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University of Bergen
Gyrid Nygård's picture

Gyrid Nygård

Researcher
The Department of Biomedicine
  • E-mailGyrid.Nygard@uib.no
  • Visitor Address
    Jonas Lies vei 91
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen

Torres A, Pedersen B, Cobo I, Ai R, Coras R, Murillo-Saich J, et al. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Arthritis Rheumatol. 2022.

Nygaard G, Szigetvari PD, Grindheim AK, Ruoff P, Martinez A, Haavik J, et al. Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia-A Focus on Tyrosine Hydroxylase Deficiency. J Pers Med. 2021;11(11).

Ansalone C, Ainsworth RI, Nygaard G, Ai R, Prideaux EB, Hammaker D, et al.Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior. ACR Open Rheumatol. 2021.

Nygaard G, Firestein GS. Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat Rev Rheumatol.2020;16(6):316-33.

Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, et al. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020;6(26):eaba4353.

Hammaker D, Nygaard G, Kuhs A, Ai R, Boyle DL, Wang W, et al. Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis Fibroblast-like Synoviocytes. ACR Open Rheumatol. 2019;1(10):640-8.

Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, et al. Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis. Biochem Pharmacol. 2018;151:282-90.

Nygaard G, Herfindal L, Asrud KS, Bjornstad R, Kopperud RK, Oveland E, et al.Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbbeta expression. Sci Rep. 2017;7(1):8725.

Nygaard G, Herfindal L, Kopperud R, Aragay AM, Holmsen H, Doskeland SO, et al. Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochem Biophys Res Commun. 2014;449(3):357-63.

Sletta H, Degnes KF, Herfindal L, Klinkenberg G, Fjaervik E, Zahlsen K, et al. Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Appl Microbiol Biotechnol. 2014;98(2):603-10.

Myhren LE, Nygaard G, Gausdal G, Sletta H, Teigen K, Degnes KF, et al. Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Mar Drugs. 2013;11(2):332-49.

Herfindal L, Nygaard G, Kopperud R, Krakstad C, Doskeland SO, Selheim F. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochem Biophys Res Commun. 2013;437(4):603-8.

Mjaavatten O, Nygaard G, Berven FS, Selheim F. Minimization of side reactions during Lys Tag derivatization of C-terminal lysine peptides. Anal Chim Acta. 2012;712:101-7.

Jensen BO, Kleppe R, Kopperud R, Nygaard G, Doskeland SO, Holmsen H, et al. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 2011;22(1):8-19.

Prestegard SK, Oftedal L, Coyne RT, Nygaard G, Skjaerven KH, Knutsen G, et al. Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity. Mar Drugs. 2009;7(4):605-23.

Jorgensen H, Degnes KF, Sletta H, Fjaervik E, Dikiy A, Herfindal L, et al.Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chem Biol. 2009;16(10):1109-21.

Academic article
  • Show author(s) (2022). Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Arthritis & Rheumatology.
  • Show author(s) (2022). Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior. ACR Open Rheumatology. 288-299.
  • Show author(s) (2020). Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Science Advances. 1-18.
  • Show author(s) (2019). oint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis Fibroblast-like Synoviocytes . ACR Open Rheumatology. 640-648.
  • Show author(s) (2018). Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis. Biochemical Pharmacology. 282-290.
  • Show author(s) (2017). Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
  • Show author(s) (2014). Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
  • Show author(s) (2014). Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
  • Show author(s) (2013). Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
  • Show author(s) (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
  • Show author(s) (2012). Minimization of side reactions during Lys Tag derivatization of C-terminal lysine peptides. Analytica Chimica Acta. 101-107.
  • Show author(s) (2011). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 8-19.
  • Show author(s) (2010). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 7-18.
  • Show author(s) (2009). Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
  • Show author(s) (2009). Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
Academic lecture
  • Show author(s) (2018). Joint Location-Specific IL6 and JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS).
  • Show author(s) (2017). Regulation of ASK1 Expression and Its Role in Rheumatoid Arthritis (RA).
  • Show author(s) (2017). Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS).
  • Show author(s) (2016). ASK1 Is Regulated By IL-1β and TNF and Modulates Key Rheumatoid Arthritis (RA) Fibroblast-like Synoviocyte Functions (FLS).
Masters thesis
  • Show author(s) (2008). Bioactive compounds from marine microorganisms: search for anti-leukemic drugs and finding mechanisms of action.
Doctoral dissertation
  • Show author(s) (2013). Role of Epac1 in hemostasis. Impact on platelet function.
Poster
  • Show author(s) (2021). ECT’s Effects on the Brain’s Motor Coordination.
  • Show author(s) (2018). Additive Effects of Functional Rheumatoid Arthritis (RA) LBH Risk Alleles on LBH Gene Transcription.
  • Show author(s) (2011). Epac1 activation induces cell cycle arrest in the human neuroblastoma cell line SH-SY5Y.
  • Show author(s) (2010). Peptide Side-Products of Lys Tag Derivatization reaction.
  • Show author(s) (2009). The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit.
  • Show author(s) (2009). Epac-induced changes in the proteome of human SH-SY5Y neuroblastoma cells.
Academic literature review
  • Show author(s) (2021). Personalized medicine to improve treatment of dopa-responsive dystonia—a focus on tyrosine hydroxylase deficiency. Journal of Personalized Medicine. 28 pages.
  • Show author(s) (2020). Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nature Reviews Rheumatology. 316-333.

More information in national current research information system (CRIStin)