Hans Petter Eikesdal's picture

Hans Petter Eikesdal

  • E-mailHans.Eikesdal@uib.no
  • Phone+47 55 58 67 36+47 55 58 63 73
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen

Hans Petter Eikesdal (HPE) is a consultant medical & radiation oncologist, working in the Dept. of Oncology, Haukeland University Hospital, Bergen, Norway (https://helse-bergen.no/en/avdelinger/kreftbehandling-og-medisinsk-fysik...).

His clinical work is dedicated to patients with breast cancer and malignant melanoma, and he is a member of the executive committee for the Norwegian Breast Cancer Group (https://nbcg.no/about/), setting the national guidelines for treatment of breast cancer in Norway (https://www.helsebiblioteket.no/retningslinjer/brystkreft/forord;jsessio...).

He is a senior researcher in the Bergen Breast Cancer Group, working in the Mohn Cancer Research Laboratory (https://www.uib.no/fg/g18). He is heading a research group studying the molecular characteristics governing resistance to endocrine therapy and chemotherapy in hormone receptor positive breast cancer and chemoresistance in triple negative breast cancer. He is the national coordinating principal investigator of the PETREMAC (ClinicalTrials.gov Identifier: NCT02624973) and p53 breast trials (ClinicalTrials.gov Identifier: NCT02965950), where patients with breast cancer are given personalized cancer therapy, based on the molecular subtype of the tumor. He is heading the Bergen Breast Cancer Group and the K.G. Jebsen Center for genome-directed therapy in cancer (https://stiftkgj.no/what-we-do/k-g-jebsen-centres-of-medical-research/k-g-jebsen-center-for-genom-directed-therapy-in-cancer/?lang=en), together with Professor Per Eystein Lønning and Professor Stian Knappskog. 

HPE completed his PhD degree in 2002, with Professor Olav Dahl as main supervisor. He worked as a postdoctoral fellow at Harvard University, USA, 2007-09 in Professor Raghu Kalluri´s Division of Matrix Biology, and has an ongoing collaboration with Professor Kalluri at his current work site at MD Anderson Cancer Center in Houston, Texas. HPE joined the Bergen Breast Cancer Group in 2009, as a senior researcher. He has been employed as Professor in a 20% position at Dept. of Clinical Science, Faculty of Medicine, University of Bergen, from January 2019.

  • Mellgren, Gunnar; Angelsen, Anders; Eikesdal, Hans Petter; Geisler, Jürgen. 2016. MEDIKAMENTELL KREFTBEHANDLING - CYTOSTATIKABOKEN Kapittel 19 - Hormoner og antihormoner . Universitetet i Oslo, Det medisinske fakultet, Institutt for klinisk medisin, Avdeling for farmakologi.
Academic article
  • Andreassen, Maren Marie Sjaastad; Goa, Pål Erik; Sjøbakk, Torill Eidhammer; Hedayati, Roja; Eikesdal, Hans Petter; Deng, Callie; Østlie, Agnes; Lundgren, Steinar; Bathen, Tone Frost; Jerome, Neil Peter. 2019. Semi-automatic segmentation from intrinsically-registered 18F-FDG-PET/MRI for treatment response assessment in a breast cancer cohort: comparison to manual DCE-MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 12 pages.
  • Ottestad, Lars; Fronth, Line; Rajendiran, Sajitha; Aksnes, Liv Hege; Eikesdal, Hans Petter; Blix, Egil Støre; Ewertz, Marianne. 2019. Observational study of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer. Acta Oncologica. 385-387.
  • Yndestad, Synnøve; Austreid, Eilin; Skaftnesmo, Kai Ove; Lønning, Per Eystein; Eikesdal, Hans Petter. 2018. Divergent activity of the pseudogene PTENP1 in ER-positive and negative breast cancer. Molecular Cancer Research. 78-89.
  • Eikesdal, Hans Petter; Becker, Lisa M; Teng, Yingqi; Kizu, Akane; Carstens, Julienne L; Kanasaki, Keizo; Sugimoto, Hikaru; LeBleu, Valerie S; Kalluri, Raghu. 2018. BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis. Molecular Cancer Research. 1568-1578.
  • Yndestad, Synnøve; Austreid, Eilin; Knappskog, Stian; Chrisanthar, Ranjan; Lilleng, Peer Kåre; Lønning, Per Eystein; Eikesdal, Hans Petter. 2017. High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function. Breast Cancer Research and Treatment. 177-190.
  • Yndestad, Synnøve; Austreid, Eilin; Svanberg, Ida; Knappskog, Stian; Lønning, Per Eystein; Eikesdal, Hans Petter. 2017. Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines. OncoTarget. 41227-41241.
  • Lund, Amanda W.; Wagner, Marek; Fankhauser, Manuel; Steinskog, Eli Sihn Samdal; Broggi, Maria A.; Spranger, Stefani; Gajewski, Thomas F.; Alitalo, Kari; Eikesdal, Hans Petter; Wiig, Helge; Swartz, Melody A. 2016. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. Journal of Clinical Investigation. 3389-3402.
  • Steinskog, Eli Sihn Samdal; Sagstad, Solfrid Johanne; Wagner, Marek; Karlsen, Tine Veronica; Yang, Ning; Markhus, Carl Erik Nordvik; Yndestad, Synnøve; Wiig, Helge; Eikesdal, Hans Petter. 2016. Impaired lymphatic function accelerates cancer growth. OncoTarget. 45789-45802.
  • Kim, J; de Sampaio, P.C.; Lundy, D.M.; Peng, Q; Evans, K.W.; Sugimoto, Hikaru; Gageo, M.; Kienast, Y.; do Amaral, N.S.; Rocha, R.M.; Eikesdal, Hans Petter; Lønning, P.E.; Meric-Bernstam, F.; LeBleu, V. 2016. Heterogenous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. JCI Insight. e90733.
  • Vetti, Hildegunn Høberg; Bjorvatn, Cathrine; Fiane, Bent; Aas, Turid; Woie, Kathrine; Espelid, Helge; Eikesdal, Hans Petter; Listøl, Wenche; Haavind, Marianne Tveit; Knappskog, Per; Rusken, Tone; Haukanes, Bjørn Ivar; Steen, Vidar Martin; Hoogerbrugge, Nicoline. 2016. BRCA1/2 testing in newly diagnosed breast and ovarian cancer patients without prior genetic counselling: the DNA-BONus study. European Journal of Human Genetics. 881-888.
  • Eikesdal, Hans Petter; Knappskog, Stian; Aas, Turid; Lønning, Per Eystein. 2014. TP53 status predicts long-term survival in locally advanced breast cancer after primary chemotherapy. Acta Oncologica. 1347-1355.
  • Schuster, Cornelia; Eikesdal, Hans Petter; Puntervoll, Hanne Eknes; Geisler, Jürgen; Geisler, Stephanie; Heinrich, Daniel; Molven, Anders; Lønning, Per Eystein; Akslen, Lars A.; Straume, Oddbjørn. 2012. Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension. PLOS ONE. 8 pages.
  • Eikesdal, Hans Petter; Sugimoto, Hikaru; Birrane, Gabriel; Maeshima, Yohei; Cooke, Vesselina; Kieran, Mark; Kalluri, Raghu. 2008. Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor therapy. Proceedings of the National Academy of Sciences of the United States of America. 15040-15045.
  • Niclou, Simone P; Danzeisen, Claude; Eikesdal, Hans Petter; Wiig, Helge; Brons, Nicolaas HC; Poli, Aurélie MF; Svendsen, Agnete; Torsvik, Anja; Enger, Per Øyvind; Terzis, Jorge A; Bjerkvig, Rolf. 2008. A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. The FASEB Journal. 3120-3128.
  • Eikesdal, Hans Petter. 1996. In vitro toksikologi på proximale tubuli celler. .
Academic lecture
  • Andersen, Knut-Jan; Holz, Eckhard; Gharenia, B.; Eikesdal, Hans Petter; Vik, Hogne; Christensen, Erik Ilsø. 1996. Renal Cellular Changes Following X-Ray Contrast Media Exposure.
Reader opinion piece
  • Storaas, Eivind; Holmaas, Gunhild; Gravdal, Karsten; Børretzen, Astrid; Eikesdal, Hans Petter. 2013. Lethal pneumonitis after docetaxel chemotherapy: Case report and review of the literature. Acta Oncologica. 1034-1040.
Short communication
  • Eikesdal, Hans Petter; Løes, Sigbjørn Suk; Herlofson, Bente Brokstad. 2014. Tannhelse ved bruk av bisfosfonater mot brystkreft. Tidsskrift for Den norske legeforening. 1451-1451.
Doctoral dissertation
  • Yndestad, Synnøve. 2018. The role of PTEN, PI3K-Akt-mTOR signaling and pseudogene PTENP1 in breast cancer.
  • Steinskog, Eli Sihn Samdal. 2017. Role of the microenvironment and lymphatics in cancer development.
Academic chapter/article/Conference paper
  • Eikesdal, Hans Petter; Kalluri, Raghu. 2011. The multifaceted role of cancer associated fibroblasts in tumor progression. 20 pages.
  • Niclou, Simone P; Danzeisen, Claude; Brons, Nicolaas HC; Eikesdal, Hans Petter; Enger, Per Øyvind; Bjerkvig, Rolf. 2008. Complete separation and phenotyping of the tumor-host cellular compartments in tumor bearing nod/scid mice. Neuro-Oncology. 1148-1148.
  • Niclou, SP; Danzeisen, C; Brons, NHC; Eikesdal, Hans Petter; Enger, Per Øyvind; Bjerkvig, Rolf. 2008. COMPLETE SEPARATION AND PHENOTYPING OF THE TUMOR-HOST CELLULAR COMPARTMENTS IN TUMOR-BEARING NOD/SCID MICE. Neuro-Oncology. 853-854.
  • Eikesdal, Hans Petter; Yndestad, Synnøve; Blix, Egil Støre; Lundgren, Steinar; Vagstad, Geirfinn; Espelid, Helge; Gilje, Bjørnar; Janssen, Emiel; Geisler, Jürgen; Aas, Turid; Aase, Hildegunn Siv; Knappskog, Stian; Lønning, Per Eystein. 2019. Neoadjuvant olaparib monotherapy in primary triple negative breast cancer.
  • Eikesdal, Hans Petter; Clausen, Christina; Blix, Egil Støre; Lundgren, Steinar; Vagstad, Geirfinn; Espelid, Helge; Gilje, Bjørnar; Janssen, Emiel; Geisler, Jürgen; Aas, Turid; Aase, Hildegunn Siv; Knappskog, Stian; Lønning, Per Eystein. 2019. Neoadjuvant endocrine therapy with palbociclib in patients with high-risk breast cancer.
Academic literature review
  • Austreid, Eilin; Lønning, Per Eystein; Eikesdal, Hans Petter. 2014. The emergence of targeted drugs in breast cancer to prevent resistance to endocrine treatment and chemotherapy. 681-700.
  • Johannessen, Tor-Christian Aase; Wagner, Marek; Straume, Oddbjørn; Bjerkvig, Rolf; Eikesdal, Hans Petter. 2013. Tumor vasculature: the Achilles' heel of cancer? 7-20.
  • Lønning, Per Eystein; Eikesdal, Hans Petter. 2013. Aromatase inhibition 2013: clinical state of the art and questions that remain to be solved. R183-R201.
  • Eikesdal, Hans Petter; Kalluri, Raghu. 2009. Drug resistance associated with antiangiogenesis therapy. 310-317.
Article in business/trade/industry journal
  • Eikesdal, Hans Petter; Løes, Sigbjørn Suk; Herlofson, Bente Brokstad. 2014. Tannproblemer og adjuvant bisfosfonatbehandling hos pasienter med brystkreft. Den norske tannlegeforenings tidende. 571.
  • Eikesdal, Hans Petter; Kvaløy, S.; Kolstad, A.; Dahl, O.; Bruland, Ø.S. 2016. Kapittel 7 - Metabolske forstyrrelser ved kreft.
  • Eikesdal, Hans Petter; Helle, S.I.; Guren, T. 2016. Kapittel 14 - Tubulinhemmere.

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