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Bengt Erik Haug

Professor
  • E-mailBengt-Erik.Haug@uib.no
  • Phone+47 55 58 34 68
  • Visitor Address
    Realfagbygget, Allégt. 41
    Room 
    3008
  • Postal Address
    Postboks 7803
    5020 BERGEN

Bengt Erik Haug holds a PhD in organic chemistry from the University of Tromsø (June of 2002). During his PhD he worked on the design and synthesis of cationic antimicrobial peptides (CAP's) and synthetic antimicrobial peptidomimetics (SAMP's). Before moving to Bergen, he was a post doc in the research group of Professor Daniel H. Rich at the School of Pharmacy, University of Wisconsin-Madison, USA (2003-2004) and worked as a scientist for Lytix Biopharma AS (2005-2006).

Current research activities include design and synthesis of biologically active peptides and peptidomimetics and synthesis of marine natural products and analogs.

 

Haug research group members

Laboratory for peptide synthesis

Journal articles
  • Fairhurst, Magnus John E.; Muhammad, Zeeshan; Haug, Bengt Erik; Bayer, Annette. 2018. Aldol condensations on a 3-alkylidene-2,5-diketopiperazine - synthesis of two marine natural products. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 29: 1303-1306. doi: 10.1055/s-0036-1591755
  • Goris, Marianne; Magin, Robert S.; Foyn, Håvard; Myklebust, Line Merethe; Varland, Sylvia; Ree, Rasmus Moen; Drazic, Adrian; Bhambra, Parminder Kaur; Støve, Svein Isungset; Baumann, Markus; Haug, Bengt Erik; Marmorstein, Ronen; Arnesen, Thomas. 2018. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proceedings of the National Academy of Sciences of the United States of America. 115: 4405-4410. Published 2018-03-26. doi: 10.1073/pnas.1719251115
  • Baumann, Markus; Hussain, Mohammad Musarraf; Henne, Nina; Garrote, Daniel Moya; Karlshøj, Stefanie; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik. 2017. Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorganic & Medicinal Chemistry. 25: 646-657. doi: 10.1016/j.bmc.2016.11.036
  • Baumann, Markus; Nome, Lina Marie; Zachariassen, Zack Georg; Karlshøj, Stepfanie; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik. 2017. Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism. Tetrahedron. 73: 3866-3877. doi: 10.1016/j.tet.2017.05.057
  • Nestvold, Janne M.; Wang, Mengyu; Camilio, Ketil Andre; Zinöcker, Severin; Tjelle, Torunn Elisabeth; Lindberg, Alf; Haug, Bengt Erik; Kvalheim, Gunnar; Sveinbjørnsson, Baldur; Rekdal, Øystein. 2017. Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model. Oncoimmunology. 6: 1-13. doi: 10.1080/2162402X.2017.1338236
  • Sveinbjørnsson, Baldur; Camilio, Ketil Andre; Haug, Bengt Erik; Rekdal, Øystein. 2017. LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment. Future Medicinal Chemistry. 9: 1339-1344. doi: 10.4155/fmc-2017-0088
  • Haug, Bengt Erik; Camilio, Ketil Andre; Eliassen, liv tone; Stensen, Wenche; Svendsen, John Sigurd Mjøen; Berg, Kristel; Mortensen, Bjarte; Serin, Guillaume; Mirjolet, Jean-Francois; Bichat, Francis; Rekdal, Øystein. 2016. Discovery of a 9-mer cationic peptide (LTX-315) as a potential first in class oncolytic peptide. Journal of Medicinal Chemistry. 59: 2918-2927. doi: 10.1021/acs.jmedchem.5b02025
  • Støve, Svein Isungset; Magin, Robert S.; Foyn, Håvard; Haug, Bengt Erik; Marmorstein, Ronen; Arnesen, Thomas. 2016. Crystal structure of the Golgi-associated human N-alpha acetyltransferase 60 (Naa60/NatF) reveals the molecular determinants for substrate-specific acetylation. Structure. 24: 1044-1056. doi: 10.1016/j.str.2016.04.020
  • Aubi Catevilla, Oscar; Flydal, Marte Innselset; Zheng, Huaixin; Skjærven, Lars; Rekand, Illimar; Leiros, Hanna-Kirsti S.; Haug, Bengt Erik; Cianciotto, Nicholas P.; Martinez, Aurora; Underhaug, Jarl. 2015. Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila. Journal of Medicinal Chemistry. 58: 8402-8412. doi: 10.1021/acs.jmedchem.5b01589
  • Liu, Liwei; Budnjo, Adnan; Jokela, Jouni; Haug, Bengt Erik; Fewer, David P.; Wahlsten, Matti; Rouhiainen, Leo; Permi, Perttu; Fossen, Torgils; Sivonen, Kaarina. 2015. Pseudoaeruginosins, nonribosomal peptides in nodularia spumigena. ACS Chemical Biology. 10: 725-733. doi: 10.1021/cb5004306
  • Pandey, Sunil Kumar; Guttormsen, Yngve; Haug, Bengt Erik; Hedberg, Christian; Bayer, Annette. 2015. A concise total synthesis of breitfussin A and B. Organic Letters. 17: 122-125. doi: 10.1021/ol503348n
  • Våbenø, Jon; Haug, Bengt Erik; Rosenkilde, Mette M. 2015. Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists. Future Medicinal Chemistry. 7: 1261-1283. doi: 10.4155/fmc.15.64
  • Zachariassen, Zack Georg; Karlshøj, Stefanie; Haug, Bengt Erik; Rosenkilde, Mette M.; Våbenø, Jon. 2015. Probing the molecular interactions between CXC chemokine receptor 4 (CXCR4) and an arginine-based tripeptidomimetic antagonist (KRH-1636). Journal of Medicinal Chemistry. 58: 8141-8153. doi: 10.1021/acs.jmedchem.5b00987
  • Budnjo, Adnan; Narawane, Shailesh; Grauffel, Cédric; Schillinger, Anne-Sophie; Fossen, Torgils; Reuter, Nathalie; Haug, Bengt Erik. 2014. Reversible ketomethylene-based inhibitors of human neutrophil proteinase 3. Journal of Medicinal Chemistry. 57: 9396-9408. doi: 10.1021/jm500782s
  • Narawane, Shailesh; Budnjo, Adnan; Grauffel, Cédric; Haug, Bengt Erik; Reuter, Nathalie. 2014. In silico design, synthesis, and assays of specific substrates for proteinase 3: Influence of fluorogenic and charged groups. Journal of Medicinal Chemistry. 57: 1111-1115. doi: 10.1021/jm401559r
  • Zachariassen, Zack Georg; Thiele, Stefanie; Berg, Erik; Rasmussen, Pernille; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik. 2014. Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorganic & Medicinal Chemistry. 22: 4759-4769. doi: 10.1016/j.bmc.2014.07.004
  • Harmsen, Rianne; Sivertsen, Annfrid; Michetti, Davide; Brandsdal, Bjørn Olav; Sydnes, Leiv K.; Haug, Bengt Erik. 2013. Synthesis and docking of novel piperidine renin inhibitors. Monatshefte für Chemie / Chemical Monthly. 144: 479-494. doi: 10.1007/s00706-012-0903-5
  • McCormack, Emmet; Silden, Elisabeth; West, Richard M.; Pavlin, Tina; Micklem, David Robert; Lorens, James; Haug, Bengt Erik; Cooper, Michael E.; Gjertsen, Bjørn Tore. 2013. Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. Cancer Research. 74: 1276-1286. doi: 10.1158/0008-5472.CAN-12-2649
  • Farooq, Tahir; Haug, Bengt Erik; Sydnes, Leiv Kristen; Törnroos, Karl Wilhelm. 2012. 1,3-Dipolar cycloaddition of benzyl azide to two highly functionalized alkynes. Monatshefte für Chemie / Chemical Monthly. 143: 505-512. doi: 10.1007/s00706-011-0691-3)
  • Farooq, Tahir; Sydnes, Leiv Kristen; Törnroos, Karl Wilhelm; Haug, Bengt Erik. 2012. Debenzylation of Functionalized 4-and 5-substituted 1,2,3-fTriazoles. Synthesis (Stuttgart). 44: 2070-2078. doi: 10.1055/s-0031-1291160
  • Harmsen, Rianne; Sivertsen, A; Michetti, Davide; Brandsdal, Bjørn Olav; Sydnes, Leiv Kristen; Haug, Bengt Erik. 2012. Synthesis and docking of 4-triazolyl substituted piperidine derivatives as novel renin inhibitors. Journal of Peptide Science. 18: S125-S125.
  • Rekdal, Øystein; Haug, Bengt Erik; Kalaaji, manar; Hunter, Howard N.; Lindin, Inger; Israelsson, Ingrid; Solstad, Terese; Yang, Nannan; Brandl, Martin; Mantzilas, Dimitrios; Vogel, Hans J. 2012. The relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determines their cytotoxicity. Journal of Biological Chemistry. 287: 233-244. doi: 10.1074/jbc.M111.279281
  • Steinkopf, Signe; Hanekam, Linda; Schaathun, Marit; Budnjo, Adnan; Haug, Bengt Erik; Nerdal, Willy. 2012. Interaction of local anaesthetic articaine enantiomers with brain lipids: A Langmuir monolayer study. European Journal of Pharmaceutical Sciences. 47: 394-401. doi: 10.1016/j.ejps.2012.06.010
  • Harmsen, Rianne; Sydnes, Leiv Kristen; Törnroos, Karl Wilhelm; Haug, Bengt Erik. 2011. Synthesis of trans-4-Triazolyl-Substituted 3-Hydroxypiperidines. Synthesis (Stuttgart). 5. 749-754. doi: 10.1055/s-0030-1259569
  • Skjevik, Åge Aleksander; Haug, Bengt Erik; Lygre, Henning; Teigen, Knut. 2011. Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration: A molecular dynamics study. Biophysical Chemistry. 154: 18-25. doi: 10.1016/j.bpc.2010.12.002
  • Zachariassen, Zack Georg; Thiele, S; Rosenkilde, MM; Haug, Bengt Erik; Våbenø, Jon. 2011. SAR and Binding Mode for CXCR4 Antagonists Based on an Arg-Arg-Nal Tripeptide Motif. Biopolymers. 96: 492-492.
  • Haug, Bengt Erik; Stensen, Wenche; Kalaaji, manar; Rekdal, Øystein; Svendsen, John Sigurd. 2008. Synthetic antimicrobial peptidomimetics with therapeutic potential. Journal of Medicinal Chemistry. 51: 4306-4314. doi: 10.1021/jm701600a
  • Svenson, Johan Karl; Stensen, Wenche; Brandsdal, Bjørn Olav; Haug, Bengt Erik; Monrad, Johnny; Svendsen, John Sigurd. 2008. Antimicrobial Peptides with Stability toward Tryptic Degradation. Biochemistry. 47: 3777-3788. doi: 10.1021/bi7019904
  • Haug, Bengt Erik; Stensen, Wenche; Svendsen, John Sigurd. 2007. Application of the Suzuki-Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials. Bioorganic & Medicinal Chemistry Letters. 17. doi: 10.1016/j.bmcl.2006.12.049
  • Haug, Bengt Erik; Strøm, Morten B.; Svendsen, John Sigurd. 2007. The medicinal chemistry of short lactoferricin-based antibacterial peptides. Current Medicinal Chemistry. 14: 1-18.
  • Haug, Bengt Erik; Brewer, M; Rich, DH. 2005. Facile degradative lactonization of Gln-Arg and Gln-Phe hydroxyethylene dipeptide derivatives. Journal of Peptide Research. 65.
  • Haug, Bengt Erik; Rich, Daniel H. 2004. Synthesis of a Gln-Phe hydroxyethylene dipeptide isostere. Organic Letters. 6: 4783-4786.
  • Haug, Bengt Erik; Stensen, Wenche; Stiberg, Trine; Svendsen, John sigurd. 2004. Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides. Journal of Medicinal Chemistry. 47: 4159-4162.
  • Eliassen, liv tone; Haug, Bengt Erik; Berge, Gerd; Rekdal, Øystein. 2003. Enhanced antitumor activity of 15-residue bovine lactoferricin derivatives containing bulky aromatic amino acids and lipophilic N-terminal modifications. Journal of Peptide Science. 9: 510-517.
  • Strøm, M. B.; Haug, Bengt Erik; Skar, Merete L.; Stiberg, Trine; Stensen, Wenche; Svendsen, John Sigurd. 2003. The Pharmacophore of Short Cationic Antibacterial Peptides. Journal of Medicinal Chemistry. 46: 1567-1570.
  • Haug, Bengt Erik; Andersen, Jill Mari; Rekdal, Øystein; Svendsen, John Sigurd. 2002. Synthesis of a 2-arylsulphonylated tryptophan: the antibacterial activity of bovine lactoferricin peptides containing Trp(2-Pmc). Journal of Peptide Science. 8: 307-313.
  • Lejon, Tore; Svendsen, John Sigurd; Haug, Bengt Erik. 2002. Simple parameterization of non-proteinogenic amino acids for QSAR of antibacterial peptides. Journal of Peptide Science. 8: 302-306.
  • Haug, Bengt Erik; Skar, Merete L.; Svendsen, John Sigurd. 2001. The effects of charge and lipophilicity on the antibacterial activity of undecapeptides derived from bovine lactoferricin. Journal of Peptide Science. 7: 425-432.
  • Haug, Bengt Erik; Skar, Merete L.; Svendsen, John Sigurd. 2001. Bulky Aromatic Amino Acids Increase the Antibacterial Activity of Bovine Lactoferricin Peptides. Journal of Peptide Science. 7: 425-432.
  • Haug, Bengt Erik; Svendsen, John Sigurd. 2001. The Role of Tryptophan in the Antibacterial Activity of a 15-Residue Bovine Lactoferricin Peptide. Journal of Peptide Science. 7: 190-196.
  • Lejon, Tore Sigvard; Haug, Bengt Erik. 2001. FARGESTOFFER I SOPP. Blekksoppen. 29: 16-19.
  • Strøm, M. B.; Haug, Bengt Erik; Rekdal, Øystein; Skar, Merete L.; Stensen, Wenche; Svendsen, John Sigurd. 2001. Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity. International Journal of Biochemistry and Cell Biology.
  • Lejon, Tore Sigvard; Haug, Bengt Erik. 2000. Fargestoffer i Sopp. Kjemi. 7.
Reports and theses
  • Bjørsvik, Hans-Rene; Sydnes, Leiv Kristen; Haug, Bengt Erik. 2010. IUPAC ICOS-18 Proceedings. Kjemisk institutt, Universitetet i Bergen, Bergen. 114 pages.

More information in national current research information system (CRIStin)

Organic synthesis

Peptide synthesis

Peptidomimetics

Medicinal chemistry

Inhibitors of N-terminal acetyl transferases

Chartering chemical space of riboswitch ligands - Toward future antibiotics

Novel drug candidates for Chronic Obstructive Pulmonary Disease treatment

Synthesis of marine natural products and analogues

Peptides for molecular imaging

Haug research group members