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Hans Petter Eikesdal's picture

Hans Petter Eikesdal

Professor
  • E-mailHans.Eikesdal@uib.no
  • Phone+47 55 58 67 36+47 55 58 63 73
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen

Hans Petter Eikesdal (HPE) is a consultant medical & radiation oncologist, working in the Dept. of Oncology, Haukeland University Hospital, Bergen, Norway (https://helse-bergen.no/en/avdelinger/kreftbehandling-og-medisinsk-fysik...).

His clinical work is dedicated to patients with breast cancer and malignant melanoma, and he is a member of the executive committee for the Norwegian Breast Cancer Group (https://nbcg.no/about/), setting the national guidelines for treatment of breast cancer in Norway (https://www.helsebiblioteket.no/retningslinjer/brystkreft/forord;jsessio...).

He is a senior researcher in the Bergen Breast Cancer Group, working in the Mohn Cancer Research Laboratory (https://www.uib.no/fg/g18). He is heading a research group studying the molecular characteristics governing resistance to endocrine therapy and chemotherapy in hormone receptor positive breast cancer and chemoresistance in triple negative breast cancer. He is the national coordinating principal investigator of the PETREMAC (ClinicalTrials.gov Identifier: NCT02624973) and p53 breast trials (ClinicalTrials.gov Identifier: NCT02965950), where patients with breast cancer are given personalized cancer therapy, based on the molecular subtype of the tumor. He is heading the Bergen Breast Cancer Group and the K.G. Jebsen Center for genome-directed therapy in cancer (https://stiftkgj.no/what-we-do/k-g-jebsen-centres-of-medical-research/k-g-jebsen-center-for-genom-directed-therapy-in-cancer/?lang=en), together with Professor Per Eystein Lønning and senior researcher Stian Knappskog. 

HPE completed his PhD degree in 2002, with Professor Olav Dahl as the main supervisor. He worked as a postdoctoral fellow at Harvard University, USA, 2007-09 in Professor Raghu Kalluri´s Division of Matrix Biology, and has an ongoing collaboration with Professor Kalluri at his current work site at MD Anderson Cancer Center in Houston, Texas. HPE joined the Bergen Breast Cancer Group in 2009, as a senior researcher. He was employed as Professor in a 20% position at Dept. of Clinical Science, Faculty of Medicine, University of Bergen, from January 2019.

Books
  • Mellgren, Gunnar; Angelsen, Anders; Eikesdal, Hans Petter; Geisler, Jürgen. 2016. MEDIKAMENTELL KREFTBEHANDLING - CYTOSTATIKABOKEN Kapittel 19 - Hormoner og antihormoner. 661 pages. ISBN: 978-82-992331-4-9.
Journal articles
  • Eikesdal, Hans Petter; Becker, Lisa M; Teng, Yingqi; Kizu, Akane; Carstens, Julienne L; Kanasaki, Keizo; Sugimoto, Hikaru; LeBleu, Valerie S; Kalluri, Raghu. 2018. BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis. Molecular Cancer Research. 16: 1568-1578. doi: 10.1158/1541-7786.MCR-18-0120
  • Yndestad, Synnøve; Austreid, Eilin; Skaftnesmo, Kai Ove; Lønning, Per Eystein; Eikesdal, Hans Petter. 2018. Divergent activity of the pseudogene PTENP1 in ER-positive and negative breast cancer. Molecular Cancer Research. 16: 78-89. doi: 10.1158/1541-7786.MCR-17-0207
  • Yndestad, Synnøve; Austreid, Eilin; Knappskog, Stian; Chrisanthar, Ranjan; Lilleng, Peer Kåre; Lønning, Per Eystein; Eikesdal, Hans Petter. 2017. High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function. Breast Cancer Research and Treatment. 163: 177-190. doi: 10.1007/s10549-017-4160-5
  • Yndestad, Synnøve; Austreid, Eilin; Svanberg, Ida; Knappskog, Stian; Lønning, Per Eystein; Eikesdal, Hans Petter. 2017. Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines. OncoTarget. 8: 41227-41241. doi: 10.18632/oncotarget.17167
  • Kim, J; de Sampaio, P.C.; Lundy, D.M.; Peng, Q; Evans, K.W.; Sugimoto, Hikaru; Gageo, M.; Kienast, Y.; do Amaral, N.S.; Rocha, R.M.; Eikesdal, Hans Petter; Lønning, P.E.; Meric-Bernstam, F.; LeBleu, V. 2016. Heterogenous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. JCI Insight. 1: e90733. doi: 10.1172/jci.insight.90733
  • Lund, Amanda W.; Wagner, Marek; Fankhauser, Manuel; Steinskog, Eli Sihn Samdal; Broggi, Maria A.; Spranger, Stefani; Gajewski, Thomas F.; Alitalo, Kari; Eikesdal, Hans Petter; Wiig, Helge; Swartz, Melody A. 2016. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. Journal of Clinical Investigation. 126: 3389-3402. doi: 10.1172/JCI79434
  • Steinskog, Eli Sihn Samdal; Sagstad, Solfrid Johanne; Wagner, Marek; Karlsen, Tine Veronica; Yang, Ning; Markhus, Carl Erik Nordvik; Yndestad, Synnøve; Wiig, Helge; Eikesdal, Hans Petter. 2016. Impaired lymphatic function accelerates cancer growth. OncoTarget. 7: 45789-45802. doi: 10.18632/oncotarget.9953
  • Vetti, Hildegunn Høberg; Bjorvatn, Cathrine; Fiane, Bent; Aas, Turid; Woie, Kathrine; Espelid, Helge; Eikesdal, Hans Petter; Listøl, Wenche; Haavind, Marianne Tveit; Knappskog, Per; Rusken, Tone; Haukanes, Bjørn Ivar; Steen, Vidar Martin; Hoogerbrugge, Nicoline. 2016. BRCA1/2 testing in newly diagnosed breast and ovarian cancer patients without prior genetic counselling: the DNA-BONus study. European Journal of Human Genetics. 24: 881-888. doi: 10.1038/ejhg.2015.196
  • Austreid, Eilin; Lønning, Per Eystein; Eikesdal, Hans Petter. 2014. The emergence of targeted drugs in breast cancer to prevent resistance to endocrine treatment and chemotherapy. Expert Opinion on Pharmacotherapy. 15: 681-700. doi: 10.1517/14656566.2014.885952
  • Eikesdal, Hans Petter; Knappskog, Stian; Aas, Turid; Lønning, Per Eystein. 2014. TP53 status predicts long-term survival in locally advanced breast cancer after primary chemotherapy. Acta Oncologica. 53: 1347-1355. doi: 10.3109/0284186X.2014.922215
  • Eikesdal, Hans Petter; Løes, Sigbjørn Suk; Herlofson, Bente Brokstad. 2014. Tannproblemer og adjuvant bisfosfonatbehandling hos pasienter med brystkreft. Den norske tannlegeforenings tidende. 124: 571.
  • Eikesdal, Hans Petter; Løes, Sigbjørn Suk; Herlofson, Bente Brokstad. 2014. Tannhelse ved bruk av bisfosfonater mot brystkreft. Tidsskrift for Den norske legeforening. 134: 1451-1451. Published 2014-08-19. doi: 10.4045/tidsskr.14.0717
  • Johannessen, Tor-Christian Aase; Wagner, Marek; Straume, Oddbjørn; Bjerkvig, Rolf; Eikesdal, Hans Petter. 2013. Tumor vasculature: the Achilles' heel of cancer? Expert opinion on therapeutic targets. 17: 7-20. doi: 10.1517/14728222.2013.730522
  • Lønning, Per Eystein; Eikesdal, Hans Petter. 2013. Aromatase inhibition 2013: clinical state of the art and questions that remain to be solved. Endocrine-Related Cancer. 20: R183-R201. doi: 10.1530/ERC-13-0099
  • Storaas, Eivind; Holmaas, Gunhild; Gravdal, Karsten; Børretzen, Astrid; Eikesdal, Hans Petter. 2013. Lethal pneumonitis after docetaxel chemotherapy: Case report and review of the literature. Acta Oncologica. 52: 1034-1040. doi: 10.3109/0284186X.2012.750734
  • Schuster, Cornelia; Eikesdal, Hans Petter; Puntervoll, Hanne Eknes; Geisler, Jürgen; Geisler, Stephanie; Heinrich, Daniel; Molven, Anders; Lønning, Per Eystein; Akslen, Lars A.; Straume, Oddbjørn. 2012. Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension. PLoS ONE. 7. 8 pages. doi: 10.1371/journal.pone.0038364
  • Eikesdal, Hans Petter; Kalluri, Raghu. 2009. Drug resistance associated with antiangiogenesis therapy. Seminars in Cancer Biology. 19: 310-317.
  • Eikesdal, Hans Petter; Sugimoto, Hikaru; Birrane, Gabriel; Maeshima, Yohei; Cooke, Vesselina; Kieran, Mark; Kalluri, Raghu. 2008. Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor therapy. Proceedings of the National Academy of Sciences of the United States of America. 105: 15040-15045.
  • Niclou, SP; Danzeisen, C; Brons, NHC; Eikesdal, Hans Petter; Enger, Per Øyvind; Bjerkvig, Rolf. 2008. COMPLETE SEPARATION AND PHENOTYPING OF THE TUMOR-HOST CELLULAR COMPARTMENTS IN TUMOR-BEARING NOD/SCID MICE. Neuro-Oncology. 10: 853-854.
  • Niclou, Simone P; Danzeisen, Claude; Brons, Nicolaas HC; Eikesdal, Hans Petter; Enger, Per Øyvind; Bjerkvig, Rolf. 2008. Complete separation and phenotyping of the tumor-host cellular compartments in tumor bearing nod/scid mice. Neuro-Oncology. 10: 1148-1148.
  • Niclou, Simone P; Danzeisen, Claude; Eikesdal, Hans Petter; Wiig, Helge; Brons, Nicolaas HC; Poli, Aurélie MF; Svendsen, Agnete; Torsvik, Anja; Enger, Per Øyvind; Terzis, Jorge A; Bjerkvig, Rolf. 2008. A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. The FASEB Journal. 22: 3120-3128. doi: 10.1096/fj.08-109611
Reports and theses
  • Eikesdal, Hans Petter; Andersen, Knut-Jan. 1996. In vitro toksikologi på proximale tubuli celler. Medisinsk særoppgave, Universitetet i Bergen. 27 pages.
Book sections
  • Eikesdal, Hans Petter; Helle, S.I.; Guren, T. 2016. Kapittel 14 - Tubulinhemmere. Kapittel 14, pages . In:
    • Dahl, Olav; Lehne, Gustav; Christoffersen, Thoralf. 2016. Medikamentell kreftbehandling - Cytostatikaboken 8. utgave 2016. 661 pages. ISBN: 978-82-992331-4-9.
  • Eikesdal, Hans Petter; Kvaløy, S.; Kolstad, A.; Dahl, O.; Bruland, Ø.S. 2016. Kapittel 7 - Metabolske forstyrrelser ved kreft. Kapittel 7, pages . In:
    • Dahl, Olav; Lehne, Gustav; Christoffersen, Thoralf. 2016. Medikamentell kreftbehandling - Cytostatikaboken 8. utgave 2016. 661 pages. ISBN: 978-82-992331-4-9.
  • Eikesdal, Hans Petter; Kalluri, Raghu. 2011. The multifaceted role of cancer associated fibroblasts in tumor progression. Chapter 19, pages 361-380. In:
    • Mueller, Margareta M.; Fusenig, Norbert E. 2011. Tumor-associated fibroblasts and their matrix. Springer. 452 pages. ISBN: 9789400706583.

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