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Elisabeth Wik's picture

Elisabeth Wik

Associate Professor
  • E-mailelisabeth.wik@uib.no
  • Phone+47 55 97 26 78
  • Visitor Address
    CCBIO/Avdeling for patologi
    Haukeland Universitetssykehus
    5020 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2024). Age-related phenotypes in breast cancer: A population-based study. International Journal of Cancer.
  • Show author(s) (2023). Vessel size as a marker of survival in estrogen receptor positive breast cancer. Breast Cancer Research and Treatment.
  • Show author(s) (2023). Hypoxia induced responses are reflected in the stromal proteome of breast cancer. Nature Communications. 1-16.
  • Show author(s) (2023). CD47 and CD68 expression in breast cancer is associated with tumor-infiltrating lymphocytes, blood vessel invasion, detection mode, and prognosis. The journal of pathology. Clinical research. 151-164.
  • Show author(s) (2022). Neurogenesis and angiogenesis are associated features of aggressive breast cancer . bioRxiv.
  • Show author(s) (2022). A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer. British Journal of Cancer. 1-11.
  • Show author(s) (2021). Tumor-associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer. The journal of pathology. Clinical research. 517-527.
  • Show author(s) (2021). Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer. PLOS ONE. 1-14.
  • Show author(s) (2021). Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer. Scientific Reports. 1-11.
  • Show author(s) (2020). Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups. Scientific Reports. 14 pages.
  • Show author(s) (2020). MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes. Breast Cancer Research and Treatment. 73-86.
  • Show author(s) (2019). PIK3CA amplification associates with aggressive phenotype but not markers of AKT-mTOR signaling in endometrial carcinoma. Clinical Cancer Research. 334-345.
  • Show author(s) (2019). Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes. The journal of pathology. Clinical research. 69-82.
  • Show author(s) (2018). Transient elevation of anti-transglutaminase and anti-endomysium antibodies in Giardia infection. Scandinavian Journal of Gastroenterology. 809-812.
  • Show author(s) (2018). Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer. PLOS ONE. 1-21.
  • Show author(s) (2018). Deblender: A semi-/unsupervised multi-operational computational method for complete deconvolution of expression data from heterogeneous samples. BMC Bioinformatics. 1-17.
  • Show author(s) (2017). Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer. Human Pathology. 72-80.
  • Show author(s) (2017). Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer. PLOS ONE. 1-15.
  • Show author(s) (2017). Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer. Scientific Reports. 1-12.
  • Show author(s) (2017). C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease. PLOS ONE. 1-12.
  • Show author(s) (2016). Tumour cell invasion into blood vessels is significantly related to breast cancer subtypes and decreased survival. Journal of Clinical Pathology. 313-319.
  • Show author(s) (2016). Evaluation of Tumor Cell Proliferation by Ki-67 Expression and Mitotic Count in Lymph Node Metastases from Breast Cancer. PLOS ONE.
  • Show author(s) (2016). Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. OncoTarget. 9696-9707.
  • Show author(s) (2015). Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses. OncoTarget. 39676-39691.
  • Show author(s) (2015). Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. OncoTarget. 1327-1339.
  • Show author(s) (2015). Intra-gene DNA methylation variability is a clinically independent prognostic marker in women's cancers. PLOS ONE.
  • Show author(s) (2015). Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer. OncoTarget. 10634-10645.
  • Show author(s) (2015). HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. Genome Medicine.
  • Show author(s) (2014). Stathmin Protein Level, a Potential Peredictive Marker for Taxane Treatment Response in Endometrial Cancer. PLOS ONE.
  • Show author(s) (2014). Risk of ovarian cancer and the NF-kB pathway: Genetic association with IL1A and TNFSF10. Cancer Research. 852-861.
  • Show author(s) (2014). Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer. Molecular Cancer.
  • Show author(s) (2014). Landscape of genomic alterations in cervical carcinomas. Nature. 371-375.
  • Show author(s) (2014). Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. OncoTarget. 1052-1061.
  • Show author(s) (2014). Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. Human Genetics. 481-497.
  • Show author(s) (2014). Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations. Gynecologic Oncology. 599-606.
  • Show author(s) (2014). Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study. Diagnostic Pathology. 8 pages.
  • Show author(s) (2014). An 18-Gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. PLOS ONE.
  • Show author(s) (2013). Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. PLoS Medicine.
  • Show author(s) (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics. 371-384.
  • Show author(s) (2013). Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. Clinical Cancer Research. 1094-1105.
  • Show author(s) (2013). Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. PLOS ONE. 9 pages.
  • Show author(s) (2013). Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nature Communications. 12 pages.
  • Show author(s) (2013). Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial. European Journal of Cancer. 3431-3441.
  • Show author(s) (2013). High phospho-stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition. Clinical Cancer Research. 2331-2341.
  • Show author(s) (2013). GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nature Genetics. 362-370.
  • Show author(s) (2013). GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer. International Journal of Gynecological Cancer. 1050-1055.
  • Show author(s) (2013). Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nature Communications. 10 pages.
  • Show author(s) (2013). ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas. Modern Pathology. 428-434.
  • Show author(s) (2012). Loss of GPER identifies new targets for therapy among a subgroup of ER alpha-positive endometrial cancer patients with poor outcome. British Journal of Cancer. 1682-1688.
  • Show author(s) (2012). Lipocalin 2 expression is associated with aggressive features of endometrial cancer. BMC Cancer. 7 pages.
  • Show author(s) (2012). KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer. British Journal of Cancer. 1997-2004.
  • Show author(s) (2012). Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective. Gynecologic Oncology. 381-387.
  • Show author(s) (2012). High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. PLOS ONE.
  • Show author(s) (2011). Stathmin Overexpression Identifies High-Risk Patients and Lymph Node Metastasis in Endometrial Cancer. Clinical Cancer Research. 3368-3377.
  • Show author(s) (2011). High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer. British Journal of Cancer. 921-926.
  • Show author(s) (2011). Evolution in endometrial cancer evidence from an immunohistochemical study. International Journal of Gynecological Cancer. 316-322.
  • Show author(s) (2011). Elevated plasma growth differentiation factor-15 correlates with lymph node metastases and poor survival in endometrial cancer. Clinical Cancer Research. 4825-4833.
  • Show author(s) (2009). Prognostic Impact of Parity in 493 Uterine Sarcoma Patients. International Journal of Gynecological Cancer. 1062-1067.
  • Show author(s) (2009). Plasma calprotectin concentrations in women with endometrial carcinoma. Gynecologic Oncology. 491-495.
  • Show author(s) (2009). Parity and time interval since childbirth influence survival in endometrial cancer patients. International Journal of Gynecological Cancer. 665-669.
  • Show author(s) (2009). Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. Proceedings of the National Academy of Sciences of the United States of America. 4834-4839.
  • Show author(s) (2009). Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting. American Journal of Obstetrics and Gynecology. 603-607.
Reader opinion piece
  • Show author(s) (2012). Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas. Histopathology. 516-519.
  • Show author(s) (2010). Stathmin is superior to AKT and phospho-AKT staining for the detection of phosphoinositide 3-kinase activation and aggressive endometrial cancer. Histopathology. 641-646.
Academic anthology/Conference proceedings
  • Show author(s) (2017). Cancer Biomarkers: Ethics, Economics and Society. Megaloceros Press.
Doctoral dissertation
  • Show author(s) (2013). Endometrial carcinoma: a step closer to individualized therapy? Exploring transcriptional alterations in relation to prognostic biomarkers.
Interview
  • Show author(s) (2017). Med forskning som ståsted i patologien.
Academic chapter/article/Conference paper
  • Show author(s) (2022). HER2 Revisited: Reflections on the Future of Cancer Biomarker Research. 23 pages.
  • Show author(s) (2017). Gene expression signatures of the tumor microenvironment: relation to tumor progress in breast cancer. 29 pages.
Abstract
  • Show author(s) (2012). Estrogen receptor a loss in endometrial carcinoma is associated with epithelial-to-mesenchymal transition and a potential for PI3Kinase inhibition. Virchows Archiv. S18-S18.
  • Show author(s) (2012). Estrogen receptor a loss in endometrial carcinoma is associated with epithelial-to-mesenchymal transition and a potential for PI3Kinase inhibition. Virchows Archiv. 18-18.
Poster
  • Show author(s) (2012). Identification of metastasis subnetworks in endometrial cancer.
  • Show author(s) (2012). An ensemble-based feature selection algorithm for identifying candidate metastasis marker genes in endometrial cancer.
  • Show author(s) (2009). Stathmin is superior to AKT and Phospho-AKT staining to detect PI3Kinase activation and aggressive endometrial cancer.
Academic literature review
  • Show author(s) (2014). Clinical value of DNA content assessment in endometrial cancer. Cytometry Part B: Clinical Cytometry. 154-163.
Chapter
  • Show author(s) (2022). Gene Expression Signatures of the Tumor Micoenvironment: Relation to Tumor Phenotypes and Progress in Breast Cancer . 401-425. In:
    • Show author(s) (2022). Biomarkers of the Tumor Microenvironment. Springer.

More information in national current research information system (CRIStin)

KEY PUBLICATIONS:

Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations.
Wik E, Trovik J, Kusonmano K, Birkeland E, Raeder MB, Pashtan I, Hoivik EA, Krakstad C, Werner HM, Holst F, Mjøs S, Halle MK, Mannelqvist M, Mauland KK, Oyan AM, Stefansson IM, Petersen K, Simon R, Cherniack AD, Meyerson M, Kalland KH, Akslen LA, Salvesen HB.
Gynecol Oncol. 2014 Sep;134(3):599-606. PMID: 24995579

High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition.
Wik E, Birkeland E, Trovik J, Werner HM, Hoivik EA, Mjos S, Krakstad C, Kusonmano K, Mauland K, Stefansson IM, Holst F, Petersen K, Oyan AM, Simon R, Kalland KH, Ricketts W, Akslen LA, Salvesen HB.
Clin Cancer Res. 2013 May 1;19(9):2331-41. PMID: 23538402

Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma.
Wik E, Ræder MB, Krakstad C, Trovik J, Birkeland E, Hoivik EA, Mjos S, Werner HM, Mannelqvist M, Stefansson IM, Oyan AM, Kalland KH, Akslen LA, Salvesen HB.
Clin Cancer Res. 2013 Mar 1;19(5):1094-105. PMID: 23319822

An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.
Mannelqvist M, Wik E, Stefansson IM, Akslen LA.
PLoS One. 2014 Jun 6;9(6):e98787.
PMID: 24905342

Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer.
Stefansson IM, Raeder M, Wik E, Mannelqvist M, Kusonmano K, Knutsvik G, Haldorsen I, Trovik J, Øyan AM, Kalland KH, Staff AC, Salvesen HB, Akslen LA.
Oncotarget. 2015 Mar 10. PMID: 25860936

Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study.
Chen Y, Klingen TA, Wik E, Aas H, Vigeland E, Liestøl K, Garred Ø, Mæhlen J, Akslen LA, Lømo J. Diagn Pathol. 2014 Dec 19;9(1):230. PMID: 25522915