Medical specialist and consultant
Prof Francisco Gómez Real, MD PhD, shares his time between scientific and clinical work. He is a professor at the Department of Clinical Science, Medicine Faculty at the University of Bergen, Norway. He a specialist in Gynaecology and Obstetrics, works as a consultant at the Women's Clinic, Haukeland University Hospital, and is responsible for the follow-up of pregnant women with obesity. He has experience from General Practice and Respiratory Medicine.
Real is a pioneer and international top-expert of research investigating the link between sex hormones, reproductive and metabolic factors and early life factors for respiratory health and disease, pioneering the field through his own PhD, postdoctoral work, PhD students, and postdoctoral research fellow. He is responsible for women´s health studies in the cohorts Respiratory Health in Northern Europe (RHINE) and Respiratory Health in Northern Europe, Spain and Australia (RHINESSA), og co-chair for women´s health studies in Europaen Community Respiratory Health Survey (ECRHS).
He leads the Research Unit for Health Surveys (RUHS), a core facility at the University of Bergen for the implementation of clinical research projects not requiring hospital infrastructure. RUHS is a collaboration between the Faculty of Medicine (MOF) and Haukeland University Hospital (HUS), administratively subject to the department of Clinical Science, and funded by the Trond Mohn Foundation/Trond Mohn Stiftelse (TMS).
There has been extensive covering of Real's research activities in both the national and international media (incl. Reuters) – newspapers (incl. the New York Times, Washington Post, Der Standard, El Pais, Aftenposten), magazines (incl. Dagens Medisin, Allergi i Praksis, Tidskriftet for den Norske Legeforeningen), women’s magazines (incl. Women’s Weekly magazine, SELF magazine), radio (incl. BBC news, ABC news, Norwegian radio stations) and online media (incl. Times News, Medical News Today, American Academy of Allergy Asthma & Immunology, RT online, Web MD, Women´s day, På Høyden).
Real has received numerous Best Paper Awards, from the Norwegian Respiratory Society. In 2007 as first author, and in 2011, 2016 and 2017 as the last author.
Real is lecturer for 5th year medical students in Obstetrics and Gynecology semester in English, at the University of Bergen.
Real was responsible for initiating and organizing the clinical praxis for 5th year medical students in Obstetrics and Gynecology semester in English, at the University of Bergen.
Real has built an excellent track record in reproductive and respiratory health in women and across generations. He has 89 peer reviewed publications, including 54 in the last 5 years. His publication output shows an upward trajectory, with 20 publications in the last two years, and 31 of his publications in top ranked journals (IF 8 or above), he is 1st/2nd/senior author on 26 of them. He has contributed to three book chapters. He is an experienced supervisor of researchers.
- (2023). Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort. Journal of Translational Medicine. 11 pages.
- (2023). Association between abdominal and general obesity and respiratory symptoms, asthma and COPD. Results from the RHINE study. Respiratory Medicine. 6 pages.
- (2022). Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts. Endocrine Connections. 11 pages.
- (2022). Parental Prepuberty Overweight and Offspring Lung Function. Nutrients.
- (2022). Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study. PLOS ONE. 13 pages.
- (2022). Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS. Thorax.
- (2022). Lifelong exposure to residential greenspace and the premenstrual syndrome: A population-based study of Northern European women. Environment International. 7 pages.
- (2022). Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort. PLOS ONE. 13 pages.
- (2022). Exposure to Antibacterial Chemicals Is Associated With Altered Composition of Oral Microbiome. Frontiers in Microbiology. 15 pages.
- (2022). Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort. BMJ Open. 18 pages.
- (2022). Association of oral bacteria with oral hygiene habits and self-reported gingival bleeding. Journal of Clinical Periodontology. 768-781.
- (2021). Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS). Maturitas. 49-55.
- (2021). Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach. European Respiratory Journal.
- (2021). Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma. Journal of Allergy and Clinical Immunology. 422-431.
- (2021). Exposure to environmental phenols and parabens, and relation to body mass index, eczema and respiratory outcomes in the Norwegian RHINESSA study. Environmental health.
- (2021). Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization. Clinical and Experimental Allergy.
- (2021). Childhood lung function as a determinant of menopause-dependent lung function decline. Maturitas. 41-47.
- (2021). CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test. Respiratory Medicine. 8 pages.
- (2021). Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status. World Allergy Organization Journal. 16 pages.
- (2021). Breathlessness across generations: Results from the RHINESSA generation study. Thorax. 172-177.
- (2020). Sleep time and sleep-related symptoms across two generations – results of the community-based RHINE and RHINESSA studies. Sleep Medicine. 8-13.
- (2020). Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern: A Longitudinal Analysis of 2 Population-Based Cohorts. American Journal of Epidemiology. 1521-1528.
- (2020). Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study. PLOS ONE. 1-20.
- (2020). One Year Change in 6-Minute Walk Test Outcomes is Associated with COPD Prognosis. COPD: Journal of Chronic Obstructive Pulmonary Disease. 662-671.
- (2020). Lung function changes over 8 years and testosterone markers in both sexes: Uk biobank. European Respiratory Journal Open Research (ERJ Open Research). 1-11.
- (2020). Early Age at Natural Menopause Is Related to Lower Post-Bronchodilator Lung Function. A Longitudinal Population-based Study. Annals of the American Thoracic Society.
- (2020). Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels. PLOS ONE.
- (2020). Association of adult lung function with accelerated biological aging. Aging. 518-542.
- (2019). Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. The Lancet Diabetes and Endocrinology. 256-266.
- (2019). Snoring and nocturnal reflux: Association with lung function decline and respiratory symptoms. European Respiratory Journal Open Research (ERJ Open Research).
- (2019). Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. Respiratory Medicine. 116-123.
- (2019). Residential surrounding greenspace and age at menopause: A 20-year European study (ECRHS). Environment International. 1-7.
- (2019). Polycystic ovary syndrome and lung function: a Mendelian randomization study. European Respiratory Journal.
- (2019). Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS). Maturitas. 29-34.
- (2019). Epigenome-wide association of father's smoking with offspring DNA methylation: A hypothesis-generating study. Environmental Epigenetics. 10 pages.
- (2019). Early menarche is associated with lower adult lung function: A longitudinal cohort study from the first to sixth decade of life. Respirology (Carlton South. Print). 1-9.
- (2019). Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? Journal of Allergy and Clinical Immunology. 1-13.
- (2019). Age at menopause and lung function: a Mendelian randomisation study. European Respiratory Journal. 1-10.
- (2018). Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway. Clinical and Experimental Allergy. 66-77.
- (2018). Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy. Pregnancy Hypertension. 32-37.
- (2018). Periodontal Health status and lung function in two Norwegian cohorts. PLOS ONE. 1-15.
- (2018). Leisure-time vigorous physical activity is associated with better lung function: The prospective ECRHS study. Thorax. 376-384.
- (2018). Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers. Environmental Research. 241-247.
- (2018). Body silhouettes as a tool to reflect obesity in the past. PLOS ONE. 1-13.
- (2018). Agreement in reporting of asthma by parents or offspring - the RHINESSA generation study. BMC Pulmonary Medicine. 1-10.
- (2018). A three-generation study on the association of tobacco smoking with asthma. International Journal of Epidemiology. 1106-1117.
- (2017). Women with symptoms of sleep-disordered breathing are less likely to be diagnosed and treated for sleep apnea than men. Sleep Medicine. 17-22.
- (2017). Validation of maternal reported pregnancy and birth characteristics against the Medical Birth Registry of Norway. PLOS ONE. 1-12.
- (2017). The effects of growing up on a farm on adult lung function and allergic phenotypes: An international population-based study. Thorax. 236-244.
- (2017). Respiratory symptoms are more common among short sleepers independent of obesity. BMJ Open Respiratory Research.
- (2017). Physical activity and asthma: A longitudinal and multi-country study. Journal of Asthma. 938-945.
- (2017). Menopause is associated with accelerated lung function decline. American Journal of Respiratory and Critical Care Medicine. 1058-1065.
- (2017). Early menarche and new onset of asthma: Results from the SAPALDIA cohort study. Maturitas. 57-63.
- (2017). Cohort Profile: Melbourne Atopy Cohort study (MACS). International Journal of Epidemiology. 25-26g.
- (2017). Asthma in reproductive-aged women with polycystic ovary syndrome and association with obesity. European Respiratory Journal. 1-8.
- (2017). Age at menarche and lung function: a Mendelian randomization study. European Journal of Epidemiology (EJE). 701-710.
- (2016). Validation of self-reported figural drawing scales against anthropometric measurements in adults. Public Health Nutrition (PHN). 1944-1951.
- (2016). The Association of gum bleeding With respiratory Health in a population based study from Northern Europe. PLOS ONE.
- (2016). Self-reported exposure to traffic pollution in relation to daytime sleepiness and habitual snoring: a questionnaire study in seven North-European cities. Sleep Medicine. 93-99.
- (2016). Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD patients. European Respiratory Journal. 82-91.
- (2016). Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study. Journal of Allergy and Clinical Immunology. 50-57.e6.
- (2016). Lower lung function associates with cessation of menstruation: UK Biobank data. European Respiratory Journal. 1288-1297.
- (2016). Father’s environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe study. International Journal of Epidemiology. 235-245.
- (2016). Early life origins of lung ageing: Early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years. PLOS ONE.
- (2015). Respiratory health in cleaners in Northern Europe: Is susceptibility established in early life? PLOS ONE. 13 pages.
- (2015). Hormonal contraception increases risk of asthma among obese but decreases it among nonobese subjects: A prospective, population-based cohort study. European Respiratory Journal Open Research (ERJ Open Research). 1-8.
- (2014). Longterm follow-up in European respiratory health studies - patterns and implications. BMC Pulmonary Medicine.
- (2012). Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort. Thorax. 625-631.
- (2011). Early age at menarche, lung function, and adult asthma. American Journal of Respiratory and Critical Care Medicine. 8-14.
- (2010). Perimenstrual increase in bronchial hyperreactivity in premenopausal women: Results from the population-based SAPALDIA 2 cohort. Journal of Allergy and Clinical Immunology. 823-829.
- (2009). Oral contraception, body mass index, and asthma: A cross-sectional Nordic-Baltic population survey. Journal of Allergy and Clinical Immunology. 391-397.
- (2009). Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies. Menopause. 385-394.
- (2008). Lung function, respiratory symptoms, and the menopausal transition. Journal of Allergy and Clinical Immunology.
- (2008). Hormonal factors and respiratory health in women - a review. Clinical Respiratory Journal. 111-119.
- (2007). Menstrual irregularity and asthma and lung function. Journal of Allergy and Clinical Immunology. 557-564.
- (2006). Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey. Thorax. 34-40.
- (2005). Association of asthma and hay fever with irregular menstruation. Thorax. 793-794.
- (2017). Repeated desaturation in 6 minute walk test increases risk for mortality in COPD patients.
- (2023). Oral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population. Respiratory Research. 183.
- (2020). Polycystic ovary syndrome and lung function: a Mendelian randomization study. American Journal of Obstetrics and Gynecology. 455-457.
- (2022). Parental body size and offspring lung health: preparing for parenthood already in childhood?
- (2017). Respiratory health in aging women. The influence of menopause on asthma incidence and lung function decline.
- (2008). Hormonal status in women and asthma, allergy and lung function. Results from population-based studies concerning menstrual irregularity, menopausal transition, hormonal replacement therapy and body mass index.
- (2021). The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome? International Journal of Environmental Research and Public Health (IJERPH).
- (2021). Exposures during the prepuberty period and future offspring's health: evidence from human cohort studies. Biology of Reproduction. 667-680.
- (2018). Maternal age at delivery, lung function and asthma in offspring: A population-based survey. European Respiratory Journal. 1-11.
- (2018). Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models. Challenges.
- (2017). Risk factors for premenstrual asthma: a systematic review and meta-analysis. Expert Review of Respiratory Medicine. 57-72.
- (2012). Respiratory health in women: from menarche to menopause. Expert Review of Respiratory Medicine. 187-202.
Project leader and collaborator
He collaborates in his research with the Respiratory Health in Northern Europe (RHINE), the European Community Respiratory Health Survey (ECRHS), Tasmanian Health Survey (TAHS), the Swiss cohort study on Air Pollution and Lung Diseases in Adults (SAPALDIA), the UK BioBank, the PregMet study, and the transgenerational Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohorts. He was PI of the ground-breaking Norwegian Research Council funded Menopause and Respiratory Health study, where ECRHS, RHINE and TAHS collaborated. He spent a 6-month postdoctoral attachment at prof Shyamali Dharmage´s Allergy and Lung Health Unit, University of Melbourne. He leads the Reproductive Respiratory Health working group of RHINE and RHINESSA studies, is co-Chair of the ECRHS Gender Working Group with AI Leynaert, and PI for ECRHS in Bergen.
Real´s main strengths as a scientist are original and innovative thinking, excellent network building capacity and extensive experience with research administration. This is reflected in papers that have contributed to paradigm shift.
Real collaborates in developing CASCADE (Centre of Multigeneration Science on Health and Disease), a centre led by professor Cecilie Svanes aimed to undertake multigenerational human research.
His PhD student and postdoctoral researcher, Kai Triebner, led recent papers showing menopause is related to new onset asthma and accelerated lung function decline (published in leading respiratory and allergy journals).
2018-2023 Partner, “Preconception exposures and related epigenetic mechanisms in Asthma and allergies”. TOPFORSK Norwegian Research Council (NRC) grant, 25,000,000 NOK
2018-2021 Supervisor, «Life course with good Health» program, West Health Council (Helse Vest) grant, PhD research fellowship, PhD candidate Marianne Lønnebotn
2017-2021 Leader, Research Unit for Health Surveys, Bergen Research Foundation (BFS) grant 11,000,000 NOK
2017-2020 Supervisor, “Post-menopausal deterioration of respiratory health: Lifestyle strategies to preserve healthy lungs in aging women”, University of Bergen grant, postdoctoral research fellowship, PhD Kai Triebner