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Gerd Haga Bringeland's picture

Gerd Haga Bringeland

PhD Candidate
  • E-mailGerd.Bringeland@uib.no
  • Phone+47 55 58 92 00
  • Visitor Address
    Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
  • Postal Address
    Postboks 7804
    5020 Bergen

Biomarkers for personalized treatment of multiple sclerosis

Natalizumab (Tysabri) is a therapeutic antibody used in treatment of multiple sclerosis. It prevents inflammation in the central nervous system by blocking leukocytes from crossing the blood-brain-barrier. To facilitate individualized natalizumab treatment we need a biomarker to measure the individual treatment response. Receptor occupancy, the ratio between amount of bound natalizumab and amount of total receptor on target cells, is a potential biomarker. We have developed a method for measuring receptor occupancy of natalizumab in the blood of treated patients with the novel technology mass cytometry (Optimization of Receptor Occupancy Assays in Mass Cytometry: Standardization Across Channels with QSC Beads. Bringeland, GH, et al., Cytometry A. 2019 Mar).

Research interests: Clinical neurology, neuroimmunology, biomarkers for personalized treatment in multiple sclerosis, mass cytometry.

Journal articles
  • Bader, Lucius; Gullaksen, Stein-Erik; Blaser, Nello; Brun, Morten; Bringeland, Gerd Haga; Sulen, Andre; Gjesdal, Clara Gram; Vedeler, Christian A.; Gavasso, Sonia. 2019. Candidate markers for stratification and classification in rheumatoid arthritis. Frontiers in Immunology. 10:1488: 1-8. doi: 10.3389/fimmu.2019.01488
  • Bringeland, Gerd Haga; Bader, Lucius; Blaser, Nello; Budzinski, Lisa; Schulz, Axel R.; Mei, Henrik E.; Myhr, Kjell-Morten; Vedeler, Christian A.; Gavasso, Sonia. 2019. Optimization of receptor occupancy assays in mass cytometry: Standardization across channels with QSC beads. Cytometry Part A. 1-10. doi: 10.1002/cyto.a.23723
  • Bringeland, Gerd Haga. 2016. Intracranial artery dissection. Tidsskrift for Den norske legeforening. doi: 10.4045/tidsskr.15.1332
  • Bringeland, Gerd Haga; Nacu, Aliona; Waje-Andreassen, Ulrike; Thomassen, Lars; Næss, Halvor. 2016. U-curve relation between cholesterol and prior ischemic stroke. Brain and Behavior. 6:e00574. doi: 10.1002/brb3.574
  • Nacu, Aliona; Bringeland, Gerd Haga; Khanevski, Andrej; Thomassen, Lars; Waje-Andreassen, Ulrike; Næss, Halvor. 2016. Early neurological worsening in acute ischaemic stroke patients. Acta Neurologica Scandinavica. 133: 25-29. doi: 10.1111/ane.12418

More information in national current research information system (CRIStin)

Early neurological worsening in acute ischaemic stroke patients. Nacu A, Bringeland GH, Khanevski A, Thomassen L, Waje-Andreassen U, Naess H. Acta Neurol Scand. 2016 Jan

Intracranial artery dissection. Gerd Haga Bringeland · Jonas Anders Lind · Solveig B Glad · Ulrike Waje-Andreassen · Jul 2016 · Tidsskrift for den Norske laegeforening

U-curve relation between cholesterol and prior ischemic stroke. Gerd Haga Bringeland · Aliona Nacu · Ulrike Waje-Andreassen · Lars Thomassen · Halvor Naess · Sep 2016 · Brain and Behavior

Optimization of Receptor Occupancy Assays in Mass Cytometry: Standardization Across Channels with QSC Beads. Gerd Haga Bringeland, Bader L, Blaser N, Budzinski L, Schulz AR, Mei HE, Myhr KM, Vedeler CA, Gavasso S. Cytometry A. 2019 Mar

Fields of competence