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Harald G Wiker

Professor
  • E-mailHarald.Wiker@uib.no
  • Phone+47 55 58 61 95
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
  • Pettersen, Veronika Kucharova; Steinsland, Hans; Wiker, Harald G. 2018. Comparative proteomics of enterotoxigenic escherichia coli reveals differences in surface protein production and similarities in metabolism. Journal of Proteome Research. 17: 325-336. doi: 10.1021/acs.jproteome.7b00593
  • Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Tangedal, Solveig; Xue, Yaxin; Husebø, Gunnar; Svanes, Øistein; Lehmann, Sverre; Aardal, Marit Elisabeth; Hoang, Tuyen; Kalananthan, Tharmini; Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Aanerud, Marianne; Nordeide, Eli; Haaland, Ingvild; Jonassen, Inge; Bakke, Per S.; Eagan, Tomas Mikal. 2017. Protected sampling is preferable in bronchoscopic studies of the airway microbiome. ERJ Open Research. 3. doi: 10.1183/23120541.00019-2017
  • Kittang, Bård Reiakvam; Pettersen, Veronika Kucharova; Oppegaard, Oddvar; Skutlaberg, Dag Harald; Dale, Håvard; Wiker, Harald G; Skrede, Steinar. 2017. Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer. BMC Infectious Diseases. 17:147: 1-8. doi: 10.1186/s12879-017-2262-7
  • Mohammed, Marwan; Pettersen, Veronika Kucharova; Nerland, Audun Helge; Wiker, Harald G; Bakken, Vidar. 2017. Quantitative proteomic analysis of extracellular matrix extracted from mono- and dual-species biofilms of Fusobacterium nucleatum and Porphyromonas gingivalis. Anaerobe. 44: 133-142. Published 2017-03-09. doi: 10.1016/j.anaerobe.2017.03.002
  • Purohit, Manju; Sviland, Lisbeth; Wiker, Harald G; Mustafa, Tehmina. 2017. Rapid and specific diagnosis of extrapulmonary tuberculosis by immunostaining of tissues and aspirates with anti-MPT64. Applied immunohistochemistry & molecular morphology (Print). 25: 282-288. doi: 10.1097/PAI.0000000000000300
  • Tangedal, Solveig; Aanerud, Marianne; Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Bakke, Per S.; Eagan, Tomas Mikal. 2017. Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients. Respiratory Research. 18:164: 1-9. doi: 10.1186/s12931-017-0645-3
  • Pettersen, Veronika Kucharova; Mosevoll, Knut Anders; Lindemann, Paul Christoffer; Wiker, Harald G. 2016. Coordination of metabolism and virulence factors expression of extraintestinal pathogenic Escherichia coli purified from blood cultures of patients with sepsis. Molecular & Cellular Proteomics. 15: 2890-2907. Published 2016-06-30. doi: 10.1074/mcp.M116.060582
  • Fortuin, Suereta; Tomazella, Gisele Guicardi; Nagaraj, Nagarjuna; Sampson, Samantha L.; Gey van Pittius, Nicolaas C.; Soares, Nelson C.; Wiker, Harald G; De Souza, Gustavo Antonio; Warren, Robin M. 2015. Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: Expanding the mycobacterial phosphoproteome catalog. Frontiers in Microbiology. 6. doi: 10.3389/fmicb.2015.00006
  • Mustafa, Tehmina; Brokstad, Karl Albert; Mfinanga, Sayoki Godfrey M.; Wiker, Harald G. 2015. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis research and treatment.
  • Pettersen, Veronika Kucharova; Steinsland, Hans; Wiker, Harald G. 2015. Improving genome annotation of enterotoxigenic Escherichia coli TW10598 by a label-free quantitative MS/MS approach. Proteomics. 15: 3826-3834. Published 2015-09-09. doi: 10.1002/pmic.201500278
  • Grønseth, Rune; Haaland, Ingvild; Wiker, Harald G; Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Husebø, Gunnar; Svanes, Øistein; Bakke, Per S.; Eagan, Tomas Mikal. 2014. The Bergen COPD microbiome study (MicroCOPD): rationale, design, and initial experiences. European Clinical Respiratory Journal. 1. doi: 10.3402/ecrj.v1.26196
  • Kucharova, Veronika; Wiker, Harald G. 2014. Proteogenomics in microbiology: Taking the right turn at the junction of genomics and proteomics. Proteomics. 14: 2360-2675. doi: 10.1002/pmic.201400168
  • Mustafa, Tehmina; Leversen, Nils Anders; Sviland, Lisbet; Wiker, Harald G. 2014. Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues. BMC Infectious Diseases. 14:535. doi: 10.1186/1471-2334-14-535
  • Sivakumaran, Dhanasekaran; Jenum, Synne; Stavrum, Ruth; Wiker, Harald G; Kenneth, John; Vaz, Mario; Doherty, Timothy Mark; Grewal, Harleen. 2014. Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management. PLoS Neglected Tropical Diseases. Published 2014-10-16. doi: 10.1371/journal.pntd.0003243
  • Hetland, Geir; Johnson, Egil; Eide, Dag Markus; Grinde, Bjørn; Samuelsen, Anne Berit C.; Wiker, Harald G. 2013. Antimicrobial effects of beta-glucans and pectin and of the Agaricus blazei-based mushroom extract, AndoSanTM. Examples of mouse models for pneumococcal-, fecal bacterial-, and mycobacterial infections. Vol.2, pages 889-898. In:
    • Mendez-Vilas, A. 2013. Microbial pathogens and strategies for combating them: science, technology and education. Formatex Research Center. 652 pages. ISBN: 978-84-942134-0-3.
  • Kommedal, Øyvind; Simmon, Keith; Karaca, Dilek; Langeland, Nina; Wiker, Harald G. 2012. Dual-priming oligonucleotides for broad-range amplification of the bacterial 16S rRNA gene directly from human clinical specimens. Journal of Clinical Microbiology. 50: 1289-1294. doi: 10.1128/JCM.06269-11
  • Leversen, Nils Anders; Sviland, Lisbeth; Wiker, Harald G; Mustafa, Tehmina. 2012. Long-term persistence of BCG Pasteur in lungs of C57BL/6 mice following intranasal infection. Scandinavian Journal of Immunology. 75: 489-499. doi: 10.1111/j.1365-3083.2012.02683.x
  • Leversen, Nils Anders; Wiker, Harald G. 2012. Improved signal peptide predictions in mycobacteria? Tuberculosis. 92: 291-292. doi: 10.1016/j.tube.2012.03.002
  • Lindemann, Paul Christoffer; Risberg, Kine; Wiker, Harald G; Mylvaganam, Haima. 2012. Aminoglycoside resistance in clinical Escherichia coli and Klebsiella pneumoniae isolates from Western Norway. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 120: 495-502. doi: 10.1111/j.1600-0463.2011.02856.x
  • Purohit, Manju; Mustafa, Tehmina; Wiker, Harald G; Sviland, Lisbet. 2012. Rapid diagnosis of tuberculosis in aspirate, effusions, and cerebrospinal fluid by immunocytochemical detection of Mycobacterium tuberculosis complex specific antigen MPT64. Diagnostic Cytopathology. 40: 782-791. doi: 10.1002/dc.21637
  • Tomazella, Gisele Guiqardi; Risberg, Kine; Mylvaganam, Haima; Lindemann, Paul Christoffer; Thiede, Bernd; De Souza, Gustavo Antonio; Wiker, Harald G. 2012. Proteomic analysis of a multi-resistant clinical Escherichia coli isolate of unknown genomic background. Journal of Proteomics. 75: 1830-1837. doi: 10.1016/j.jprot.2011.12.024
  • De Souza, Gustavo Antonio; Leversen, Nils Anders; Målen, Hiwa; Wiker, Harald G. 2011. Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway. Journal of Proteomics. 75: 502-510. doi: 10.1016/j.jprot.2011.08.016
  • De Souza, Gustavo Antonio; Wiker, Harald G. 2011. A proteomic view of mycobacteria. Proteomics. 11: 3118-3127. doi: 10.1002/pmic.201100043
  • De Souza, Gustavo; Arntzen, Magnus Øverlie; Fortuin, Suereta; Schürch, Anita; Målen, Hiwa; McEvoy, Christopher R; Van Soolingen, Dick; Thiede, Bernd; Warren, Robin M; Wiker, Harald G. 2011. Proteogenomic analysis of polymorphisms and gene annotation divergences in prokaryotes using a clustered mass spectrometry-friendly database. Molecular & Cellular Proteomics. 10. 10 pages. doi: 10.1074/mcp.M110.002527
  • Fossum, Even; Leversen, Nils Anders; Wiker, Harald G; Bogen, Bjarne. 2011. Targeted Vaccibodies against Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 73: 383-384.
  • Kommedal, Øyvind; Lekang, Katrine; Langeland, Nina; Wiker, Harald G. 2011. Characterization of polybacterial clinical samples using a set of group-specific broad-range primers targeting the 16S rRNA gene followed by DNA sequencing and RipSeq analysis. Journal of Medical Microbiology. 60: 927-936. doi: 10.1099/jmm.0.028373-0
  • Målen, Hiwa; De Souza, Gustavo Antonio; Pathak, Sharad; Søfteland, Tina; Wiker, Harald G. 2011. Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains. BMC Microbiology. 11. doi: 10.1186/1471-2180-11-18
  • Wiker, Harald G; Tomazella, Gisele Guiqardi; De Souza, Gustavo Antonio. 2011. A quantitative view on Mycobacterium leprae antigens by proteomics. Journal of Proteomics. 74: 1711-1719. doi: 10.1016/j.jprot.2011.01.004
  • Beyene, Demissew Balcha; Franken, Kees Lumc; Yamuah, Lawrence; Aseffa, Abraham; Wiker, Harald G; Kolk, Arend; Engers, Howard; Klatser, Paul R.; Sviland, Lisbet. 2010. Serodiagnosis of tuberculous lymnphadenitis using a combination of antigens. Journal of Infection in Developing Countries. 4: 96-102.
  • De Souza, Gustavo; Arntzen, Magnus Øverlie; Wiker, Harald G. 2010. MSMSpdbb: providing protein databases of closely related organisms to improve proteomic characterization of prokaryotic microbes. Bioinformatics.
  • De Souza, Gustavo; Fortuin, Suereta; Aguilar, Diana; Pando, Rogelio Hernandez; McEvoy, Christopher R.E.; van Helden, Paul D.; Koehler, Christian J; Thiede, Bernd; Warren, Robin M; Wiker, Harald G. 2010. Using a Label-free Proteomics Method to Identify Differentially Abundant Proteins in Closely Related Hypo- and Hypervirulent Clinical Mycobacterium tuberculosis Beijing Isolates. Molecular & Cellular Proteomics. 9: 2414-2423. doi: 10.1074/mcp.M900422-MCP200
  • De Souza, Gustavo; Wiker, Harald G. 2010. Proteomic Approaches to Study Immunity in Infection. Methods in Microbiology. 37: 101-114. doi: 10.1016/S0580-9517(10)37005-X
  • Leversen, Nils Anders; Mustafa, Tehmina; Wiker, Harald G. 2010. Comparison of Immune Response in Mice Infected with M-Bovis BCG Russia and M-Bovis BCG Pasteur. Scandinavian Journal of Immunology. 71: 536-536.
  • Målen, Hiwa; Pathak, Sharad; Søfteland, Tina; De Souza, Gustavo; Wiker, Harald G. 2010. Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv. BMC Microbiology. 10. doi: 10.1186/1471-2180-10-132
  • Tomazella, Gisele Guiqardi; daSilva, Idalete; Thomé, Carolina H.; Greene, Lewis J; Koehler, Christian J; Thiede, Bernd; Wiker, Harald G; De Souza, Gustavo. 2010. Analysis of detergent-insoluble and whole cell lysate fractions of resting neutrophils using high-resolution mass spectrometry. Journal of Proteome Research. 9: 2030-2036. doi: 10.1021/pr1000253
  • Wiker, Harald G; Mustafa, Tehmina; Bjune, Gunnar; Harboe, Morten. 2010. Evidence for waning of latency in a cohort study of tuberculosis. BMC Infectious Diseases. 10. doi: 10.1186/1471-2334-10-37
  • Beyene, Demissew Balcha; Bergval, Indra; Hailu, Elena; Ashenafi, Senait; Yamuah, Lawrence; Aseffa, Abraham; Wiker, Harald G; Engers, Howard; Klatser, Paul R.; Sviland, Lisbet. 2009. Identification and genotyping of the etiological agent of tuberculous lymphadenitis in Ethiopia. Journal of Infection in Developing Countries. 3: 412-419.
  • De Souza, Gustavo; Wiker, Harald G. 2009. The impact of proteomic advances on bacterial gene annotation. Current Protoemics. 6: 84-92.
  • Ellertsen, Linda Kathrine; Storla, Dag G; Diep, Lien M; Brokstad, Karl A; Wiker, Harald G; Hetland, Geir. 2009. Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy. BMC Infectious Diseases. 9. 9 pages. doi: 10.1186/1471-2334-9-100
  • Kommedal, Øyvind; Kvello, Kristine Ringheim; Skjåstad, Rune; Langeland, Nina; Wiker, Harald G. 2009. Direct 16S rDNA sequencing from clinical specimens with special focus on poly-bacterial samples and interpretation of mixed DNA chromatograms. Journal of Clinical Microbiology. 47: 3562-3568. doi: 10.1128/JCM.00973-09
  • Leversen, Nils Anders; De Souza, Gustavo; Målen, Hiwa; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. 2009. Evaluation of signal peptide prediction algorithms for identification of mycobacterial signal peptides using sequence data from proteomic methods. Microbiology. 155: 2375-2383. doi: 10.1099/mic.0.025270-0
  • Olsen, Ingrid; Wiker, Harald G. 2009. Diffusion blotting for rapid production of multiple identical imprints from sodium dodecyl sulfate polyacrylamide gel electrophoresis on a solid support. Methods in Molecular Biology. 536: 35-38. doi: 10.1007/978-1-59745-542-8_5
  • Pathak, Sharad; De Souza, Gustavo; Salte, Tore; Wiker, Harald G; Åsjø, Birgitta. 2009. HIV Induces both a Down-Regulation of IRAK-4 that Impairs TLR Signalling and an Up-regulation of the Antibiotic Peptide Dermcidin in Monocytic Cells. Scandinavian Journal of Immunology. 70: 264-276. doi: 10.1111/j.1365-3083.2009.02299.x
  • Tomazella, Gisele G; da Silva, Idalete; Laure, Helen J; Rosa, Jose C; Chammas, Roger; Wiker, Harald G; De Souza, Gustavo; Greene, Lewis J. 2009. Proteomic analysis of total cellular proteins of human neutrophils. Proteome Science. 7. doi: 10.1186/1477-5956-7-32
  • Wiker, Harald G. 2009. MPB70 and MPB83 - Major Antigens of Mycobacterium bovis. Scandinavian Journal of Immunology. 59: 492-499. doi: 10.1111/j.1365-3083.2009.02256.x
  • de Souza, GA; De Souza, Gustavo; Søfteland, Tina; Softeland, T; Koehler, Christian J; Thiede, Bernd; Wiker, Harald G. 2009. Validating divergent ORF annotation of the Mycobacterium leprae genome through a full translation dataset and peptide identification by tandem mass spectrometry. Proteomics. 9: 3233-3243. doi: 10.1002/pmic.200800955
  • Baba, Kamaldeen; Dyrhol-Riise, Anne Ma; Sviland, Lisbet; Langeland, Nina; Hoosen, Anwar A.; Wiker, Harald G; Mustafa, Tehmina. 2008. Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium tuberculosis Complex Specific Antigen MPT64 in Patients From a HIV Endemic Area. Applied immunohistochemistry & molecular morphology (Print). 16: 554-561. doi: 10.1097/PAI.0b013e31816c3f79
  • Beyene, Demissew Balcha; Ashenafi, Senait; Yamuah, Lawrence; Aseffa, Abraham; Wiker, Harald G; Engers, Howard; Klatser, Paul R.; Sviland, Lisbet. 2008. Diagnosis of tuberculous lymphadenitis in Ethiopia: correlation with culture, histology and HIV status. The International Journal of Tuberculosis and Lung Disease. 12: 1030-1036.
  • De Souza, Gustavo Antonio; Målen, Hiwa; Søfteland, Tina; Sælensminde, Gisle; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. 2008. High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example. BMC Genomics. 9. 13 pages. Published 2008-07-02. doi: 10.1186/1471-2164-9-316
  • Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd; Sviland, Lisbet. 2008. Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. Virchows Archiv. 452: 449-456. doi: 10.1007/s00428-008-0575-z
  • Målen, Hiwa; Berven, Frode; Søfteland, Tina; Arntzen, Magnus Øverlie; D Santos, Clive; De Souza, Gustavo Antonio; Wiker, Harald G. 2008. Membrane- and membrane associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies. Proteomics. 8: 1859-1870. doi: 10.1002/pmic.200700528
  • Målen, Hiwa; Søfteland, Tina; Wiker, Harald G. 2008. Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate proteins. Scandinavian Journal of Immunology. 67: 245-252. doi: 10.1111/j.1365-3083.2007.02064.x
  • Wiker, Harald G; Bruarøy, Linda Selstad. 2008. Etiologi og resistensmønster ved urinveisinfeksjoner. 85 pages.
  • Abebe, F; Holm-Hansen, Carol; Wiker, HG; Bjune, G. 2007. Progress in serodiagnosis of Mycobacterium tuberculosis infection. Scandinavian Journal of Immunology. 66: 176-191. doi: 10.1111/j.1365-3083.2007.01978.x
  • Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd; Sviland, Lisbet. 2007. Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response. Clinical and Experimental Immunology. 150: 105-113. doi: doi:10.1111/j.1365-2249.2007.03476.x
  • Målen, Hiwa; Berven, Frode; Fladmark, Kari Espolin; Wiker, Harald G. 2007. Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics. 7: 1702-1718. doi: 10.1002/pmic.200600853
  • Purohit, Manju Raj; Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd; Sviland, Lisbet. 2007. Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64. Diagnostic Pathology. 2. doi: 10.1186/1746-1596-2-36
  • Rydjord, Britt; Eduard, W.; Stensby, Berit Arvesen; Sandven, Per; Michaelsen, Terje Einar; Wiker, H.G. 2007. Antibody response to long-term and high-dose mould-exposed sawmill workers. Scandinavian Journal of Immunology. 66: 711-718. doi: 10.1111/j.1365-3083.2007.02022.x
  • Rydjord, Britt; Namork, Ellen; Nygaard, Unni Cecilie; Wiker, Harald G.; Hetland, Geir. 2007. Quantification and characterisation of IgG binding to mould spores by flow cytometry and scanning electron microscopy. JIM - Journal of Immunological Methods. 323: 123-131. doi: 10.1016/j.jim.2007.04.001
  • Sviland, Lisbet; Mustafa, Tehmina; Purohit, Manju; Wiker, Harald G. 2007. Immunohistochemistry for the detection of Mycobacterium tuberculosis complex specific antigen (MPT64) improves the diagnosis of extrapulmonary tuberculosis caused by pathogenic mycobacteria. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 115: 1316-1316.
  • Al-Attiyah, Raja; Madi, Nada M; El-shamy, Abdul Salaam M; Wiker, Harald G; Andersen, Peter; Mustafa, AS. 2006. Cytokine profiles in tuberculosis patients and healthy subjects in response to complex and single antigens of Mycobacterium tuberculosis. FEMS Immunology and Medical Microbiology. 47: 254-261. doi: 10.1111/j.1574-695X.2006.00110.x
  • Hetland, G.; Rydjord, Britt; Svenningsen, V.; Wiker, H. G. 2006. Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor. Vox Sanguinis. 91: 73-73.
  • Mustafa, Tehmina; Wiker, Harald G; Mfinanga, Sayoki Godfrey M.; Mørkve, Odd; Sviland, Lisbet. 2006. Immunohistochemistry using a Mycobacterium tuberculosis complex specific antibody for improved diagnosis of tuberculous lymphadenitis. Modern Pathology. 19: 1606-1614.
  • Shrivastava, Rashmi; Das, Dibya Ranjan; Wiker, Harald G; Das, Amit Kumar. 2006. Functional insights from the molecular modelling of a novel two-component system. Biochemical and Biophysical Research Communications - BBRC. 344: 1327-1333. doi: 10.1016/j.bbrc.2006.04.019
  • Wiker, Harald G. 2006. Mykobakterieinfeksjoner. Naturen. 130: 114-120.
  • Wiker, Harald G.; Bjune, Gunnar Aksel. 2006. Vaksiner mot tuberkulose. Tidsskrift for Den norske legeforening. 20: 2678-2681.
  • Wiker, Harald G; Bjune, Gunnar Aksel. 2006. Vaksiner mot tuberkulose. Tidsskrift for Den norske legeforening. 126: 2678-2681.
  • Wiker, Harald G; Mustafa, Tehmina; Målen, Hiwa; Riise, Anne Ma Dyrhol. 2006. Vaccine approaches to prevent tuberculosis. Scandinavian Journal of Immunology. 64: 243-250. doi: 10.1111/j.1365-3083.2006.01815.x
  • Charlet, Danielle; Mostowy, Serge; Alexander, David; Sit, Louis; Wiker, Harald G; Behr, Marcel A. 2005. Reduced expression of antigenic proteins MPB70 and MPB83 in Mycobacterium bovis BCG strains due to a start codon mutation in sigK. Molecular Microbiology. 56: 1302-1313.
  • Ellertsen, Linda Katrine; Wiker, Harald G; Egeberg, NT; Hetland, Geir. 2005. Allergic sensitization in tuberculosis and leprosy patients. International Archives of Allergy and Immunology. 138: 217-224. doi: 10.1159/000088722
  • Madhurantakam, Chaithanya; Rajakumara, Eerappa; Mazumdar, Pooja Anjali; Saha, Baisakhee; Mitra, Devrani; Wiker, Harald G; Sankaranarayanan, Rajan; Das, Amit Kumar. 2005. Crystal Structure of Low Molecular Weight Protein Tyrosine Phosphatase (MPtpA) from Mycobacterium tuberculosis at 1.9 Å resolution. Journal of Bacteriology. 187: 2175-2181.
  • Mitra, Devrani; Saha, Baisakhee; Das, Debabrata; Wiker, Harald G; Das, Amit Kumar. 2005. Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis by homology modeling. Tuberculosis. 85: 337-345. doi: 10.1016/j.tube.2005.08.010
  • Rydjord, Britt; Hetland, Geir; Wiker, Harald G. 2005. Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor. Scandinavian Journal of Immunology. 62: 281-288.
  • Faeste, CK; Løvik, M; Wiker, Harald G; Egaas, E. 2004. A Case of Peanut Cross-Allergy to Lupine Flour in a Hot Dog Bread. International Archives of Allergy and Immunology. 135: 36-39.
  • Harboe, M; Das, AK; Mitra, D; Ulvund, G; Ahmad, S; Harkness, RE; Das, D; Mustafa, AS; Wiker, Harald G. 2004. Immunodominant B-cell epitope in the Mce1A mammalian cell entry protein of Mycobacterium tuberculosis cross-reacting with glutathione S-transferase. Scandinavian Journal of Immunology. 59: 190-197.
  • Instanes, C; Ormstad, H; Rydjord, Britt; Wiker, Harald G; Hetland, G. 2004. Mould extracts increase the allergic response to ovalbumin in mice. Clinical and Experimental Allergy. 34: 1634-1641. doi: 10.1111/j.1365-2222.2004.0
  • Wiker, Harald G. 2004. Unmatched sequences in public databases - Exemplified by tuberculin-active protein. Scandinavian Journal of Immunology. 59: 607-608.
  • Das, A. K.; Mitra, D.*; Harboe, Morten; Nandi, B.*; Harkness, R.E.; Das, D.*; Wiker, Harald G. 2003. Predicted molecular structure of the mammalian cell entry protein Mce1A of Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications - BBRC. 302: 442-447.
  • Tollefsen, Stig; Pollock, J.M.; Lea, Tor Erling; Harboe, Morten; Wiker, Harald G. 2003. T- and B-cell epitopes in the secreted Mycobacterium bovis antigen MPB70 in mice. Scandinavian Journal of Immunology. 57: 151-161.
  • Harboe, Morten; Christensen, A.; Ahmed, S.; Ulvund, Gunni; Harkness, R.E.; Mustafa, AS; Wiker, Harald G. 2002. Cross-reaction between mammalian cell entry (Mce) proteins of Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 56: 580-587.
  • Harboe, Morten; Whelan, A.O.; Ulvund, Gunni; McNair, J.; Pollock, J.M.; Hewinson, R.G.; Wiker, Harald G. 2002. Generation of antibodies to the signal peptide of the MPT83 lipoprotein of Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 55: 82-87.
  • Tollefsen, Stig; Tjelle, Torunn Elisabet; Schneider, J.; Harboe, Morten; Wiker, Harald G.; Hewinson, G.; Huygen, K.; Mathiesen, Iacob. 2002. Improved cellular and humoral immune responses against Mycobacterium tuberculosis antigens after intramuscular DNA immunisation combined with muscle electroporation. Vaccine. 10;20: 3370-3378.
  • Johnson, S.; Brusasca, P.; Lyashcencko, K.; Spencer, J.S.; Wiker, Harald G.; Bifani, P.; Shashkina, E.; Kreiswirth, B.; Harboe, Morten; Schluger, N.; Gomez, M.; Gennaro, M.L. 2001. Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis. Infection and Immunity. 69: 5936-5939.
  • Lyashcencko, K.; Wiker, Harald G.; Harboe, Morten; McNair, J.; Komissarenko, S.V.; Pollock, J.M. 2001. Novel monoclonal antibodies against major antigens of Mycobacterium bovis. Scandinavian Journal of Immunology. 53: 498-502.
  • Olsen, Ingar; Wiker, Harald G.; Johnson, Egil; Langeggen, Harald; Reitan, L.J. 2001. Elevated antibody responses in patients with Crohn's disease against a 14 kDa secreted protein purified from Mycobacterium avium subspecies paratuberculosis. Scandinavian Journal of Immunology. 53: 198-203.
  • Olsen, Ingrid; Wiker, Harald G; Johnson, E; Langeggen, H; Reitan, Liv Jorun. 2001. Elevated antibody responses in patients with Crohn’s disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis. Scandinavian Journal of Immunology. 53: 198-203.
  • Olsen, Ingrid; Holstad, Gudmund; Wiker, Harald G; Reitan, Liv Jorun. 2000. Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosi. Infection and Immunity. 68: 801-808.
  • Olsen, Ingrid; Reitan, Liv Jorun; Wiker, Harald G. 2000. Distinct differences in repertoires of low-molecular-mass secreted antigens of Mycobacterium avium complex and Mycobacterium tuberculosis. Journal of Clinical Microbiology. 38: 4453-4458.
  • Ahmed, S.; Akbar, P.K.; Wiker, Harald G.; Harboe, Morten; Mustafa, AS. 1999. Cloning, expression and immunological reactivity of two mammalian cell entry proteins encoded by the mce1 operon pf Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 50: 510-518.
  • Harboe, Morten; Christensen, A.; Haile, Y.; Ulvund, Gunni; Ahmed, S.; Mustafa, AS; Wiker, Harald G. 1999. Demonstration of expression of six proteins of the mammalian cell entry (mce1) operon of Mycobacterium tuberculosis by anti-peptide antibodies, enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction. Scandinavian Journal of Immunology. 50: 519-527.
  • Harboe, Morten; Wiker, Harald G. 1999. Searching for secreted proteins of Mycobacterium leprae. Indian Journal of Leprosy. 71: 19-35.
  • Wiker, Harald G.; Michell, S.Ll; Hewinson, R.G.; Spierings, E.; Nagi, S.; Harboe, Morten. 1999. Cloning, expression and significance of MPT53 for identification of secreted proteins of Mycobacterium tuberculosis. Microbial Pathogenesis. 26: 207-219.
  • Wiker, Harald G.; Spierings, E.; Kolkman, M.A.B.; Ottenhoff, T.H.M.; Harboe, Morten. 1999. The mammalian cell entry operon 1 (mce1) of Mycobacterium leprae and Mycobacterium tuberculosis. Microbial Pathogenesis. 27: 173-177.
  • Harboe, Morten; Malin, A.S.; Dockrell, H.S.; Wiker, Harald G.; Ulvund, Gunni; Holm, Arne; Jørgensen, M.C.; Andersen, Per. 1998. B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis. Infection and Immunity. 66: 717-723.
  • Harboe, Morten; Wiker, Harald G. 1998. Secreted proteins of Mycobacterium leprae. Scandinavian Journal of Immunology. 48: 577-584.
  • Harboe, Morten; Wiker, Harald G.; Ulvund, Gunni; Lund-Pedersen, B.; Andersen, Å.B.; Hewinson, R.G.; Nagai, S. 1998. MPB70 and MPB83 as indicators of protein localization in mycobacterial cells. Infection and Immunity. 66: 289-296.
  • Hetland, Geir; Løvik, M.; Wiker, Harald G. 1998. Protective effect of beta-glucan against Mycobacterium bovis BCG infection in Balb/c mice. Scandinavian Journal of Immunology. 47: 548-553.
  • Hetland, Geir; Wiker, Harald G.; Høgåsen, Kolbjørn; Hamasur, Beston; Svenson, Stefan; Harboe, Morten. 1998. Involvement of antilipoarabinomannan antibodies in classical complement activation in tuberculosis. Clinical and Laboratory Immunology. 5: 211-218.
  • Mustafa, AS; Amoudy, H.A.; Wiker, Harald G.; Abal, A.T.; Ravn, P.; Oftung, Fredrik; Andersen, Per. 1998. Comparison of antigen-specific T-cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis. Scandinavian Journal of Immunology. 48. 535-543.
  • Olsen, Ingrid; Wiker, Harald G. 1998. Diffusion blotting for rapid production of multiple identical imprints from SDS-PAGE on a solid support. JIM - Journal of Immunological Methods. 220: 77-84.
  • Wiker, Harald G.; Lyashcencko, K.; Aksoy, A.M.; Lightbody, K.A.; Pollock, J.M.; Komissarenko, S.V.; Bobrovnik, S.O.; Kolnesnikova, I.N.; Mykhalsky, L.O.; Gennaro, M.L.; Harboe, Morten. 1998. Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterium bovis. Infection and Immunity. 66: 1445-1452.
  • Harboe, Morten; Wiker, Harald G. 1997. Different localization of the homologous MPB70 and MPB83 proteins of Mycobacterium bovis. Medical principles and practice. 6: 84-90.
  • Manca, C.; Lyashcencko, K.; Wiker, Harald G.; Usai, D.; Colangeli, R.; Gennaro, M.L. 1997. Molecular cloning, purification, and serological characterization of MPT63, a novel antigen secreted by Mycobacterium tuberculosis. Infection and Immunity. 65: 16-23.
  • Manca, C.; Lyashcencko, K.; Wiker, Harald G.; Usai, D.; Colangeli, R.; Gennaro, M.L. 1997. Gene cloning, expression and sequence determination of MPT63, a novel secreted antigen from Mycobacterium tuberculosis. Infection and Immunity. 65: 16-23.
  • Oftung, Fredrik; Wiker, Harald G.; Deggerdal, Arne; Mustafa, AS. 1997. A novel mycobacterial antigen relevant to cellular immunity belongs to a family of secreted lipoproteins. Scandinavian Journal of Immunology. 46: 445-451.
  • Harboe, Morten; Oettinger, T; Wiker, Harald G.; Rosenkrands, I; Andersen, P. 1996. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infection and Immunity. 64: 16-22.
  • Wiker, Harald G.; Nagai, S; Hewinson, R.G.; Russel, WP; Harboe, Morten. 1996. Heterogenous expression of the related MPB70 and MPB83 proteins distinguish various substrains of Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv. Scandinavian Journal of Immunology. 43: 374-380.

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