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Diego Rodríguez Hernández

Postdoctoral Fellow, SEAS (Shaping European Research Leaders for Marine Sustainability)
  • E-maildiego.hernandez@uib.no
  • Visitor Address
    Allégaten 41 Realfagbygget
    5007 Bergen
    Room 
    3035
  • Postal Address
    Postboks 7803
    5020 Bergen

I am a Postdoctoral Researcher for the SEAS program, in Monica Jordheim’s group (https://www.uib.no/en/persons/Monica.Jordheim#uib-tabs-research). This research program (2022-2025) emphasizes the chemical studies of natural products of sustainable organisms living in areas of hydrothermal vents from deep-sea in the Artic and Artic Mid-Ocean Ridge, with an ecological and pharmacological approach, using metabolomics, bio-guided fractionation, modern mass spectrometry and NMR analyses.

The SEAS project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101034309. SEAS project is aimed at training future research leaders for the conservation and sustainable use of the ocean, seas, and marine resources. We are an interdisciplinary group of postdoctoral fellows at the University of Bergen, Norway who aim to deliver high-quality research with a positive, on the ground impact. Our goals are healthy marine ecosystems and equitable livelihoods (https://seas.w.uib.no/seas/).

 

Courses:

KJEM235 https://www.uib.no/emne/KJEM235    (10 ECTS)

Objectives and Content

The course addresses analysis of organic compounds using spectroscopic methods as infrared (IR), ultraviolet-visible (UV-Vis) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry (MS). The course concentrates on interpretation of data, and the focus will be to understand and to utilize data from NMR and MS.

  • Bourgard C, Rodríguez-Hernández D, Rudenko A, Rutgersson C, Palm M, Larsson DGJ, Farewell A, Grøtli M, Sunnerhagen P. Development of Dicationic Bisguanidine-Arylfuran Derivatives as Potent Agents against Gram-Negative Bacteria. Antibiotics. v. 11 p. 1115, 2022 https://doi.org/10.3390/antibiotics11081115

  • Ries LNA, Pardeshi L, Dong Z, Tan K, Steenwyk JL, Colabardini AC, Ferreira Filho JA, de Castro PA, Silva LP, Preite NW, Almeida F, de Assis LJ, dos Santos RAC, Bowyer P, Bromley M, Owens RA, Doyle S, Demasi M, Rodríguez-Hernández D, Netto LES, Pupo MT, Rokas A, Loures FV, Wong KH, Goldman GH. The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence. PLoS Pathog, v 16, p. e1008645, 2020. https://doi.org/10.1371/journal.ppat.1008645

  •  Menegatti C, Lourenzon BV, Rodríguez-Hernández D, Melo WGP, Gomes Ferreira LL, Andricopulo AD, do Nascimento FS, Pupo MT. Meliponamycins: Antimicrobials from Stingless Bee Associated Streptomyces sp. Journal of Natural Products, v 83, p. 610-616, 2020. https://doi.org/10.1021/acs.jnatprod.9b01011

  • Nain‐Perez A, Barbosa LCA, Rodríguez-Hernández D, Mota YCC, Silva TF, Ramalho TC, Modolo LV. Antiureolytic Activity of Substituted 2, 5‐Diaminobenzoquinones. Chemistry & biodiversity, v 16, p. e1900503, 2019. https://doi.org/10.1002/cbdv.201900503

  • Rodríguez-Hernández D*, Secondary metabolites as a survival strategy in plants of high mountain habitats. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, v. 18, p. 444-458, 2019. https://doi.org/10.35588/blacpma.19.18.4.29

  • Rodríguez-Hernández D, Melo WGP, Menegatti C, Lourenzon BV, do Nascimento FS, Pupo MT. Actinobacteria associated with stingless bee biosynthesize bioactive polyketides against bacterial pathogen. New Journal of Chemistry, v. 43, p. 10109-10117, 2019. https://doi.org/10.1039/C9NJ01619H

  • Rodríguez-Hernández D, Barbosa LCA, Demuner AJ, Ataide-Martins JP, Fischer L. (nee Heller) Csuk R. Hederagenin Amide Derivatives as Potential Antiproliferative Agents. European Journal of Medicinal Chemistry, v. 168, p. 436-446, 2019. https://doi.org/10.1016/j.ejmech.2019.02.057

  • Rodríguez-Hernández D*, Oliveros-Bastidas A, Alonso-Amelot ME, Calcagno-Pissarelli MP. Two new labdane diterpenoids from the foliar exudates of Blakiella bartsiifolia. Phytochemistry Letters, v. 20, p. 269-273, 2017. https://doi.org/10.1016/j.phytol.2017.05.001

  • Rodríguez-Hernández D, Barbosa LCA, Demuner AJ, Nain-Perez A, Ferreira SR, Fujiwara RT, de Almeida RM, Heller L, Csuk R. Leishmanicidal and cytotoxic activity of hederagenin-bistriazolyl derivatives. European Journal of Medicinal Chemistry, v. 140, p. 624-635, 2017. https://doi.org/10.1016/j.ejmech.2017.09.045

  • Nain-Perez A, Barbosa LCA, Rodríguez-Hernández D, Kramell AE, Heller L, Csuk R. Natural abenquines and synthetic analogues: Preliminary exploration of their cytotoxic activity. Bioorganic & Medicinal Chemistry Letters (Print), v. 27, p. 1141-1144, 2017. https://doi.org/10.1016/j.bmcl.2017.01.079

  • Rodríguez-Hernández D, Barbosa LCA, Demuner AJ, de Almeida RM, Fujiwara RT, Ferreira SR. Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from Sapindus saponaria L. European Journal of Medicinal Chemistry, v. 124, p. 153-159, 2016. https://doi.org/10.1016/j.ejmech.2016.08.030

  • Rodríguez-Hernández D, Demuner AJ, Barbosa LCA, Heller L, Csuk R. Novel hederagenin triazolyl derivatives as potential anti-cancer agents. European Journal of Medicinal Chemistry, v. 115, p. 257-267, 2016. https://doi.org/10.1016/j.ejmech.2016.03.018

  • Rodríguez-Hernández D*, Demuner AJ, Montanari RM, Barbosa LCA. Cyanolipids from Sapindus saponaria L. seeds oil. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, v. 15, p. 364-372, 2016.

  • Rodríguez-Hernández D, Demuner AJ, Barbosa LCA, Csuk R, Heller L. Hederagenin as a triterpene template for the development of new antitumor compounds. European Journal of Medicinal Chemistry, v. 105, p. 57-62, 2015. https://doi.org/10.1016/j.ejmech.2015.10.006

  • Rodríguez-Hernández D*, Demuner AJ, Nain-Perez A, Barbosa LCA, Oliveros-Bastidas A. Phytochemicals contributions to the dipsacaceae systematic. Avances en Ciencias e Ingenieria, v. 5, p. 61-81, 2014.

  • Rodríguez-Hernández D, Oliveros-Bastidas A, Alonso-Amelot M, Calcagno MP. Diterpene Foliar Exudates of Blakiella bartsiifolia and Phytotoxicity of Clerodanes. Natural Product Communications, v. 9, p. 1407, 2014. https://doi.org/10.1177/1934578X1400901003

  • Nain-Perez A, Abad J, Santiago C, Rodríguez-Hernández D. Synthesis and characterization of new podophyllotoxin derivative. Avances en Ciencias e Ingeniería, v. 5, p. 57, 2014.

  • Oliveros-Bastidas A, Rodríguez-Hernández D, Calcagno MP. Bioassay standardization looking for phytotoxic compounds in vegetable extracts. Ciencias (Maracaibo), v. 19, p. 187-202, 2011.

  • Calcagno-Pissarelli MP, Alonso-Amelot M, Mora R, Rodríguez D, Ávila-Núñez JL. Foliar exudates of Blakiella bartsiifolia (S.F. Blake) Cuatrec. (Asteraceae, Astereae). A Preliminary study of the Chemical Composition. Avances en Quimica, v. 5, p. 161-166, 2010.

Patents

  • Rodríguez-Hernández D, Demuner AJ, Barbosa LCA, Almeida RM, Fujiwara RT, Ferreira SR. Patent. Register number: BR1020160193370, título: "Derivados da Hederagenina, Processo de Obtenção e Uso" (Hederagenin Derivatives, Obtaining Process and Use), Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial. Depósito: 23/08/2016. (National Institute of Industrial Property. Deposit: 08/23/2016).

  • Nain-Perez A, Barbosa LCA, Maltha CRA, Csuk R, Rodríguez-Hernández D, Forlani G. Patent. Register number: BR1020170227464, título: "Análogos de Abenquinas, Processo de Obtenção, Composição Farmacêutica E Usos" (Abenquines Analogs, Obtaining Process, Pharmaceutical Composition and Uses), Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial. Depósito: 23/10/2017. (National Institute of Industrial Property. Deposit: 10/23/2017)