Christian Dölle's picture

Christian Dölle

Senior Engineer
  • E-mailChristian.Doelle@uib.no
  • Phone+47 55 58 45 39
  • Visitor Address
    Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Osuagwu, Nelson Uchechukwu; Dölle, Christian; Tzoulis, Charalampos. 2019. Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix. PLOS ONE. 14:E0219909: 1-14. Published 2019-07-19. doi: 10.1371/journal.pone.0219909
  • Buonvicino, Daniela; Mazzola, Francesca; Zamporlini, Federica; Resta, Francesco; Ranieri, Giuseppe; Camaioni, Emidio; Muzzi, Mirko; Zecchi, Riccardo; Pieraccini, Giuseppe; Dölle, Christian; Calamante, Massimo; Bartolucci, Gianluca; Ziegler, Mathias; Stecca, Barbara; Raffaelli, Nadia; Chiarugi, Alberto. 2018. Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites. Cell Chemical Biology. 25: 471-482.e7. doi: 10.1016/j.chembiol.2018.01.012
  • Dölle, Christian; Bindoff, Laurence; Tzoulis, Charalampos. 2018. 3,3'-Diaminobenzidine staining interferes with PCR-based DNA analysis. Scientific Reports. 8:1272: 1-8. doi: 10.1038/s41598-018-19745-9
  • Sanchez Nido, Gonzalo; Dölle, Christian; Flønes, Irene Hana; Tuppen, Helen A.; Alves, Guido; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Tzoulis, Charalampos. 2018. Ultradeep mapping of neuronal mitochondrial deletions in Parkinson's disease. Neurobiology of Aging. 63: 120-127. doi: 10.1016/j.neurobiolaging.2017.10.024
  • Brakedal, Brage; Flønes, Irene Hana; Reiter, Simone B. C. Frizell; Torkildsen, Øivind; Dölle, Christian; Assmus, Jörg; Haugarvoll, Kristoffer; Tzoulis, Charalampos. 2017. Glitazone use associated with reduced risk of Parkinson's disease. Movement Disorders. 32: 1594-1599. doi: 10.1002/mds.27128
  • Dölle, Christian; Ziegler, Mathias. 2017. ADP-ribosylation of DNA moving into focus. The FEBS Journal. 284: 3999-4001. doi: 10.1111/febs.14326
  • Flønes, Irene Hana; Fernandez-Vizarra, Erika; Lykouri, Maria; Brakedal, Brage; Skeie, Geir Olve; Miletic, Hrvoje; Lilleng, Peer Kåre; Alves, Guido; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Dölle, Christian; Zeviani, Massimo; Tzoulis, Charalampos. 2017. Neuronal complex I deficiency occurs throughout the Parkinson's disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage. Acta Neuropathologica. 135: 409-425. Published 2017-12-21. doi: 10.1007/s00401-017-1794-7
  • Van Linden, Magali R; Niere, Marc; Nikiforov, Andrey; Ziegler, Mathias; Dölle, Christian. 2017. Compartment-Specific Poly-ADP-Ribose Formation as a Biosensor for Subcellular NAD Pools. Methods in molecular biology. 1608: 45-56. doi: /10.1007/978-1-4939-6993-7_4
  • Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos. 2016. Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nature Communications. 7:13548. 11 pages. doi: 10.1038/ncomms13548
  • Flønes, Irene Hana; Sztromwasser, Pawel Szymon; Haugarvoll, Kristoffer; Dölle, Christian; Lykouri, Maria; Schwarzlmüller, Thomas; Jonassen, Inge; Miletic, Hrvoje; Johansson, Stefan; Knappskog, Per; Bindoff, Laurence; Tzoulis, Charalampos. 2016. Novel SLC19A3 promoter deletion and allelic silencing in biotin-thiamine-responsive basal ganglia encephalopathy. PLOS ONE. 11. doi: 10.1371/journal.pone.0149055
  • Kulikova, Veronika; Shabalin, Konstantin; Nerinovski, Kirill; Dölle, Christian; Niere, Marc; Yakimov, Alexander; Redpath, Philip; Khodorkovskiy, Mikhail; Migaud, Marie E.; Ziegler, Mathias; Nikiforov, Andrey. 2015. Generation, release, and uptake of the NAD precursor nicotinic acid riboside by human cells. Journal of Biological Chemistry. 290: 27124-27137. Published 2015-11-06. doi: 10.1074/jbc.M115.664458
  • Love, Nick R.; Pollak, Nadine; Dölle, Christian; Niere, Marc; Chen, Yaoyao; Oliveri, Paola; Amaya, Enrique; Patel, Sandip; Ziegler, Mathias. 2015. NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 112: 1386-1391. doi: 10.1073/pnas.1417290112
  • Van Linden, Magali R; Dölle, Christian; Pettersen, Ina Katrine Nitschke; Kulikova, Veronika; Niere, Marc; Agrimi, Gennaro; Dyrstad, Sissel Elisabeth; Palmieri, Ferdinando; Nikiforov, Andrey; Tronstad, Karl Johan; Ziegler, Mathias. 2015. Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 290: 27644-27659. Published 2015-11-13. doi: 10.1074/jbc.M115.654129
  • Skoge, Renate Hvidsten; Dölle, Christian; Ziegler, Mathias. 2014. Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. DNA Repair. 23: 33-38. doi: 10.1016/j.dnarep.2014.04.011
  • Dölle, Christian; Rack, Johannes Gregor M; Ziegler, Mathias. 2013. NAD and ADP-ribose metabolism in mitochondria. The FEBS Journal. 280: 3530-3541. doi: 10.1111/febs.12304
  • Dölle, Christian; Skoge, Renate Hvidsten; Van Linden, Magali R; Ziegler, Mathias. 2013. NAD biosynthesis in humans - enzymes, metabolites and therapeutic aspects. Current Topics in Medicinal Chemistry. 13: 2907-2917.
  • Livinskaya, V; Afanasyeva, A; Dölle, Christian; Niere, Marc; Khodorkovskiy, M; Ziegler, Mathias; Nikiforov, Andrey. 2013. Potential role of cytosolic 5'- nucleotidases in human NAD metabolism. The FEBS Journal. 280: 181-181.
  • Chiarugi, Alberto; Dølle, Christian; Felici, Roberta; Ziegler, Mathias. 2012. The NAD metabolome - a key determinant of cancer cell biology. Nature Reviews. Cancer. 12: 741-752. doi: 10.1038/nrc3340
  • Niere, Marc; Mashimo, Masato; Agledal, Line; Dølle, Christian; Kasamatsu, Atsushi; Kato, Jiro; Moss, Joel; Ziegler, Mathias. 2012. ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose)glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). Journal of Biological Chemistry. 287: 16088-16102. doi: 10.1074/jbc.M112.349183
  • Nikiforov, Andrey; Dølle, Christian; Niere, Marc; Ziegler, Mathias. 2011. Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells FROM ENTRY OF EXTRACELLULAR PRECURSORS TO MITOCHONDRIAL NAD GENERATION. Journal of Biological Chemistry. 286: 21767-21778. doi: 10.1074/jbc.M110.213298
  • Dølle, Christian; Niere, Marc; Lohndal, Emilia; Ziegler, Mathias. 2010. Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation. Cellular and Molecular Life Sciences (CMLS). 67: 433-443. doi: 10.1007/s00018-009-0190-4
  • Lau, Corinna; Dølle, Christian; Gossmann, Toni I.; Agledal, Line; Niere, Marc; Ziegler, Mathias. 2010. Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. Journal of Biological Chemistry. 285: 18868-18876. doi: 10.1074/jbc.M110.107631
  • Dølle, Christian; Ziegler, Mathias. 2009. Application of a coupled enzyme assay to characterize nicotinamide riboside kinases. Analytical Biochemistry. 385: 377-379. doi: 10.1016/j.ab.2008.10.033
  • Pollak, Nadine; Dølle, Christian; Ziegler, Mathias. 2007. The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochemical Journal. 402: 205-218. doi: 10.1042/BJ20061638

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