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Dag Rune Olsen's picture

Dag Rune Olsen

Professor
  • E-mailDag.Rune.Olsen@uib.no
  • Phone+47 930 85 881
  • Visitor Address
    Kalfarveien 31, 2. etasje
  • Postal Address
    Postboks 7800
    5020 Bergen

Adaptive radiation therapy of cancer - molecular imaging and biophysical modelling

Radiation therapy is a critical component in modern management of cancer. Still, approximately 1 out of 5 cancer patients die due to loco-regional failure. Radiation oncology is developing into the paradigm of focused biology, and radiobiological factors may be incorporated into optimization of radiation therapy.

Radiation therapy of tumours aims traditionally at delivering a homogeneous dose to the entire target volume, although intra-tumour variations in cellular and physiological factors of importance for response to therapy have been demonstrated. Biological adaptive radiation therapy (BioART) aims at tailoring the radiation dose distribution on a sub-regional level in the tumour according regional variations in radiobiological factors, like hypoxia.

It has been suggested that non-invasive biological imaging (like MRI, MRSi and PET) may provide the pertinent information to guide the painting or sculpting of the optimal dose distribution to the tumour. Simulations of tumour control probability (TCP) have demonstrated that increasing the dose to hypoxic regions, while keeping the mean dose constant may increase TCP. Moreover, tailored dose distribution is feasible with modern irradiation techniques like intensitymodulated radiation therapy (IMRT) and computer-controlled HDR brachytherapy. The aims of this project are:

 

- To utilize biological imaging (cedMRI, MRSi and PET) in visualizing cellular and tumour physiological factors of importance for radiation response

 

- Design models for optimizing dose distribution with respect to tumour control probability, based on biological imaging

- Demonstrate enhanced local control in experimental and clinical studies

 

Selected publications

Søvik A, Malinen E, Olsen DR. Adapting biological feedback in radiotherapy. Semin Radiat Oncol. 2010 Apr;20(2):138-46. 

Søvik A, Malinen E, Olsen DR. Strategies for biologic image-guided dose escalation: a review. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):650-8. 

Malinen E, Søvik A, Hristov D, Bruland ØS, Olsen DR. Adapting radiotherapy to hypoxic tumours. Phys Med Biol. 2006 Oct 7;51(19):4903-21.

 

Education: The faculty provides a wide range of bachelor and master programmes within the field of mathematics, sciences and technology, closely related with our research activities. As dean it is my reasonability that the faculty provides teaching of high quality to the best of our students and in the interest of our society.

Research is a core component of our activities – the dean aims at providing an international competitive research environment within mathematics, sciences and technology.

The health and safety of our employees and students is a prioritized area for this administration of the faculty.

Economy: Funding, optimal use of financial resources and resource allocation is a critical component in the realization of our strategic plans.

Additional functions:

board member of the Nansen Environmental and Remote Sensing Center

board member of L. Melzers fund for research

board member of Bjerknes Centre for Climate Research

Academic article
  • Show author(s) 2018. Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts. Acta Radiologica. 1-10.
  • Show author(s) 2015. Radiation treatment monitoring using multimodal functional imaging: PET/CT (18F-Fluoromisonidazole & 18F-Fluorocholine) and DCE-US. Journal of Translational Medicine. 10 pages.
  • Show author(s) 2015. Multimodal approach to assess tumour vasculature and potential treatment effect with DCE-US and DCE-MRI quantification in CWR22 prostate tumour xenografts. Contrast Media & Molecular Imaging. 428-437.
  • Show author(s) 2014. Associations between tumor vascularization assessed by in vivo DCE-MRI and the presence of disseminated tumor cells in bone marrow in breast cancer patients at the time of diagnosis. Journal of Magnetic Resonance Imaging. 1382-1391.
  • Show author(s) 2013. The clinical impact of mean vessel size and solidity in breast carcinoma patients. PLOS ONE. 11 pages.
  • Show author(s) 2013. Routine pelvic MRI using phased-array coil for detection of extraprostatic tumour extension: accuracy and clinical significance. European Radiology. 1158-1166.
  • Show author(s) 2013. Hypoxic tumor kinase signaling mediated by STAT5A in development of castration-resistant prostate cancer. PLOS ONE. 11 pages.
  • Show author(s) 2012. Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer. Radiation Oncology. 13 pages.
  • Show author(s) 2012. The updated ESTRO core curricula 2011 for clinicians, medical physicists and RTTs in radiotherapy/radiation oncology. Radiotherapy and Oncology. 103-108.
  • Show author(s) 2012. Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation. International Journal of Radiation Biology. 311-319.
  • Show author(s) 2012. Iterative reconstruction reduces abdominal CT dose. European Journal of Radiology. 1483-1487.
  • Show author(s) 2012. Assessment of liposome biodistribution by non-invasive optical imaging: a feasibility study in tumour-bearing mice. Journal of Nanoscience and Nanotechnology. 2912-2918.
  • Show author(s) 2011. Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice. Journal of drug targeting (Print). 701-708.
  • Show author(s) 2011. Quantification of Angiogenesis in Breast Cancer by Automated Vessel Identification in CD34 Immunohistochemical Sections. Anticancer Research. 4053-4060.
  • Show author(s) 2011. Predicted Risk of Radiation-Induced Cancers After Involved Field and Involved Node Radiotherapy With or Without Intensity Modulation for Early-Stage Hodgkin Lymphoma in Female Patients. International Journal of Radiation Oncology, Biology, Physics. 490-497.
  • Show author(s) 2011. Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion-weighted MR imaging. European Radiology. 1188-1199.
  • Show author(s) 2011. Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts. Radiation Oncology. 10 pages.
  • Show author(s) 2011. Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study. Radiation Oncology.
  • Show author(s) 2011. Dose evaluation and risk estimation for secondary cancer in contralateral breast and a study of correlation between thorax shape and dose to organs at risk following tangentially breast irradiation during deep inspiration breath-hold and free breathing. Acta Oncologica. 563-568.
  • Show author(s) 2011. Dose distribution in the thyroid gland following radiation therapy of breast cancer-a retrospective study. Radiation Oncology. 7 pages.
  • Show author(s) 2010. Preclinical dynamic F-18-FDG PET - tumor characterization and radiotherapy response assessment by kinetic compartment analysis. Acta Oncologica. 914-921.
  • Show author(s) 2010. Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions. Neoplasia. 818-825.
  • Show author(s) 2010. LATE EFFECTS AFTER RADIOTHERAPY FOR LOCALLY ADVANCED CERVICAL CANCER: COMPARISON OF TWO BRACHYTHERAPY SCHEDULES AND EFFECT OF DOSE DELIVERED WEEKLY. International Journal of Radiation Oncology, Biology, Physics. 713-718.
  • Show author(s) 2010. Improved image quality of low-dose thoracic CT examinations with a new postprocessing software. Journal of Applied Clinical Medical Physics. 250-258.
  • Show author(s) 2010. Diffusion-weighted magnetic resonance imaging for pretreatment prediction and monitoring of treatment response of patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. Acta Oncologica. 354-360.
  • Show author(s) 2010. CT Density in Lung Cancer Patients After Radiotherapy Sensitized by Metoclopramide A Subgroup Analysis of a Randomized Trial. Strahlentherapie und Onkologie (Print). 163-168.
  • Show author(s) 2010. Adapting Biological Feedback in Radiotherapy. Seminars in Radiation Oncology. 138-146.
  • Show author(s) 2009. The elimination of low dose hyper-radiosensitivity by transfer of irradiated-cell conditioned medium depends on dose rate. Radiation Research. 22-32.
  • Show author(s) 2009. Pediatric digital chest radiography, comparison of grid vs. non-grid techniques. European Journal of Radiography. 201-206.
  • Show author(s) 2009. Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology. 1157-1165.
  • Show author(s) 2009. Late regional density changes of the lung after radiotherapy for breast cancer. Radiotherapy and Oncology. 148-152.
  • Show author(s) 2009. Hybrid intelligent modeling and prediction of texture segmented lesion from 4DCT scans of thorax. 2009. IEEE International Fuzzy Systems conference proceedings. 1801-1805.
  • Show author(s) 2009. DCEMRI of spontaneous canine tumors during fractionated radiotherapy: A pharmacokinetic analysis. Radiotherapy and Oncology. 618-624.
  • Show author(s) 2009. DCEMRI of spontaneous canine tumors during fractionated radiotherapy: A pharmacokinetic analysis. Radiotherapy and Oncology. 618-624.
  • Show author(s) 2009. Cancer treatment by radiotherapy in Western Nepal: a hospital-based study. Asian Pacific Journal of Cancer Prevention.
  • Show author(s) 2009. Cancer Treatment by Radiotherapy in Western Nepal: A Hospital-based Retrospective study. Asian Pacific Journal of Cancer Prevention. 205-208.
  • Show author(s) 2009. Automatic segmentation and recognition of lungs and lesion from CT scans of thorax. Computerized Medical Imaging and Graphics. 72-82.
  • Show author(s) 2009. Artificial neural networks for prediction of response to chemoradiation in ht29 xenografts. International Journal of Radiation Oncology, Biology, Physics. 506-511.
  • Show author(s) 2009. Artificial neural networks for prediction of response to chemoradiation in HT29 xenografts. International Journal of Radiation Oncology, Biology, Physics. 506-511.
  • Show author(s) 2009. A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and volumetric modulated arc treatment techniques. Acta Oncologica.
  • Show author(s) 2009. A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and Volumetric modulated arc treatment techniques. Acta Oncologica. 495-503.
  • Show author(s) 2008. Teleradiology with satellite units - six years experience at the norwegian radium hospital. Studies in Health Technology and Informatics. 209-216.
  • Show author(s) 2008. Reduction in dose from CT examinations of liver lesions with a new postprocessing filter: A ROC phantom study. Acta Radiologica.
  • Show author(s) 2008. Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation. Acta Oncologica. 248-254.
  • Show author(s) 2008. Quality assurance of dosimetry and the impact on sample size in randomized clinical trials. Radiotherapy and Oncology.
  • Show author(s) 2008. Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high–resolution magic angle spinning 1H magnetic resonance spectroscopy. Molecular Cancer. 33.
  • Show author(s) 2008. Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy. Molecular Cancer. 33.
  • Show author(s) 2008. Kreftterapi med lette ioner. HMT - Helsetjenesten Medisinsk Teknikk : helse, medisin, teknikk. 7-8.
  • Show author(s) 2008. Inclusion of Biological Information in Treatment Plan Optimization. Medical Physics (Lancaster). 2873-2874.
  • Show author(s) 2008. Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer. Acta Oncologica.
  • Show author(s) 2008. Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer. Acta Oncologica.
  • Show author(s) 2008. Dynamic contrast enhanced magnetic resonance imaging of bladder cancer and implications for biological image-adapted radiotherapy. Acta Oncologica. 1257-1264.
  • Show author(s) 2008. Dynamic contrast enhanced magnetic resonance imaging of bladder cancer and implications for biological image-adapted radiotherapy. Acta Oncologica. 1257-1264.
  • Show author(s) 2008. DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica. 1249-1256.
  • Show author(s) 2008. DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica. 1249-1256.
  • Show author(s) 2008. DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica. 1249-1256.
  • Show author(s) 2007. Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate. International Journal of Low Radiation. 69-86.
  • Show author(s) 2007. Reconstruction of a ring applicator using CT imaging: impact of the reconstruction method and applicator orientation. Physics in Medicine and Biology. 4893-4904.
  • Show author(s) 2007. Radiotherapy adapted to spatial and temporal variability in tumor hypoxia. International Journal of Radiation Oncology, Biology, Physics. 1496-1504.
  • Show author(s) 2007. Radiotherapy Adapted to Spatial and Temporal Variability in Tumor Hypoxia. International Journal of Radiation Oncology, Biology, Physics. 1496-1504.
  • Show author(s) 2007. Radiobiological responses for two cell lines following continuous low dose-rate (CLDR) and pulsed dose rate (PDR) brachytherapy. Acta Oncologica. 602-611.
  • Show author(s) 2007. Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study. Physics in Medicine and Biology. 499-513.
  • Show author(s) 2007. On the parameter describing the generalised equivalent uniform dose (gEUD) for tumours. Physica Medica. 100-106.
  • Show author(s) 2007. Noninvasive monitoring of radiation-induced treatment respons using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model. Radiotherapy and Oncology. 187-194.
  • Show author(s) 2007. Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabine, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice. Neoplasia. 392-400.
  • Show author(s) 2007. Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabene, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice. Neoplasia. 392-400.
  • Show author(s) 2007. Contralateral breast doses following radiotherapy of the breast and regional lymph nodes: Measurements and treatment planning calculations. Radiotherapy and Oncology.
  • Show author(s) 2007. Consequences of leaf calibration errors on IMRT delivery. Physics in Medicine and Biology. 1147-1156.
  • Show author(s) 2006. EPR dosimetry of radiotherapy photon beams in inhomogeneous media using alanine films. Physics in Medicine and Biology. 6315-6328.
  • Show author(s) 2006. Dose optimisation in single plane interstitial brachytherapy. Radiotherapy and Oncology. 105-111.
  • Show author(s) 2006. Analysis of normal tissue complication probability of the lung using a reliability model. Acta Oncologica. 610-617.
  • Show author(s) 2006. Adapting radiotherapy to hypoxic tumours. Physics in Medicine and Biology. 4903-4921.
  • Show author(s) 2005. Telemedicine in radiotherapy: A study exploring remote treatment planning, supervision and economics. Journal of Telemedicine and Telecare. 245-250.
  • Show author(s) 2005. Respiratory motion prediction by using the adaptive neuro fuzzy inference system (ANFIS). Physics in Medicine and Biology. 4721-4278.
  • Show author(s) 2005. Image quality preferences among radiographers and radiologists. A conjoint analysis. Radiography. 191-197.
  • Show author(s) 2005. Comparative analyses of the dynamic properties of the bladder wall studied by repetitive pelvic CT scans of patients and cryo-sections of cadavers. British Journal of Radiology (BJR). 528-532.
  • Show author(s) 2004. Electron paramagnetic resonance (EPR) dosimetry using lithium formate in radiotherapy: comparison with thermoluminescence (TL) dosimetry using lithium fluoride rods. Physics in Medicine and Biology. 4701-4715.
  • Show author(s) 2003. Definitive radiotherapy of prostate cancer: the possible role of staging lymphdenectomy. International Journal of Radiation Oncology, Biology, Physics. 33-41.
  • Show author(s) 2003. Changes in treatment volume of hormonally treated and untreated cancerous prostate and its impact on rectal dose. Acta Oncologica. 10-14.
  • Show author(s) 2003. Brachytherapy for prostate cancer: A systematic review of clinical and cost effectiveness. European Urology. 40-46.
  • Show author(s) 2002. Side effects and quality of life after inadvertent radiation overdosage in brachytherapy of head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics. 944-952.
  • Show author(s) 2002. Relationship between normal tissue complication probabilities and lung function in patients with lung cancer receiving radiotherapy. International Journal of Cancer. 457-457.
  • Show author(s) 2002. Preoperative irradiation and surgery for recurrent rectal cancer. Will intraoperative radiotherapy (IORT)be of additional benefit? A prospective study. Radiotherapy and Oncology. 207-213.
  • Show author(s) 2002. Preoperative irradiation and surgery for recurrent rectal cancer. Will intraoperative radiotherapy (IORT) be of additional benefit? A prospective study. Radiotherapy and Oncology. 207-213.
  • Show author(s) 2002. Modelling volume effects of experimental brachytherapy in the rat rectum: uncovering the limitations of a radiologic concept. International Journal of Radiation Oncology, Biology, Physics. 1014-1022.
  • Show author(s) 2002. Modelling volume effects of experimental brachytherapy in the rat rectum: uncovering the limitations of a radiobiological concept. International Journal of Radiation Oncology, Biology, Physics. 1014-1022.
  • Show author(s) 2002. Long-term renal function after treatment for malignant germ-cell tumours. Annals of Oncology. 222-228.
  • Show author(s) 2002. Imaging for radiotherapy treatment planning. Radiotherapy and Oncology. 03-13.
  • Show author(s) 2002. Dynamic properties of the rectum wall with implications for radiotherapy planning. Comparative studies using cryosections of human cadavers and pelvic CT-scans of patients. British Journal of Radiology (BJR).
  • Show author(s) 2002. Cell Cycle Inhibitors and Outcome after Radiotherapy in Bladder Cancer Patients. Acta Oncologica. 463-470.
  • Show author(s) 2002. Brakyterapi ved prostatakreft. Tidsskrift for Den norske legeforening. 2795-2798.
  • Show author(s) 2002. Brachytherapy for prostate cancer - a systematic review of the evidence. International Journal of Cancer. 124.
  • Show author(s) 2001. Stråleterapisatellittenheten i Kristiansand ¿ en modell for norske regionsykehus. Tidsskrift for Den norske legeforening. 2179-2182.
  • Show author(s) 2001. Inter-fraction variations in rectum and bladder volumes and dose distribution during HDR brachytherapy treatment of the uterine cervix investigated by repetitive CT-examinations. Radiotherapy and Oncology. 273-280.
  • Show author(s) 1999. Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal radiotherapy. International Journal of Radiation Oncology, Biology, Physics. 385-391.
  • Show author(s) 1999. Measurement of dose rate at the interfase of cell culture medium and glass dishes by means of ESR dosimetry using thin films of alanine. Radiation Research. 76-82.
  • Show author(s) 1999. Long-term morbidity and Quality of Life in patients with localised prostate cancer undergoing definitive radiotherapy or radical prostatectomy. International Journal of Radiation Oncology, Biology, Physics. 735-743.
  • Show author(s) 1999. Inverse dose-rate effect due to pre-mitotic accumulation during continuous low dose rate irradiation of cervix carcinoma cells. International Journal of Radiation Biology. 699-707.
  • Show author(s) 1999. Comparison of radiation side-effects in prostate cancer. The Lancet.
  • Show author(s) 1997. Strålebiologisk forskning vil gi framskritt for strålebehandlingen. Kreftnytt. 9-12.
  • Show author(s) 1997. Strålebehandling mot år 2000. Langs nye veier, eller "paa gjengrodde stier". Kreftnytt. 4-8.
  • Show author(s) 1997. Radiotherapy in the Management of Bladder Cancer. European urology update series. 80-85.
  • Show author(s) 1997. External beam abdominal radiotherapy in patients with seminoma stage I: Field type, testicular dose and spermatogenesis. International Journal of Radiation Oncology, Biology, Physics. 95-102.
  • Show author(s) 1997. Combined modality treatment including intraoperative radiotherapy in locally advanced and recurrent rectal cancer. Radiotherapy and Oncology. 277-282.
Report
  • Show author(s) 2006. Protonterapi. 11. 11. .
  • Show author(s) 2002. Brachyterapy ved prostatakreft. Medisinsk metodevurdering basert på egen litteraturgjennomgang. 2. 2. .
Popular scientific lecture
  • Show author(s) 2014. Innlegg og debatt om Universitetet før, nå og i fremtiden. Debattleder: Per Buvik.
  • Show author(s) 2001. Planlagt opplegg for utdanning av medisinske fysikere ved Fysisk Institutt, Universietet i Oslo.
Academic lecture
  • Show author(s) 2012. Particle therapy – leveraging clinical performance?
  • Show author(s) 2009. Diffusion-weighted MRI for pretreatment prediction and monitoring of treatment response for patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy.
  • Show author(s) 2009. Chest image interpretation: Quality improvement.
  • Show author(s) 2008. Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming.
  • Show author(s) 2008. Klaas Breur Lecture 2008:ADAPTIVE RADIATION ONCOLOGY BASED ON MOLECULAR AND FUNCTIONAL IMAGING.
  • Show author(s) 2008. Inclusion of Biological Information in Treatment Plan Optimization.
  • Show author(s) 2007. LOW DOSE HYPER-RADIOSENSITIVITY IN T-47D CELLS.
  • Show author(s) 2006. Lav-dosis hypersensitivitet hos T-47D brystkræftceller.
  • Show author(s) 2006. Intracellular signalling through medium transfer and low dose hyper-radiosensitivity.
  • Show author(s) 2005. When is grid technique required in paediatric chest radiography?
  • Show author(s) 2005. Recovery of low-dose HRS following a small priming dose depends on priming dose rate.
  • Show author(s) 2005. Radiation-induced late effects after breast cancer treatment.
  • Show author(s) 2005. Proton therapy: current evidence challenge evidence based for implementation of new methods and strengthens the importance of integrating ethical and juridical considerations into the HTA process.
  • Show author(s) 2005. Predicting treatment outcome of biologically optimized IMRT for hypoxic tumors.
  • Show author(s) 2005. Modellering av behandlingsutfall ved biologisk optimalisert IMRT av hypoksiske tumorer.
  • Show author(s) 2004. Optimization of TCP in hypoxic tumors by dose redistribution.
  • Show author(s) 2004. Analysis of NTCP of the lung using a reliability model.
  • Show author(s) 2002. The role of modern radiobiology in optimized radiation therapy.
  • Show author(s) 2002. Non-uniform tumour dose based on tumour-physiological imaging - a novel strategy for improved tumour control.
  • Show author(s) 2001. The benefit of NTCP modelling in predicting rectal complications.
  • Show author(s) 2001. Telemedicine in oncology.
  • Show author(s) 2001. Non-invasive monitoring of tumor reoxygenation following irradiation by 31P MR spectroscopy.
  • Show author(s) 2001. Intensitetsmodulert stråleterapi (IMRT) - "Keiserens nye klær" eller stråleterapi langs nye veier ? - en strålebiologisk vurdering.
  • Show author(s) 2001. Ein Strahlentherapiesatellit fur ein dezentralisiertes/zentralisiertes telemedizinisches Diagnose- und Therapieangebot.
Editorial
  • Show author(s) 2010. Leveraging clinical performance by technological excellence - The case of particle therapy. Radiotherapy and Oncology. 1-2.
  • Show author(s) 2010. Biology-guided adaptive radiation therapy - presence or future? Acta Oncologica. 884-887.
Reader opinion piece
  • Show author(s) 2020. Tre uomtvistelige fakta. Aftenposten (morgenutg. : trykt utg.).
  • Show author(s) 2020. Ingen forskning, ingen omstilling. Dagens næringsliv.
  • Show author(s) 2015. Samarbeid om fremragende og innovativ forskning. Forskningspolitikk. 4-5.
  • Show author(s) 2013. Akademia og næringsliv i skjønn forening. Morgenbladet. 19-19.
  • Show author(s) 2011. Styrk finansieringen! Aftenposten (morgenutg. : trykt utg.).
Non-fiction book
  • Show author(s) 2008. Targeted high-LET therapy of bone metastases. Springer Science+Business Media B.V..
Thesis at a second degree level
  • Show author(s) 1998. Matematiske modellering av seneffekter ved strålebehandling.
Feature article
  • Show author(s) 2011. Kunnskap-nøkkelen til fremtidens verdiskapning. Bergens Tidende.
  • Show author(s) 2008. Protonterapi – men hva så? Dagsavisen.
Doctoral dissertation
  • Show author(s) 2012. Treatment response evaluation in experimental prostate cancer by functional magnetic resonance imaging and molecular profiling.
  • Show author(s) 2010. Late side effects and modern radiotherapy techniques in the tratment of breast cancer.
  • Show author(s) 2008. Pulmonary changes following thoracic irradiation. 695.
  • Show author(s) 2008. Magnetic resoncance spectroscopy and diffusion for prediction and monitoring of treatment response in rectal cancer. 711.
  • Show author(s) 2007. Biologically adapted radiotherapy and evaluation of non-uniform dose distributions. 625.
  • Show author(s) 1999. 31P NMR Sepctroscopy in measurements of physiological parameters and response to therapy of human melanoma xenografts.
Interview
  • Show author(s) 2020. No får dei første 16.000 studentane kome tilbake.
  • Show author(s) 2020. Fortsatt høy beredskap og kriseledelse flere steder.
  • Show author(s) 2019. Rektorer på Vestlandet tenker høyt om en strukturprosess 2.0.
  • Show author(s) 2013. Venstres miljøpris til Bjerknessenteret og CICERO.
  • Show author(s) 2013. Klimaforskinga og tusenkroners-spørsmålet / Klimaforskinga og tusenkronersspørsmålet.
  • Show author(s) 2012. Roper på næringslivet.
  • Show author(s) 2010. Startskot for klimasenter.
  • Show author(s) 2010. Kreftbehandling og protonterapi.
  • Show author(s) 2009. Kvantemedisin - Mirakelmaskin eller bedrageri?
  • Show author(s) 2009. Dag Rune Olsen, stråleekspert om ny lungekreftbehandling.
  • Show author(s) 2008. Protonterapi ved kreft - ikke et tilbud i Norge ?
Documentary
  • Show author(s) 2016. En banebrytende sosialantropolog ved veis ende. Professor Fredrik Barth som døde 24. januar i år, har hatt en internasjonal posisjon som svært få andre norske samfunnsforskere.
Programme participation
  • Show author(s) 2009. Debatt om 'kvantemedisin' i Kveldsåpent, NRK P1.
Academic chapter/article/Conference paper
  • Show author(s) 2009. Radiation therapy- ionizing radiation in the treatment of cancer. 8 pages.
  • Show author(s) 2005. Fysikk og medisin. 15 pages.
Abstract
  • Show author(s) 2014. DCE-MRI and DCE-US quantification in CWR22 prostate tumour xenografts. Radiotherapy and Oncology. S4.
  • Show author(s) 2012. DCEMRI IN ASSESSMENT OF TUMOR NEOVASCULARIZATION AFTER ANDROGEN-DEPRIVATION IN EXPERIMENTAL PROSTATE CANCER: CORRELATION TO QUANTITATIVE IMMUNOHISTOCHEMISTRY. Radiotherapy and Oncology. S68.
  • Show author(s) 2010. Prediction of response to cancer therapy from functional magnetic resonance image parameters - an artificial neural network approach. European Journal of Cancer. 39-40.
  • Show author(s) 2010. Predicted Risk of Radiation-Induced Cancers after Involved Field- and Involved-Node Radiotherapy with or without Intensity Modulation for Early Stage Hodgkin Lymphoma in Female Patients. International Journal of Radiation Oncology, Biology, Physics. S546-S546.
  • Show author(s) 2009. Chest image interpretation: Quality improvement. European Radiology.
  • Show author(s) 2008. Klaas Breur Lecture 2008:ADAPTIVE RADIATION ONCOLOGY BASED ON MOLECULAR AND FUNCTIONAL IMAGING. Radiotherapy and Oncology. S120-S120.
  • Show author(s) 2007. Treatment response following combined capecitabine, oxaliplatin and radiation therapy monitored by diffusion weighted magnetic resonance imaging (DW-MRI) in a xenograft model. European Journal of Cancer Supplements. 62-62.
  • Show author(s) 2007. The influence of rectal movement on dose during fractionated radiotherapy. Radiotherapy and Oncology.
  • Show author(s) 2006. Automated texture based CT segmentation by Gabor filtering and fuzzy clustering. Medical Physics (Lancaster). 2170-2170.
  • Show author(s) 2006. Automated texture based CT segmentation by Gabor filtering and Fuzzy clustering. AAPM 48th Annual meeting , Florida.
  • Show author(s) 2005. Dose measurements in heterogeneous media using alanine film dosimetry. Radiotherapy and Oncology. s205-s206.
Poster
  • Show author(s) 2010. Quantitative in vivo DCE MRI of prostate cancer xenografts: assessment of ADT and RT efficacy.
  • Show author(s) 2010. Early prediction of treatment response in xenografts using quantitative diffusion weighted MRI.
  • Show author(s) 2007. Treatment response following combined capecitabine, oxaliplatin and radiation therapy monitored by diffusion weighted magnetic resonance imaging (DW-MRI) in a xenograft model.
  • Show author(s) 2006. ESR-dosimetri med alaninfilm i heterogene medier.
  • Show author(s) 2005. Dose measurements in heterogeneous media using alanine film dosimetry.
  • Show author(s) 2000. Inter-fraction variations of doses to organs at risk and NTCP-calculations for patients treated with gynaecological HDR brachytherapy-.
Errata
  • Show author(s) 2016. Erratum to: Radiation treatment monitoring using multimodal functional imaging: PET/CT (18F-Fluoromisonidazole F-Fluorocholine) and DCE-US. Journal of Translational Medicine.
Academic literature review
  • Show author(s) 2010. Optimal Use of Automatic Exposure Control in CT: a Literature Review. Radiologic Technology. 309-317.
  • Show author(s) 2009. STRATEGIES FOR BIOLOGIC IMAGE-GUIDED DOSE ESCALATION: A REVIEW. International Journal of Radiation Oncology, Biology, Physics. 650-658.
  • Show author(s) 2007. Proton therapy - A systematic review of clinical effectiveness. Radiotherapy and Oncology. 123-132.
Interview Journal
  • Show author(s) 2010. Jukset på etikkeksamen. Bergens Tidende.

More information in national current research information system (CRIStin)

Publications in international peer-review journals 2005-date

 

2012:

Kathrine Røe, Lars TG Mikalsen, Albert J van der Kogel, Johan Bussink, Heidi Lyng, Anne H Ree, Laure Marignol and Dag R Olsen. (2012) Vascular responses to radiotherapy and androgendeprivation therapy in experimental prostate cancer.  Radiation Oncology 2012, 7:75 

Eriksen JG, Beavis AW, Coffey MA, Leer JW, Magrini SM, Benstead K, Boelling T, Hjälm-Eriksson M, Kantor G, Maciejewski B, Mezeckis M, Oliveira A, Thirion P, Vitek P, Olsen DR, Eudaldo T, Enghardt W, François P, Garibaldi C, Heijmen B, Josipovic M, Major T, Nikoletopoulos S, Rijnders A, Waligorski M, Wasilewska-Radwanska M, Mullaney L, Boejen A, Vaandering A, Vandevelde G, Verfaillie C, Pötter R. (2012) The updated ESTRO core curricula 2011 for clinicians, medical physicists and RTTs in radiotherapy/radiation oncology. Radiother Oncol. 103(1):103-8

Edin NJ, Olsen DR, Sandvik JA, Malinen E, Pettersen EO. (2011) Low dose
hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation. Int J Radiat Biol.  88(4):311-9.

2011:

Mikalsen LT, Dhakal HP, Bruland OS, Nesland JM, Olsen DR. (2011 Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections. Anticancer Res. 31(12):4053-60.

Hagtvet E, Roe K, Olsen DR. (2011) Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts. Radiat Oncol. 6(1):135.

Johansen S, Reinertsen K, Knutstad K, Olsen D, Fossa S. (2011) Dose distribution in the thyroid gland following radiation therapy of breast cancer-a retrospective study. Radiat Oncol. 6:68.

Roe K, Kakar M, Seierstad T, Ree AH, Olsen DR. (2011) Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study. Radiation Oncology  6:65.

Martinsen AC, Sæther HK, Hol PK, Olsen DR, Skaane  (2011).Iterative reconstruction reduces abdominal CT dose. Eur J Radiol. [Epub ahead of print]

Hagtvet E, Evjen TJ, Olsen DR, Fossheim SL, Nilssen EA (2011). Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice. J Drug Target. 19(8):701-8 

Johansen S, Vikström J, Hjelstuen MH, Mjaaland I, Dybvik KI, Olsen DR (2011). Dose evaluation and risk estimation for secondary cancer in contralateral breast and a study of correlation between thorax shape and dose to organs at risk following tangentially breast irradiation during deep inspiration breath-hold and free breathing. Acta Oncol. 50(4):563-8.

Fangberget A, Nilsen LB, Hole KH, Holmen MM, Engebraaten O, Naume B, Smith HJ, Olsen DR, Seierstad T (2011). Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion weighted MR imaging. Eur Radiol. 21(6):1188-99.

Weber DC, Johanson S, Peguret N, Cozzi L, Olsen DR (2011). Predicted Risk of Radiation-Induced Cancers after Involved Field and Involved Node Radiotherapy with or without Intensity Modulation for Early-Stage Hodgkin Lymphoma in Female Patients.  Int J Radiat Oncol Biol Phys. 81(2):490-7

2010:

Røe K, Seierstad T, Kristian A, Mikalsen LTG, Mælamdsmo GM, van der Kogel AJ, Ree AH, Olsen DR (2010). Longitudinal MRI-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions. Neoplasia 12(10): 818-25.

Røe K, Aleksandersen TB, Kristian A, Nilsen LB, Seierstad T, Qu H, Ree AH,
Olsen DR, Malinen E. (2010) Preclinical dynamic (18)F-FDG PET - tumor characterization and radiotherapy response assessment by kinetic compartment analysis. Acta Oncol. 49(7):914-21.

Grau C, Olsen DR, Overgaard J, Høyer M, Lindegaard JC, Muren LP (2010).
Biology-guided adaptive radiation therapy - presence or future? Acta Oncol. 49(7):884-7.

Martinsen AC, Saether HK, Olsen DR, Wolff PA, Skaane P. Improved image quality of low-dose thoracic CT examinations with a new postprocessing software. J Appl Clin Med Phys. 2010 May 25;11(3):3242.

Nilsen L, Fangberget A, Geier O, Olsen DR and Seierstad T. Diffusion-weighted magnetic resonance imaging for pretreatment prediction and monitoring of treatment response of patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. Acta Oncol. (2010) Apr;49(3):354-60.  

Gudjónsdóttir J, Ween B, Olsen DR (2010). Optimal use of AEC in CT: a literature review. Radiol Technol. 81(4):309-17.

Søvik A, Malinen E, Olsen DR (2010). Adapting biological feedback in radiotherapy. Semin Radiat Oncol. 20(2):138-46.

Olsen DR, Overgaard J (2010). Leveraging clinical performance by technological excellence - The case of particle therapy. Radiother Oncol. 95(1):1-2. (editorial)

Dale,E, Harsaker,V, Kristoffersen,DT, Bruland,O, and Olsen,DR (2010). CT Density in Lung Cancer Patients After Radiotherapy Sensitized by Metoclopramide A Subgroup Analysis of a Randomized Trial. Strahlentherapie und Onkologie 186(3):163-168.

Hellebust,TP, Kristensen,GB, and Olsen,DR (2010). Late Effects After Radiotherapy for Locally Advanced Cervical Cancer: Comparison of Two Brachytherapy Schedules and Effect of Dose Delivered Weekly. International Journal of Radiation Oncology Biology Physics 76(3):713-718.

2009:

Edin,NJ, Olsen,DR, Stokke,T, Sandvik,JA, Ebbesen,P, and Pettersen,EO (2009). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology 85(12):1157-1165.

Sovik,A, Skogmo,HK, Andersen,EKF, Bruland,OS, Olsen,DR, and Malinen,E (2009). DCEMRI of spontaneous canine tumors during fractionated radiotherapy: A pharmacokinetic analysis. Radiotherapy and Oncology 93(3):618-624.

Kakar,M, Seierstad,T, Roe,K, and Olsen,DR (2009). Artificial Neural Networks for Prediction of Response to Chemoradiation in Ht29 Xenografts. International Journal of Radiation Oncology Biology Physics 75(2):506-511.

Johansen,S, Cozzi,L, and Olsen,DR (2009). A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and Volumetric modulated arc treatment techniques. Acta Oncologica 48(4):495-503.

Sovik,A, Malinen,E, and Olsen,DR (2009). Strategies for Biologic Image-Guided Dose Escalation: A Review. International Journal of Radiation Oncology Biology Physics 73(3):650-658.

Vagane,R, Danielsen,T, Fossa,SD, Lokkevik,E, and Olsen,DR (2009). Late regional density changes of the lung after radiotherapy for breast cancer. Radiotherapy and Oncology 90(1):148-152.

Kakar,M and Olsen,DR (2009). Automatic segmentation and recognition of lungs and lesion from CT scans of thorax. Computerized Medical Imaging and Graphics 33(1):72-82.

Edin,NJ, Sandvik,JA, Olsen,DR, and Pettersen,EO (2009). The Elimination of Low-Dose Hyper-radiosensitivity by Transfer of Irradiated-Cell Conditioned Medium Depends on Dose Rate. Radiation Research 171(1):22-32.

2008:

Sovik,A, Skogmo,HK, Bruland,OS, Olsen,DR, and Malinen,E (2008). DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica 47(7):1249-1256.

Roe,K, Muren,LP, Rorvik,J, Olsen,DR, Dahl,O, Bakke,A et al. (2008). Dynamic contrast enhanced magnetic resonance imaging of bladder cancer and implications for biological image-adapted radiotherapy. Acta Oncologica 47(7):1257-1264.

Seierstad,T, Roe,K, Sitter,B, Halgunset,J, Flatmark,K, Ree,AH et al. (2008). Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning H-1 magnetic resonance spectroscopy. Molecular Cancer 7.

Martinsen,ACT, Saether,HK, Olsen,DR, Skaane,P, and Olerud,HM (2008). Reduction in dose from CT examinations of liver lesions with a new postprocessing filter: A ROC phantom study. Acta Radiologica 49(3):303-309.

Vagane,R, Bruland,OS, Fossa,SD, and Olsen,DR (2008). Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation. Acta Oncologica 47(2):248-254.

Johansen,S, Danielsen,T, and Olsen,DR (2008). Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer. Acta Oncologica 47(3):391-396.

Pettersen,MN, Aird,E, and Olsen,DR (2008). Quality assurance of dosimetry and the impact on sample size in randomized clinical trials. Radiotherapy and Oncology 86(2):195-199.

2007:

Sovik,A, Ovrum,J, Olsen,DR, and Malinen,E (2007). On the parameter describing the generalised equivalent uniform dose (gEUD) for tumours. Physica Medica 23(3-4):100-106. 

Olsen,DR and Thwaites,DI (2007). Now you see it... Imaging in radiotherapy treatment planning and delivery. Radiotherapy and Oncology 85(2):173-175.

Seierstad,T, Roe,K, and Olsen,DR (2007). Noninvasive monitoring of radiation-induced treatment response using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model. Radiotherapy and Oncology 85(2):187-194.

Sovik,A, Malinen,E, Skogmo,HK, Bentzen,SM, Bruland,OS, and Olsen,DR (2007). Radiotherapy adapted to spatial and temporal variability in tumor hypoxia. International Journal of Radiation Oncology Biology Physics 68(5):1496-1504.

Hellebust,TP, Tanderup,K, Bergstrand,ES, Knutsen,BH, Roislien,J, and Olsen,DR (2007). Reconstruction of a ring applicator using CT imaging: impact of the reconstruction method and applicator orientation. Physics in Medicine and Biology 52(16):4893-4904.

Hanisch,PH, Furre,T, Olsen,DR, and Pettersen,EO (2007). Radiobiological responses for two cell lines following continuous low dose-rate (CLDR) and pulsed dose rate (PDR) brachytherapy. Acta Oncologica 46(5):602-611.

Olsen,DR, Bruland,OS, Frykholm,G, and Norderhaug,IN (2007). Proton therapy - A systematic review of clinical effectiveness. Radiotherapy and Oncology 83(2):123-132.

Seierstad,T, Folkvord,S, Roe,K, Flatmark,K, Skretting,A, and Olsen,DR (2007). Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabine, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice. Neoplasia 9(5):392-400.

Johansen,S, Olsen,DR, Danielsen,T, and Malinen,E (2007). Contralateral breast doses following radiotherapy of the breast and regional lymph nodes: Measurements and treatment planning calculations. Radiotherapy and Oncology 82(3):332-336.

Sastre-Padro,M, Welleweerd,J, Malinen,E, Eilertsen,K, Olsen,DR, and van der Heide,UA (2007). Consequences of leaf calibration errors on IMRT delivery. Physics in Medicine and Biology 52(4):1147-1156.

2006:

Sovik,A, Malinen,E, Bruland,OS, Bentzen,SM, and Olsen,DR (2007). Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study. Physics in Medicine and Biology 52(2):499-513.

Osteras,BH, Hole,EO, Olsen,DR, and Malinen,E (2006). EPR dosimetry of radiotherapy photon beams in inhomogeneous media using alanine films. Physics in Medicine and Biology 51(24):6315-6328.

Tanderup,K, Hellebust,TP, Honore,HB, Nielsen,SK, Olsen,DR, Grau,C et al. (2006). Dose optimisation in single plane interstitial brachytherapy. Radiotherapy and Oncology 81(1):105-111.

Malinen,E, Sovik,A, Hristov,D, Bruland,OS, and Olsen,DR (2006). Adapting radiotherapy to hypoxic tumours. Physics in Medicine and Biology 51(19):4903-4921.

Tanderup,K, Olsen,DR, and Grau,C (2006). Dose painting: Art or science? Radiotherapy and Oncology 79(3):245-248.

Vagane,R and Olsen,DR (2006). Analysis of normal tissue complication probability of the lung using a reliability model. Acta Oncologica 45(5):610-617.

Dahle,J, Borrebaek,J, Melhus,KB, Bruland,OS, Salberg,G, Olsen,DR et al. (2006). Initial evaluation of Th-227-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy. Nuclear Medicine and Biology 33(2):271-279.

2005:

Brurberg,KG, Skogmo,HK, Graff,BA, Olsen,DR, and Rofstad,EK (2005). Fluctuations in pO(2) in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy. Radiotherapy and Oncology 77(2):220-226.

Kakar,M, Nystrom,H, Aarup,LR, Nottrup,TJ, and Olsen,DR (2005). Respiratory motion prediction by using the adaptive neuro fuzzy inference system (ANFIS). Physics in Medicine and Biology 50(19):4721-4728.

Norum,J, Bruland,OS, Spanne,O, Bergmo,T, Green,T, Olsen,DR et al. (2005). Telemedicine in radiotherapy: a study exploring remote treatment planning., supervision and economics. Journal of Telemedicine and Telecare 11(5):245-250.

Dale,E, Hellebust,TP, Bruland,OS, and Olsen,DR (2005). Comparative analyses of the dynamic properties of the bladder wall studied by repetitive pelvic CT scans of patients and cryo-sections of cadavers. British Journal of Radiology 78(930):528-532.

Book chapters

Eilertsen K, Olsen DR. Data format, Networking, Archiving and Telemedicine.  In: New Technologies in Radiation Therapy. Schlegel W, Bortfeld T and Grosu AL. (eds.). Springer Verlag, ISBN 3-540-00321-5, pp. 53-65 (2006).

Bruland, Ø.S., Dahle, J., Olsen, D.R., and Larsen, R.H.: Targeted high-LET therapy of bone metastases. In: Tageted radionuclide tumor therapy - Biological aspects. Stigbrand, Adams & Carlsson (eds.). Springer Verlag. ISBN 978 1 4020 8695 3, pp. 181-194 (2008).

 

 EDUCATION:  

  • MSc of Biophysics and biomedical technology, Norwegian Institute of Technology, Trondheim, 1986.
  • PhD of Medical physics, University of Oslo, Oslo, 1999.
  • Management program, Norwegian School of Economics and Business Administration, Bergen, 2006.

PREVIOUS POSITIONS:

  • Medical physicist, The Norwegian Radium Hospital, Oslo, 1986-2004.         
  • Assistant and later associate professor, Oslo University College, Oslo, 1996-2000.
  • Professor of Medical Physics, University of Oslo, Oslo, 2000-2010.
  • Head of department, Institute of Cancer Research, Oslo University Hospital, Oslo, 2004-2010.

CURRENT POSITION:

Dean, Faculty of Mathematics and Natural Sciences, University of Bergen, 2010-date.

INTERNATIONAL RESEARCH AWARDS:

Klaas Breur Gold Medal 2008

 

 

 

PROFESSIONAL ACTIVITIES (previous and current):

  • Editorial board member of Acta Oncologica and Radiotherapy and Oncology, and Physics in Medicine and Biology.
  • Referee for several international journals: Radiotherapy and Oncology, Acta Oncological, Medical Physics, Physics in Medicine and Biology, International Journal of Radiation Oncology, Biology and Physics, International Journal of Radiation Biology, Lancet Oncology.
  • Reviewer of research programs for Cancer Research Campaign, UK, Medical Research Council, UK, The Danish Medical Research Council and EURATOM, EC.
  • Member of evaluation committees for professorship/associated professorship at Karolinska Institute, University of Stockholm, University of Århus, University of Umeå, University of Bergen, Oslo University College, Gjøvik University College, University of  Oslo, Trinity College Dublin, University of Madison, Wisconsin, University of Vienna and University of Lund.
  • External evaluator and opponent of PhD thesis at Norwegian University for Technology and Science, University of Bergen, University of Lund, University of Århus, University of Oslo, University of Lindköping.
  • External examiner at Trinity College, University of Dublin, Norwegian University for Technology and Science and Oslo University College.
  • Member of committee for evaluation of higher education, the Swedish National Agency for Higher Education.
  • Chairman and member of working groups on heath technology assessment at the Norwegian Knowledge Centre for the Health Services.
  • Member of Council for Translational Research, The Norwegian Radium Hospital and member of the management group of Institute of Cancer Research.
  • Member of the committee on science and education, and chairman of the education subcommittee in the merger process between The Norwegian Radium Hospital and Rikshospitalet, University of Oslo.
  • Member of working group on research strategy for South-Eastern Norway Regional Health Authority
  • Delegate to the WHO Global Initiative on Radiation Safety in Health Care Settings  and to the IAEA Interregional Technical Cooperation Project in medical physics.
  • Member of the international advisory board for the National Radiation Oncology Plan, Ireland
  • Member of review committee of clinical research, University of Gothenburg.

Professional society memberships: 

  • European Society of Radiotherapy and Oncology, acting past chair of physics committee and member of the education and training committee.
  • European Institute of Radiotherapy, past board member
  • Norwegian Association of Medical Physics, past board member and chair.
  • board member European Society of Radiotherapy and Oncology