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Harald Barsnes

Professor
The Department of Biomedicine
Barsnes Group
github
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Harald Barsnes is a research group leader at both the Proteomics Unit (PROBE) at the Department of Biomedicine and at the Computational Biology Unit (CBU) at the Department of Informatics.

The main focus of the group is the development of user-friendly open source bioinformatics tools that enable and empower researchers to analyze and share their own data. For more information about the group see www.cbu.uib.no/barsnes.

Barsnes obtained his PhD from the Department of Informatics at the University of Bergen in 2010, with a focus on bioinformatics and proteomics. Since then he worked at the Proteomics Unit at the Department of Biomedicine, first as a senior engineer and later as a Postdoc funded by the Research Council of Norway. He then worked as a researcher at the Department of Clinical Science as part of the Ræder lab, until starting his own research group in 2016 funded by the Bergen Research Foundation and the Research Council of Norway. The research has resulted in numerous publications and a long list of freely available software, including PeptideShaker, SearchGUI and PRIDE Converter.

Barsnes has also been a guest editor in PROTEOMICS and has co-authored a Wiley text book called Computational and Statistical Methods for Protein Quantification by Mass Spectrometry. In 2015 he received the prestigious Meltzer Award for Excellent Young Researchers at the University of Bergen, and in 2016 he was awarded a recruitment fellowship from the Bergen Research Foundation.

When not working, you will most likely find him hiking in the mountains. For more details, please see: https://peakbook.org/hbar.

Academic article
  • Show author(s) (2023). Extending protein interaction networks using proteoforms and small molecules. Bioinformatics. 8 pages.
  • Show author(s) (2022). Automated splitting into batches for observational biomedical studies with sequential processing. Biostatistics. 1031-1044.
  • Show author(s) (2021). PeptideShaker Online: A User-Friendly Web-Based Framework for the Identification of Mass Spectrometry-Based Proteomics Data. Journal of Proteome Research. 5419-5423.
  • Show author(s) (2021). Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis. Scientific Reports. 16 pages.
  • Show author(s) (2020). Leptin receptor signaling regulates protein synthesis pathways and neuronal differentiation in pluripotent stem cells. Stem Cell Reports. 1067-1079.
  • Show author(s) (2020). Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis. Clinical Proteomics. 1-21.
  • Show author(s) (2020). Connecting MetaProteomeAnalyzer and PeptideShaker to Unipept for Seamless End-to-End Metaproteomics Data Analysis. Journal of Proteome Research. 3562-3566.
  • Show author(s) (2019). ThermoRawFileParser: Modular, Scalable, and Cross-Platform RAW File Conversion. Journal of Proteome Research. 537-542.
  • Show author(s) (2019). Proteomics Standards Initiative Extended FASTA Format. Journal of Proteome Research. 2686-2692.
  • Show author(s) (2019). PathwayMatcher: proteoform-centric network construction enables fine-granularity multi-omics pathway mapping. GigaScience. 1-13.
  • Show author(s) (2019). Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. Stem Cells. 542-555.
  • Show author(s) (2019). Detecting single amino acids and small peptides by combining isobaric tags and peptidomics. European Journal of Mass Spectrometry.
  • Show author(s) (2018). SearchGUI: a highly adaptable common interface for proteomics search and de novo engines. Journal of Proteome Research. 2552-2555.
  • Show author(s) (2018). Analyzing the Structure of Pathways and Its Influence on the Interpretation of Biomedical Proteomics Data Sets. Journal of Proteome Research. 3801-3809.
  • Show author(s) (2017). The mzIdentML data standard version 1.2, supporting advances in proteome informatics. Molecular & Cellular Proteomics. 1275-1285.
  • Show author(s) (2017). PeptideMapper: Efficient and versatile amino acid sequence and tag mapping. Bioinformatics. 2042-2044.
  • Show author(s) (2017). OLS Client and OLS Dialog: Open source tools to annotate public omics datasets. Proteomics.
  • Show author(s) (2017). In-depth cerebrospinal fluid quantitative proteome and deglycoproteome analysis: presenting a comprehensive picture of pathways and processes affected by multiple sclerosis. Journal of Proteome Research. 179-194.
  • Show author(s) (2017). BioContainers: An open-source and community-driven framework for software standardization. Bioinformatics.
  • Show author(s) (2016). Using Proteomics Bioinformatics Tools and Resources in Proteogenomic Studies. Advances in Experimental Medicine and Biology. 65-75.
  • Show author(s) (2016). Systemic Analysis of Regulated Functional Networks. Methods in molecular biology. 287-310.
  • Show author(s) (2016). Practical considerations for omics experiments in biomedical sciences. Current Pharmaceutical Biotechnology. 105-114.
  • Show author(s) (2016). Pladipus enables universal distributed computing in proteomics bioinformatics. Journal of Proteome Research. 707-712.
  • Show author(s) (2016). Label-free analysis of human cerebrospinal fluid addressing various normalization strategies and revealing protein groups affected by multiple sclerosis. Proteomics. 1154-1165.
  • Show author(s) (2016). CSF-PR 2.0: an interactive literature guide to quantitative cerebrospinal fluid mass spectrometry data from neurodegenerative disorders. Molecular & Cellular Proteomics. 300-309.
  • Show author(s) (2016). A pipeline for differential proteomics in unsequenced species. Journal of Proteome Research. 1963-1970.
  • Show author(s) (2015). Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis. Proteomics. 3361-3369.
  • Show author(s) (2015). JSparklines: Making tabular proteomics data come alive. Proteomics. 1428-1431.
  • Show author(s) (2015). Distributed and interactive visual analysis of omics data. Journal of Proteomics. 78-82.
  • Show author(s) (2014). Shedding light on black boxes in protein identification. Proteomics. 1001-1005.
  • Show author(s) (2014). In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR). Molecular & Cellular Proteomics. 3152-3163.
  • Show author(s) (2014). Distributed computing and data storage in proteomics: many hands make light work, and a stronger memory. Proteomics. 367-377.
  • Show author(s) (2014). DeNovoGUI: an open source graphical user interface for de novo sequencing of tandem mass spectra. Journal of Proteome Research. 1143-1146.
  • Show author(s) (2014). Carboxyl-ester lipase maturity-onset diabetes of the young disease protein biomarkers in secretin-stimulated duodenal juice. Journal of Proteome Research. 521-530.
  • Show author(s) (2013). Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM. Journal of Proteomics. 312-325.
  • Show author(s) (2012). Use of stable isotope dimethyl labeling coupled to selected reaction monitoring to enhance throughput by multiplexing relative quantitation of targeted proteins. Analytical Chemistry. 4999-5006.
  • Show author(s) (2012). The PRoteomics IDEntification (PRIDE) Converter 2 Framework: An Improved Suite of Tools to Facilitate Data Submission to the PRIDE Database and the ProteomeXchange Consortium. Molecular & Cellular Proteomics. 1682-1689.
  • Show author(s) (2011). thermo-msf-parser: An Open Source Java Library to Parse and Visualize Thermo Proteome Discoverer msf Files. Journal of Proteome Research. 3840-3843.
  • Show author(s) (2011). compomics-utilities: an open-source Java library for computational proteomics. BMC Bioinformatics. 5 pages.
  • Show author(s) (2011). Submitting proteomics data to PRIDE using PRIDE Converter. Methods in molecular biology. 237-253.
  • Show author(s) (2011). SearchGUI: An open-source graphical user interface for simultaneous OMSSA and X!Tandem searches. Proteomics. 996-999.
  • Show author(s) (2011). IsobariQ: Software for Isobaric Quantitative Proteomics using IPTL, iTRAQ, and TMT. Journal of Proteome Research. 913-920.
  • Show author(s) (2011). A global analysis of peptide fragmentation variability. Proteomics. 1181-1188.
  • Show author(s) (2010). ms_lims, a simple yet powerful open source LIMS for mass spectrometry-driven proteomics. Proteomics. 1261-1264.
  • Show author(s) (2010). XTandem Parser: An open-source library to parse and analyse X!Tandem MS/MS search results. Proteomics. 1522-1524.
  • Show author(s) (2010). The Proteomics Identifications database: 2010 update. Nucleic Acids Research (NAR). D736-D742.
  • Show author(s) (2010). The Ontology Lookup Service: bigger and better. Nucleic Acids Research (NAR). W155-W160.
  • Show author(s) (2010). OLS Dialog: An open-source front end to the Ontology Lookup Service. BMC Bioinformatics.
  • Show author(s) (2010). Fragmentation Analyzer: An open-source tool to analyze MS/MS fragmentation data. Proteomics. 1087-1090.
  • Show author(s) (2009). Proteomics data collection - 4th ProDaC workshop 15 August 2008, Amsterdam, The Netherlands. Proteomics. 218-222.
  • Show author(s) (2009). Proteomics Data Collection - 5th ProDaC Workshop: 4 March 2009, Kolympari, Crete, Greece. Proteomics. 3626-3629.
  • Show author(s) (2009). OMSSA Parser: an open-source library to parse and extract data from OMSSA MS/MS search results. Proteomics. 3772-3774.
  • Show author(s) (2009). Getting a grip on proteomics data - Proteomics Data Collection (ProDaC). Proteomics. 3928-3933.
  • Show author(s) (2008). Protease-dependent fractional mass and peptide properties. European Journal of Mass Spectrometry. 311-317.
  • Show author(s) (2008). Blind search for post-translational modifications and amino acid substitutions using peptide mass fingerprints from two proteases. BMC Research Notes.
  • Show author(s) (2006). MassSorter: a tool for administrating and analyzing data from mass spectrometry experiments on proteins with known amino acid sequences. BMC Bioinformatics. 9 pages.
Reader opinion piece
  • Show author(s) (2009). PRIDE Converter: making proteomics data-sharing easy. Nature Biotechnology. 598-599.
Short communication
  • Show author(s) (2017). An accessible proteogenomics informatics resource for cancer researchers. Cancer Research. e43-e46.
  • Show author(s) (2013). Pride-asap: automatic fragment ion annotation of identified PRIDE spectra. Journal of Proteomics. 89-92.
Academic monograph
  • Show author(s) (2013). Computational and Statistical Methods for Protein Quantification by Mass Spectrometry.
Masters thesis
  • Show author(s) (2023). Evaluation of protein biomarker candidates for multiple sclerosis using mass spectrometry-based proteomics.
Letter to the editor
  • Show author(s) (2015). PeptideShaker enables reanalysis of MS-derived proteomics data sets. Nature Biotechnology. 22-24.
Doctoral dissertation
  • Show author(s) (2016). Proteome and deglycopeptide analyses of neurologically healthy and multiple sclerosis affected cerebrospinal fluid: Mass spectrometry experiments, literature mining and data sharing .
Academic chapter/article/Conference paper
  • Show author(s) (2019). Essential Features and Use Cases of the Cerebrospinal Fluid Proteome Resource (CSF-PR). 15 pages.
  • Show author(s) (2016). Visualization, Inspection and Interpretation of Shotgun Proteomics Identification Results. 10 pages.
  • Show author(s) (2016). Tandem Mass Spectrum Sequencing: An Alternative to Database Search Engines in Shotgun Proteomics. 10 pages.
  • Show author(s) (2016). Interpretation of Quantitative Shotgun Proteomic Data. 14 pages.
  • Show author(s) (2016). Database Search Engines: Paradigms, Challenges and Solutions. 10 pages.
  • Show author(s) (2016). A Simple Workflow for Large Scale Shotgun Glycoproteomics. 12 pages.
  • Show author(s) (2014). Bioinformatics for Proteomics: Opportunities at the interface between the scientists, their experiments and the community. 10 pages.
  • Show author(s) (2008). MassSorter: Peptide Mass Fingerprinting Data Analysis. 15 pages.
Poster
  • Show author(s) (2011). IsobariQ: Software for isobaric quantitative proteomics using IPTL, iTRAQ and TMT.
Academic literature review
  • Show author(s) (2021). Importance of Block Randomization When Designing Proteomics Experiments. Journal of Proteome Research. 122-128.
  • Show author(s) (2017). Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows. Mass spectrometry reviews (Print). 292-306.
  • Show author(s) (2016). Exploring the potential of public proteomics data. Proteomics. 214-225.
  • Show author(s) (2015). Viewing the proteome: How to visualize proteomics data? Proteomics. 1341-1355.
  • Show author(s) (2014). Machine learning applications in proteomics research: How the past can boost the future. Proteomics. 353-366.
  • Show author(s) (2013). Crowdsourcing in proteomics: public resources lead to better experiments. Amino Acids. 1129-1137.

More information in national current research information system (CRIStin)

Fields of competence 
Bioinformatics
Computational biology
Mass Spectrometry
Proteomics
Software development