Hans Petter Eikesdal (HPE) is a consultant medical & radiation oncologist, working in the Dept. of Oncology, Haukeland University Hospital, Bergen, Norway (https://helse-bergen.no/en/avdelinger/kreftbehandling-og-medisinsk-fysik...).
His clinical work is dedicated to patients with breast cancer and malignant melanoma, and he is a member of the executive committee for the Norwegian Breast Cancer Group (https://nbcg.no/about/), setting the national guidelines for treatment of breast cancer in Norway (https://www.helsebiblioteket.no/retningslinjer/brystkreft/forord;jsessio...).
He is a senior researcher in the Bergen Breast Cancer Group, working in the Mohn Cancer Research Laboratory (https://www.uib.no/fg/g18). He is heading a research group studying the molecular characteristics governing resistance to endocrine therapy and chemotherapy in hormone receptor positive breast cancer and chemoresistance in triple negative breast cancer. He is the national coordinating principal investigator of the PETREMAC (ClinicalTrials.gov Identifier: NCT02624973) and p53 breast trials (ClinicalTrials.gov Identifier: NCT02965950), where patients with breast cancer are given personalized cancer therapy, based on the molecular subtype of the tumor. He is heading the Bergen Breast Cancer Group and the K.G. Jebsen Center for genome-directed therapy in cancer (https://stiftkgj.no/what-we-do/k-g-jebsen-centres-of-medical-research/k-g-jebsen-center-for-genom-directed-therapy-in-cancer/?lang=en), together with Professor Per Eystein Lønning and Professor Stian Knappskog.
HPE completed his PhD degree in 2002, with Professor Olav Dahl as main supervisor. He worked as a postdoctoral fellow at Harvard University, USA, 2007-09 in Professor Raghu Kalluri´s Division of Matrix Biology, and has an ongoing collaboration with Professor Kalluri at his current work site at MD Anderson Cancer Center in Houston, Texas. HPE joined the Bergen Breast Cancer Group in 2009, as a senior researcher. He has been employed as Professor in a 20% position at Dept. of Clinical Science, Faculty of Medicine, University of Bergen, from January 2019.
Media appearances regarding breast cancer and breast cancer research - Hans Petter Eikesdal:
Podcast (Kreftpodden, opens in Spotify): https://open.spotify.com/episode/5aacuVvGdHuEV2XOcBrDtp?si=1GUvUQIcRGGh8...
- (2016). MEDIKAMENTELL KREFTBEHANDLING - CYTOSTATIKABOKEN Kapittel 19 - Hormoner og antihormoner . Universitetet i Oslo, Det medisinske fakultet, Institutt for klinisk medisin, Avdeling for farmakologi.
- (2022). PARP-inhibition reprograms macrophages toward an anti-tumor phenotype. Cell reports. 1-23.
- (2022). Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers. Clinical Cancer Research. 4714-4723.
- (2022). DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival. Breast Cancer Research. 14 pages.
- (2022). Constitutional BRCA1 methylation and risk of incident triple-negative breast cancer and high-grade serous ovarian cancer. JAMA Oncology. 1-9.
- (2022). Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy. Genome Medicine. 1-18.
- (2020). Olaparib monotherapy as primary treatment in unselected triple negative breast cancer. Annals of Oncology. 1-10.
- (2020). An ultrasensitive routine LC-MS/MS method for estradiol and estrone in the clinically relevant sub-picomolar range. Journal of the Endocrine Society (JES). 1-15.
- (2019). Semi-automatic segmentation from intrinsically-registered 18F-FDG-PET/MRI for treatment response assessment in a breast cancer cohort: comparison to manual DCE-MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 317-323.
- (2019). Observational study of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer. Acta Oncologica. 385-387.
- (2018). Divergent activity of the pseudogene PTENP1 in ER-positive and negative breast cancer. Molecular Cancer Research. 78-89.
- (2018). BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis. Molecular Cancer Research. 1568-1578.
- (2017). High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function. Breast Cancer Research and Treatment. 177-190.
- (2017). Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines. OncoTarget. 41227-41241.
- (2016). Lymphatic vessels regulate immune microenvironments in human and murine melanoma. Journal of Clinical Investigation. 3389-3402.
- (2016). Impaired lymphatic function accelerates cancer growth. OncoTarget. 45789-45802.
- (2016). Heterogenous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. JCI Insight. e90733.
- (2016). BRCA1/2 testing in newly diagnosed breast and ovarian cancer patients without prior genetic counselling: the DNA-BONus study. European Journal of Human Genetics. 881-888.
- (2014). TP53 status predicts long-term survival in locally advanced breast cancer after primary chemotherapy. Acta Oncologica. 1347-1355.
- (2012). Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension. PLOS ONE. 8 pages.
- (2008). Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor therapy. Proceedings of the National Academy of Sciences of the United States of America. 15040-15045.
- (2008). A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. The FASEB Journal. 3120-3128.
- (1996). In vitro toksikologi på proximale tubuli celler. .
- (1996). Renal Cellular Changes Following X-Ray Contrast Media Exposure.
- (2013). Lethal pneumonitis after docetaxel chemotherapy: Case report and review of the literature. Acta Oncologica. 1034-1040.
- (2014). Tannhelse ved bruk av bisfosfonater mot brystkreft. Tidsskrift for Den norske legeforening. 1451-1451.
- (2018). The role of PTEN, PI3K-Akt-mTOR signaling and pseudogene PTENP1 in breast cancer.
- (2017). Role of the microenvironment and lymphatics in cancer development.
- (2011). The multifaceted role of cancer associated fibroblasts in tumor progression. 20 pages.
- (2008). Complete separation and phenotyping of the tumor-host cellular compartments in tumor bearing nod/scid mice. Neuro-Oncology. 1148-1148.
- (2008). COMPLETE SEPARATION AND PHENOTYPING OF THE TUMOR-HOST CELLULAR COMPARTMENTS IN TUMOR-BEARING NOD/SCID MICE. Neuro-Oncology. 853-854.
- (2019). Neoadjuvant olaparib monotherapy in primary triple negative breast cancer.
- (2019). Neoadjuvant endocrine therapy with palbociclib in patients with high-risk breast cancer.
- (2020). Correction to: Semi-automatic segmentation from intrinsically-registered 18F-FDG–PET/MRI for treatment response assessment in a breast cancer cohort: comparison to manual DCE–MRI (Magnetic Resonance Materials in Physics, Biology and Medicine, (2020), 33, 2, (317-328), 10.1007/s10334-019-00778-8). Magnetic Resonance Materials in Physics, Biology and Medicine. 329-330.
- (2019). Correction to: Semi-automatic segmentation from intrinsically-registered 18F-FDG?PET/MRI for treatment response assessment in a breast cancer cohort: comparison to manual DCE?MRI (Magnetic Resonance Materials in Physics, Biology and Medicine, (2019), 10.1007/s10334-019-00778-8). Magnetic Resonance Materials in Physics, Biology and Medicine.
- (2019). Constitutional mosaic epimutations - A hidden cause of cancer? Cell stress. 118-135.
- (2014). The emergence of targeted drugs in breast cancer to prevent resistance to endocrine treatment and chemotherapy. Expert Opinion on Pharmacotherapy. 681-700.
- (2013). Tumor vasculature: the Achilles' heel of cancer? Expert opinion on therapeutic targets. 7-20.
- (2013). Aromatase inhibition 2013: clinical state of the art and questions that remain to be solved. Endocrine-Related Cancer. R183-R201.
- (2009). Drug resistance associated with antiangiogenesis therapy. Seminars in Cancer Biology. 310-317.
- (2014). Tannproblemer og adjuvant bisfosfonatbehandling hos pasienter med brystkreft. Den norske tannlegeforenings tidende. 571.
- (2016). Kapittel 7 - Metabolske forstyrrelser ved kreft. 661 pages. In:
- (2016). Medikamentell kreftbehandling - Cytostatikaboken 8. utgave 2016. Avdeling for farmakologi, Universitetet i Oslo.
- (2016). Kapittel 14 - Tubulinhemmere. 661 pages. In: