten; Opsahl, Jill Anette; Barsnes, Harald; Berven, Frode. 2014. In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR). Molecular & Cellular Proteomics. 13: 3152-3163. doi: 10.1074/mcp.M114.038554
  • Kroksveen, Ann Cathrine; Guldbrandsen, Astrid; Vedeler, Christian A.; Myhr, Kjell-Morten; Opsahl, Jill Anette; Berven, Frode. 2012. Cerebrospinal fluid proteome comparison between multiple sclerosis patients and controls. Acta Neurologica Scandinavica. 126: 90-96. doi: 10.1111/ane.12029
Reports and theses
  • Guldbrandsen, Astrid. 2016. Proteome and deglycopeptide analyses of neurologically healthy and multiple sclerosis affected cerebrospinal fluid: Mass spectrometry experiments, literature mining and data sharing. Universitetet i Bergen, Bergen. 187 pages.
Book sections
  • Guldbrandsen, Astrid; Barsnes, Harald; Kroksveen, Ann Cathrine; Berven, Frode; Vaudel, Marc. 2016. A Simple Workflow for Large Scale Shotgun Glycoproteomics. Chapter 20, pages 275-286. In:
    • Reinders, Jörg. 2016. Proteomics in Systems Biology. Springer. 313 pages. ISBN: 978-1-4939-3339-6.

More information in national current research information system (CRIStin)

Development of probe.uib.no/csf-pr-2.0

Development of a targeted (PRM, parallelel reaction monitoring) assay for absolute quantification of proteins in cerebrospinal fluid (CSF).

Research groups