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Harald G Wiker

Professor
  • E-mailHarald.Wiker@uib.no
  • Phone+47 55 58 61 95
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
  • Hoel, Ida Marie; Sviland, Lisbeth; Syre, Heidi; Dyrhol-Riise, Anne Ma; Skarstein, Ingerid; Jebsen, Peter Wilhelm; Jørstad, Melissa Davidsen; Wiker, Harald G; Mustafa, Tehmina. 2020. Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting. BMC Infectious Diseases.
  • Tangedal, Solveig; Nielsen, Rune; Aanerud, Marianne; Persson, Louise Jeanette Pauline; Wiker, Harald G; Bakke, Per S.; Hiemstra, Pieter S.; Eagan, Tomas Mikal. 2019. Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients. PLOS ONE. 1-18.
  • Nielsen, Rune; Xue, Yaxin; Jonassen, Inge; Haaland, Ingvild; Kommedal, Øyvind; Wiker, Harald G; Drengenes, Christine; Bakke, Per S.; Eagan, Thomas M. 2019. Repeated bronchoscopy examination of the airway microbiome. European Respiratory Journal.
  • Machado, Karla C.T.; Fortuin, Suereta; Tomazella, Gisele Guicardi; Fonseca, André F.; Warren, Robin Mark; Wiker, Harald G; de Souza, Sandro José; De Souza, Gustavo Antonio. 2019. On the impact of the pangenome and annotation discrepancies while building protein sequence databases for bacteria proteogenomics. Frontiers in Microbiology. 1-13.
  • Drengenes, Christine; Wiker, Harald G; Kalananthan, Tharmini; Nordeide, Eli; Eagan, Tomas Mikal; Nielsen, Rune. 2019. Laboratory contamination in airway microbiome studies. BMC Microbiology. 1-13.
  • Riaz, Syeda Mariam; Sviland, Lisbeth; Wiker, Harald G; Mustafa, Tehmina. 2018. Mycobacterial antigen accumulation in foamy macrophages in pulmonary tuberculosis lesions is associated with tissue destruction and disease severity.
  • Pettersen, Veronika Kucharova; Steinsland, Hans; Wiker, Harald G. 2018. Comparative proteomics of enterotoxigenic escherichia coli reveals differences in surface protein production and similarities in metabolism. Journal of Proteome Research. 325-336.
  • Kittang, Bård Reiakvam; Pettersen, Veronika Kucharova; Oppegaard, Oddvar; Skutlaberg, Dag Harald; Dale, Håvard; Wiker, Harald G; Skrede, Steinar. 2017. Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer. BMC Infectious Diseases. 1-8.
  • Purohit, Manju; Sviland, Lisbeth; Wiker, Harald G; Mustafa, Tehmina. 2017. Rapid and specific diagnosis of extrapulmonary tuberculosis by immunostaining of tissues and aspirates with anti-MPT64. Applied immunohistochemistry & molecular morphology (Print). 282-288.
  • Mohammed, Marwan; Pettersen, Veronika Kucharova; Nerland, Audun Helge; Wiker, Harald G; Bakken, Vidar. 2017. Quantitative proteomic analysis of extracellular matrix extracted from mono- and dual-species biofilms of Fusobacterium nucleatum and Porphyromonas gingivalis. Anaerobe. 133-142.
  • Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Tangedal, Solveig; Xue, Yaxin; Husebø, Gunnar; Svanes, Øistein; Lehmann, Sverre; Aardal, Marit Elisabeth; Hoang, Tuyen; Kalananthan, Tharmini; Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Aanerud, Marianne; Nordeide, Eli; Haaland, Ingvild; Jonassen, Inge; Bakke, Per S.; Eagan, Tomas Mikal. 2017. Protected sampling is preferable in bronchoscopic studies of the airway microbiome. European Respiratory Journal Open Research (ERJ Open Research).
  • Hoel, Ida Marie; Sviland, Lisbeth; Wiker, Harald G; Mustafa, Tehmina. 2017. Implementation of a new immunohistochemistry-based test for diagnosing extrapulmonary tuberculosis by detection of mycobacterial antigen MPT64.
  • Tangedal, Solveig; Aanerud, Marianne; Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Bakke, Per S.; Eagan, Tomas Mikal. 2017. Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients. Respiratory Research. 1-9.
  • Pettersen, Veronika Kucharova; Mosevoll, Knut Anders; Lindemann, Paul Christoffer; Wiker, Harald G. 2016. Coordination of metabolism and virulence factors expression of extraintestinal pathogenic Escherichia coli purified from blood cultures of patients with sepsis. Molecular & Cellular Proteomics. 2890-2907.
  • Fortuin, Suereta; Tomazella, Gisele Guicardi; Nagaraj, Nagarjuna; Sampson, Samantha L.; Gey van Pittius, Nicolaas C.; Soares, Nelson C.; Wiker, Harald G; De Souza, Gustavo Antonio; Warren, Robin M. 2015. Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: Expanding the mycobacterial phosphoproteome catalog. Frontiers in Microbiology.
  • Mustafa, Tehmina; Brokstad, Karl Albert; Mfinanga, Sayoki Godfrey M.; Wiker, Harald G. 2015. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis research and treatment.
  • Pettersen, Veronika Kucharova; Steinsland, Hans; Wiker, Harald G. 2015. Improving genome annotation of enterotoxigenic Escherichia coli TW10598 by a label-free quantitative MS/MS approach. Proteomics. 3826-3834.
  • Grønseth, Rune; Haaland, Ingvild; Wiker, Harald G; Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Husebø, Gunnar; Svanes, Øistein; Bakke, Per S.; Eagan, Tomas Mikal. 2014. The Bergen COPD microbiome study (MicroCOPD): rationale, design, and initial experiences. European Clinical Respiratory Journal.
  • Kucharova, Veronika; Wiker, Harald G. 2014. Proteogenomics in microbiology: Taking the right turn at the junction of genomics and proteomics. 2360-2675.
  • Mustafa, Tehmina; Wiker, Harald G; Harboe, Morten; Bjune, Gunnar Aksel. 2014. Mycobacterial antigens disappear from host tissue during latent Mycobacterium tuberculosis infection.
  • Sivakumaran, Dhanasekaran; Jenum, Synne; Stavrum, Ruth; Wiker, Harald G; Kenneth, John; Vaz, Mario; Doherty, Timothy Mark; Grewal, Harleen. 2014. Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management. PLoS Neglected Tropical Diseases.
  • Mustafa, Tehmina; Leversen, Nils Anders; Sviland, Lisbet; Wiker, Harald G. 2014. Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues. BMC Infectious Diseases.
  • Hetland, Geir; Johnson, Egil; Eide, Dag Markus; Grinde, Bjørn; Samuelsen, Anne Berit C.; Wiker, Harald G. 2013. Antimicrobial effects of beta-glucans and pectin and of the Agaricus blazei-based mushroom extract, AndoSanTM. Examples of mouse models for pneumococcal-, fecal bacterial-, and mycobacterial infections. 10 pages.
  • Purohit, Manju; Mustafa, Tehmina; Wiker, Harald G; Sviland, Lisbet. 2012. Rapid diagnosis of tuberculosis in aspirate, effusions, and cerebrospinal fluid by immunocytochemical detection of Mycobacterium tuberculosis complex specific antigen MPT64. Diagnostic Cytopathology. 782-791.
  • Tomazella, Gisele Guiqardi; Risberg, Kine; Mylvaganam, Haima; Lindemann, Paul Christoffer; Thiede, Bernd; De Souza, Gustavo Antonio; Wiker, Harald G. 2012. Proteomic analysis of a multi-resistant clinical Escherichia coli isolate of unknown genomic background. Journal of Proteomics. 1830-1837.
  • Leversen, Nils Anders; Sviland, Lisbeth; Wiker, Harald G; Mustafa, Tehmina. 2012. Long-term persistence of BCG Pasteur in lungs of C57BL/6 mice following intranasal infection. Scandinavian Journal of Immunology. 489-499.
  • Leversen, Nils Anders; Wiker, Harald G. 2012. Improved signal peptide predictions in mycobacteria? Tuberculosis. 291-292.
  • Kommedal, Øyvind; Simmon, Keith; Karaca, Dilek; Langeland, Nina; Wiker, Harald G. 2012. Dual-priming oligonucleotides for broad-range amplification of the bacterial 16S rRNA gene directly from human clinical specimens. Journal of Clinical Microbiology. 1289-1294.
  • Lindemann, Paul Christoffer; Risberg, Kine; Wiker, Harald G; Mylvaganam, Haima. 2012. Aminoglycoside resistance in clinical Escherichia coli and Klebsiella pneumoniae isolates from Western Norway. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 495-502.
  • Fossum, Even; Leversen, Nils Anders; Wiker, Harald G; Bogen, Bjarne. 2011. Targeted Vaccibodies against Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 383-384.
  • De Souza, Gustavo; Arntzen, Magnus Øverlie; Fortuin, Suereta; Schürch, Anita; Målen, Hiwa; McEvoy, Christopher R; Van Soolingen, Dick; Thiede, Bernd; Warren, Robin M; Wiker, Harald G. 2011. Proteogenomic analysis of polymorphisms and gene annotation divergences in prokaryotes using a clustered mass spectrometry-friendly database. Molecular & Cellular Proteomics. 10 pages.
  • Målen, Hiwa; De Souza, Gustavo Antonio; Pathak, Sharad; Søfteland, Tina; Wiker, Harald G. 2011. Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains. BMC Microbiology.
  • Kommedal, Øyvind; Lekang, Katrine; Langeland, Nina; Wiker, Harald G. 2011. Characterization of polybacterial clinical samples using a set of group-specific broad-range primers targeting the 16S rRNA gene followed by DNA sequencing and RipSeq analysis. Journal of Medical Microbiology. 927-936.
  • De Souza, Gustavo Antonio; Leversen, Nils Anders; Målen, Hiwa; Wiker, Harald G. 2011. Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway. Journal of Proteomics. 502-510.
  • Wiker, Harald G; Tomazella, Gisele Guiqardi; De Souza, Gustavo Antonio. 2011. A quantitative view on Mycobacterium leprae antigens by proteomics. 1711-1719.
  • De Souza, Gustavo Antonio; Wiker, Harald G. 2011. A proteomic view of mycobacteria. 3118-3127.
  • De Souza, Gustavo; Fortuin, Suereta; Aguilar, Diana; Pando, Rogelio Hernandez; McEvoy, Christopher R.E.; van Helden, Paul D.; Koehler, Christian J; Thiede, Bernd; Warren, Robin M; Wiker, Harald G. 2010. Using a Label-free Proteomics Method to Identify Differentially Abundant Proteins in Closely Related Hypo- and Hypervirulent Clinical Mycobacterium tuberculosis Beijing Isolates. Molecular & Cellular Proteomics. 2414-2423.
  • Beyene, Demissew Balcha; Franken, Kees Lumc; Yamuah, Lawrence; Aseffa, Abraham; Wiker, Harald G; Kolk, Arend; Engers, Howard; Klatser, Paul R.; Sviland, Lisbet. 2010. Serodiagnosis of tuberculous lymnphadenitis using a combination of antigens. Journal of Infection in Developing Countries. 96-102.
  • De Souza, Gustavo; Wiker, Harald G. 2010. Proteomic Approaches to Study Immunity in Infection. 101-114.
  • De Souza, Gustavo; Arntzen, Magnus Øverlie; Wiker, Harald G. 2010. MSMSpdbb: providing protein databases of closely related organisms to improve proteomic characterization of prokaryotic microbes. Bioinformatics.
  • Wiker, Harald G; Mustafa, Tehmina; Bjune, Gunnar; Harboe, Morten. 2010. Evidence for waning of latency in a cohort study of tuberculosis. BMC Infectious Diseases.
  • Målen, Hiwa; Pathak, Sharad; Søfteland, Tina; De Souza, Gustavo; Wiker, Harald G. 2010. Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv. BMC Microbiology.
  • Leversen, Nils Anders; Mustafa, Tehmina; Wiker, Harald G. 2010. Comparison of Immune Response in Mice Infected with M-Bovis BCG Russia and M-Bovis BCG Pasteur. Scandinavian Journal of Immunology. 536-536.
  • Tomazella, Gisele Guiqardi; daSilva, Idalete; Thomé, Carolina H.; Greene, Lewis J; Koehler, Christian J; Thiede, Bernd; Wiker, Harald G; De Souza, Gustavo. 2010. Analysis of detergent-insoluble and whole cell lysate fractions of resting neutrophils using high-resolution mass spectrometry. Journal of Proteome Research. 2030-2036.
  • Wiker, Harald G. 2009. Virulensfaktorer og immunitet ved mykobakterieinfeksjoner.
  • De Souza, Gustavo; Søfteland, Tina; Koehler, Christian J; Thiede, Bernd; Wiker, Harald G. 2009. Validating divergent ORF annotation of the Mycobacterium leprae genome through a full translation dataset and peptide identification by tandem mass spectrometry. Proteomics. 3233-3243.
  • De Souza, Gustavo; Wiker, Harald G. 2009. The impact of proteomic advances on bacterial gene annotation. 84-92.
  • Wiker, Harald G. 2009. Searching for new vaccine candidates - Proteomics against tuberculosis.
  • Tomazella, Gisele G; da Silva, Idalete; Laure, Helen J; Rosa, Jose C; Chammas, Roger; Wiker, Harald G; De Souza, Gustavo; Greene, Lewis J. 2009. Proteomic analysis of total cellular proteins of human neutrophils. Proteome Science.
  • Wiker, Harald G. 2009. MPB70 and MPB83 - Major Antigens of Mycobacterium bovis. 492-499.
  • Totland, Karin; Wiker, Harald G. 2009. Kongelig tuberkulose-innblikk.
  • Kvello, Kristine Ringheim. 2009. Identifisering av inntil tre ulike bakteriar direkte frå prøvematerialet ved hjelp av direkte 16S rDNA sekvensering.
  • Beyene, Demissew Balcha; Bergval, Indra; Hailu, Elena; Ashenafi, Senait; Yamuah, Lawrence; Aseffa, Abraham; Wiker, Harald G; Engers, Howard; Klatser, Paul R.; Sviland, Lisbet. 2009. Identification and genotyping of the etiological agent of tuberculous lymphadenitis in Ethiopia. Journal of Infection in Developing Countries. 412-419.
  • Pathak, Sharad; De Souza, Gustavo; Salte, Tore; Wiker, Harald G; Åsjø, Birgitta. 2009. HIV Induces both a Down-Regulation of IRAK-4 that Impairs TLR Signalling and an Up-regulation of the Antibiotic Peptide Dermcidin in Monocytic Cells. Scandinavian Journal of Immunology. 264-276.
  • Wiker, Harald G. 2009. Fra krysset immunelektroforese til tandem massespektrometri.
  • Leversen, Nils Anders; De Souza, Gustavo; Målen, Hiwa; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. 2009. Evaluation of signal peptide prediction algorithms for identification of mycobacterial signal peptides using sequence data from proteomic methods. Microbiology. 2375-2383.
  • Leversen, Nils Anders; De Souza, Gustavo; Målen, Hiwa; Wiker, Harald G. 2009. Evaluation of signal peptide prediction algorithms for identification of mycobacterial signal peptides using sequence data from proteomic methods.
  • Kommedal, Øyvind; Kvello, Kristine Ringheim; Skjåstad, Rune; Langeland, Nina; Wiker, Harald G. 2009. Direct 16S rDNA sequencing from clinical specimens with special focus on poly-bacterial samples and interpretation of mixed DNA chromatograms. Journal of Clinical Microbiology. 3562-3568.
  • Olsen, Ingrid; Wiker, Harald G. 2009. Diffusion blotting for rapid production of multiple identical imprints from sodium dodecyl sulfate polyacrylamide gel electrophoresis on a solid support. Methods in molecular biology. 35-38.
  • Mustafa, Tehmina; Wiker, Harald G; Sviland, Lisbet. 2009. Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis.
  • Ellertsen, Linda Kathrine; Storla, Dag G; Diep, Lien M; Brokstad, Karl A; Wiker, Harald G; Hetland, Geir. 2009. Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy. BMC Infectious Diseases. 9 pages.
  • De Souza, Gustavo; Fortuin, Suereta; McEvoy, Christopher R; Pando, Rogelio Hernandez; Koehler, Christian J; Thiede, Bernd; Warren, Robin M; Wiker, Harald G. 2009. A label-free method identified differentially abundant proteins in related M.tuberculosis Beijing strains.
  • De Souza, Gustavo; Målen, Hiwa; Søfteland, Tina; Sælensminde, Gisle; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. 2008. Validating divergent ORF annotation in M. tuberculosis datasets using a LTQ-Orbitrap.
  • De Souza, Gustavo Antonio; Målen, Hiwa; Søfteland, Tina; Sælensminde, Gisle; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. 2008. Validating divergent ORF annotation in M. tuberculosis datasets using a LTQ-Orbitrap.
  • De Souza, Gustavo; Målen, Hiwa; Søfteland, Tina; Sælensminde, Gisle; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. 2008. Validating divergent ORF annotation in M. tuberculosis datasets using LTQ-Orbitrap.
  • Wiker, Harald G. 2008. TB antigen identification.
  • Pathak, Sharad; Leversen, Nils Anders; Wiker, Harald G; Åsjø, Birgitta. 2008. Rapid and reliable quantification of mycobacteria inside macrophages in vitro and mice using real-time quantitative PCR.
  • Pathak, Sharad; Leversen, Nils Anders; Wiker, Harald G; Åsjø, Eva Birgitta. 2008. Rapid and reliable quantification of Mycobacteria inside macrophages in vitro and mice mice using real-taime quantitative PCR.
  • Baba, Kamaldeen; Dyrhol-Riise, Anne Ma ; Sviland, Lisbet; Langeland, Nina; Hoosen, Anwar A.; Wiker, Harald G; Mustafa, Tehmina. 2008. Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium tuberculosis Complex Specific Antigen MPT64 in Patients From a HIV Endemic Area. Applied immunohistochemistry & molecular morphology (Print). 554-561.
  • De Souza, Gustavo; Søfteland, Tina; Wiker, Harald G. 2008. Proteomic analysis of Mycobacterium leprae.
  • De Souza, Gustavo Antonio; Søfteland, Tina; Wiker, Harald G. 2008. Proteomic analysis of Mycobacterium leprae.
  • Målen, Hiwa; Berven, Frode; Søfteland, Tina; Arntzen, Magnus Øverlie; D Santos, Clive; Wiker, Harald G. 2008. Membrane- and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies.
  • Målen, Hiwa; Berven, Frode; Søfteland, Tina; Arntzen, Magnus Øverlie; D Santos, Clive; Wiker, Harald G. 2008. Membrane- and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies.
  • Målen, Hiwa; Berven, Frode; Søfteland, Tina; Arntzen, Magnus Øverlie; D Santos, Clive; De Souza, Gustavo Antonio; Wiker, Harald G. 2008. Membrane- and membrane associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies. Proteomics. 1859-1870.
  • Wiker, Harald G; Namork, Ellen; Løvik, Martinus; Stensby, Berit. 2008. Matallergi - Hvor alvorlig er det? og hva er det man ikke tåler?
  • Wiker, Harald G. 2008. Historieløst om kost og leddgikt.
  • De Souza, Gustavo Antonio; Målen, Hiwa; Søfteland, Tina; Sælensminde, Gisle; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. 2008. High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example. BMC Genomics. 13 pages.
  • Leversen, Nils Anders; De Souza, Gustavo Antonio; Målen, Hiwa; Wiker, Harald G. 2008. Evaluation of signal peptide prediction algoritms using sequence data from proteomic methods.
  • Leversen, Nils Anders; De Souza, Gustavo; Målen, Hiwa; Wiker, Harald G. 2008. Evaluation of signal peptide prediction algorithms using sequence data from proteomic methods.
  • Bruarøy, Linda Selstad. 2008. Etiologi og resistensmønster ved urinveisinfeksjoner.
  • Wiker, Harald G; Mustafa, Tehmina; Bjune, Gunnar; Harboe, Morten. 2008. Estimating the half-life of latent Mycobacterium tuberculosis infection based on the decline of tuberculosis in Norway.
  • Wiker, Harald G. 2008. En vaksine mot nye epidemier.
  • Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd; Sviland, Lisbet. 2008. Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. Virchows Archiv. 449-456.
  • Beyene, Demissew Balcha; Ashenafi, Senait; Yamuah, Lawrence; Aseffa, Abraham; Wiker, Harald G; Engers, Howard; Klatser, Paul R.; Sviland, Lisbet. 2008. Diagnosis of tuberculous lymphadenitis in Ethiopia: correlation with culture, histology and HIV status. The International Journal of Tuberculosis and Lung Disease. 1030-1036.
  • Wiker, Harald G. 2008. Den norske vaksinen - venn eller fiende?
  • Målen, Hiwa; Søfteland, Tina; Wiker, Harald G. 2008. Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate proteins.
  • Målen, Hiwa; Søfteland, Tina; Wiker, Harald G. 2008. Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate proteins. Scandinavian Journal of Immunology. 245-252.
  • Målen, Hiwa; Søfteland, Tina; Wiker, Harald G. 2008. Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate.
  • Målen, Hiwa; Søfteland, Tina; Wiker, Harald G. 2008. Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate.
  • Wiker, Harald G; Fugelsnes, Elin. 2007. Vaksiner - Dårligere tuberkulose-vaksine.
  • Målen, Hiwa; Berven, Frode; Fladmark, Kari; Wiker, Harald G. 2007. The secreted subproteome and determination of cleavage sites for Signal peptidase I.
  • Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd; Sviland, Lisbet. 2007. Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response. Clinical and Experimental Immunology. 105-113.
  • Rydjord, Britt; Namork, Ellen; Nygaard, Unni Cecilie; Wiker, Harald G.; Hetland, Geir. 2007. Quantification and characterisation of IgG binding to mould spores by flow cytometry and scanning electron microscopy. JIM - Journal of Immunological Methods. 123-131.
  • Abebe, F; Holm-Hansen, Carol; Wiker, HG; Bjune, G. 2007. Progress in serodiagnosis of Mycobacterium tuberculosis infection. 176-191.
  • Wiker, Harald G; Storvik, Anne Grete. 2007. Nyttig Vaksine.
  • Wiker, Harald G. 2007. Innate and specific immune responses to Mycobacterium turberculosis.
  • Sviland, Lisbet; Mustafa, Tehmina; Purohit, Manju; Wiker, Harald G. 2007. Immunohistochemistry for the detection of Mycobacterium tuberculosis complex specific antigen (MPT64) improves the diagnosis of extrapulmonary tuberculosis caused by pathogenic mycobacteria. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 1316-1316.
  • Purohit, Manju Raj; Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd; Sviland, Lisbet. 2007. Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64. Diagnostic Pathology.
  • Wiker, Harald G. 2007. Hvor lenge varer tuberkuløs latens?
  • Purohit, Manju; Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd; Sviland, Lisbet. 2007. Detection of mycobacterium tuberculosis specific antigens by immunohistochemical technique: application for improved diagnosis of abdominal tuberculosis.
  • Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd; Sviland, Lisbet. 2007. Correlation of Mycobacterium tuberculosis antigen MPT64 expression and apoptosis in human tuberculosis lesions.
  • Målen, Hiwa; Berven, Frode; Fladmark, Kari Espolin; Wiker, Harald G. 2007. Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics. 1702-1718.
  • Rydjord, Britt; Eduard, W.; Stensby, Berit Arvesen; Sandven, Per; Michaelsen, Terje Einar; Wiker, H.G. 2007. Antibody response to long-term and high-dose mould-exposed sawmill workers. Scandinavian Journal of Immunology. 711-718.
  • Wiker, Harald G; Westbrook, Jules. 2007. Analysis of exported proteins from Mycobacterium tuberculosis H37Rv.
  • Wiker, Harald G.; Bjune, Gunnar Aksel. 2006. Vaksiner mot tuberkulose. Tidsskrift for Den norske legeforening. 2678-2681.
  • Wiker, Harald G; Bjune, Gunnar Aksel. 2006. Vaksiner mot tuberkulose. 2678-2681.
  • Wiker, Harald G. 2006. Vaccine research in Norway: Status and future prospects.
  • Wiker, Harald G; Mustafa, Tehmina; Målen, Hiwa; Riise, Anne Ma Dyrhol. 2006. Vaccine approaches to prevent tuberculosis. 243-250.
  • Wiker, Harald G. 2006. Secreted antigens of Mycobacterium tuberculosis H37Rv for novel vaccine design.
  • Wiker, Harald G. 2006. Secreted antigens of Mycobacterium tuberculosis H37Rv for novel vaccine design.
  • Wiker, Harald G. 2006. Revealing the secreted proteome of Mycobacterium tuberculosis H37Rv.
  • Wiker, Harald G. 2006. Ny vaksine mot tuberkulose i Bergen.
  • Wiker, Harald G. 2006. Mykobakterieinfeksjoner. Naturen. 114-120.
  • Wiker, Harald G. 2006. MRSA - status og framtid.
  • Wiker, Harald G; Målen, Hiwa; Berven, Frode; Fladmark, Kari Espolin. 2006. Late breaker: Revealing the secreted proteome of Mycobacterium tuberculosis H37Rv.
  • Wiker, Harald G. 2006. Kommentarer til MRSA retningslinjene basert på erfaringer fra epidemien i Hordaland.
  • Mustafa, Tehmina; Wiker, Harald G; Mfinanga, Sayoki Godfrey M.; Mørkve, Odd; Sviland, Lisbet. 2006. Immunohistochemistry using a Mycobacterium tuberculosis complex specific antibody for improved diagnosis of tuberculous lymphadenitis. Modern Pathology. 1606-1614.
  • Hetland, G.; Rydjord, Britt; Svenningsen, V.; Wiker, H. G. 2006. Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor. Vox Sanguinis. 73-73.
  • Wiker, Harald G. 2006. Identification of secreted proteins of M. tuberculosis as a basis for vaccine development.
  • Shrivastava, Rashmi; Das, Dibya Ranjan; Wiker, Harald G; Das, Amit Kumar. 2006. Functional insights from the molecular modelling of a novel two-component system. Biochemical and Biophysical Research Communications - BBRC. 1327-1333.
  • Al-Attiyah, Raja; Madi, Nada M; El-shamy, Abdul Salaam M; Wiker, Harald G; Andersen, Peter; Mustafa, AS. 2006. Cytokine profiles in tuberculosis patients and healthy subjects in response to complex and single antigens of Mycobacterium tuberculosis. FEMS Immunology and Medical Microbiology. 254-261.
  • Berven, Frode; Målen, Hiwa; Fladmark, Kari Espolin; Wiker, Harald G. 2006. Comparing the protein identifications obtained using two-dimensional gel electrophoresis or liquid chromatography mass spectrometry on the secreted proteome of Mycobacterium tuberculosis.
  • Wiker, Harald G; Hafstad, Anne. 2006. Aldri har flere blitt smittet.
  • Wiker, Harald G. 2005. Regulation of expression of MPB70 and MPB83 in Mycobacterium bovis BCG substrains.
  • Charlet, Danielle; Mostowy, Serge; Alexander, David; Sit, Louis; Wiker, Harald G; Behr, Marcel A. 2005. Reduced expression of antigenic proteins MPB70 and MPB83 in Mycobacterium bovis BCG strains due to a start codon mutation in sigK. Molecular Microbiology. 1302-1313.
  • Wiker, Harald G. 2005. Predicting proteins exported through the general secretory pathway in Mycobacterium tuberculosis H37Rv.
  • Wiker, Harald G. 2005. Predicting proteins exported through the general secretory pathway in Mycobacterium tuberculosis H37Rv.
  • Wiker, Harald G. 2005. Plenary lecture: The secreted proteomes of Mycobacterium tuberculosis and Mycobacterium leprae.
  • Wiker, Harald G. 2005. Molekylær epidemiologi av MRSA utenfor sykehus.
  • Wiker, Harald G; Gripsrud, Silje. 2005. Klistreprotein skaper vaksinekomplikasjoner.
  • Rydjord, Britt; Hetland, Geir; Wiker, Harald G. 2005. Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor. Scandinavian Journal of Immunology. 281-288.
  • Målen, Hiwa; Wiker, Harald G. 2005. Identification of N-terminal peptides by MALDI-TOF of processed proteins secreted through the general secretory pathway.
  • Målen, Hiwa; Wiker, Harald G. 2005. Identification of N-terminal peptides by MALDI-TOF of processed proteins secreted through the general secretory pathway.
  • Wiker, Harald G. 2005. Får vi snart en ny og bedre vaksine mot tuberkulose?
  • Charlet, D; Mostowy, S; Alexander, D; Sit, Louis; Wiker, Harald G; Behr, Marcel A. 2005. Expression of Mycobacterium bovis antigenic proteins MPB70 and MPB83 is controlled by the alternate sigma factor sigK.
  • Charlet, D; Mostowy, S; Alexander, D; Sit, Louis; Wiker, Harald G; Behr, Marcel A. 2005. Expression of Mycobacterium bovis antigenic proteins MPB70 and MPB83 is controlled by the alternate sigma factor sigK.
  • Kindingstad, L; Fylkesnes, Svein Ivar; Harthug, Stig; Mylvaganam, Haima; Wiker, Harald G. 2005. Epidemiological analysis of MRSA in two counties in western Norway.
  • Kindingstad, Louise; Fylkesnes, Svein Ivar; Harthug, Stig; Mylvaganam, Haima; Wiker, Harald G. 2005. Epidemiological analysis of MRSA in two counties in Western Norway.
  • Madhurantakam, Chaithanya; Rajakumara, Eerappa; Mazumdar, Pooja Anjali; Saha, Baisakhee; Mitra, Devrani; Wiker, Harald G; Sankaranarayanan, Rajan; Das, Amit Kumar. 2005. Crystal Structure of Low Molecular Weight Protein Tyrosine Phosphatase (MPtpA) from Mycobacterium tuberculosis at 1.9 Å resolution. Journal of Bacteriology. 2175-2181.
  • Mitra, D; Saha, B; Das, D; Wiker, Harald G; Das, AK. 2005. Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis by homology modeling.
  • Mitra, Devrani; Saha, Baisakhee; Das, Debabrata; Wiker, Harald G; Das, Amit Kumar. 2005. Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis by homology modeling. Tuberculosis. 337-345.
  • Rydjord, B; Wiker, Harald G; Hetland, G. 2005. Assay for quantifying mould-specific IgG antibodies in serum by flow cytometry using intact mould spores.
  • Ellertsen, Linda Katrine; Wiker, Harald G; Egeberg, NT; Hetland, Geir. 2005. Allergic sensitization in tuberculosis and leprosy patients. International Archives of Allergy and Immunology. 217-224.
  • Wiker, Harald G. 2004. Unmatched sequences in public databases - Exemplified by tuberculin-active protein. Scandinavian Journal of Immunology. 607-608.
  • Instanes, C; Ormstad, Heidi; Rydjord, Britt; Wiker, Harald G; Hetland, G. 2004. Mould extracts increase the allergic response to ovalbumin in mice. Clinical and Experimental Allergy. 1634-1641.
  • Harboe, M; Das, AK; Mitra, D; Ulvund, G; Ahmad, S; Harkness, RE; Das, D; Mustafa, AS; Wiker, Harald G. 2004. Immunodominant B-cell epitope in the Mce1A mammalian cell entry protein of Mycobacterium tuberculosis cross-reacting with glutathione S-transferase. Scandinavian Journal of Immunology. 190-197.
  • Faeste, CK; Løvik, M; Wiker, Harald G; Egaas, E. 2004. A Case of Peanut Cross-Allergy to Lupine Flour in a Hot Dog Bread. International Archives of Allergy and Immunology. 36-39.
  • Tollefsen, Stig; Pollock, J.M.; Lea, Tor Erling; Harboe, Morten; Wiker, Harald G. 2003. T- and B-cell epitopes in the secreted Mycobacterium bovis antigen MPB70 in mice. Scandinavian Journal of Immunology. 151-161.
  • Das, A. K.; Mitra, D.*; Harboe, Morten; Nandi, B.*; Harkness, R.E.; Das, D.*; Wiker, Harald G. 2003. Predicted molecular structure of the mammalian cell entry protein Mce1A of Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications - BBRC. 442-447.
  • Tollefsen, Stig; Tjelle, Torunn Elisabet; Schneider, J.; Harboe, Morten; Wiker, Harald G.; Hewinson, G.; Huygen, K.; Mathiesen, Iacob. 2002. Improved cellular and humoral immune responses against Mycobacterium tuberculosis antigens after intramuscular DNA immunisation combined with muscle electroporation. Vaccine. 3370-3378.
  • Harboe, Morten; Whelan, A.O.; Ulvund, Gunni; McNair, J.; Pollock, J.M.; Hewinson, R.G.; Wiker, Harald G. 2002. Generation of antibodies to the signal peptide of the MPT83 lipoprotein of Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 82-87.
  • Harboe, Morten; Christensen, A.; Ahmed, S.; Ulvund, Gunni; Harkness, R.E.; Mustafa, AS; Wiker, Harald G. 2002. Cross-reaction between mammalian cell entry (Mce) proteins of Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 580-587.
  • Lyashcencko, K.; Wiker, Harald G.; Harboe, Morten; McNair, J.; Komissarenko, S.V.; Pollock, J.M. 2001. Novel monoclonal antibodies against major antigens of Mycobacterium bovis. Scandinavian Journal of Immunology. 498-502.
  • Olsen, Ingrid; Wiker, Harald G; Johnson, E; Langeggen, H; Reitan, Liv Jorun. 2001. Elevated antibody responses in patients with Crohn’s disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis. Scandinavian Journal of Immunology. 198-203.
  • Olsen, Ingar; Wiker, Harald G.; Johnson, Egil; Langeggen, Harald; Reitan, L.J. 2001. Elevated antibody responses in patients with Crohn's disease against a 14 kDa secreted protein purified from Mycobacterium avium subspecies paratuberculosis. Scandinavian Journal of Immunology. 198-203.
  • Johnson, S.; Brusasca, P.; Lyashcencko, K.; Spencer, J.S.; Wiker, Harald G.; Bifani, P.; Shashkina, E.; Kreiswirth, B.; Harboe, Morten; Schluger, N.; Gomez, M.; Gennaro, M.L. 2001. Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis. Infection and Immunity. 5936-5939.
  • Olsen, Ingrid; Reitan, Liv Jorun; Wiker, Harald G. 2000. Distinct differences in repertoires of low-molecular-mass secreted antigens of Mycobacterium avium complex and Mycobacterium tuberculosis. Journal of Clinical Microbiology. 4453-4458.
  • Olsen, Ingrid; Holstad, Gudmund; Wiker, Harald G; Reitan, Liv Jorun. 2000. Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosi. Infection and Immunity. 801-808.
  • Wiker, Harald G.; Spierings, E.; Kolkman, M.A.B.; Ottenhoff, T.H.M.; Harboe, Morten. 1999. The mammalian cell entry operon 1 (mce1) of Mycobacterium leprae and Mycobacterium tuberculosis. Microbial Pathogenesis. 173-177.
  • Harboe, Morten; Wiker, Harald G. 1999. Searching for secreted proteins of Mycobacterium leprae. Indian Journal of Leprosy. 19-35.
  • Harboe, Morten; Christensen, A.; Haile, Y.; Ulvund, Gunni; Ahmed, S.; Mustafa, AS; Wiker, Harald G. 1999. Demonstration of expression of six proteins of the mammalian cell entry (mce1) operon of Mycobacterium tuberculosis by anti-peptide antibodies, enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction. Scandinavian Journal of Immunology. 519-527.
  • Wiker, Harald G.; Michell, S.Ll; Hewinson, R.G.; Spierings, E.; Nagi, S.; Harboe, Morten. 1999. Cloning, expression and significance of MPT53 for identification of secreted proteins of Mycobacterium tuberculosis. Microbial Pathogenesis. 207-219.
  • Ahmed, S.; Akbar, P.K.; Wiker, Harald G.; Harboe, Morten; Mustafa, AS. 1999. Cloning, expression and immunological reactivity of two mammalian cell entry proteins encoded by the mce1 operon pf Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 510-518.
  • Harboe, Morten; Wiker, Harald G. 1998. Secreted proteins of Mycobacterium leprae. Scandinavian Journal of Immunology. 577-584.
  • Hetland, Geir; Løvik, M.; Wiker, Harald G. 1998. Protective effect of beta-glucan against Mycobacterium bovis BCG infection in Balb/c mice. Scandinavian Journal of Immunology. 548-553.
  • Harboe, Morten; Wiker, Harald G.; Ulvund, Gunni; Lund-Pedersen, B.; Andersen, Å.B.; Hewinson, R.G.; Nagai, S. 1998. MPB70 and MPB83 as indicators of protein localization in mycobacterial cells. Infection and Immunity. 289-296.
  • Hetland, Geir; Wiker, Harald G.; Høgåsen, Kolbjørn; Hamasur, Beston; Svenson, Stefan; Harboe, Morten. 1998. Involvement of antilipoarabinomannan antibodies in classical complement activation in tuberculosis. Clinical and Laboratory Immunology. 211-218.
  • Wiker, Harald G.; Lyashcencko, K.; Aksoy, A.M.; Lightbody, K.A.; Pollock, J.M.; Komissarenko, S.V.; Bobrovnik, S.O.; Kolnesnikova, I.N.; Mykhalsky, L.O.; Gennaro, M.L.; Harboe, Morten. 1998. Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterium bovis. Infection and Immunity. 1445-1452.
  • Olsen, Ingrid; Wiker, Harald G. 1998. Diffusion blotting for rapid production of multiple identical imprints from SDS-PAGE on a solid support. JIM - Journal of Immunological Methods. 77-84.
  • Mustafa, AS; Amoudy, H.A.; Wiker, Harald G.; Abal, A.T.; Ravn, P.; Oftung, Fredrik; Andersen, Per. 1998. Comparison of antigen-specific T-cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 535-543.
  • Harboe, Morten; Malin, A.S.; Dockrell, H.S.; Wiker, Harald G.; Ulvund, Gunni; Holm, Arne; Jørgensen, M.C.; Andersen, Per. 1998. B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis. Infection and Immunity. 717-723.
  • Manca, C.; Lyashcencko, K.; Wiker, Harald G.; Usai, D.; Colangeli, R.; Gennaro, M.L. 1997. Molecular cloning, purification, and serological characterization of MPT63, a novel antigen secreted by Mycobacterium tuberculosis. Infection and Immunity. 16-23.
  • Manca, C.; Lyashcencko, K.; Wiker, Harald G.; Usai, D.; Colangeli, R.; Gennaro, M.L. 1997. Gene cloning, expression and sequence determination of MPT63, a novel secreted antigen from Mycobacterium tuberculosis. Infection and Immunity. 16-23.
  • Harboe, Morten; Wiker, Harald G. 1997. Different localization of the homologous MPB70 and MPB83 proteins of Mycobacterium bovis. Medical principles and practice. 84-90.
  • Oftung, Fredrik; Wiker, Harald G.; Deggerdal, Arne; Mustafa, AS. 1997. A novel mycobacterial antigen relevant to cellular immunity belongs to a family of secreted lipoproteins. Scandinavian Journal of Immunology. 445-451.
  • Wiker, Harald G.; Nagai, S; Hewinson, R.G.; Russel, WP; Harboe, Morten. 1996. Heterogenous expression of the related MPB70 and MPB83 proteins distinguish various substrains of Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv. Scandinavian Journal of Immunology. 374-380.
  • Harboe, Morten; Oettinger, T; Wiker, Harald G.; Rosenkrands, I; Andersen, P. 1996. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infection and Immunity. 16-22.

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