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Even Birkeland

Chief Engineer
  • E-mailEven.Birkeland@uib.no
  • Phone+47 55 58 63 68
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Holst, Frederik; Werner, Henrica Maria Johanna; Mjøs, Siv; Høivik, Erling Andre; Kusonmano, Kanthida; Wik, Elisabeth; Berg, Anna; Birkeland, Even; Gibson, William J.; Halle, Mari Kyllesø; Trovik, Jone; Cherniack, Andrew D.; Kalland, Karl-Henning; Mills, Gordon B.; Singer, Christian F.; Krakstad, Camilla; Beroukhim, Rameen; Salvesen, Helga. 2019. PIK3CA amplification associates with aggressive phenotype but not markers of AKT-mTOR signaling in endometrial carcinoma. Clinical Cancer Research. 25: 334-345. doi: 10.1158/1078-0432.CCR-18-0452
  • Krüger, Kristi; Wik, Elisabeth; Knutsvik, Gøril; Nalwoga, Hawa; Klingen, Tor Audun; Arnes, Jarle; Chen, Ying; Mannelqvist, Monica; Dimitrakopoulou, Konstantina; Stefansson, Ingunn; Birkeland, Even; Aas, Turid; Tobin, Nicholas P.; Jonassen, Inge; Bergh, Jonas; Foulkes, William D; Akslen, Lars A. 2017. Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer. Scientific Reports. 7:1089: 1-12. doi: 10.1038/s41598-017-00862-w
  • Mjøs, Siv; Werner, Henrica Maria Johanna; Birkeland, Even; Holst, Frederik; Berg, Anna; Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Kusonmano, Kanthida; Mauland, Karen Klepsland; Øyan, Anne Margrete; Kalland, Karl-Henning; Lewis, Aurelia Eva; Mills, Gordon B.; Krakstad, Camilla; Trovik, Jone; Salvesen, Helga; Høivik, Erling Andre. 2017. PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. Scientific Reports. 7:10240: 1-12. doi: 10.1038/s41598-017-10717-z
  • Bredholt, Geir; Mannelqvist, Monica; Stefansson, Ingunn; Birkeland, Even; Bø, Trond Hellem; Øyan, Anne Margrete; Trovik, Jone; Kalland, Karl-Henning; Jonassen, Inge; Salvesen, Helga; Wik, Elisabeth; Akslen, Lars A. 2015. Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses. OncoTarget. 6: 39676-39691. doi: 10.18632/oncotarget.5344
  • Werner, Henrica Maria Johanna; Trovik, Jone; Halle, Mari Kyllesø; Wik, Elisabeth; Akslen, Lars A.; Birkeland, Even; Bredholt, Therese; Tangen, Ingvild Løberg; Krakstad, Camilla; Salvesen, Helga Birgitte. 2014. Stathmin Protein Level, a Potential Peredictive Marker for Taxane Treatment Response in Endometrial Cancer. PLoS ONE. 9. doi: 10.1371/journal.pone.0090141
  • Wik, Elisabeth; Trovik, Jone; Kusonmano, Kanthida; Birkeland, Even; Ræder, Maria B; Pashtan, I; Høivik, Erling Andre; Krakstad, Camilla; Werner, Henrica Maria Johanna; Holst, Frederik; Mjøs, Siv; Halle, Mari Kyllesø; Mannelqvist, Monica; Mauland, Karen Klepsland; Øyan, Anne Margrete; Stefansson, Ingunn; Petersen, Kjell; Simon, R; Cherniack, AD; Meyerson, M; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga Birgitte. 2014. Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations. Gynecologic Oncology. 134: 599-606. doi: 10.1016/j.ygyno.2014.06.026
  • Ræder, Maria B; Birkeland, Even; Trovik, Jone; Krakstad, Camilla; Shehata, Shyemaa; Schumacher, Steven; Zack, Travis I.; Krohn, Antje; Werner, Henrica Maria Johanna; Moody, Susan E.; Wik, Elisabeth; Stefansson, Ingunn Marie; Holst, Frederik; Øyan, Anne Margrete; Tamayo, Pablo; Mesirov, Jill P.; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Beroukhim, Rameen; Salvesen, Helga Birgitte. 2013. Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. PLoS ONE. 8. 9 pages. doi: 10.1371/journal.pone.0054873
  • Werner, Henrica Maria Johanna; Berg, Anna; Wik, Elisabeth; Birkeland, Even; Krakstad, Camilla; Kusonmano, Kanthida; Petersen, Kjell; Kalland, Karl-Henning; Øyan, Anne Margrete; Akslen, Lars A.; Trovik, Jone; Salvesen, Helga Birgitte. 2013. ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas. Modern Pathology. 26: 428-434. doi: 10.1038/modpathol.2012.174
  • Wik, Elisabeth; Birkeland, Even; Trovik, Jone; Werner, Henrica Maria Johanna; Høivik, Erling Andre; Mjøs, Siv; Krakstad, Camilla; Kusonmano, Kanthida; Mauland, Karen Klepsland; Stefansson, Ingunn Marie; Holst, Frederik; Petersen, Kjell; Øyan, Anne Margrete; Simon, Roland; Kalland, Karl-Henning; Ricketts, William; Akslen, Lars A.; Salvesen, Helga Birgitte. 2013. High phospho-stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition. Clinical Cancer Research. 19: 2331-2341. doi: 10.1158/1078-0432.CCR-12-3413
  • Wik, Elisabeth; Ræder, Maria B; Krakstad, Camilla; Trovik, Jone; Birkeland, Even; Høivik, Erling Andre; Mjøs, Siv; Werner, Henrica Maria Johanna; Mannelqvist, Monica; Stefansson, Ingunn Marie; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga Birgitte. 2013. Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. Clinical Cancer Research. 19: 1094-1105. doi: 10.1158/1078-0432.CCR-12-3039
  • Birkeland, Even; Wik, Elisabeth; Mjøs, Siv; Høivik, Erling Andre; Trovik, Jone; Werner, Henrica Maria Johanna; Kusonmano, Kanthida; Petersen, Kjell; Ræder, Maria B; Holst, Frederik; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Simon, R; Krakstad, Camilla; Salvesen, Helga Birgitte. 2012. KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer. British Journal of Cancer. 107: 1997-2004. doi: 10.1038/bjc.2012.477
  • Halle, Mari Kyllesø; Werner, Henrica Maria Johanna; Krakstad, Camilla; Birkeland, Even; Wik, Elisabeth; Trovik, Jone; Salvesen, Helga Birgitte. 2012. Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas. Histopathology. 60: 516-519. doi: 10.1111/j.1365-2559.2011.04057.x
  • Krakstad, Camilla; Birkeland, Even; Seidel, Danila; Kusonmano, Kanthida; Petersen, Kjell; Mjøs, Siv; Høivik, Erling Andre; Wik, Elisabeth; Halle, Mari Kyllesø; Øyan, Anne Margrete; Kalland, Karl-Henning; Werner, Henrica Maria Johanna; Trovik, Jone; Salvesen, Helga Birgitte. 2012. High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. PLoS ONE. 7. doi: 10.1371/journal.pone.0052795
  • Krakstad, Camilla; Trovik, Jone; Wik, Elisabeth; Engelsen, Ingeborg Bøe; Werner, Henrica Maria Johanna; Birkeland, Even; Ræder, Maria B; Øyan, Anne Margrete; Stefansson, Ingunn Marie; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga Birgitte. 2012. Loss of GPER identifies new targets for therapy among a subgroup of ER alpha-positive endometrial cancer patients with poor outcome. British Journal of Cancer. 106: 1682-1688. doi: 10.1038/bjc.2012.91
  • Birkeland, Even; Nygaard, G; Oveland, Eystein; Mjaavatten, Olav; Ljones, M; Doskeland, Stein Ove; Krakstad, Camilla; Selheim, Frode. 2009. Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. Journal of Proteomics & Bioinformatics. 244-245.
Reports and theses
  • Birkeland, Even. 2013. Mutations and gene amplifications in Endometrial Carcinomas. “Clinical characteristics and potential targets for therapyrelated to KRAS, MYC, ATAD2, PIK3CA and FGFR2 alterations. University of Bergen.
  • Birkeland, Even. 2008. Quantitative proteomics of Epac signaling in differentiating human SH-SY5Y neuroblastoma cells. Institutt for biomedisin, Universitetet i Bergen.

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