- E-mailGyrid.Nygard@uib.no
- Visitor AddressJonas Lies vei 915009 Bergen
- Postal AddressPostboks 78045020 Bergen
Torres A, Pedersen B, Cobo I, Ai R, Coras R, Murillo-Saich J, et al. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Arthritis Rheumatol. 2022.
Nygaard G, Szigetvari PD, Grindheim AK, Ruoff P, Martinez A, Haavik J, et al. Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia-A Focus on Tyrosine Hydroxylase Deficiency. J Pers Med. 2021;11(11).
Ansalone C, Ainsworth RI, Nygaard G, Ai R, Prideaux EB, Hammaker D, et al.Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior. ACR Open Rheumatol. 2021.
Nygaard G, Firestein GS. Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat Rev Rheumatol.2020;16(6):316-33.
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, et al. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020;6(26):eaba4353.
Hammaker D, Nygaard G, Kuhs A, Ai R, Boyle DL, Wang W, et al. Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis Fibroblast-like Synoviocytes. ACR Open Rheumatol. 2019;1(10):640-8.
Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, et al. Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis. Biochem Pharmacol. 2018;151:282-90.
Nygaard G, Herfindal L, Asrud KS, Bjornstad R, Kopperud RK, Oveland E, et al.Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbbeta expression. Sci Rep. 2017;7(1):8725.
Nygaard G, Herfindal L, Kopperud R, Aragay AM, Holmsen H, Doskeland SO, et al. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochem Biophys Res Commun. 2014;449(3):357-63.
Sletta H, Degnes KF, Herfindal L, Klinkenberg G, Fjaervik E, Zahlsen K, et al. Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Appl Microbiol Biotechnol. 2014;98(2):603-10.
Myhren LE, Nygaard G, Gausdal G, Sletta H, Teigen K, Degnes KF, et al. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Mar Drugs. 2013;11(2):332-49.
Herfindal L, Nygaard G, Kopperud R, Krakstad C, Doskeland SO, Selheim F. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochem Biophys Res Commun. 2013;437(4):603-8.
Mjaavatten O, Nygaard G, Berven FS, Selheim F. Minimization of side reactions during Lys Tag derivatization of C-terminal lysine peptides. Anal Chim Acta. 2012;712:101-7.
Jensen BO, Kleppe R, Kopperud R, Nygaard G, Doskeland SO, Holmsen H, et al. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 2011;22(1):8-19.
Prestegard SK, Oftedal L, Coyne RT, Nygaard G, Skjaerven KH, Knutsen G, et al. Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity. Mar Drugs. 2009;7(4):605-23.
Jorgensen H, Degnes KF, Sletta H, Fjaervik E, Dikiy A, Herfindal L, et al.Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chem Biol. 2009;16(10):1109-21.
- (2022). Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Arthritis & Rheumatology.
- (2022). Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior. ACR Open Rheumatology. 288-299.
- (2020). Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Science Advances. 1-18.
- (2019). oint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis Fibroblast-like Synoviocytes . ACR Open Rheumatology. 640-648.
- (2018). Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis. Biochemical Pharmacology. 282-290.
- (2017). Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
- (2014). Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
- (2014). Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
- (2013). Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
- (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
- (2012). Minimization of side reactions during Lys Tag derivatization of C-terminal lysine peptides. Analytica Chimica Acta. 101-107.
- (2011). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 8-19.
- (2010). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 7-18.
- (2009). Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
- (2009). Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
- (2018). Joint Location-Specific IL6 and JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS).
- (2017). Regulation of ASK1 Expression and Its Role in Rheumatoid Arthritis (RA).
- (2017). Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS).
- (2016). ASK1 Is Regulated By IL-1β and TNF and Modulates Key Rheumatoid Arthritis (RA) Fibroblast-like Synoviocyte Functions (FLS).
- (2008). Bioactive compounds from marine microorganisms: search for anti-leukemic drugs and finding mechanisms of action.
- (2013). Role of Epac1 in hemostasis. Impact on platelet function.
- (2021). ECT’s Effects on the Brain’s Motor Coordination.
- (2018). Additive Effects of Functional Rheumatoid Arthritis (RA) LBH Risk Alleles on LBH Gene Transcription.
- (2011). Epac1 activation induces cell cycle arrest in the human neuroblastoma cell line SH-SY5Y.
- (2010). Peptide Side-Products of Lys Tag Derivatization reaction.
- (2009). The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit.
- (2009). Epac-induced changes in the proteome of human SH-SY5Y neuroblastoma cells.
- (2021). Personalized medicine to improve treatment of dopa-responsive dystonia—a focus on tyrosine hydroxylase deficiency. Journal of Personalized Medicine. 28 pages.
- (2020). Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nature Reviews Rheumatology. 316-333.
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