Endocrinology and Medical Biochemistry
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- (2022). Reference Curves for Pediatric Endocrinology: Leveraging Biomarker Z-Scores for Clinical Classifications. Journal of Clinical Endocrinology and Metabolism (JCEM). 2004-2015.
- (2022). Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment. International Journal of Cardiology: Cardiovascular Risk and Prevention (IJCCRP). 6 pages.
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- (2022). Distinct T cell subsets in adipose tissue are associated with obesity. European Journal of Immunology.
- (2022). Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC). Clinical Nutrition. 2345-2355.
- (2022). Consumption of a light meal affects serum concentrations of one-carbon metabolites and B-vitamins. A clinical intervention study. British Journal of Nutrition. 10 pages.
- (2021). Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients. Journal of Clinical Endocrinology and Metabolism (JCEM). 1368-1374.
- (2021). Serglycin Is Involved in Adipose Tissue Inflammation in Obesity. Journal of Immunology. 121-132.
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- (2021). Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study. PLOS ONE. 1-14.
- (2021). Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. Arteriosclerosis, Thrombosis and Vascular Biology. 2563-2574.
- (2021). Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial. European Journal of Nutrition. 3237-3248.
- (2021). Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites. Journal of Personalized Medicine. 11 pages.
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- (2021). Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats. Nutrition Research. 72-83.
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- (2021). A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metabolism. 615-628.
- (2020). Testicular Ultrasound to Stratify Hormone References in a Cross-Sectional Norwegian Study of Male Puberty . Journal of Clinical Endocrinology and Metabolism (JCEM). 1888-1898.
- (2020). Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen. Molecular Oncology. 11 pages.
- (2020). Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty. Journal of Clinical Endocrinology and Metabolism (JCEM). e4886-e4895.
- (2020). Five salmon dinners per week were not sufficient to prevent the reduction in serum vitamin D in autumn at 60° north latitude: A randomised trial. British Journal of Nutrition. 419-427.
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- (2020). Effects of high intake of cod or salmon on gut microbiota profile, faecal output and serum concentrations of lipids and bile acids in overweight adults: a randomised clinical trial. European Journal of Nutrition. 1-18.
- (2020). COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. Scientific Reports. 1-11.
- (2020). A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 684-701.
- (2020). 3-hydroxyisobutyrate, a strong marker of insulin resistance in type 2 diabetes and obesity that modulates white and brown adipocyte metabolism. Diabetes. 1903-1916.
- (2019). Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys. British Journal of Nutrition. 262-273.
- (2019). The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
- (2019). The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 1-12.
- (2019). Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Journal of Clinical Endocrinology and Metabolism (JCEM). 27 pages.
- (2019). TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity. European Journal of Nutrition. 1-11.
- (2019). Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
- (2019). Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease. Frontiers in Immunology. 1-13.
- (2019). Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer. The Pharmacogenomics Journal. 1-8.
- (2019). Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. European Journal of Nutrition. 1-17.
- (2019). Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database. Breast Cancer Research and Treatment. 185-195.
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- (2018). The short cosyntropin test revisited: new normal reference range using LC-MS/MS. Journal of Clinical Endocrinology and Metabolism (JCEM). 1696-1703.
- (2018). The effect of lean-seafood and non-seafood diets on fecal metabolites and gut microbiome: results from a randomized crossover intervention study. Molecular Nutrition & Food Research. 1-8.
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- (2018). Salmon fillet intake led to higher serum triacylglycerol in obese zucker Fa/Fa rats but not in normolipidemic Long-Evans rats. Nutrients. 1-13.
- (2018). LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells. Toxicology in Vitro. 332-341.
- (2018). Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats. Nutrients. 1-15.
- (2018). Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery. PLOS ONE. 1-14.
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- (2018). Daily intake of protein from cod residual material lowers serum concentrations of nonesterified fatty acids in overweight healthy adults: A randomized double-blind pilot study. Marine Drugs. 1-15.
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- (2017). Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. International Journal of Neuropsychopharmacology. 1005-1012.
- (2017). High visceral fat percentage is associated with poor outcome in endometrial cancer. OncoTarget. 105184-105195.
- (2017). High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. British Journal of Nutrition. 1368-1378.
- (2017). Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats. Food & Nutrition Research. 1-12.
- (2017). Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population. Hormone and Metabolic Research. 838-846.
- (2017). Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery. Translational Research: The Journal of Laboratory and Clinical Medicine. 35-44.e4.
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- (2016). The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. Molecular and Cellular Endocrinology. 92-101.
- (2016). Prospective associations of systemic and urinary choline metabolites with incident type 2 diabetes. Clinical Chemistry. 755-765.
- (2016). Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism . OncoTarget. 1878-1894.
- (2016). Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study. Molecular Nutrition & Food Research. 1661-1672.
- (2016). Lean seafood intake reduces postprandial c-peptid and lactate concentrations in healthy adults in a randomized controlled trial with a crossover design. Journal of Nutrition. 1027-1034.
- (2016). High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: A randomised trial. British Journal of Nutrition. 648-657.
- (2016). DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells. Cellular Signalling. 1593-1603.
- (2016). A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen. Breast Cancer Research and Treatment. 97-108.
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- (2014). Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. E210-E224.
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- (2014). Estradiol determines the effects of PTH on ERα-dependent transcription in MC3T3-E1 cells. Biochemical and Biophysical Research Communications - BBRC. 360-365.
- (2014). Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats. Nutrition and Diabetes. 6 pages.
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- (2014). COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 1807-1813.
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- (2013). 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism apa1 influence bone mineral density in primary hyperparathyroidism. PLOS ONE. 8 pages.
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Gjerde, J., Hauglid, M., Breilid, H., Lundgren, S., Varhaug, J.E., Kisanga, E.R., Mellgren, G., Steen, V.M., and Lien, E.A. (2007). Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol., 19:56-61.
Fenne, I.S., Hoang, T., Hauglid, M, Sagen, JV, Lien, E.A., and Mellgren, G. (2008). Recruitment of coactivator GRIP1 to an estrogen receptor transcription complex is regulated by cAMP-dependent protein kinase. Endocrinology, 149:4336-45.
Moi, L.H.L., Hauglid, M., Gandini, S, Aliana, G.G., Bonanni, B., Lazzeroni, M., Gjerde, J, Lien, E.A., Decensi, A, and Mellgren G. (2010) Effects of low dose tamoxifen on Steroid Receptor Coactivator 1/Amplified in Breast Cancer 1 in normal an malignant breast tissue. Clin. Cancer Res., 16:2176-86
Dankel SE, Fadnes D, Stavrum AK, Stansberg C, Holdhus R, Hoang T, Veum V, Christensen B, Vaage V, Sagen JV, Steen VM, Mellgren G (2010) Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE, 9;5(6):e11033
Monika H.E. Christensen, Eva K.R. Pedersen, Yngve Nordbø, Jan Erik Varhaug, Øyvind Midttun, Per M. Ueland, Ottar K. Nygaard, Gunnar Mellgren, Ernst A. Lien (2012) Vitamin B6 Status and Interferon-γ Mediated Immune Activation in Primary Hyperparathyroidism. J Intern Medicine. Jul 3. doi: 10.1111/j.1365-2796.2012.02570.x
Hoang, T. Fenne, I, Johannessen, M, Lien, E.A., Moens, U and Mellgren, G. (2013) cAMP Response Element Binding Protein (CREB) Interacts with the nuclear receptor coactivator GRIP1 and mediates its degradation. Endocrinology,Apr;154(4):1513-27. doi: 10.1210/en.2012-2049. Epub 2013 Mar 5.
Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 2014 Jan 16;156(1-2):343-58
Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine, 2014, 6(247);247ra103.
Aadland EK, Lavigne C, Graff IE, Eng Ø, Paquette M, Holthe A, Mellgren G, Jacques H, Liaset B. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. Am J Clin Nutr. 2015 Sep;102(3):582-92.
Melina Claussnitzer, Simon Nitter Dankel, Gerald Quon, Kyoung-Han Kim, Wouter Meuleman, Christine Haugen, Viktoria Glunk, Isabel Sousa, Jacqueline L. Beaudry, Vijitha Puviindran, Nezar A. Abdennur, Jannel Liu, Per-Arne Svensson, Yi-Hsiang Hsu, Daniel J. Drucker, Gunnar Mellgren, Chi-Chung Hui, Hans Hauner, Manolis Kellis. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. New Engl. J. Medicine, 2015 Sep 3;373(10):895-907
Vivian L. Veum, Johnny Laupsa-Borge, Øyvin Eng, Espen Rostrup, Terje H. Larsen, Jan Erik Nordrehaug, Ottar Nygård, Jørn V. Sagen, Oddrun A. Gudbrandsen, Simon N. Dankel, Gunnar Mellgren. Visceral adiposity and metabolic syndrome after very-high-fat and low-fat isocaloric diets: a randomized controlled trial (FATFUNC). Am J Clin Nutr. 2017 Jan;105(1):85-99
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. Helland T, Henne N, Bifulco E, Naume B, Borgen E, Kristensen VN, Kvaløy JT, Lash TL, Alnæs GIG, van Schaik RH, Janssen EAM, Hustad S, Lien EA, ‡Mellgren G, ‡Søiland H. Breast Cancer Res. 2017 Nov 28;19(1):125. doi: 10.1186/s13058-017-0916-4.
IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Int J Obes (Lond). 2019 Nov;43(11):2151-2162
The homeobox factor Irx3 maintains adipogenic identity. Bjune JI, Dyer L, Røsland GV, Tronstad KJ, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Metabolism. 2019 Nov 18;103:154014. doi: 10.1016/j.metabol.2019.154014.
Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Madsen A, Oehme NB, Roelants M, Bruserud IS, Eide GE, Viste K, Bjerknes R, Almås B, Rosendahl K, Sagen JV, Mellgren G, Juliusson PB. J Clin Endocrinol Metab. 2019 Oct 26. pii: dgz094. doi: 10.1210/clinem/dgz094.
3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism. Nilsen MS, Jersin RÅ, Ulvik A, Madsen A, McCann A, Svensson P-A, Svensson M-E, Nedrebø B-G, Gudbrandsen OA, Tell GS, Kahn CR,Ueland PM, Mellgren G, and Dankel SN. Diabetes 2020; 69:1–14 https://doi.org/10.2337/db19-1174.
Specialist in Internal medicine, Endocrinology, and Medical biochemistry