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  • E-mailClive.Bramham@uib.no
  • Phone+47 55 58 60 32+47 481 25 046
  • Visitor Address
    Department of Biomedicine
    Jonas Lies vei 91
    5009 Bergen, Norway
  • Postal Address
    Postboks 7804
    5020 Bergen

The overriding goal is to explain how information is physically stored and represented in the brain, and how these processes are disrupted, altered, or destroyed in disorders of cognition including memory loss. Our research focus is the molecular control of synaptic plasticity. We aim to uncover the logic of synaptic plasticity at the level of protein synthesis, protein functional properties, and the dynamics of protein interaction networks.

Specific research areas:

  • Arc as a master regulator of long-term synaptic plasticity and cognition
  • Translational control of synaptic plasticity
  • Non-coding RNA regulation and function in synaptic plasticity
Papers by topic

 

ARC 

Zhang, H. and Bramham, C.R. (2020) Arc function in long-term synaptic plasticity: emerging mechanisms and unresolved issues. Eur J Neurosci, doi.org/10.1111/ejn.14958

Berentsen B, Patil S, Wibrand K, Goff KM, Pajak M, Simpson IT, and Bramham CR. (2020) microRNA-34a acutely regulates synaptic efficacy in the adult dentate gyrus in vivo. Molecular Neurobiology doi.org/10.1007/s12035-019-01816-1

Eriksen, M. S., Nikolaienko, O., Hallin, E. I., Grødem, S., Bustad, H. J., Flydal, M. I., O’Connell, R., Hosokawa, T., Lascu, D., Akerkar, S., Cuéllar, J. Chambers, J.J.,  Muruganandam, G., Loris, R., Kanhema, T., Hayashi, Y., Stratton, M.M., Valpuesta, J.M., Kursula P., Martinez, A., and Bramham, C. R. (2019). Molecular determinants of Arc oligomerization and formation of virus-like capsids. Preprint BioRxiv, 667956. https://doi.org/10.1101/667956.

Hallin, EI, Eriksen, M., Baryshnikov, S., Nikolaienko, Grødem, S., Hosokawa, Y.

Hayashi, Y., *Bramham, C.R. and *Kursula, P.  (2018) Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities.

J. Neurochem. doi.org/10.1111/jnc.14556.  

 

Nikolaienko, O., Patil, S, Eriksen, M.S., and Bramham, C.R., (2018) Arc protein: a flexible hub for synaptic plasticity and cognition. Semin Cell Dev Biol, 77:33-42.

dx.doi.org/10.1016/j.semcdb.2017.09.006

 

Nair, R.R., Patil S., Tiron, A, Kanhema, T., Panja, D., Schiro, L., Parobzak, K., Wilczynski, G., and Bramham, C.R. (2017) Dynamic Arc SUMOylation and selective interaction with F-actin binding protein drebrin A in LTP consolidation in vivo.

Front Synaptic Neurosci. doi: 10.3389/fnsyn.2017.00008

 

Gozdz, A., Nikolaienko, O., Urbanska, M., Cymerman, I.A., Sitkiewicz, E., Dadlez, M., Bramham. C.R., and Jaworski, J (2017) GSK3α and GSK3β phosphorylate Arc and regulate its degradation. Front Mol Neurosci. http://doi: 10.3389/fnmol.2017.00192

 

Nikolaienko O, Eriksen MS, Patil S, Bito H, and Bramham CR (2017)  Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience 360:68–80. http://doi: 10.1016/j.neuroscience.2017.07.026.

 

Myrum, C., Soulé, J., Bittins, M., Cavagnini, K., Eriksen, M.S., Goff, K., Ziemek, S., Patil, S., Szum, A., Nair, R.R. and Bramham, C.R. (2017) Arc interacts with the integral ER protein, calnexin. Frontiers Cell Neurosci. doi.org/10.3389/fncel.2017.00294.

 

Kuipers, S., Trentani, A., Tiron, A, Mao, X., Kuhl, D., and Bramham, C.R.  (2016) BDNF-induced LTP is associated with rapid Arc-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports, http://doi: 10.1038/srep21222.

 

Myrum,C., Baumann, A., Bustad, H.J., Flydal, M.I., Mariaule,V., Alvira, S., Cuéllar, J., Soulé, J., Valpuesta J.M., Márquez, J.A., *Martinez, A., and *Bramham,C.R. (2015) Arc is a flexible modular protein capable of reversible self-oligomerization. Biochem J. 468, 145-158. http://doi 10.1042/BJ20141446

 

Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold A J, Haavik J, Nilsson L, Reinvang I, Steen V M, Johansson S, Wibrand K, *Le Hellard S, and *Bramham C R. (2015) Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior, doi: 10.1002/brb3.376.

 

Soule J, Alme MN, Myrum C, Schubert M, Kanhema T, Bramham CR (2012) Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by REM sleep-like bursts of muscarinic cholinergic receptor stimulation.

J Biological Chemistry, 287(26): 22354-66.

 

Wibrand, K., Pai, B., Siripornmongcolchai, T, Bittins, M., Berentsen, B., Ofte, M.L,  Weigel, A., Skaftnesmo, K.O., and Bramham C.R.   (2012) MicroRNA regulation of the synaptic plasticity related gene Arc. PLoS ONE 7(7): e41688.

 

Bramham CR, Alme MN, Bittins M, Kuipers SD, Nair RR, Pai B, Panja D, Schubert M, Soule J, Tiron A, Wibrand K (2010) The Arc of synaptic memory. Exp Brain Res 200:125-140.

 

Kuipers SD, Tiron A, Soule J, Messaoudi E, Trentani A, Bramham CR (2009) Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. PLoS ONE 4(3): e4885.

 

Bramham CR, Worley PF, Moore MJ, Guzowski JF (2008) The immediate early gene Arc/Arg.1: regulation, mechanisms, and function. J Neurosci. 27(39): 10445-10455.

 

Soule J, Penke-Verdier Z, Alme M, Kanhema T, Laroche S, Bramham CR (2008) Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins  in the rat dentate gyrus.   Neural Plasticity, Article ID 269097, 12 pages.    

Messaoudi,E., Kanhema,T., Soule,J., Tiron,A., Dagyte,G., da Silva,B., and Bramham,C.R.  (2007) Sustained Arc synthesis controls LTP consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.  J. Neurosci. 27: 10445-10455.  

 

Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22: 1532-1540.

 

 

BDNF

Panja, D and Bramham, C.R. (2017) BDNF function in long-term synaptic plasticity in the dentate gyrus in vivo:  methods for local drug delivery and biochemical analysis of translation. In: Neuromethods. Humana Press. doi.org/10.1007/7657_2017_7

 

Kuipers, S., Trentani, A., Tiron, A, Mao, X., Kuhl, D., and Bramham, C.R.  (2016) BDNF-induced LTP is associated with rapid Arc-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports, doi: 10.1038/srep21222.

 

Panja, D., Kenney, J.W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., and Bramham, C.R. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep. 9, 1430–1445.

 

Panja, D., and Bramham, C. R. (2014). BDNF mechanisms in late LTP formation: a synthesis and breakdown. Neuropharmacology, 76: 664-676 . doi:10.1016/j.neuropharm.2013.06.024

 

Coppens, C. M., Siripornmongcolchai, T., Wibrand, K., Alme, M. N., Buwalda, B., de Boer, S. F., Koolhaas, J. M., and Bramham, C. R. (2011) Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes. Front Behav. Neurosci. 5:72., Epub Nov 2.

 

Messaoudi,E., Kanhema,T., Soule,J., Tiron,A., Dagyte,G., da Silva,B., and Bramham,C.R.  (2007) Sustained Arc synthesis controls LTP consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.  J. Neurosci. 27: 10445-10455.  

 

Alme MN, Wibrand K, Dagestad G, Bramham CR (2007) Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural Plast 2007: 26496. PMID: 18301726

 

Wibrand K, Messaoudi E, Havik B, Steenslid V, Løvlie R, Steen VM, and Bramham CR (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in the adult rat dentate gyrus in vivo. Eur J Neurosci 23: 1501-1511.

 

Kanhema, T.,  Dagestad, G., Panja, D., Messaoudi, E., Haavik, B., Ying, S.W.,  Nairn, A.C., Sonenberg, N. and Bramham, C.R.  (2006) Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.  J Neurochem. 99:1328-1337.   

 

Bramham,C.R  and Messaoudi, E. (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis.  Prog. Neurobiol, 76: 99-125. 

 

Gooney, M., Messaoudi, E., Maher, F.O., *Bramham, C.R., and *Lynch, M.A. (2004) BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signalling events. Neurbiol Aging.  25: 1323-1331.

 

Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22: 1532-1540.

 

Messaoudi E, Ying SW, Kanhema T, Croll SD, Bramham CR (2002) BDNF triggers transcription-dependent, late phase LTP in vivo. J Neurosci 22: 7453-7461.

 

Messaoudi, E., Bårdsen, K.,  Srebro, B., and C.R. Bramham (1998) Acute intrahippocampal infusion of brain-derived neurotrophic factor induces lasting potentiation of synaptic transmission in the rat dentate gyrus.  J. Neurophysiol. 79: 496-499.

 

Translational control and dendritic protein synthesis

 

Bramham, C.R., Jensen, K, and Proud, CG. (2016) Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis.  Trends in Biochemistry, 41: 847-858. dx.doi.org/10.1016/j.tibs.2016.07.008.

 

Panja, D., Kenney, J.W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., and Bramham, C.R. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep. 9, 1430–1445.

 

Grønli, J., Soulé, J., and Bramham, C.R. (2014). Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Front. Behav. Neurosci. 7, 1–18.

 

Grønli,J., Dagestad,G., Milde,A.M., Murison,R., and Bramham,C.R. (2012). Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behav. Brain Res. 235, 251-262.

 

Panja, D., Dagyte, G., Bidinosti, M.,. Wibrand, K.,  Kristiansen, A.M., Sonenberg, N., and Bramham, C.R.  (2009) Novel translational control in Arc-dependent long-term potentiation consolidation in vivo.  J. Biological Chemistry 284: 31498-31511.  

 

Bramham, C.R.  (2008) Local protein synthesis, actin dynamics, and LTP consolidation.

Curr Opin Neurobiol. 18: 524-531.

 

Bramham C. R. and Wells D. G. (2007) Dendritic mRNA: transport, translation, and function. Nature Rev Neurosci, 8 (10): 776 – 789.

 

Dagestad,G., Messaoudi,E., and Bramham,C.R. (2006). Chronic fluoxetine induces region specific changes in translation factor eIF4E and eEF2 activity in the rat brain.  Eur J Neurosci., 23: 2814-2818.

 

Kanhema, T.,  Dagestad, G., Panja, D., Messaoudi, E., Haavik, B., Ying, S.W.,  Nairn, A.C., Sonenberg, N. and Bramham, C.R.  (2006) Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.  J Neurochem. 99:1328-1337.   

 

Håvik, B., Røkke, H., Bårdsen, K., Davanger, S. and Bramham, C.R. (2003) High-frequency bursts trigger rapid delivery of pre-existing CaMKII mRNA to synapses: a mechanism in dendritic protein synthesis during long-term potentiation in adult awake rats.  Eur. J. Neurosci., 17: 2679-2689.

 

 

Gene expression and non-coding RNAs

 

Maag, J.L.V. Panja, D, Kaczorowski, D.C. Peters, T.J., Bramham, C.R., Wibrand, K.,    and Dinger, M.E.  (2017) Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. BMC Genomics. 18 (2017) 250. doi:10.1186/s12864-017-3621-x.

 

Maag, J.L.V., Panja,D., Sporild, I, Patil, S., Kaczorowski, D.C., *Bramham, C.R., *Dinger, M., and *Wibrand, K. (2015) Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Frontiers in Neuroscience.  9:351. doi:10.3389/fnins.2015.00351

 

Pai, B., Siripornmongcolchai, T., Berentsen, B., Pakzad, A., Vieuille, C., Pallesen, S., Pajak, M., Simpson, T.I., Armstrong, J.D., Wibrand, K., and Bramham, C.R. (2014). NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo. Front. Cell. Neurosci. 7, 1–15.

 

Wibrand, K., Pai, B., Siripornmongcolchai, T, Bittins, M., Berentsen, B., Ofte, M.L,  Weigel, A., Skaftnesmo, K.O., and Bramham C.R.   (2012) MicroRNA regulation of the synaptic plasticity related gene Arc. PLoS ONE 7(7): e41688.

 

Wibrand, K., Panja, D., Tiron, A., Ofte, M.L., Skaftnesmo, K. Sohn-Lee, C., Pena, J., Tuschl, T. and Bramham, C.R. (2010) Differential regulation of mature and precursor microRNA expression by NMDAR and metabotropic glutamate receptor expression activation during LTP in the dentate gyrus in vivo. Eur J Neurosci 31: 636-645. 

 

Håvik, B., Røkke, H., Dagyte, G., Stavrum, A-K., *Bramham, C.R., and *Steen, V.M. (2007) Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: induction of immunity-linked gene sets. (*Equal contribution).  Neuroscience, 148: 925-936.

 

Wibrand K, Messaoudi E, Havik B, Steenslid V, Løvlie R, Steen VM, and Bramham CR (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in the adult rat dentate gyrus in vivo. Eur J Neurosci 23: 1501-1511.

 

Human Genetics

 

Myrum, C., Nikolaienko, O. Bramham, C.R. Haavik, J., and Zayats, T. Implication of the APP gene in intellectual abilities. (2017) J Alz Dis. 59(2):723-735. doi: 10.3233/JAD-170049.

 

Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold A J, Haavik J, Nilsson L, Reinvang I, Steen V M, Johansson S, Wibrand K, *Le Hellard S, and *Bramham C R. (2015) Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior, doi: 10.1002/brb3.376.

 

Havik, B., Degenhardt, F. A., Johansson, S., Fernandes, C. P., Hinney, A., Scherag, A., Lybaek, H., Djurovic, S., Christoforou, A., Ersland, K. M., Giddaluru, S., O'Donovan, M. C., Owen, M. J., Craddock, N., Muhleisen, T. W., Mattheisen, M., Schimmelmann, B. G., Renner, T., Warnke, A., Herpertz-Dahlmann, B., Sinzig, J., Albayrak, O., Rietschel, M., Nothen, M. M., Bramham, C. R., Werge, T., Hebebrand, J., Haavik, J., Andreassen, O. A., Cichon, S., Steen, V. M., and Le Hellard S. (2012) DCLK1 Variants are associated across schizophrenia and attention deficit/hyperactivity disorder PLoS ONE 7, e35424

 

Le Hellard S, Havik B, Espeseth T, Breilid H, Lovlie R, Luciano M, Gow AJ, Harris SE, Starr JM, Wibrand K, Lundervold AJ, Porteous DJ, Bramham CR, Deary IJ, Reinvang I, Steen VM (2009) Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities. PLoS One 4:e7534.

 

Publications in CRIStin database with links:

 

  • Show author(s) 2020. eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition. Current Biology. 3507-3521.
  • Show author(s) 2020. Investigation of Arc interaction with mRNA in the nucleus of SH-SY5Y Neuroblastoma cells.
  • Show author(s) 2020. Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids. Scientific Reports.
  • Show author(s) 2020. CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons. Journal of Neuroscience. 1405-1426.
  • Show author(s) 2020. Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders. Frontiers in Synaptic Neuroscience.
  • Show author(s) 2020. Arc/Arg3.1 function in long-term synaptic plasticity: Emerging mechanisms and unresolved issues. European Journal of Neuroscience.
  • Show author(s) 2020. Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif. The FEBS Journal.
  • Show author(s) 2019. MicroRNA-34a acutely regulates synaptic efficacy in the adult dentate gyrus in vivo. Molecular Neurobiology. 1-14.
  • Show author(s) 2019. A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons. Journal of Neuroscience Methods.
  • Show author(s) 2018. The immediate early protein Arc: an exploration of protein structure and regulation.
  • Show author(s) 2018. Structure of monomeric full‐length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. Journal of Neurochemistry. 323-343.
  • Show author(s) 2018. Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light. .
  • Show author(s) 2018. Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.
  • Show author(s) 2018. Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.
  • Show author(s) 2017. Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. BMC Genomics.
  • Show author(s) 2017. The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons. eNeuro.
  • Show author(s) 2017. Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience. 68-80.
  • Show author(s) 2017. No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. Frontiers in Neural Circuits. 1-12.
  • Show author(s) 2017. Implication of the APP gene in intellectual abilities. Journal of Alzheimer's Disease. 723-735.
  • Show author(s) 2017. GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation. Frontiers in Molecular Neuroscience.
  • Show author(s) 2017. Dynamics of actin cytoskeleton in dendritic spines -interactions between Arc and Drebrin A.
  • Show author(s) 2017. Dynamic Arc SUMOylation and selective interaction with F-actin-binding protein Drebrin A in LTP consolidation in vivo. Frontiers in Synaptic Neuroscience. 1-|14.
  • Show author(s) 2017. Dynamic Analysis of Arc Protein Oligomerization by Förster Resonance Energy Transfer.
  • Show author(s) 2017. Arc protein: a flexible hub for synaptic plasticity and cognition. Seminars in Cell and Developmental Biology. 33-42.
  • Show author(s) 2017. Arc interacts with the integral endoplasmic reticulum protein, calnexin. Frontiers in Cellular Neuroscience. 1-12.
  • Show author(s) 2017. Arc expression and protein-protein interactions in a mouse model of Alzheimer’s disease: Exercise- and novelty-induced changes in Arc, BDNF, and PS1 expression and Arc PS1 interaction in APP/PS1 and WT mice.
  • Show author(s) 2017. Activity-Regulated Cytoskeleton-associated (Arc) Protein: Interaction with Actin-Binding Proteins in the adult rat brain.
  • Show author(s) 2016. Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis. TIBS -Trends in Biochemical Sciences. Regular ed.. 847-858.
  • Show author(s) 2016. The localization and function of Arc in the neuronal cell nucleus.
  • Show author(s) 2016. Stimulation-induced expression of immediate early gene proteins in the dorsal horn is increased in neuropathy. Scandinavian Journal of Pain. 43-51.
  • Show author(s) 2016. Corrigendum to Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity [Front. Neurosci. (2015), 9:351. doi: 10.3389/fnins.2015.00351]. Frontiers in Neuroscience. 1-1.
  • Show author(s) 2016. BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports.
  • Show author(s) 2016. BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports.
  • Show author(s) 2015. Time course of immediate early gene protein expression in the spinal cord following conditioning stimulation of the sciatic nerve in rats. PLOS ONE.
  • Show author(s) 2015. PKR inhibition rescues memory deficit and atf4 overexpression in apoe ε4 human replacement mice. Journal of Neuroscience. 12986-12993.
  • Show author(s) 2015. Localization and regulation of PML bodies in the adult mouse brain. Brain Structure and Function. 15 pages.
  • Show author(s) 2015. Expression of Argonaute 2 and associated proteins following LTP induction in the dentate gyrus in vivo: comparsion between lysates and fractionated synaptoneurosomes.
  • Show author(s) 2015. Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Frontiers in Neuroscience.
  • Show author(s) 2015. Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior. 8 pages.
  • Show author(s) 2015. Chronic morphine treatment enhances sciatic nerve stimulation-induced immediate early gene expression in the rat dorsal horn. Acta Neurobiologiae Experimentalis. 305-313.
  • Show author(s) 2015. Arc is a flexible modular protein capable of reversible self-oligomerization. Biochemical Journal. 145-158.
  • Show author(s) 2014. Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell reports. 1430-1445.
  • Show author(s) 2014. Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Frontiers in Behavioral Neuroscience. 18 pages.
  • Show author(s) 2014. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathologica. 835-852.
  • Show author(s) 2014. NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo. Frontiers in Cellular Neuroscience.
  • Show author(s) 2014. Characterization of two predicted long non-coding RNAs in long-term synaptic plasticity in rat hippocampus.
  • Show author(s) 2014. BDNF regulation of synaptic structure, function, and plasticity. Neuropharmacology. 601-602.
  • Show author(s) 2014. BDNF mechanisms in late LTP formation: A synthesis and breakdown. Neuropharmacology. 664-676.
  • Show author(s) 2014. Arc protein-protein interaction in long-term potentiation in the rat dentate gyrus in vivo.
  • Show author(s) 2013. The changing brain – Insights into the mechanisms of neural and behavioral adaptation to the environment. Neuroscience. 412-422.
  • Show author(s) 2013. The Role of miR-­‐326 in Basal Synaptic Transmission and Long-­‐Term Potentiation in the Rat Dentate Gyrus In Vivo.
  • Show author(s) 2013. MicroRNA regulation in synaptic plasticity and expression of plasticity-associated genes during social defeat stress.
  • Show author(s) 2013. In search of a binding site for extracellular signal-regulated kinase (ERK) to the synaptic plasticity-related protein Arc.
  • Show author(s) 2013. Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats. Lipids in Health and Disease. 13 pages.
  • Show author(s) 2013. Early life stress influences on stress handling in adulthood - development of depressive- and anxiety-like behavior in Wistar rats.
  • Show author(s) 2012. miRNA-mediated regulation of translation in synaptic plasticity.
  • Show author(s) 2012. Remodeling of the microRNA-induced silencing complex during LTP in the adult rat brain in vivo.
  • Show author(s) 2012. Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behavioural Brain Research. 251-262.
  • Show author(s) 2012. Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo.
  • Show author(s) 2012. MicroRNA regulation of the synaptic plasticity-related gene arc. PLOS ONE. 15 pages.
  • Show author(s) 2012. DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. PLOS ONE. 12 pages.
  • Show author(s) 2012. Consolidation and translation regulation. Learning & memory (Cold Spring Harbor, N.Y.). 410-422.
  • Show author(s) 2012. Chronic mild stress abolishes a relationship between sleep architecture and translational control. Journal of Sleep Research. 41-41.
  • Show author(s) 2012. Balancing arc synthesis, mRNA decay, and proteasomal degradation : maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation. Journal of Biological Chemistry. 22354-22366.
  • Show author(s) 2012. Activity-dependent local translation of matrix metalloproteinase-9. Journal of Neuroscience. 14538-14547.
  • Show author(s) 2011. The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia. Biological Psychiatry. 35-42.
  • Show author(s) 2011. Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes. Frontiers in Behavioral Neuroscience.
  • Show author(s) 2011. Regulation of micro-RNA induced silencing complex during long-term potentiation in the dentate gyrus In vivo.
  • Show author(s) 2011. Chronic mild stress and acute sleep deprivation: interactive and brain-region specific effects on regulation of translation factor and CPEB phosphorylation.
  • Show author(s) 2010. The Arc of synaptic memory. Experimental Brain Research. 125-140.
  • Show author(s) 2010. Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Molecular Cell. 797-808.
  • Show author(s) 2010. Identification of Arc/Arg3.1 Binding Partners.
  • Show author(s) 2010. Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. European Journal of Neuroscience. 636-645.
  • Show author(s) 2009. microRNA-34a Function in Long-Term Potentiation in the Dentate Gyrus of the Anaesthetised Rat.
  • Show author(s) 2009. Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are Associated with memory and general cognitive abilities. PLOS ONE.
  • Show author(s) 2009. Time-lapse imaging of Arc/Arg3.1 protein degradation in hippocampal neurons using the novel photoconvertible fluorescent protein Dendra2.
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  • Show author(s) 2009. Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. PLOS ONE.
  • Show author(s) 2009. Novel Translational Control in Arc-dependent Long Term Potentiation Consolidation in Vivo. Journal of Biological Chemistry. 31498-31511.
  • Show author(s) 2009. Impairment of in vivo theta-burst long term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus. 130-140.
  • Show author(s) 2009. Arc/Arg3.1 synthesis and control of LTp consolidation in the adult dentate gyrus in vivo. European Neuropsychopharmacology. S190-S190.
  • Show author(s) 2008. The immediate early gene arc/arg3.1: regulation, mechanisms, and function. Journal of Neuroscience. 11760-11767.
  • Show author(s) 2008. Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers. Neuroscience. 1568-1575.
  • Show author(s) 2008. Sleep deprivation as an antidepressant treatment following chronic mild stress: effects on translation factor EIF4E and EEF2 activity. Journal of Sleep Research. 221-221.
  • Show author(s) 2008. Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus. Neural Plasticity.
  • Show author(s) 2008. Local protein synthesis, actin dynamics, and LTP consolidation. Current Opinion in Neurobiology. 524-531.
  • Show author(s) 2008. Effect of Antidepressant Treatment on the Expression of LTP-associated MicroRNAs.
  • Show author(s) 2007. Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: Induction of immunity-linked genes. Neuroscience. 925-936.
  • Show author(s) 2007. Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus In vivo. Journal of Neuroscience. 10445-10445.
  • Show author(s) 2007. Dendritic mRNA: transport, translation and function. Nature Reviews Neuroscience. 776-789.
  • Show author(s) 2007. Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications. Progress in Brain Research. 453-471.
  • Show author(s) 2007. Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Journal of Neural Plasticity.
  • Show author(s) 2007. Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines. Oncology Reports. 1501-1510.
  • Show author(s) 2006. Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment. Neuropharmacology. 428-440.
  • Show author(s) 2006. Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo. European Journal of Neuroscience. 1501-1511.
  • Show author(s) 2006. Genaktivering ved langtidspotensiering (LTP) i spinale smertesystem.
  • Show author(s) 2006. Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. Journal of Neurochemistry. 1328-1337.
  • Show author(s) 2006. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology, Biochemistry and Behavior. 842-849.
  • Show author(s) 2006. Chronic fluoxetine induces region-specific changes in translation factor eIF4E and eEF2 activity in the rat brain. European Journal of Neuroscience. 2814-2818.
  • Show author(s) 2006. Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: New insights and implications for therapy. Current opinion in drug discovery & development. 580-586.
  • Show author(s) 2006. Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain. Biochemical Society Transactions. 600-604.
  • Show author(s) 2005. Molecular mechanisms of synaptic consolidation during sleep: BDNF function and dendritic protein synthesis. Behavioral and Brain Sciences.
  • Show author(s) 2005. Chronic mild stress, an animal model of depression, affects the expression of BDNF and 5-HT levels over the sleep/wake cycle in hippocampus in rats. Sleep.
  • Show author(s) 2005. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol. Progress in Neurobiology. 99-125.
  • Show author(s) 2004. BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signalling events. Neurobiology of Aging. 1323-1333.
  • Show author(s) 2003. Understanding synaptic plasicity.
  • Show author(s) 2003. Trophic factors and plasticity.
  • Show author(s) 2003. The coupling of a TrkB tyrosine residue to LTP. Trends in Neurosciences. 171-173.
  • Show author(s) 2003. På sporet av hukommelsen.
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  • Show author(s) 2003. BDNF-induced synaptic consolidation requires ongoing translation of the immediate early gene Arc.
  • Show author(s) 2003. BDNF, translation control and dendritic protein synthesis in adult synaptic plasticity.
  • Show author(s) 2003. BDNF as a consolidation factor in adult synaptic plasticity.
  • Show author(s) 2003. BDNF as a consolidation factor in adult synaptic plasisity.
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  • Show author(s) 2003. BDNF as a consolidation factor in adult synaptic plasicity.
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  • Show author(s) 2003. BDNF as a consolidation factor in adult synaptic plasicity.
  • Show author(s) 2003. BDNF as a consolidation factor in adult synaptic plasicity.
  • Show author(s) 2003. BDNF as a consolidation factor in adult synaptic plasicity.
  • Show author(s) 2002. The instructive role of BDNF in long-term potentiation.
  • Show author(s) 2002. Rapid dendritic trafficking and translation of pre-existing CaMKII mRNA during LTP in awake rats.
  • Show author(s) 2002. Neurotrophins and synaptic plasticity in the adult hippocampus. 17 pages.
  • Show author(s) 2002. Modulation of neuronal calcium signaling by neurotrophic factors. International Journal of Developmental Neuroscience. 199-207.
  • Show author(s) 2002. Making memories last: brain-derived neurotrophic factor (BDNF) as a trigger for synaptic consolidation. 2 pages.
  • Show author(s) 2002. LTP-induced regulation of the immediate early genes arc and zif268 in the dentate gyrus of freely moving rats: effect of sleep-wakefulness state.
  • Show author(s) 2002. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learning & memory (Cold Spring Harbor, N.Y.). 224-237.
  • Show author(s) 2002. Effect of acute intrahippocampal BDNF infusion on synaptic efficacy at Schaffer collateral-CA1 synapses in vivo.
  • Show author(s) 2002. Effect of LTP induction in awake rats on the expression and dendritic trafficking of Arc and alpha-CaMKII mRNA: a real-time PCR analysis of synaptodendrosomes.
  • Show author(s) 2002. Det gåtefulle minnet.
  • Show author(s) 2002. Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. Journal of Neuroscience. 7453-7461.
  • Show author(s) 2002. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. Journal of Neuroscience. 1532-1540.
  • Show author(s) 2002. BDNF triggers transcription-dependent, late phase LTP in vivo.
  • Show author(s) 2001. Characterization of BDNF-induced LTP in the dentate gyrus in vivo.
  • Show author(s) 2001. Brain-derived neurotrophophic factor (BDNF) and Long-Term synaptic plasticity.
  • Show author(s) 2001. BDNF-induced long-term potentiation in the dentate gyrus in vivo is associated with phosphorylation of elongation factor-2.
  • Show author(s) 2001. BDNF-induced long-term potentiation in the dentate gyrus in vivo is associated with phosphorylation of elongation factor-2.
  • Show author(s) 2001. BDNF, LTP and neuroprotection.
  • Show author(s) 2001. BDNF and synaptic plasticity in the hippocampus in vivo.
  • Show author(s) 2001. BDNF and synaptic plasticity in the hippicampus in vivo.
  • Show author(s) 2001. BDNF and synaptic plasticity in the hippicampus in vivo.
  • Show author(s) 2001. BDNF and synaptic plasticity in the hippicampus in vivo.
  • Show author(s) 2001. BDNF and synaptic plasticity in the hippicampus in vivo.
  • Show author(s) 2000. Symposium: Neurotrophins and synaptic plasticity in the hippocampus.
  • Show author(s) 2000. Pairing of low frequency perforant path stimulation and endogenous exitatory events in dentate gyrus of the freely behaving rat.
  • Show author(s) 2000. LTP induction in wakefulness and sleep-effect on expression patterns of immediate early genes.
  • Show author(s) 2000. In vivo monitoring of TrkB-Fc efficacy and time course using paired-pulse inhibition in the dentate gyrus.
  • Show author(s) 2000. GFP-ERKII translocation in neurons: a marker for long-term synaptic plasticity.
  • Show author(s) 2000. Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression. Brain Research. Molecular Brain Research. 337-341.
  • Show author(s) 2000. Characterization of BDNF-induced long-term potentiation in the rat dentate gyrus.
  • Show author(s) 2000. Activation of MAPK signaling pathway is required in BDNF-induced long-term potentation in the adult hippocampus in vivo.
  • Show author(s) 1999. NMDA receptor activation is not required for BDNF-induced LTP in the rat dentate gyrus in vivo.
  • Show author(s) 1999. Mitogen and stress activated protein kinase signaling pathways: emerging functions in the nervous system. Recent Research Developments in Neurochemistry. 71-89.
  • Show author(s) 1999. MAP and SAP kinase signaling pathways: emerging functions in the nervous system. Recent Research Developmental in Neurochemistry. 71-89.
  • Show author(s) 1999. LTP induction in the dentate gyrus of freely moving rats is modulated by dentate EEG spikes.
  • Show author(s) 1999. BDNF-induced LTP is associated with enhanced ZIF/268 protein expression in rat dantate gyrus in vivo.
  • Show author(s) 1998. Phasic boosting of medial perforant path-evoked granule cell output time-locked to spontaneous dentate EEG spikes in awake rats. Journal of Neurophysiology. 2825-2832.
  • Show author(s) 1998. Neurotrophin regulation of synaptic plasticity in the adult nervous system.
  • Show author(s) 1998. In vivo BDNF-induced long-lasting potentiation in the rat dentate gyrus.
  • Show author(s) 1998. Endogenous neurotrophins and LTP in the dentate gyrus in vivo: effect of BDNF-scavenger Trk-IgG.
  • Show author(s) 1998. Effect of the BDNF-scavenger TrkB-IgF on LTP in the rat dentate gyrus in vivo.
  • Show author(s) 1998. Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus. Journal of Neurophysiology. 496-499.
  • Show author(s) 1998. Acute cold stress leading to elevated corticosterone neither enhances synaptic efficacy nor impairs tetanus-evoked LTP in the dentate gyrus of free moving rats. Brain Research. 245-255.
  • Show author(s) 1996. Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: Evidence for interhemisp communication. Journal of Comparative Neurology. 371-382.
  • Show author(s) 1996. Endogenous Activation of µ and -1 Opioid Receptors Is Required for Long-Term Potentiation Induction in the Lateral Perforant Path: Dependence on GABAergic Inhibition. Journal of Comparative Neurology. 8123-8131.
  • Show author(s) 1992. In vivo studies on long-term potentiation (LTP) in the dentate gyrus : role of opioid and NMDA receptors, and modulation by behavioral state.
  • Show author(s) 1991. Is arachidonic acid a retrograde messenger in long-term potentiation? Biochemical Society Transactions. 391-396.
  • Show author(s) 1991. Delta opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo. Brain Research. 42-50.
  • Show author(s) 1991. Activation of AP5-sensitive NMDA-receptors is required to induce LTP of synaptic transmission in the lateral perforant path. European Journal of Neuroscience. 1300-1308.

More information in national current research information system (CRIStin)

  • Arc as a master regulator of long-term synaptic plasticity 
  • Translational control of synaptic plasticity
  • Non-coding RNA regulation and function in synaptic plasticity

Links to funded projects:

Molecular control of Arc protein. Research Council of Norway, Top Research Project.

Synaptic circuit protection in Alzheimer´s disease (AD) and Huntington´s disease (HD). CircProt. EU-H2020: Joint programme in Neurodegenerative disorders

The impact of cytoplasmic polyadenylation on local translation in neurons. EEA grant. Poland-Norway Research Cooperation. 2020-2024.

POSTDOC AVAILABLE:  SYNAPTIC PLASTICITY MECHANSIMS/ELECTROPHYSIOLOGY. 

Deadline: October 4, 2020. Applications must be submitted through the JobbNorge website. Jobbnorge ID: 192194

In vivo electrophysiological studies of synaptic plasticity combined with genetic and local pharmacological manipulations.

Live-cell imaging in primary neuronal cultures, brain tissue slices, and intact rodents. Two-photon laser-scanning microscopy.  FRET imaging and single-particle tracking.  Single-cell electroporation.

Biochemical analysis of signal transduction mechanisms, protein-protein interactions, and functional analysis of post-translational modifications.  

Research groups

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