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  • E-mailGunnar.Mellgren@uib.no
  • Phone+47 55 97 43 66+47 911 32 124
  • Visitor Address
    Haukeland University Hospital
    N-5021 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen

Diabetes, obesity and nutrition

Hormones, diagnostics and breast cancer

Hormone Laboratory Research Group

Mohn Nutrition Research Laboratory www.uib.no/mohn-elab

Endocrinology and Medical Biochemistry

Academic article
  • Show author(s) 2021. Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes. 680-695.
  • Show author(s) 2021. Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes.
  • Show author(s) 2021. Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study. PLOS ONE. 1-14.
  • Show author(s) 2021. Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. Arteriosclerosis, Thrombosis and Vascular Biology. 2563-2574.
  • Show author(s) 2021. Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial. European Journal of Nutrition. 3237-3248.
  • Show author(s) 2021. Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites. Journal of Personalized Medicine. 11 pages.
  • Show author(s) 2021. Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study. Clinical Nutrition. 2556-2575.
  • Show author(s) 2021. Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children. Journal of the Endocrine Society (JES). 1-8.
  • Show author(s) 2021. Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations without affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats. Nutrition Research. 72-83.
  • Show author(s) 2021. Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial. NPJ breast cancer. 1-34.
  • Show author(s) 2021. A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metabolism. 615-628.
  • Show author(s) 2020. Testicular Ultrasound to Stratify Hormone References in a Cross-Sectional Norwegian Study of Male Puberty . Journal of Clinical Endocrinology and Metabolism. 1888-1898.
  • Show author(s) 2020. Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen. Molecular Oncology. 11 pages.
  • Show author(s) 2020. Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty. Journal of Clinical Endocrinology and Metabolism. e4886-e4895.
  • Show author(s) 2020. Five salmon dinners per week were not sufficient to prevent the reduction in serum vitamin D in autumn at 60° north latitude: A randomised trial. British Journal of Nutrition. 419-427.
  • Show author(s) 2020. First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: A case study. ESMO Open. 1-5.
  • Show author(s) 2020. Effects of high intake of cod or salmon on gut microbiota profile, faecal output and serum concentrations of lipids and bile acids in overweight adults: a randomised clinical trial. European Journal of Nutrition. 1-18.
  • Show author(s) 2020. COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. Scientific Reports. 1-11.
  • Show author(s) 2020. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 684-701.
  • Show author(s) 2020. 3-hydroxyisobutyrate, a strong marker of insulin resistance in type 2 diabetes and obesity that modulates white and brown adipocyte metabolism. Diabetes. 1903-1916.
  • Show author(s) 2019. Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys. British Journal of Nutrition. 262-273.
  • Show author(s) 2019. The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
  • Show author(s) 2019. The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 1-12.
  • Show author(s) 2019. Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Journal of Clinical Endocrinology and Metabolism. 27 pages.
  • Show author(s) 2019. TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity. European Journal of Nutrition. 1-11.
  • Show author(s) 2019. Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
  • Show author(s) 2019. Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease. Frontiers in Immunology. 1-13.
  • Show author(s) 2019. Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer. The Pharmacogenomics Journal. 1-8.
  • Show author(s) 2019. Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. European Journal of Nutrition. 1-17.
  • Show author(s) 2019. Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database. Breast Cancer Research and Treatment. 185-195.
  • Show author(s) 2019. Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.
  • Show author(s) 2018. The short cosyntropin test revisited: new normal reference range using LC-MS/MS. Journal of Clinical Endocrinology and Metabolism. 1696-1703.
  • Show author(s) 2018. The effect of lean-seafood and non-seafood diets on fecal metabolites and gut microbiome: results from a randomized crossover intervention study. Molecular Nutrition & Food Research. 1-8.
  • Show author(s) 2018. The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species: Results from a randomized crossover intervention study in healthy adults. Nutrients. 1-12.
  • Show author(s) 2018. Salmon fillet intake led to higher serum triacylglycerol in obese zucker Fa/Fa rats but not in normolipidemic Long-Evans rats. Nutrients. 1-13.
  • Show author(s) 2018. LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells. Toxicology in Vitro. 332-341.
  • Show author(s) 2018. Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats. Nutrients. 1-15.
  • Show author(s) 2018. Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery. PLOS ONE. 1-14.
  • Show author(s) 2018. IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. International Journal of Obesity.
  • Show author(s) 2018. Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats. Journal of the American Society of Hypertension : JASH. 294-302.
  • Show author(s) 2018. Daily intake of protein from cod residual material lowers serum concentrations of nonesterified fatty acids in overweight healthy adults: A randomized double-blind pilot study. Marine Drugs. 1-15.
  • Show author(s) 2018. A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology. 57-70.
  • Show author(s) 2017. Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. American Journal of Clinical Nutrition. 85-99.
  • Show author(s) 2017. The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease. Diabetologia. 1712-1721.
  • Show author(s) 2017. Simultaneous assay of cortisol and dexamethasone improved diagnostic accuracy of the dexamethasone suppression test. European Journal of Endocrinology (EJE). 705-713.
  • Show author(s) 2017. Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. Breast Cancer Research.
  • Show author(s) 2017. Serum acylcarnitines and risk of cardiovascular death and acute myocardial infarction in patients with stable angina pectoris. Journal of the American Heart Association (JAHA). 1-28.
  • Show author(s) 2017. Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Molecular and Cellular Endocrinology. 146-157.
  • Show author(s) 2017. High visceral fat percentage is associated with poor outcome in endometrial cancer. OncoTarget. 105184-105195.
  • Show author(s) 2017. High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. British Journal of Nutrition. 1368-1378.
  • Show author(s) 2017. Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats. Food & Nutrition Research. 1-12.
  • Show author(s) 2017. Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population. Hormone and Metabolic Research. 838-846.
  • Show author(s) 2017. Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery. Translational Research: The Journal of Laboratory and Clinical Medicine. 35-44.e4.
  • Show author(s) 2016. Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers. Journal of Steroid Biochemistry and Molecular Biology. 228-235.
  • Show author(s) 2016. The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. Molecular and Cellular Endocrinology. 92-101.
  • Show author(s) 2016. Prospective associations of systemic and urinary choline metabolites with incident type 2 diabetes. Clinical Chemistry. 755-765.
  • Show author(s) 2016. Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism . OncoTarget. 1878-1894.
  • Show author(s) 2016. Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study. Molecular Nutrition & Food Research. 1661-1672.
  • Show author(s) 2016. Lean seafood intake reduces postprandial c-peptid and lactate concentrations in healthy adults in a randomized controlled trial with a crossover design. Journal of Nutrition. 1027-1034.
  • Show author(s) 2016. High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: A randomised trial. British Journal of Nutrition. 648-657.
  • Show author(s) 2016. DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells. Cellular Signalling. 1593-1603.
  • Show author(s) 2016. A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen. Breast Cancer Research and Treatment. 97-108.
  • Show author(s) 2015. The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLOS ONE. 19 pages.
  • Show author(s) 2015. Novel inflammatory biomarkers in primary hyperparathyroidism. European Journal of Endocrinology (EJE). 9-17.
  • Show author(s) 2015. Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). Scientific Reports.
  • Show author(s) 2015. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. American Journal of Clinical Nutrition. 582-592.
  • Show author(s) 2015. FTO obesity variant circuitry and adipocyte browning in humans. New England Journal of Medicine. 895-907.
  • Show author(s) 2015. Estrogens correlate with PELP1 expression in ER positive breast cancer. PLOS ONE. 12 pages.
  • Show author(s) 2015. Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease. European Journal of Preventive Cardiology (EJPC). 743-752.
  • Show author(s) 2015. Efficacy of fish intake on Vitamin D status: A meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition. 837-847.
  • Show author(s) 2015. Determination of 21-hydroxylase autoantibodies: Inter-laboratory concordance in the Euradrenal International Serum Exchange Program. Clinical Chemistry and Laboratory Medicine. 1761-1770.
  • Show author(s) 2015. Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells. BBA - Molecular Cell Research. 2383-2391.
  • Show author(s) 2015. COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology. 134-146.
  • Show author(s) 2015. Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. Arteriosclerosis, Thrombosis and Vascular Biology. 455-462.
  • Show author(s) 2014. Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. E210-E224.
  • Show author(s) 2014. Leveraging cross- species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 343-358.
  • Show author(s) 2014. Estradiol determines the effects of PTH on ERα-dependent transcription in MC3T3-E1 cells. Biochemical and Biophysical Research Communications - BBRC. 360-365.
  • Show author(s) 2014. Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats. Nutrition and Diabetes. 6 pages.
  • Show author(s) 2014. Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: A two-year follow-up study. BMC Surgery.
  • Show author(s) 2014. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 1807-1813.
  • Show author(s) 2014. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine.
  • Show author(s) 2013. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 1513-1527.
  • Show author(s) 2013. Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment. Breast Cancer Research and Treatment. 243-248.
  • Show author(s) 2013. Predictors for remission of major components of the metabolic syndrome after biliopancreatic diversion with duodenal switch (BPDDS). Obesity Surgery. 80-86.
  • Show author(s) 2013. Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue. PLOS ONE. 12 pages.
  • Show author(s) 2013. Efficacy of adrenal venous sampling is increased by point of care cortisol analysis. Endocrine Connections. 236-242.
  • Show author(s) 2013. Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLOS ONE. 10 pages.
  • Show author(s) 2013. Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity. 2495-2503.
  • Show author(s) 2013. 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism apa1 influence bone mineral density in primary hyperparathyroidism. PLOS ONE. 8 pages.
  • Show author(s) 2012. Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism. Journal of Internal Medicine. 583-591.
  • Show author(s) 2012. Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. Breast Cancer Research and Treatment. 693-700.
  • Show author(s) 2012. The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 1195-1202.
  • Show author(s) 2012. Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer. BMC Cancer. 12 pages.
  • Show author(s) 2011. Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLOS ONE. 10 pages.
  • Show author(s) 2011. Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. Journal of Biological Chemistry. 28382-28395.
  • Show author(s) 2011. Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial. The Pharmacogenomics Journal. 100-107.
  • Show author(s) 2010. cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. BBA - Molecular Cell Research. 1013-1019.
  • Show author(s) 2010. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLOS ONE. 12 pages.
  • Show author(s) 2010. Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. Endocrinology. 2151-2161.
  • Show author(s) 2010. Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. Clinical Cancer Research. 2176-2186.
  • Show author(s) 2010. Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. BMC Cancer. 13 pages.
  • Show author(s) 2009. The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: The major autoantigen in autoimmune Addison's disease. Journal of Autoimmunity. 58-67.
  • Show author(s) 2009. Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors. British Journal of Cancer. 1253-1260.
  • Show author(s) 2009. Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 254-262.
  • Show author(s) 2009. A pan-PPAR ligand induces hepatic fatty acid oxidation in PPAR alpha-/- mice possibly through PGC-1 mediated PPAR delta coactivation. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1076-1083.
  • Show author(s) 2008. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 4336-4345.
  • Show author(s) 2008. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Annals of Oncology. 56-61.
  • Show author(s) 2007. A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment. Breast Cancer Research and Treatment. S144-S144.
  • Show author(s) 2005. Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. Journal of Steroid Biochemistry and Molecular Biology. 489-498.
  • Show author(s) 2005. Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A. 6-14.
  • Show author(s) 2005. Excretion of hydroxylated metabolites of tamoxifen in human bile and urine. Anticancer Research. 4487-4492.
  • Show author(s) 2004. cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. Journal of Biological Chemistry. 49120-49130.
  • Show author(s) 2004. Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. European Journal of Endocrinology (EJE). 49-56.
  • Show author(s) 1998. Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. Endocrine Research. 497-504.
  • Show author(s) 1997. Transcriptional regulation of the bovine CYP17 gene by cAMP. Steroids. 43-45.
  • Show author(s) 1997. Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. Endocrinology. 4373-4383.
  • Show author(s) 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
  • Show author(s) 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
  • Show author(s) 1995. Sensitive and rapid detection of _b-galactosidase expression in intact cells by microinjection of fluorescent substrate. Experimental Cell Research. 372-378.
  • Show author(s) 1995. Okadaic acid, cAMP, and selected nutrients inhibit hepatocyte proliferation at different stages in G%b: Modulation of the cAMP effect by phosphatase inhibitors and nutrients. Journal of Cellular Physiology. 232-240.
  • Show author(s) 1995. Novel Rp-cAMPS analogs as tools for inhibition of type I cAMP-dependent protein kinase in cell culture. Basal cAMP-kinase activity modulates hepatocyte DNA replication and interleukin-1_b action. Journal of Biological Chemistry. 22599-20607.
  • Show author(s) 1995. Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis. Molecular and Cellular Biology. 2051-2062.
  • Show author(s) 1994. Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. British Journal of Cancer. 834-840.
  • Show author(s) 1993. Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. Exp Cell Res. 293-301.
Lecture
  • Show author(s) 2019. Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity .
Popular scientific lecture
  • Show author(s) 2009. Hva skal til for å lykkes i forskning?
Academic lecture
  • Show author(s) 2019. Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity.
  • Show author(s) 2018. Amino acid metabolism in adipocytes.
  • Show author(s) 2015. Lean seafood intake reduces cardiovascular risk factors in healthy subjects.
  • Show author(s) 2012. Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism.
  • Show author(s) 2012. Novel transcription factors in obesity.
  • Show author(s) 2012. Integrative genomics links homeobox transcription factors to intra-abdominal obesity.
  • Show author(s) 2012. Homeobox transcription factors IRX3 and 5 in obesity.
  • Show author(s) 2012. Effects of a high fish intake on lipid and bile acid levels in serum and feces from overweight and obese adults.
  • Show author(s) 2012. Effects of a high fish intake on leukocyte membrane fatty acid composition and leukocyte function ex vivo in overweight and obese adults.
  • Show author(s) 2012. Effect of a high fish intake on glucose tolerance and GLP-1 levels in overweight and obese adults.
  • Show author(s) 2010. Presentasjon av strategisk satsing innen ernæring og overvekt.
  • Show author(s) 2010. Oppregulering av østrogen-receptor koaktivatorer og HER-2/neu under endokrin behandling av brystkreft.
  • Show author(s) 2009. Hva kan vi lære av sykelig fedme? Fedme og genekspresjon.
  • Show author(s) 2009. Bariatric surgery dramatically alters global gene expression in adipose tissue.
  • Show author(s) 2009. Adipogen – en studie av fettvev til pasienter som har gjennomgått overvektskirurgi.
  • Show author(s) 2008. Nuclear Receptor Coactivators.
  • Show author(s) 2008. Marine macronutrients, metabolic homeostasis and obesity.
  • Show author(s) 2007. Role of cAMP in Regulation of the Nuclear Receptor Coactivator GRIP1.
  • Show author(s) 2006. NUCLEAR RECEPTORS IN ENDOCRINE FUNCTION AND DISEASE.
  • Show author(s) 2005. Regulering av steroidhormonreseptorer ved protein-protein interaksjon.
  • Show author(s) 2005. Endocrine regulation of a nuclear receptor coactivator.
  • Show author(s) 2005. Cellular immunity to 21-hydroxylase in patients with autoimmune Addison's disease.
  • Show author(s) 2005. A pan-PPAR ligand induces differential coactivation of PPARs by SRCs and PGC-1.
  • Show author(s) 2004. cAMP-depentent protein kinase regulates ubiquitin-proteasome mediated degradation of the nuclear receptor coactivator GRIP1.
  • Show author(s) 2004. Tetradecylthioacetic acid induces ligand dependent coactivation of PPARs by PGC-1 and SRC coactivators.
  • Show author(s) 2004. Prisforedrag - Novo Nordisk pris for fremragende forskning i endokrinologi.
  • Show author(s) 2004. Nuclear Receptor Interacting Proteins as Molecular Targets in Breast Carcinoma.
  • Show author(s) 2004. Intracellulære hormonreseptorer - betydning av nye koregulator proteiner.
  • Show author(s) 2004. Hormonal regulation of the Glucocorticoid receptor interacting protein 1 (GRIP1).
  • Show author(s) 2004. Hormonal regulation of nuclear receptor coactivator GRIP1.
  • Show author(s) 1998. Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity.
Compendium
  • Show author(s) 2004. Endokrinologi. Kompendium for studenter i biokjemi II.
Popular scientific article
  • Show author(s) 2013. Steroid reseptor koaktivatorer, HER-2 og hormonbehandling ved brystkreft. Bestpractice : dialog mellom leger. 8-13.
Doctoral dissertation
  • Show author(s) 2019. Tamoxifen in the treatment of luminal breast cancer. Implications of active metabolites on gene expression, side effects and clinical outcome.
  • Show author(s) 2019. Improved diagnostic workup of hyper- and hypocortisolism.
  • Show author(s) 2018. Salmon and cod fillet consumption and effects on metabolic risk factors. Intervention studies in humans and rats with overweight and obesity.
  • Show author(s) 2017. Nuclear phosphoinositide 3-kinase signalling in adipogenesis and the role of DNA topoisomerase IIα as a potential nuclear polyphosphoinositide-binding protein.
  • Show author(s) 2015. Regulation and function of steroid receptor coactivator 2 in hepatoma and breast cancer cells.
  • Show author(s) 2012. Endocrine treatment of breast cancer: Tamoxifen metabolism, steroid receptor coactivators and growth factor receptors.
  • Show author(s) 2007. Nuclear Receptor Coregulators- Role of Protein-Protein Interactions and cAMP/PKA Signaling.
  • Show author(s) 1996. Hepatocyte growth inhibition by cAMP-dependent protein kinase and other signaling pathways. -.
Academic chapter/article/Conference paper
  • Show author(s) 2020. Analysis of Megavariate Data in Functional Omics. 52 pages.
  • Show author(s) 2012. Tamoxifen metabolism and biological activity. 22 pages.
  • Show author(s) 2011. Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer. 18 pages.
  • Show author(s) 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 32 pages.
  • Show author(s) 1996. Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate.
Abstract
  • Show author(s) 2020. Relationship between CYP2D6 genotype, tamoxifen metabolites, and adverse events, tumor biomarkers and breast cancer recurrence in a low-dose phase III trial in noninvasive disease. Journal of Clinical Oncology.
  • Show author(s) 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 1 pages.
  • Show author(s) 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. S429-S429.
  • Show author(s) 2010. Effects of CYP2C19 genotype on tamoxifen and estrogen metabolism. European Journal of Cancer. 60-60.
  • Show author(s) 2007. Effect of CYP2D6 and SULT1A1 genotypes on the serum concentration of 4-hydroxytamoxifen and 4-hydroxy-N-demethyltamoxifen during steady state treatment of breast cancer patients. Breast. S15-S15.
  • Show author(s) 2007. A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. Breast Cancer Research and Treatment.
  • Show author(s) 2005. Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. Breast Cancer Research and Treatment. S236-S237.
Poster
  • Show author(s) 2014. Metabolomic studies on the urinary response to a diet based on either lean seafood or other protein sources.
  • Show author(s) 2013. Vitamin D levels in patients with primary hyperparathyroidism; a follow-up study after parathyroidectomy.
  • Show author(s) 2013. Role of homeobox transcription factor IRX5 in obesity and metabolic health.
  • Show author(s) 2013. Deficiency of Irx5 is associated with decreased fat mass in male CD1 mice.
  • Show author(s) 2013. A controlled randomized intervention study with lean seafood vs terrestrial animal proteins in healthy subjects: data on body mass and body composition.
  • Show author(s) 2012. Systemic Inflammation in Primary Hyperparathyroidism: Influences on Plasma Vitamin B6 Levels and Interferon-γ Mediated Immune Activation.
  • Show author(s) 2012. Inverse regulation of Neuregulin 1 and HER-3 during treatment with aromatase inhibitors of estrogen receptor-positive breast cancer.
  • Show author(s) 2012. Candidate genes for fat regain after weight cycling in mice.
  • Show author(s) 2012. CDKN1A associates with fat regain after weight cycling in mice.
  • Show author(s) 2010. Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity.
  • Show author(s) 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss.
  • Show author(s) 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery.
  • Show author(s) 2010. Expression of Steroid Receptor Coactivators and HER-2/neu in normal and malignant breast tissue in controls and tamoxifen treated patients.
  • Show author(s) 2010. Epidermal growth factor receptors (ErbB/HER) and the ligand Neuregulin 1 (NRG1) increase in breast tumors during short time treatment with aromatase inhibitors.
  • Show author(s) 2010. Distribution of tamoxifen and five metabolites into normal and malignant human breast cancer tissue during conventional and low dose treatment.
  • Show author(s) 2005. Effects of low-dose tamoxifen treatment on expression of drug-metabolising enzymes in rat liver in relation to administration route.
  • Show author(s) 2005. A pan-PPAR ligand induces differential coactivation of PPARs by SRCs and PGC-1.
  • Show author(s) 2004. Tamoxifen metabolism and induction of hepatic drug-metabolizing enzymes in nude rats.
Academic literature review
  • Show author(s) 2021. Generating a precision endoxifen prediction algorithm to advance personalized tamoxifen treatment in patients with breast cancer. Journal of Personalized Medicine. 1-23.
  • Show author(s) 2019. Natural killer cells as sensors of adipose tissue stress. Trends in endocrinology and metabolism. 1-10.
  • Show author(s) 2011. Tissue-specific effects of bariatric surgery including mitochondrial function. International Journal of Obesity. 435245.

More information in national current research information system (CRIStin)

Selected publications:

Mellgren, G., Gjertsen, B.T, Otten, A., Maronde, E., Genieser, H-G., Jasdorff, B., Vintermyr, O.K., McKnight, G.S., and Døskeland, S.O. (1995) Novel Rp-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1b action. J. Biol. Chem., 270:20599-20607.

Fladmark, K.E, Brustugun, O.T, Mellgren, G, Krakstad, C, Bøe, R., Vintermyr, O.K., Schulman, H., and Døskeland, S.O. (2002) Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. J. Biol. Chem., 277:2804-2811.

Børud, B., Hoang, T., Bakke, M, Jacob, A., Lund, J, and Mellgren, G (2002). The nuclear coactivators p/CIP and TIF2 differentially regulate PKA-dependent transcriptional activity of Steroidogenic factor-1. Mol. Endocrinol., 16:757-773.

Børud, B., Mellgren, G., Lund, J. and Bakke, M. (2003) Cloning and Characterization of a Novel Zinc-finger Protein that Modulates the Transcriptional Activity of Nuclear Receptors. Mol. Endocrinol., 17:2303-2319 

Hoang, T., Fenne, I., Cook, C., Børud, B., Bakke, M., Lien, E.A and Mellgren, G (2004) cAMP-dependent Protein Kinase Regulates Ubiquitin-proteasome mediated Degradation and Subcellular Localization of the Nuclear Receptor Coactivator GRIP1. J. Biol. Chem., 279:49120-49130.

Gjerde, J., Hauglid, M., Breilid, H., Lundgren, S., Varhaug, J.E., Kisanga, E.R., Mellgren, G., Steen, V.M., and Lien, E.A. (2007). Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol., 19:56-61.

Fenne, I.S., Hoang, T., Hauglid, M, Sagen, JV, Lien, E.A., and Mellgren, G. (2008). Recruitment of coactivator GRIP1 to an estrogen receptor transcription complex is regulated by cAMP-dependent protein kinase. Endocrinology, 149:4336-45.

Moi, L.H.L., Hauglid, M., Gandini, S, Aliana, G.G., Bonanni, B., Lazzeroni, M., Gjerde, J, Lien, E.A., Decensi, A, and Mellgren G. (2010) Effects of low dose tamoxifen on Steroid Receptor Coactivator 1/Amplified in Breast Cancer 1 in normal an malignant breast tissue. Clin. Cancer Res., 16:2176-86

Dankel SE, Fadnes D, Stavrum AK, Stansberg C, Holdhus R, Hoang T, Veum V, Christensen B, Vaage V, Sagen JV, Steen VM, Mellgren G (2010) Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE, 9;5(6):e11033

Monika H.E. Christensen, Eva K.R. Pedersen, Yngve Nordbø, Jan Erik Varhaug, Øyvind Midttun, Per M. Ueland, Ottar K. Nygaard, Gunnar Mellgren, Ernst A. Lien (2012) Vitamin B6 Status and Interferon-γ Mediated Immune Activation in Primary Hyperparathyroidism. J Intern Medicine. Jul 3. doi: 10.1111/j.1365-2796.2012.02570.x

Hoang, T. Fenne, I,  Johannessen, M, Lien, E.A., Moens, U and Mellgren, G. (2013) cAMP Response Element Binding Protein (CREB) Interacts with the nuclear receptor coactivator GRIP1 and mediates its degradation. Endocrinology,Apr;154(4):1513-27. doi: 10.1210/en.2012-2049. Epub 2013 Mar 5.

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 2014 Jan 16;156(1-2):343-58

Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine, 2014, 6(247);247ra103. 

Aadland EK, Lavigne C, Graff IE, Eng Ø, Paquette M, Holthe A, Mellgren G, Jacques H, Liaset B. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. Am J Clin Nutr. 2015 Sep;102(3):582-92. 

Melina Claussnitzer, Simon Nitter Dankel, Gerald Quon, Kyoung-Han Kim, Wouter Meuleman, Christine Haugen, Viktoria Glunk, Isabel Sousa, Jacqueline L. Beaudry, Vijitha Puviindran, Nezar A. Abdennur, Jannel Liu, Per-Arne Svensson, Yi-Hsiang Hsu, Daniel J. Drucker, Gunnar Mellgren, Chi-Chung Hui, Hans Hauner, Manolis Kellis. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. New Engl. J. Medicine, 2015 Sep 3;373(10):895-907

Vivian L. Veum, Johnny Laupsa-Borge, Øyvin Eng, Espen Rostrup, Terje H. Larsen, Jan Erik Nordrehaug, Ottar Nygård, Jørn V. Sagen, Oddrun A. Gudbrandsen, Simon N. Dankel, Gunnar Mellgren. Visceral adiposity and metabolic syndrome after very-high-fat and low-fat isocaloric diets: a randomized controlled trial (FATFUNC). Am J Clin Nutr. 2017 Jan;105(1):85-99

Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. Helland T, Henne N, Bifulco E, Naume B, Borgen E, Kristensen VN, Kvaløy JT, Lash TL, Alnæs GIG, van Schaik RH, Janssen EAM, Hustad S, Lien EA, ‡Mellgren G, ‡Søiland H. Breast Cancer Res. 2017 Nov 28;19(1):125. doi: 10.1186/s13058-017-0916-4. 

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Int J Obes (Lond). 2019 Nov;43(11):2151-2162

The homeobox factor Irx3 maintains adipogenic identity. Bjune JI, Dyer L, Røsland GV, Tronstad KJ, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Metabolism. 2019 Nov 18;103:154014. doi: 10.1016/j.metabol.2019.154014.

Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Madsen A, Oehme NB, Roelants M, Bruserud IS, Eide GE, Viste K, Bjerknes R, Almås B, Rosendahl K, Sagen JV, Mellgren G, Juliusson PB. J Clin Endocrinol Metab. 2019 Oct 26. pii: dgz094. doi: 10.1210/clinem/dgz094.

3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism. Nilsen MS, Jersin RÅ, Ulvik A, Madsen A, McCann A, Svensson P-A, Svensson M-E, Nedrebø B-G, Gudbrandsen OA, Tell GS, Kahn CR,Ueland PM, Mellgren G, and Dankel SN. Diabetes 2020; 69:1–14 https://doi.org/10.2337/db19-1174.

https://www.uib.no/en/rg/hormonelaboratory

Mohn Nutrition Research Laboratory funded by Trond Mohn stiftelse www.uib.no/mohn-elab

https://www.uib.no/diabetes/en

Specialist in Internal medicine, Endocrinology, and Medical biochemistry