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Christian Dölle

Senior Engineer
  • E-mailChristian.Doelle@uib.no
  • Phone+47 55 58 45 39
  • Visitor Address
    Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • 2019. Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix. PLOS ONE. 1-14.
  • 2018. Ultradeep mapping of neuronal mitochondrial deletions in Parkinson's disease. Neurobiology of Aging. 120-127.
  • 2018. Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites. Cell Chemical Biology. 471-482.e7.
  • 2018. 3,3'-Diaminobenzidine staining interferes with PCR-based DNA analysis. Scientific Reports. 1-8.
  • 2017. Neuronal complex I deficiency occurs throughout the Parkinson's disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage. Acta Neuropathologica. 409-425.
  • 2017. Glitazone use associated with reduced risk of Parkinson's disease. Movement Disorders. 1594-1599.
  • 2017. Compartment-Specific Poly-ADP-Ribose Formation as a Biosensor for Subcellular NAD Pools. Methods in molecular biology. 45-56.
  • 2017. ADP-ribosylation of DNA moving into focus. The FEBS Journal. 3999-4001.
  • 2016. Novel SLC19A3 promoter deletion and allelic silencing in biotin-thiamine-responsive basal ganglia encephalopathy. PLOS ONE.
  • 2016. Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nature Communications. 11 pages.
  • 2015. Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 27644-27659.
  • 2015. NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 1386-1391.
  • 2015. Generation, release, and uptake of the NAD precursor nicotinic acid riboside by human cells. Journal of Biological Chemistry. 27124-27137.
  • 2014. Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. DNA Repair. 33-38.
  • 2012. ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose)glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). Journal of Biological Chemistry. 16088-16102.
  • 2011. Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells FROM ENTRY OF EXTRACELLULAR PRECURSORS TO MITOCHONDRIAL NAD GENERATION. Journal of Biological Chemistry. 21767-21778.
  • 2010. Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation. Cellular and Molecular Life Sciences (CMLS). 433-443.
  • 2010. Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. Journal of Biological Chemistry. 18868-18876.
Academic lecture
  • 2012. Identification of the pathways generating organellar NAD pools using targeted poly-ADP ribose formation.
  • 2010. Dissection of candidate enzymes involved in mitochondrial poly-ADP-ribose degradation.
  • 2009. Alteration of compartment-specific NAD biosynthesis by reduction of individual subcellular NAD pools.
  • 2007. Visualization of an enzymatic activity to determine the suborganellar location of mitochondrial proteins.
Editorial
  • 2009. Application of a coupled enzyme assay to characterize nicotinamide riboside kinases. Analytical Biochemistry. 377-379.
Masters thesis
  • 2017. High-resolution subcellular localization of pathogenic proteins in Parkinson's disease.
Doctoral dissertation
  • 2019. Mitochondrial mechanisms in neurodegeneration.
Abstract
  • 2013. Potential role of cytosolic 5'- nucleotidases in human NAD metabolism. The FEBS Journal. 181-181.
Poster
  • 2008. Alteration of isoform-specific NMNAT expression by reduction of subcellular NAD pools.
  • 2007. Expression of NAD biosynthetic enzymes in response to decreased mitochondrial and cytosolic NAD levels.
  • 2005. A new potential ADP-ribose acceptor protein in mitochondria.
  • 2005. A new potential ADP-ribose acceptor protein in mitochondria.
Academic literature review
  • 2013. NAD biosynthesis in humans - enzymes, metabolites and therapeutic aspects. 2907-2917.
  • 2013. NAD and ADP-ribose metabolism in mitochondria. 3530-3541.
  • 2012. The NAD metabolome - a key determinant of cancer cell biology. 741-752.
  • 2007. The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. 205-218.

More information in national current research information system (CRIStin)