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Ernst Asbjørn Lien's picture

Ernst Asbjørn Lien

Adjunct Professor
  • E-mailErnst.Lien@uib.no
  • Phone+47 55 97 43 71+47 414 79 213
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Helland, Thomas; Hagen, Kari Britt; Haugstøyl, Martha Eimstad; Kvaløy, Jan Terje; Lunde, Siri; Lode, Kirsten; Lind, Ragna Anne; Gripsrud, Birgitta Haga; Jonsdottir, Kristin; Gjerde, Jennifer; Bifulco, Ersilia; Hustad, Simon Steinar; Jonassen, Janne; Aas, Turid; Lende, Tone Hoel; Lien, Ernst Asbjørn; Janssen, Emiel; Søiland, Håvard; Mellgren, Gunnar. 2019. Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database. Breast Cancer Research and Treatment. 177: 185-195. doi: 10.1007/s10549-019-05294-w
  • Helland, Thomas; Henne, Nina; Bifulco, Ersilia; Naume, Bjørn; Borgen, Elin; Kristensen, Vessela N.; Kvaløy, Jan Terje; Lash, Timothy L; Grenaker, Grethe Irene; van Schaik, RHN; Janssen, Emiel; Hustad, Simon Steinar; Lien, Ernst Asbjørn; Mellgren, Gunnar; Søiland, Håvard. 2017. Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. Breast Cancer Research. 19. doi: 10.1186/s13058-017-0916-4
  • Johansson, Harriet; Gandini, Sara; Serrano, Davide; Gjerde, Jennifer; Lattanzi, Monia; Macis, Debora; Guerrieri-Gonzaga, Aliana; Aristarco, Valentina; Mellgren, Gunnar; Lien, Ernst Asbjørn; Decensi, Andrea; Bonanni, Bernardo. 2016. A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen. Breast Cancer Research and Treatment. 159: 97-108. doi: 10.1007/s10549-016-3932-7
  • Christensen, Monika; Fenne, Ingvild Sveinsgjerd; Nordbø, Yngve; Varhaug, Jan Erik; Nygård, Ottar; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2015. Novel inflammatory biomarkers in primary hyperparathyroidism. European Journal of Endocrinology. 173: 9-17. doi: 10.1530/EJE-14-1038
  • Helland, Thomas; Gjerde, Jennifer; Dankel, Simon N; Fenne, Ingvild Sveinsgjerd; Skartveit, Linn; Drangevåg, Andreas; Bozickovic, Olivera; Flågeng, Marianne Hauglid; Søiland, Håvard; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2015. The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLoS ONE. 10. 19 pages. doi: 10.1371/journal.pone.0122339
  • Christensen, Monika; Fenne, Ingvild Sveinsgjerd; Flågeng, Marianne Hauglid; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2014. Estradiol determines the effects of PTH on ERα-dependent transcription in MC3T3-E1 cells. Biochemical and Biophysical Research Communications - BBRC. 450: 360-365. doi: 10.1016/j.bbrc.2014.05.109
  • Hagen, Kari Britt; Aas, Turid; Lode, Kirsten; Gjerde, Jennifer; Lien, Ernst Asbjørn; Kvaløy, Jan Terje; Lash, Timothy L; Søiland, Håvard; Lind, Ragna Anne. 2014. Illness uncertainty in breast cancer patients: Validation of the 5-item short form of the Mishel Uncertainty in Illness Scale. European Journal of Oncology Nursing. 1-7. doi: 10.1016/j.ejon.2014.10.009
  • Christensen, Monika; Apalset, Ellen M; Nordbø, Yngve; Varhaug, Jan Erik; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2013. 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism apa1 influence bone mineral density in primary hyperparathyroidism. PLoS ONE. 8. 8 pages. doi: 10.1371/journal.pone.0056019
  • Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Madsen, Andre Greger; Bozickovic, Olivera; Johannessen, Mona; Bergsvåg, Mari; Lien, Ernst Asbjørn; Stallcup, Michael R.; Sagen, Jørn V.; Moens, Ugo; Mellgren, Gunnar. 2013. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 154: 1513-1527. doi: 10.1210/en.2012-2049
  • Lien, Ernst Asbjørn; Søiland, Håvard; Gjerde, Jennifer. 2013. Associations between tamoxifen and age during steady state tamoxifen treatment of postmenopausal women with breast cancer. Experimental and clinical endocrinology & diabetes. 121. 1 pages. doi: 10.1055/s-0033-1336763
  • Lien, Ernst Asbjørn; Søiland, Håvard; Lundgren, Steinar; Aas, Turid; Steen, Vidar Martin; Mellgren, Gunnar; Gjerde, Jennifer. 2013. Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment. Breast Cancer Research and Treatment. 141: 243-248. doi: 10.1007/s10549-013-2677-9
  • Serrano, Davide; Lazzeroni, Matteo; Gandini, Sara; Macis, Debora; Johansson, Harriet; Gjerde, Jennifer; Lien, Ernst Asbjørn; Feroce, Irene; Pruneri, Giancarlo; Sandri, Maria T; Bassi, Fabio; Brenelli, Fabricio; Luini, Alberto; Cazzaniga, Massimiliano; Varricchio, Clara; Guerrieri-Gonzaga, Aliana; Decensi, Andrea; Bonanni, Bernardo. 2013. A randomized phase II presurgical trial of weekly low-dose tamoxifen versus raloxifene versus placebo in premenopausal women with estrogen receptor-positive breast cancer. Breast Cancer Research. 15. 11 pages. doi: 10.1186/bcr3439
  • Søiland, Håvard; Hagen, Kari Britt; Gjerde, Jennifer; Lende, Tone Hoel; Lien, Ernst Asbjørn. 2013. Breaking away: High fracture rates may merit a new trial of adjuvant endocrine therapy in Scandinavian breast cancer patients. Acta Oncologica. 52: 861-U216. doi: 10.3109/0284186X.2012.742963
  • Christensen, Monika; Pedersen, Eva Kristine Ringdal; Nordbø, Yngve; Varhaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Nygård, Ottar; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2012. Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism. Journal of Internal Medicine. 272: 583-591. doi: 10.1111/j.1365-2796.2012.02570.x
  • Gjerde, Jennifer; Gandini, Sara; Guerrieri-Gonzaga, Aliana; Moi, Line Leonore Haugan; Aristarco, Valentina; Mellgren, Gunnar; Decensi, Andrea; Lien, Ernst Asbjørn. 2012. Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. Breast Cancer Research and Treatment. 134: 693-700. doi: 10.1007/s10549-012-2074-9
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Gjerde, Jennifer; Madsen, Andre Greger; Røst, Therese Halvorsen; Gudbrandsen, Oddrun Anita; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2012. Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer. BMC Cancer. 12. 12 pages. doi: 10.1186/1471-2407-12-247
  • Christensen, Monika; Dankel, Simon E Nitter; Nordbø, Yngve; Varhaug, Jan Erik; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLoS ONE. 6. 10 pages. doi: 10.1371/journal.pone.0020481
  • Decensi, Andrea; Guerrieri-Gonzaga, Aliana; Gandini, Sara; Serrano, Davide; Cazzaniga, Massimiliano; Mora, Serena; Johansson, Harriet Ann; Lien, Ernst Asbjørn; Pruneri, Giancarlo; Viale, Giuseppe; Bonanni, Bernardo. 2011. Prognostic significance of Ki-67 labeling index after short-term presurgical tamoxifen in women with ER-positive breast cancer. Annals of Oncology. 22: 582-587. doi: 10.1093/annonc/mdq427
  • Methlie, Paal; Husebye, Eystein Sverre; Hustad, Simon Steinar; Lien, Ernst Asbjørn; Løvås, Kristian. 2011. Grapefruit juice and licorice increase cortisol availability in patients with Addison's disease. European Journal of Endocrinology. 165: 761-769. doi: 10.1530/EJE-11-0518
  • Christensen, Monika; Lien, Ernst Asbjørn; Hustad, Simon Steinar; Almås, Bjørg. 2010. Seasonal and age-related differences in serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone in patients from Western Norway. Scandinavian Journal of Clinical and Laboratory Investigation. 70: 281-286. doi: 10.3109/00365511003797172
  • Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2010. Effects of CYP2C19 genotype on tamoxifen and estrogen metabolism. European Journal of Cancer. 8: 60-60.
  • Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2010. Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. BMC Cancer. 10. 13 pages. doi: 10.1186/1471-2407-10-313
  • Methlie, Paal; Løvås, Kristian; Lien, Ernst Asbjørn; Husebye, Eystein Sverre. 2010. Grapefruit and Liquorice Increase Bioavailable Cortisol in Addison's Disease. Endocrine reviews. 31. 1 pages.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Gandini, Sara; Guerrieri-Gonzaga, Aliana; Bonanni, Bernardo; Lazzeroni, Matteo; Gjerde, Jennifer; Lien, Ernst Asbjørn; De Censi, Andrea; Mellgren, Gunnar. 2010. Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. Clinical Cancer Research. 16: 2176-2186. doi: 10.1158/1078-0432.CCR-09-1859
  • Bonanni, B; Serrano, D; Gandini, S; Guerrieri-Gonzaga, A; Johansson, H; Macis, Debora; Cazzaniga, M; Luini, A; Cassano, Enrico; Oldani, S; Lien, Ernst Asbjørn; Pelosi, G; Decensi, A. 2009. Randomized Biomarker Trial of Anastrozole or Low-Dose Tamoxifen or Their Combination in Subjects with Breast Intraepithelial Neoplasia. Clinical Cancer Research. 15: 7053-7060. doi: 10.1158/1078-0432.CCR-09-1354
  • Decensi, A; Guerrieri-Gonzaga, A; Gandini, S; Serrano, D; Cazzaniga, M; Mora, S; Johansson, H; Lien, Ernst Asbjørn; Luini, A; Pelosi, G; Bonanni, B. 2009. Ki-67 Expression after Tamoxifen Given Preoperatively Predicts Disease Free Survival and Overall Survival in Women with Operable ER-Positive Breast Cancer. Cancer Research. 69: 517S-518S.
  • Decensi, Andrea; Robertson, Chris; Guerrieri-Gonzaga, Aliana; Serrano, Davide; Cazzaniga, Massimiliano; Mora, Serena; Gulisano, Marcella; Johansson, Harriet; Galimberti, Viviana; Cassano, Enrico; Moroni, Simona; Formelli, Franca; Lien, Ernst Asbjørn; Pelosi, Giuseppe; Johnson, Karen A.; Bonanni, Bernardo. 2009. Randomized double-blind 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women. Journal of Clinical Oncology. 27: 3749-3756. doi: 10.1200/JCO.2008.19.3797
  • Flageng, MH; Hauglid, Marianne; Moi, Line Leonore Haugan; Dixon, J. Michael; Geisler, Jurgen; Lien, Ernst Asbjørn; Miller, William Russell; Lonning, PE; Lønning, Per Eystein; Mellgren, Gunnar. 2009. Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors. British Journal of Cancer. 101: 1253-1260. doi: 10.1038/sj.bjc.6605324
  • Lash, Timothy L; Lien, Ernst Asbjørn; Sørensen, Henrik Toft; Hamilton-Dutoit, Stephen. 2009. Genotype-guided tamoxifen therapy: time to pause for reflection? The Lancet Oncology. 10: 825-833. doi: 10.1016/S1470-2045(09)70030-0
  • Christensen, Monika; Lien, Ernst Asbjørn; Almås, Bjørg. 2008. Vitamin D-metabolism and PTH levels show a biphasic seasonal pattern but are not correlated to osteocalcin levels in outpatients from western Norway. Calcified Tissue International. 82: S150-S151.
  • Fenne, Ingvild Sveinsgjerd; Hoang, Tuyen; Hauglid, Marianne; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2008. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 149: 4336-4345. doi: 10.1210/en.2008-0037
  • Gjerde, Jennifer Fernandez; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, Harald; Hauglid, Marianne; Hauglid, M; Varhaug, EJ; Varhaug, Jan Erik; Steen, Vidar Martin; Lønning, Per Eystein; Lonning, PE; Lien, Ernst Asbjørn. 2008. A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. Breast Cancer Research and Treatment. 109: 592-592.
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Hauglid, M; Breilid, Harald; Lundgren, S.; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2008. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Annals of Oncology. 19: 56-61. doi: 10.1093/annonc/mdm434
  • Karimian, Elham; Chagin, Andrei S; Gjerde, Jennifer Fernandez; Heino, Terhi; Lien, Ernst Asbjørn; Ohlsson, Claes; Sävendahl, Lars. 2008. Tamoxifen impairs both longitudinal and cortical bone growth in young male rats. Journal of Bone and Mineral Research. 23: 1267-1277. doi: 10.1359/JBMR.080319
  • Gjerde, Jennifer Fernandez; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, Harald; Hauglid, Marianne; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lønning, Per Eystein; Lien, Ernst Asbjørn. 2007. A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. Breast Cancer Research and Treatment. S106.
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald; Lundgren, Steinar; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2007. Effect of CYP2D6 and SULT1A1 genotypes on the serum concentration of 4-hydroxytamoxifen and 4-hydroxy-N-demethyltamoxifen during steady state treatment of breast cancer patients. Breast. 16: S15-S15.
  • Gjerde, Jennifer; Geisler, Jurgen; Lundgren, Steinar; Ekse, Dagfinn; Breilid, H; Hauglid, M; Varhaug, Jan Erik; Mellgren, G; Steen, VM; Lønning, Per Eystein; Lien, Ernst A. 2007. A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment. Breast Cancer Research and Treatment. 106: S144-S144. Published 2007-10-24. doi: 10.1007/s10549-007-9793-3
  • Geisler, J; Lønning, Per Eystein; Krag, LE; Løkkevik, Erik; Løkkevik, Erik; Risberg, Terje; Hagen, AI; Schlichting, E; Lien, EA; Ofjord, ES; Øfjord, Erik S.; Eide, GE; Di Salle, Enrico; Polli, A; di Salle, E; Paolini, J. 2006. Changes in bone and lipid metabolism in postmenopausal women with early breast cancer after terminating 2-year treatment with exemestane: A randomised, placebo-controlled study. European Journal of Cancer. 42: 2968-75.
  • Schjøtt, Jan; Gjerde, Jennifer; Kisanga, Elton Richard; Lien, Ernst Asbjørn. 2006. Pretreatment with tamoxifen does not change acute epirubicin cardiotoxicity in rats. Basic & Clinical Pharmacology & Toxicology. 98: 231-234. doi: Se sammendrag
  • Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald; Lundgren, Steinar; Varhaug, Jan Erik; Kisanga, Elton Richard; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn. 2005. Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. Breast Cancer Research and Treatment. 94: S236-S237.
  • Gjerde, Jennifer Fernandez; Kisanga, Elton Richard; Hauglid, Marianne; Holm, Pål Ivar; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A. 1082: 6-14. doi: 10.1016/j.chroma.2005.01.004
  • Kisanga, Elton Richard; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Excretion of hydroxylated metabolites of tamoxifen in human bile and urine. Anticancer Research. 25: 4487-4492.
  • Kisanga, Elton Richard; Moi, Line Leonore Haugan; Gjerde, Jennifer; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2005. Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. Journal of Steroid Biochemistry and Molecular Biology. 94: 489-498. doi: 10.1016/j.jsbmb.2004.12.037
  • Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Cook, Carol Ann; Børud, Bente; Bakke, Marit; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2004. cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. Journal of Biological Chemistry. 279: 49120-49130.
  • Holm, Pål Ivar; Bleie, Øyvind; Ueland, Per Magne; Lien, Ernst Asbjørn; Refsum, Helga; Nordrehaug, Jan Erik; Nygård, Ottar. 2004. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation. Arteriosclerosis, Thrombosis and Vascular Biology. 24: 301-307.
  • Hustad, Simon Steinar; Nedrebø, Bjørn Gunnar; Ueland, Per Magne; Schneede, Jørn; Vollset, Stein Emil; Ulvik, Arve; Lien, Ernst Asbjørn. 2004. Phenotypic expression of the methylenetetrahydrofolate reductase 677C->T polymorphism and flavine cofactor availability in thyroid dysfunction. American Journal of Clinical Nutrition. 80: 1050-1057.
  • Kisanga, Elton Richard; Gjerde, Jennifer; Guerrieri-gonzaga, Aliana; Pigatto, Francesca; Pesci - feltri, Adriana; Robertson, Chris; Serrano, Davide; Pelosi, Giuseppe; Decensi, Andrea; Lien, Ernst Asbjørn. 2004. Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in randomized preoperative trial. Clinical Cancer Research. 10: 2336-2343.
  • Lien, Ernst Asbjørn; Ueland, Per Magne; Lønning, Per Eystein. 2004. Letter. Journal of the National Cancer Institute. 96: 883-883.
  • Bonanni, B; Johansson, H; Gandini, S; Guerrieri-Gonzaga, M; Sandri, MT; Mariette, F; Lien, Ernst Asbjørn; Decensi, A. 2003. Effect of tamoxifen at low doses on ultrasensitive C-reactive protein in healty women. Journal of Thrombosis and Haemostasis. 1: 2149-2152.
  • Decensi, A; Robertson, C; Viale, G; Pigatto, F; Johansson, H; Kisanga, Elton Richard; Veronesi, P; Torrisi, R; Cazzaniga, M; Mora, S; Sandri, MT; Pelosi, G; Goldhirsch, A; Lien, Ernst Asbjørn. 2003. A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers. Journal of the National Cancer Institute. 95: 779-790.
  • Holm, Pål Ivar; Ueland, Per Magne; Kvalheim, Gry; Lien, Ernst Asbjørn. 2003. Determination of choline, betaine, and dimethylglycine in plasma by a high-troughput metod based on normal-phase chromatography-tandem mass spectrometry. Clinical Chemistry. 49: 286-294.
  • Kisanga, Elton Richard; Gjerde, Jennifer; Schjøtt, Jan; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2003. Tamoxifen administration and metabolism in nude mice and nude rats. Journal of Steroid Biochemistry and Molecular Biology. 84: 361-367.
  • Mellgren, Gunnar; Børud, Bente; Hoang, Tuyen Thi Van; Yri, Olav Erich; Fladeby, Cathrine; Lien, Ernst Asbjørn; Lund, Johan. 2003. Characterization of receptor-interacting protein RIP140 in the regulation of SF-1 responsive target genes. Molecular and Cellular Endocrinology. 203: 91-103.
  • Nedrebø, Bjørn Gunnar; Hustad, Steinar; Schneede, Jørn; Ueland, Per Magne; Vollset, Stein Emil; Holm, Pål Ivar; Aanderud, Sylvi J; Lien, Ernst Asbjørn. 2003. Homocysteine and its relations to B-vitamins and smoking in graves' disease before and after treatment. Journal of Internal Medicine. 254: 504-512.
  • Mellgren, Gunnar; Holm, Pål Ivar; Lien, Ernst Asbjørn; Bleskestad, Inger Hjørdis; Aanderud, Sylvi J; Bindoff, Laurence Albert. 2002. Tyreotoksisk periodisk paralyse - en uvanlig komplikasjon ved hypertyreose. Tidsskrift for Den norske legeforening. 122: 1029-1031.
  • Nedrebø, Bjørn G; Holm, Pål Ivar; Uhlving, Sverre; Sørheim, Jan I; Skeie, Svein; Eide, Geir Egil; Husebye, Eystein; Lien, Ernst Asbjørn; Aanderud, Sylvi J. 2002. Predictors of outcome and comparison of different drug regimens for the prevention of relapse in patients with Graves' disease. European Journal of Endocrinology. 147: 583-589.
  • Bonanni, B; Johansson, H; Gandini, S; Guerrieri-Gonzaga, A; Torisi, R; Sandri, MT; Cazzaniga, M; Robertson, C; Lien, Ernst Asbjørn; Decensi, Andrea. 2001. Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women. Breast Cancer Research and Treatment. 69: 21-27.
  • Guerrieri-Gonzaga, A; Baglietto, L; Johansson, H; Bonanni, B; Robertson, C; Sandri, MT; Canigiula, L; Lampreda, C; Diani, S; Lien, Ernst Asbjørn; Decensi, A. 2001. Correlation between tamoxifen elimination and biomarker recovery in a primary prevention trial. Cancer Epidemiology, Biomarkers and Prevention. 10: 967-970.
  • Lien, Ernst Asbjørn; Hustad, Steinar; Nedrebø, Bjørn Gunnar; Nygård, Ottar; Ueland, Per Magne. 2001. Total plasma homocysteine in hypo- and hyperthyroidism: Covariations and causality. Journal of Clinical Endocrinology and Metabolism. 86: 1846.
  • Nedrebø, Bjørn G; Nygård, Ottar; Ueland, Per Magne; Lien, Ernst Asbjørn. 2001. Plasma total homocysteine in hyper- and hypothyroid patients before and during 12 months of treatment. Clinical Chemistry. 47: 1738-1741.
  • Ulvik, Arve; Evensen, Espen Thiis; Lien, Ernst Asbjørn; Hoff, Geir; Vollset, Stein Emil; Majak, Bernhard M; Ueland, Per Magne. 2001. Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum. American Journal of Medical Genetics. 101: 246-254.
  • Lien, Ernst Asbjørn; Lønning, Per Eystein. 2000. Selective oestrogen receptor modifiers (SERMs) and breast cancer therapy. Cancer Treatment Reviews. 26: 205-227.
  • Lien, Ernst Asbjørn; Lønning, Per Eystein. 2000. Selective oestrogen receptor modifiers (SERMs) and breast cancer therapy. Cancer Treatment Reviews. 26: 205-227.
  • Lien, Ernst Asbjørn; Nedrebø, Bjørn Gunnar; Varhaug, Jan Erik; Nygård, Ottar; Aakvag, Asbjørn; Ueland, Per Magne. 2000. Plasma total homocysteine levels during short-term iatrogenic hypothyreoidism. Journal of Clinical Endocrinology and Metabolism. 85: 1049-1053.
  • Anker, Gun Birgitta; Refsum, Helga; Ueland, Per Magne; Johannessen, Dag Clement; Lien, Ernst Asbjørn; Lønning, Per Eystein. 1999. Influence of aromatase inhibitors on plasma total homocysteine levels in postmenopausal breast cancer patients. Clinical Chemistry. 45: 252-256.
  • Anker, Gun Birgitta; Refsum, Helga; Ueland, Per Magne; Johannessen, Dag Clement; Lien, Ernst Asbjørn; Lønning, Per Eystein. 1999. Influence of aromatase inhibitors on plasma total homocysteine in postmenopausal breast cancer patients. Clinical Chemistry. 45: 252-256.
  • Decensi, A; Gandini, S; Guerrieri-Gonzaga, A; Bonannai, B; Barreca, A; Costa, A; Robertson, C; Lien, Ernst Asbjørn. 1999. Effect of blood tamoxifen concentrations on surrogate biomarkers in a trial of dose reduction. Journal of Clinical Oncology. 2633-2688.
  • Love, RR; Anker, Gun Birgitta; Yang, Y; Refsum, Helga; Ueland, Per Magne; Lønning, Per Eystein; Lien, Ernst Asbjørn. 1999. Serum homocysteine levels in postmenopausal breast cancer patients treated with tamoxifen. Cancer Letters. 145: 73-77.
  • Anker, Gun Birgitta; Aakvaag, Asbjørn; Lønning, Per Eystein; Lien, Ernst Asbjørn. 1998. Thyroid function in postmenopausal breast cancer patients treated with tamoxifen. Scandinavian Journal of Clinical and Laboratory Investigation. 58: 103-107.
  • Anker, Gun Birgitta; Lønning, Per Eystein; Aakvaag, Asbjørn; Lien, Ernst Asbjørn. 1998. Thyroid function in postmenopausal breast cancer patients treated with tamoxifen. Scandinavian Journal of Clinical and Laboratory Investigation. 58: 103-107.
  • Anker, Gun Birgitta; Lønning, Per Eystein; Aakvaag, Asbjørn; Lien, Ernst Asbjørn. 1998. Thyroid function in postmenopausal breast cancer patients treated with tamoxifen. Scandinavian Journal of Clinical and Laboratory Investigation. 58: 103-107.
  • Nedrebø, B.G.; Ericsson, U.-B.; Nygård, Ottar; Refsum, Helga; Ueland, Per Magne; Aakvaag, Asbjørn; Aanderud, Sylvi; Lien, Ernst Asbjørn. 1998. Plasma total homocysteine levels in hyperthyroid and hypothyroid patients. Metabolism: Clinical and Experimental. 47: 89-93.
  • Nedrebø, B.G.; Ericsson, U.-B.; Nygård, Ottar; Refsum, Helga; Ueland, Per Magne; Aakvaag, Asbjørn; Aanderud, Sylvi; Lien, Ernst Asbjørn. 1998. Plasma total homocysteine levels in hyperthyroid and hypothyroid patients. Metabolism: Clinical and Experimental. 47: 89-93.
  • Nedrebø, B.G.; Ericsson, U.-B.; Nygård, Ottar; Refsum, Helga; Ueland, Per Magne; Aakvaag, Asbjørn; Aanderud, Sylvi; Lien, Ernst Asbjørn. 1998. Plasma total homocysteine levels in hyperthyroid and hypothyroid patients. Metabolism: Clinical and Experimental. 47: 89-93.
  • Nedrebø, B.G.; Ericsson, U.-B.; Nygård, Ottar; Refsum, Helga; Ueland, Per Magne; Aakvaag, Asbjørn; Aanderud, Sylvi; Lien, Ernst Asbjørn. 1998. Plasma total homocysteine levels in hyperthyroid and hypothyroid patients. Metabolism: Clinical and Experimental. 47: 89-93.
  • Lien, Ernst Asbjørn; Anker, Gun Birgitta; Lønning, Per Eystein; Refsum, Helga; Ueland, Per Magne. 1997. Effects of hormones on the plasma levels of the atherogenic amino acid homocysteine. Biochemical Society Transactions. 25: 33-35.
  • Lien, Ernst Asbjørn; Anker, Gun Birgutta; Lønning, Per Eystein; Refsum, Helga; Ueland, Per Magne. 1997. Effects of hormones on the plasma level of the atherogenic amino acid homocysteine. Biochemical Society Transactions. 25: 33-35.
  • Lien, Ernst Asbjørn; Overå, O. 1997. Treatment of small cell lung cancer (SCLC) with high dose tamoxifen in combination with epirubicin, cyclophosphamide and oncovin. European Journal of Clinical Pharmacology. 52: 102.
  • Anker, Gun Birgitta; Lønning, Per Eystein; Ueland, Per Magne; Refsum, Helga; Lien, Ernst Asbjørn. 1995. Plasma levels of the atherogenic amino acid homocysteine in post-menopausal women with breast cancer treated with tamoxifen. International Journal of Cancer. 60: 365-368.
  • Anker, Gun Birgitta; Lønning, Per Eystein; Ueland, Per Magne; Refsum, Helga; Lien, Ernst Asbjørn. 1995. Plasma levels of the atherogenic amino acid homocysteine in post-menopausal women with breast cancer treated with tamoxifen. International Journal of Cancer. 60: 365-368.
  • Lien, Ernst Asbjørn; Anker, Gun Birgitta; Lønning, Per Eystein; Ueland, Per Magne. 1995. Determination of droloxifene and two metabolites in serum by high pressure liquid chromatography. Therapeutic Drug Monitoring. 17: 259-265.
  • Lien, Ernst Asbjørn; Anker, Gun Birgitta; Lønning, Per Eystein; Ueland, Per Magne. 1995. Determination of droloxifene and two metabolites in serum by high-pressure liquid chromatography. Therapeutic Drug Monitoring. 17: 259-265.
  • Lien, Ernst Asbjørn; Anker, Gun Birgitta; Ueland, Per Magne. 1995. Pharmacokinetics of tamoxifen in pre- and post-menopausal women with breast cancer. Journal of Steroid Biochemistry and Molecular Biology. 55: 229-231.
  • Lønning, Per Eystein; Helle, Svein Inge; Johannesen, Dag Clement; Adlercreutz, Herman; Lien, Ernst Asbjørn; Tally, M.; Ekse, Dagfinn; Fotsis, T.; Anker, Gun Birgitta; Hall, K.J. 1995. Influence of tamoxifen on sex hormones, gonadotropins and sex hormone binding globulin in postmenopausal breast cancer patients. Journal of Steroid Biochemistry and Molecular Biology. 52: 491-496.
  • Lønning, Per Eystein; Helle, Svein Inge; Johannessen, Dag Clement; Adlercreutz, Herman; Lien, Ernst Asbjørn; Tally, M; Eske, Dagfinn; Fotsis, T; Anker, Gun Birgitta; Hall, K. 1995. Relations between sex hormones, sex hormone binding globulin, insulin-like growth factor-I and insulin-like growth factor binding protein-1 in post-menopausal breast cancer patients. Clinical Endocrinology. 42: 23-30.
  • Lønning, Per Eystein; Johannesen, Dag Clement; Helle, Svein Inge; Adlercreutz, Herman; Lien, Ernst Asbjørn; Ekse, Dagfinn; Anker, Gun Birgitta; Hall, K.J. 1995. Relations between sex hormones, sex hormone binding globulin insulin-like growth factor binding protein-1 in postmenopausal breast cancer patients. Clinical Endocrinology. 42: 23-30.
  • Lønning, Per Eystein; Johannessen, Dag Clement; Lien, Ernst Asbjørn; Eske, Dagfinn; Fotsis, T; Adlercreutz, Herman. 1995. Influence of tamoxifen on sex hormones, gonadotrophins and sex hormone binding globulin in postmenopausal breast cancer patients. Journal of Steroid Biochemistry and Molecular Biology. 52: 491-496.
  • Lønning, Per Eystein; Lien, Ernst Asbjørn. 1994. Pharmacokinetics of anti-endocrine agents. Cancer Surveys. 17: S. 343-370.
  • Millward, M. J.; Lien, Ernst Asbjørn; Robinson, A.; Cantwell, B. M. J. 1994. High-dose (480 mg/day) tamoxifen with etoposide: a study of a potential multi-drug resistance modulator. Oncology. 51: 79-83.
  • Lien, Ernst Asbjørn; Johannesen, D. C.; Aakvaag, A.; Lønning, Per Eystein. 1992. Influence of tamoxifen, aminoglutethimide and goserelin on human plasma IGF-1 levels in breast cancer patients. Journal of Steroid Biochemistry and Molecular Biology. 41: 541-543.
  • Lien, Ernst Asbjørn; Johannessen, Dag Clement; Aakvaag, A.; Lønning, Per Eystein. 1992. Influence of tamoxifen, aminoglutethimide and goserelin on human plasma IGF-1 levels in breast cancer patients. Journal of Steroid Biochemistry and Molecular Biology. 41: 541-543.
  • Lien, Ernst Asbjørn; Johannessen, Dag Clement; Aakvaag, A.; Lønning, Per Eystein. 1992. Influence of tamoxifen, aminoglutethimide and goserelin on human plasma IGF-1 levels in breast cancer patients. Journal of Steroid Biochemistry and Molecular Biology. 41: 541-543.
  • Lien, Ernst Asbjørn; Johannessen, Dag Clement; Aakvaag, A.; Lønning, Per Eystein. 1992. Influence of tamoxifen, aminoglutethimide and goserelin on human plasma IGF-I levels in breast cancer patients. Journal of Steroid Biochemistry and Molecular Biology. 41: 541-543.
  • Lønning, Per Eystein; Hall, K.; Aakvaag, A.; Lien, Ernst Asbjørn. 1992. Influence of tamoxifen on plasma levels of IGF-I and IGFBP-I in breast cancer patients. Cancer Research. 52: 4719-4723.
  • Lønning, Per Eystein; Hall, K.; Aakvaag, A.; Lien, Ernst Asbjørn. 1992. Influence of tamoxifen on plasma levels of IGF-I and IGFBP-I in breast cancer patients. Cancer Research. 52: 4719-4723.
  • Lønning, Per Eystein; Hall, K.; Aakvaag, A.; Lien, Ernst Asbjørn. 1992. Influence of tamoxifen on plasma levels of insulin-like growth factor I and insulin-like growth factor binding protein I in breast cancer patients. Cancer Research. 52: 4719-4723.
  • Lønning, Per Eystein; Hall, K.; Aakvaag, A.; Lien, Ernst Asbjørn. 1992. Influence of tamoxifen on plasma levels of insulinelike growth factor I and insulin-like growth factor binding protein I in breast cancer patients. Cancer Research. 52: 4719-4723.
  • Milward, M. J.; Cantwell, B. M. J.; Lien, Ernst Asbjørn; Carmichael, J.; Harris, A. L. 1992. Intermittent high dose tamoxifen as a potential modifier of multi-drug resistance. European Journal of Cancer. 28A: 805-810.
  • Stuart, N. S. A.; Philip, P.; Harris, A. L.; Tonkin, K.; Houlbrook, S.; Kirk, J.; Lien, Ernst Asbjørn; Carmichael, J. 1992. High dose tamoxifen as an enhancer of etoposide cytotoxicity.Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines. British Journal of Cancer. 66: 833-839.
  • Lien, Ernst Asbjørn; Solheim, E.; Ueland, P. M. 1991. Distribution of tamoxifen and its metabolites in tissues of rat and man during steady state treatment. Cancer Research. 51: 4837-4844.
  • Lien, Ernst Asbjørn; Solheim, E.; Ueland, P. M. 1991. Distribution of tamoxifen and its metabolites in rat and human tissues during steady state treatment. Cancer Research. 51: 4837-4844.
  • Lien, Ernst Asbjørn; Wester, Knut; Lønning, Per Eystein; Solheim, E.; Ueland, P. M. 1991. Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients. British Journal of Cancer. 63: 641-645.
  • Lien, Ernst Asbjørn; Wester, Knut; Lønning, Per Eystein; Solheim, E.; Ueland, P. M. 1991. Distribution of tamoxifen and metabolites into brain tissue metastases in breast cancer patients. British Journal of Cancer. 63: 641-645.
  • Lien, Ernst Asbjørn; Wester, Knut; Lønning, Per Eystein; Solheim, E.; Ueland, P. M. 1991. Distribution of Tamoxifen and meta-bolites into brain tissue and brain metastases in brain cancer patients. British Journal of Cancer. 63: 641-645.
  • Lien, Ernst Asbjørn; Anker, Gun Birgitta; Lønning, Per Eystein; Solheim, E.; Ueland, Per Magne. 1990. Decreased serum concentrations of tamoxifen and its metabolites induced by aminogluethimide. Cancer Research. 50: 5851-5857.
Reports and theses
  • Kisanga, Elton Richard; Lien, Ernst Asbjørn. 2004. Pharmacology of low-dose tamoxifen regimens in breast cancer treatment. 100 pages.
  • Lien, Ernst Asbjørn. 1991. Tamoxifen pharmacokinetics in breast cancer patients. Analytical methods, pharmacokinetics, tissue distribution and drug interactions. (dr.med.).
Book sections
  • Gjerde, Jennifer; Moi, Line Leonore Haugan; Mellgren, Gunnar; Lien, Ernst Asbjørn. 2012. Tamoxifen metabolism and biological activity. chapter 2, pages 7-28. In:
    • de Mello, R.A. 2012. Tamoxifen concepts and cancer: New paradigms. 196 pages. ISBN: 978-1-62081-520-5.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Hoang, Tuyen; Gjerde, Jennifer; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 2, pages 35-66. In:
    • Bates, Margaret K; Kerr, Regina M. 2011. Nuclear Receptors. Nova Science Publishers, Inc.. 174 pages. ISBN: 978-1-61209-980-4.
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Fenne, Ingvild Sveinsgjerd; Gjerde, Jennifer; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer. 35, pages 715-732. In:
    • Gunduz, Mehmet; Gunduz, Esra. 2011. Breast Cancer - Carcinogenesis, Cell Growth and Signalling Pathways. INTECH. 732 pages. ISBN: 978-953-307-714-7.
  • Lønning, Per Eystein; Lien, Ernst Asbjørn; Tveter, K; Christoffersen, T. 1999. Hormoner og hormonantagonister. 226-240. In:
    • Dahl, Olav; Christoffersen, Thoralf; Kvaløy, Stein O; Baksaas, Ingebjørg. 1999. Cytostatika. Medikamentell kreftbehandling [6. utg.].
  • Aamo, Trond; Brørs, Odd; Lien, Ernst Asbjørn. 1998. Legemiddelanalyser og rusmiddelanalyser. 1043-1050. In:
    • [Mangler etternavn], [Mangler fornavn]. 1998. Norsk legemiddelhåndbok 1998-99 for helsepersonell.
  • Lien, Ernst Asbjørn. 1994. Utprøving av dataprogrammet "Aldus Persuasion" og "Davis Transview Presenter" som hjelpemidler i forberedelse og gjennomføring av undervisning. 100-109. In:
    • [Mangler etternavn], [Mangler fornavn]. 1994. [Mangler tittel].
  • Lien, Ernst Asbjørn; Wester, Knut; Lønning, Per Eystein; Solheim, E.; Ueland, P. M. 1991. Tamoxifen uptake in brain tissue and brain metastases in man. In:
    • [Mangler etternavn], [Mangler fornavn]. 1991. Plasma Binding of Drugs and its Consequences.

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