Einar Svarstad's picture

Einar Svarstad

Guest Researcher
  • E-maileinar.svarstad@uib.no
  • Visitor Address
    Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2023). Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing. Kidney International. 803-819.
  • Show author(s) (2023). Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla <sup> −/−</sup> zebrafish model of Fabry disease. Journal of Translational Medicine.
  • Show author(s) (2023). Development of an automated estimation of foot process width using deep learning in kidney biopsies from patients with Fabry, minimal change, and diabetic kidney diseases. Kidney International.
  • Show author(s) (2022). Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype. Molecular Genetics and Metabolism Reports. 1-11.
  • Show author(s) (2022). Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca<sup>2+</sup> Signaling Similar to Fabry Disease. International Journal of Molecular Sciences.
  • Show author(s) (2022). Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use. American Society of Nephrology. Clinical Journal. 518-526.
  • Show author(s) (2022). A novel unbiased method reveals progressive podocyte globotriaosylceramide accumulation and loss with age in females with Fabry disease. Kidney International. 173-182.
  • Show author(s) (2021). Standardising clinical outcomes measures for adult clinical trials in Fabry disease: A global Delphi consensus. Molecular Genetics and Metabolism. 234-243.
  • Show author(s) (2021). Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series. Human Pathology. 102-111.
  • Show author(s) (2021). Elevated Ambulatory Blood Pressure Measurements are Associated with a Progressive Form of Fabry Disease. High Blood Pressure & Cardiovascular Prevention. 309-319.
  • Show author(s) (2021). Case Report: Polyvinylpyrrolidone deposition disease from repeated injection of opioid substitution drugs: Report of a case with a fatal outcome. F1000 Research.
  • Show author(s) (2021). Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination. Scientific Reports. 7 pages.
  • Show author(s) (2020). The changing landscape of Fabry disease. Journal of the American Society of Nephrology. 569-576.
  • Show author(s) (2020). Early indicators of disease progression in Fabry disease that may indicate the need for disease-specific treatment initiation: Findings from the opinion-based PREDICT-FD modified Delphi consensus initiative. BMJ Open. 1-12.
  • Show author(s) (2020). Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss. Journal of the American Society of Nephrology. 865-875.
  • Show author(s) (2019). Developing nephrology services in low income countries: A case of Tanzania. BMC Nephrology. 1-9.
  • Show author(s) (2018). Low birth weight associates with glomerular area in young male IgA nephropathy patients. BMC Nephrology. 1-10.
  • Show author(s) (2018). In vivo detection of chronic kidney disease using tissue deformation fields from dynamic MR imaging. IEEE Transactions on Biomedical Engineering. 1779-1790.
  • Show author(s) (2017). Pathomechanisms of renal Fabry disease. Cell and Tissue Research. 53-62.
  • Show author(s) (2017). Outcome in biopsy-proven Lupus nephritis: Evaluation of biopsies from the Norwegian Kidney Biopsy Registry. Lupus. 881-885.
  • Show author(s) (2017). Long-term dose-dependent agalsidase effects on kidney histology in fabry disease. American Society of Nephrology. Clinical Journal. 1470-1479.
  • Show author(s) (2017). Iohexol plasma clearance in children: validation of multiple formulas and single-point sampling times. Pediatric nephrology (Berlin, West). 1-14.
  • Show author(s) (2017). Bedside stereomicroscopy of Fabry kidney biopsies: An easily available method for diagnosis and assessment of sphingolipid deposits. Nephron. 13-21.
  • Show author(s) (2016). The variation in high sensitive cardiac troponin concentration during haemodialysis treatment is not similar to the biological variation observed in stable end stage renal disease patients. Scandinavian Journal of Clinical and Laboratory Investigation. 645-652.
  • Show author(s) (2016). Reaccumulation of globotriaosylceramide in podocytes after agalsidase dose reduction in young Fabry patients. Nephrology, Dialysis and Transplantation. 807-813.
  • Show author(s) (2016). Quantifcation of single-kidney function and volume in living kidney donors using dynamic contrast-enhanced MRI. American Journal of Roentgenology. 1022-1030.
  • Show author(s) (2016). Polyvinylpyrrolidone induced artefactual prolongation of activated partial thromboplastin times in intravenous drug users with renal failure. Journal of Thrombosis and Haemostasis. 936-939.
  • Show author(s) (2016). One Year of Enzyme Replacement Therapy Reduces Globotriaosylceramide Inclusions in Podocytes in Male Adult Patients with Fabry Disease. PLOS ONE.
  • Show author(s) (2016). Low birth weight and risk of progression to end stage renal disease in IgA nephropathy - A retrospective registry-based cohort study. PLOS ONE.
  • Show author(s) (2016). Iohexol plasma clearance in children: validation of multiple formulas and two-point sampling times. Pediatric nephrology (Berlin, West). 311-320.
  • Show author(s) (2016). Familial Factors, Low Birth Weight, and Development of ESRD: A Nationwide Registry Study. American Journal of Kidney Diseases. 601-608.
  • Show author(s) (2016). End stage renal disease predicts increased risk of death in first degree relatives in the Norwegian population. PLOS ONE.
  • Show author(s) (2016). Dynamic contrast-enhanced MRI measurement of renal function in healthy participants. Acta Radiologica. 748-757.
  • Show author(s) (2015). Use of 3D DCE-MRI for the estimation of renal perfusion and glomerular filtration rate: An intrasubject comparison of FLASH and KWIC with a comprehensive framework for evaluation. American Journal of Roentgenology. W273-W281.
  • Show author(s) (2015). Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: The European Fabry Working Group consensus document. Orphanet Journal of Rare Diseases. 1-10.
  • Show author(s) (2015). Global collaboration bears fruit: Tanzania report. Kidney International. 1211-1214.
  • Show author(s) (2015). Foot process effacement is an early marker of nephropathy in young classic fabry patients without albuminuria. Nephron. 16-21.
  • Show author(s) (2015). Chronic kidney disease and an uncertain diagnosis of Fabry disease: approach to a correct diagnosis. Molecular Genetics and Metabolism. 242-247.
  • Show author(s) (2015). Addition of eGFR and age improves the prognostic absolute renal risk-model in 1,134 norwegian patients with IgA nephropathy. American Journal of Nephrology. 210-219.
  • Show author(s) (2014). Weekly and 90-minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls. Clinical Chemistry. 838-847.
  • Show author(s) (2014). Uncertain diagnosis of fabry disease in patients with neuropathic pain, angiokeratoma or cornea verticillata: consensus on the approach to diagnosis and follow-up. JIMD Reports. 83-90.
  • Show author(s) (2014). Mosaicism of podocyte involvement is related to podocyte injury in females with Fabry disease. PLOS ONE.
  • Show author(s) (2014). Familial clustering of ESRD in the Norwegian population. American Society of Nephrology. Clinical Journal. 1692-1700.
  • Show author(s) (2014). CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. Acta Dermato-Venereologica. 173-178.
  • Show author(s) (2013). Preeclampsia in healthy women and endothelial dysfunction 10 years later. American Journal of Obstetrics and Gynecology. 569.e1-569.e10.
  • Show author(s) (2013). Preeclampsia and prevalence of microalbuminuria 10 years later. American Society of Nephrology. Clinical Journal. 1126-1134.
  • Show author(s) (2013). Mortality in patients with IgA nephropathy. American Journal of Kidney Diseases. 883-890.
  • Show author(s) (2013). Agalsidase Benefits Renal Histology in Young Patients with Fabry Disease. Journal of the American Society of Nephrology. 137-148.
  • Show author(s) (2012). Safety and complications of percutaneous kidney biopsies in 715 children and 8573 adults in Norway 1988-2010. American Society of Nephrology. Clinical Journal. 1591-1597.
  • Show author(s) (2012). Renal outcomes of agalsidase beta treatment for Fabry disease: role of proteinuria and timing of treatment initiation. Nephrology, Dialysis and Transplantation. 1042-1049.
  • Show author(s) (2012). Recommendations on Reintroduction of Agalsidase Beta for Patients with Fabry Disease in Europe, Following a Period of Shortage. JIMD Reports.
  • Show author(s) (2011). Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease. Kidney International. 663-670.
  • Show author(s) (2011). Laboratory investigation and follow-up of chronic kidney disease stage 3 in primary care. Clinica Chimica Acta. 1138-1142.
  • Show author(s) (2010). Scoring system for renal pathology in Fabry disease: Report of the International Study Group of Fabry Nephropathy (ISGFN). Nephrology, Dialysis and Transplantation. 2168-2177.
  • Show author(s) (2010). Phenotypic Variation in a Large Family with Autosomal Dominant Hypocalcaemia. Hypertension in Pregnancy. 399-405.
  • Show author(s) (2010). Monitoring renal function in children with Fabry disease: comparisons of measured and creatinine-based estimated glomerular filtration rate. Nephrology, Dialysis and Transplantation. 1507-1513.
  • Show author(s) (2010). Modelling the resource implications of managing adults with Fabry disease in Norway favours home infusion. European Journal of Clinical Investigation. 1104-1112.
  • Show author(s) (2009). The MDRD equation may mask decline of glomerular filtration rate in Fabry patients with normal or nearly normal kidney function. Clinical Nephrology. 118-124.
  • Show author(s) (2009). Nephrogenic systemic fibrosis and use of MR contrast media. Tidsskrift for Den norske legeforening. 180-182.
  • Show author(s) (2009). Monitoring renal Function in Fabry children: comparisons of measured and creatinine-based estimated Glomerular Filtration Rate. Nephrology, Dialysis and Transplantation. 7 pages.
  • Show author(s) (2008). Renal biopsy findings in children and adolescents with Fabry disease and minimal albuminuria. American Journal of Kidney Diseases. 767-776.
  • Show author(s) (2008). En kvinne med kronisk nyresvikt, progredierende hudforkalkninger og sepsis. Tidsskrift for Den norske legeforening.
  • Show author(s) (2007). Long-term risk of cancer in membranous nephropathy patients. American Journal of Kidney Diseases. 396-403.
  • Show author(s) (2005). Focal and segmental glomerular sclerosis (FSGS) in a man and a woman with Fabry's disease. Clinical Nephrology. 394-401.
  • Show author(s) (2005). Critical renal artery stenoses may cause a spectrum of cardiorenal failure and associated thromboembolic events. Clinical Nephrology. 487-492.
  • Show author(s) (2004). Bedside stereomicroscopy of renal biopsies may lead to a rapid diagnosis of Fabry's disease. Nephrology, Dialysis and Transplantation. 3202-3203.
  • Show author(s) (2003). C2 monitoring in maintenance renal transplant recipients: is it worthwhile? Transplantation. 1236-1238.
  • Show author(s) (2002). Effect of light excercise on renal hemodynamics in patients with hypertension and chronic renal disease. Scandinavian Journal of Urology and Nephrology. 464-473.
  • Show author(s) (2001). Sympathetic nervous system overactivity in hypertensive patients with chronic renal failure. Role of upright body position. Scandinavian Journal of Urology and Nephrology. 393-400.
  • Show author(s) (2001). Renal hemodynamic effects of captopril and doxazosin during slight physical activity in hypertensive patients with type-1 diabetes mellitus. Kidney and Blood Pressure Research. 64-70.
  • Show author(s) (2001). Akutt nyresvikt, nyrearteriestenose og angiotensinkonvertase (ACE)-hemmer. Tidsskrift for Den norske legeforening. 1784-1788.
  • Show author(s) (2001). Akutt dialysebehandling ved Haukeland Sykehus i 1999. Tidsskrift for Den norske legeforening. 1774-1779.
Academic lecture
  • Show author(s) (2021). Cleared Podocytes and Normal Kidney Function in Classical Fabry Males 15 Years After Start of Enzyme Replacement Therapy at Young Age.
  • Show author(s) (2020). Polyvinylpyrrolidon (PVP) lagringssykdom hos ruspasienter – en case-serie.
  • Show author(s) (2019). Renal Polyvinylpyrrolidone Deposition from Illicit Drug Use is Associated with Tubulointerstitial Nephropathy.
  • Show author(s) (2019). Fabry Nephropathy: First mRNA-seq Findings from Kidney Biopsies Before and After Enzyme Replacement Therapy.
  • Show author(s) (2013). Podocytes: Therapeutic Target in Fabry Disease?
  • Show author(s) (2009). Corneal changes in Fabry's disease.
  • Show author(s) (2001). Ultralyd og Doppler av nyrer.
  • Show author(s) (2001). Akutt nyresvikt, epidemiologi og nyreerstattende behandling.
  • Show author(s) (2001). Akutt nyresvikt (forekomst, diagnostikk, dialyseindikasjon).
  • Show author(s) (2001). ACE-hemmere og nyresvikt.
  • Show author(s) (2011). A Mother and Daughter with Unexplained Renal Failure. Nephron. C1-C9.
Reader opinion piece
  • Show author(s) (2013). Week-to-Week Biological Variation in the N-terminal Prohormone of Brain Natriuretic Peptide in Hemodialysis Patients and Healthy Individuals. Clinical Chemistry. 1813-1814.
  • Show author(s) (2012). En mann i 50-årene med feber, hoste og anuri. Tidsskrift for Den norske legeforening. 1621-1624.
  • Show author(s) (2012). En kvinne i 50-årene med smerter i beina og nyresvikt. Tidsskrift for Den norske legeforening. 960-961.
  • Show author(s) (2011). Fabry or not Fabry – a question of ascertainment. European Journal of Human Genetics. 1111-1112.
  • Show author(s) (2002). Renal artery thrombosis with acute renal failure after withdrawal of angiotensin converting enzyme inhibitor: a case report. Nephrology, Dialysis and Transplantation. 687-689.
Letter to the editor
  • Show author(s) (2019). Oral Chaperone Therapy Migalastat for the Treatment of Fabry Disease: Potentials and Pitfalls of Real-World Data. Clinical Pharmacology and Therapeutics. 925-926.
  • Show author(s) (2015). Renal failure due to excessive intake of almonds in the absence of Oxalobacter Formigenes. American Journal of Medicine. e29-e30.
  • Show author(s) (2015). Renal Failure due to Excessive Intake of Almonds in the Absence of Oxalobacter formigenes. American Journal of Medicine.
  • Show author(s) (2004). Renal artery thrombosis and acute renal failure after ACE inhibition. Nephrology, Dialysis and Transplantation. 565.
Doctoral dissertation
  • Show author(s) (2001). Renal hemodynamics in ambulatory patients with chronic renal disease. -.
  • Show author(s) (2013). Enzyme replacement in Fabry disease.
Academic chapter/article/Conference paper
  • Show author(s) (2009). Ultralydveiledet biopsi og annen intervensjon. 4 pages.
  • Show author(s) (2009). Ultralyd av nyrer og urinveier. 12 pages.
  • Show author(s) (2013). Renal structural-functional relationship (SFR) studies suggest that podocyte GL-3 accumulation predicts urine protein creatinine ratio in Fabry disease (FD) nephropathy (FDN). Molecular Genetics and Metabolism. S68-S69.
  • Show author(s) (2012). VALIDATION OF FRENCH MODEL TO PREDICT ESRD AND DEATH IN IGA NEPHROPATHY PATIENTS. Nephrology, Dialysis and Transplantation. 189-190.
  • Show author(s) (2012). STANDARDIZED MORTALITY RATE IN IGA NEPHROPATHY PATIENTS. Nephrology, Dialysis and Transplantation. 188-188.
  • Show author(s) (2012). OUTCOME IN BIOPSY-PROVEN LUPUS NEPHRITIS. Nephrology, Dialysis and Transplantation. 182-182.
  • Show author(s) (2012). Mosaicism of Podocyte Involvement in Untreated Females with Fabry Disease. Molecular Genetics and Metabolism. S47-S48.
  • Show author(s) (2010). The Potential Importance of Renal Biopsies in Early Management Decisions in Young Fabry Patients. Clinical Therapeutics. S97-S98.
  • Show author(s) (2010). Natural history and structural-functional relationships (SFR) in Fabry nephropathy (FN). Molecular Genetics and Metabolism. S27-S28.
  • Show author(s) (2009). Monitoring renal Function in Fabry children; estimated or measured glomerular Filtration rate? Molecular Genetics and Metabolism. 74-75.
  • Show author(s) (2009). Fabry Disease: Unusual Symptoms in two Boys Treated with Lamotrigine and Fabrazyme, Respectively. Clinical Therapeutics. S43-S43.
  • Show author(s) (2008). Prominence of glomerular and vascular changes in renal biopsies in children and adolescents with Fabry disease and microalbuminuria. Clinical Therapeutics. S42-S42.
  • Show author(s) (2023). The spectrum of podocyte injury in later onset (LO) variants of Fabry disease (FD).
  • Show author(s) (2023). Development of an online cloud-based tool for automatic measurement of foot process width (FPW) using deep learning (DL): Applications in assessment of podocyte injury in Fabry disease (FD).
  • Show author(s) (2022). Globotriaosylceramide (GL3) accumulation in Fabry podocytes in female patients is progressive with age and associated with podocyte loss and proteinuria.
  • Show author(s) (2019). Clinical Consequences of Paired Cardiac and Kidney Biopsies in a Treatment Naive Female Fabry Patient with a Classical Mutation and Minor Clnical Symptoms.
  • Show author(s) (2019). Accumulation of Globotriaosylceramide in Podocytes (PC) in Fabry Nephropathy Is Associated with Progressive PC Loss.
  • Show author(s) (2018). Podocyte structural parameters predict glomerular filtration rate (GFR) loss in male patients with classic Fabry disease.
  • Show author(s) (2018). Fabry nephropathy: Transcriptome sequencing of microdissected renal compartments from archival kidney biopsies at baseline, and after 5 & 10 years of enzyme replacement therapy.
  • Show author(s) (2017). Single-point iohexol plasma clearance in children: validation of multiple formulas and sampling times.
  • Show author(s) (2017). Simplified Clinical Pre-histologic Scoring Method of Kidney Biopsies in Fabry Disease.
  • Show author(s) (2017). Podocyte globotriaosylceramide (GL-3) content strongly impacts age-dependent podocyte loss in ERT-naïve male Fabry patients.
  • Show author(s) (2016). Podocyte Hypertrophy and Globotriaosylceramide (GL-3) Accumulation Are Strong Predictors of Podocyte Loss in Enzyme Replacement Therapy Naïve Male Patients with Fabry Disease.
  • Show author(s) (2016). Differential response of glomerular parietal epithelial cells and podocytes to enzyme replacement therapy in Fabry nephropathy.
  • Show author(s) (2015). Podocyte Globotriaosylceramide (GL3) Accumulation in Fabry Disease Is Influenced by Age and Genotype .
  • Show author(s) (2014). Renal Biopsies after 6-11 Years of Enzyme Replacement Therapy in 9 Young Classic Fabry Disease Patients.
  • Show author(s) (2014). Quantification of glomerular filtration rate (GFR) using a modelbased MR renography technique provides good agreement with IohexolGFR and eGFR in 20 healthy subjects. .
  • Show author(s) (2014). Five Children with Fabry Disease and Significant Tissue Damage in Renal Biopsies Despite Normal Clinical Renal Parameters.
  • Show author(s) (2014). Fabry nephropathy (FN) outcome and the impact of diagnostic kidney biopsies after 10 years enzyme replacement therapy (ERT).
  • Show author(s) (2014). Enzyme Replacement Therapy (ERT) in Fabry Disease (FD) Reduces Podocyte (PC) Globotriaosylceramide (GL3) Content within a Year (yr).
  • Show author(s) (2014). Consensus recommendation on Fabry disease diagnosis in adult patients with kidney disease.
  • Show author(s) (2013). Glomerular filtration rate (GFR) measured by iohexolclearance in children; how many sample points are necessary?
  • Show author(s) (2009). Renal follow-up biopsies in young male Fabry patients on enzyme replacement therapy.
  • Show author(s) (2008). Renal biopsies in children in Norway 1988-2005: clinical variables, complications and prognosis.
  • Show author(s) (2008). Formula GFR overestimates Renal Function in Children and Adult Males with Fabry Disease and Stage 1-2 CKD.
  • Show author(s) (2005). Glomerular and vascular changes are prominent in renal biopsies in children and adolescents with Fabry disease and microalbuminuria.
  • Show author(s) (2004). Early signs of focal and segmental glomerulosclerosis (FSGS) and arteriolopathy is prevalent in Fabry patients with minimal proteinuria or slightly reduced GFR.
  • Show author(s) (2001). Vitamin D, tartrate-resistent acid phosphatase 5B and osteocalcin in bone metabolism in patients undergoing hemodialysis (HD).
  • Show author(s) (2001). Vitamin D Resistant Acid Phosphatase 5B and Osteocalcin in Bone Metabolism in Patients (PTS) Undergoing Hemodialysis (HD).
  • Show author(s) (2001). Substatntial loss of 1.25 (OH)2 D3 in the urine in patients with nephrotic syndrome.
  • Show author(s) (2001). A simplified therapy regimen with epoetin alfa is sufficient in most HD-patients.
  • Show author(s) (2016). Erratum to: Iohexol plasma clearance in children: validation of multiple formulas and two-point sampling times (Pediatric Nephrology, (2017), 32, 2, (311-320), 10.1007/s00467-016-3436-z). Pediatric nephrology (Berlin, West). 375-376.
Academic literature review
  • Show author(s) (2020). Proteomics for the study of new biomarkers in Fabry disease: State of the art. Molecular Genetics and Metabolism. 86-93.
  • Show author(s) (2013). Renal complications of Fabry disease in children. Pediatric nephrology (Berlin, West). 679-687.
  • Show author(s) (2012). Assessment of Kidney Volumes From MRI: Acquisition and Segmentation Techniques. American Journal of Roentgenology. 1060-1069.
  • Show author(s) (2009). Nephropathy in Fabry disease: the importance of early diagnosis and testing in high-risk populations. Nephrology, Dialysis and Transplantation. 1736-1743.
  • Show author(s) (2009). Nefrogen systemisk fibrose ved bruk av MR-kontrastmiddel. Tidsskrift for Den norske legeforening. 180-182.
  • Show author(s) (2009). Kognitiv svikt ved terminal nyresykdom. Tidsskrift for Den norske legeforening. 296-299.

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