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Heidrun Vethe's picture
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Anne Sidsel Herdlevær

Heidrun Vethe

Researcher
Department of Clinical Medicine
  • E-mailheidrun.vethe@uib.no
  • Visitor Address
    Gades lab for Patologi
    Sentralblokken, 2. etg. Haukeland Universitetssjukehus
    5021 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen

I am a molecular biologist, with a PhD from University of Bergen on stem cell research and diabetes. My current research work focuses on identifying protein biomarkers and novel targets in aggressive breast cancer, with special emphasis on tumor cell plasticity and nerve involvement in the tumor microenvironment. To study the interaction between cancer cells and nerves, we use a combination of methods including mass spectrometry-based proteomics, imaging mass cytometry and cell models.

Academic article
  • Show author(s) (2023). Hypoxia induced responses are reflected in the stromal proteome of breast cancer. Nature Communications. 1-16.
  • Show author(s) (2022). Neurogenesis and angiogenesis are associated features of aggressive breast cancer . bioRxiv.
  • Show author(s) (2022). Mapping Proteome Changes in Microsatellite Stable, Recurrent Colon Cancer Reveals a Significant Immune System Signature. Cancer Genomics & Proteomics. 130-144.
  • Show author(s) (2020). Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor. International Journal of Molecular Sciences. 1-19.
  • Show author(s) (2020). Leptin receptor signaling regulates protein synthesis pathways and neuronal differentiation in pluripotent stem cells. Stem Cell Reports. 1067-1079.
  • Show author(s) (2020). In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. Frontiers in Cell and Developmental Biology. 1-14.
  • Show author(s) (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . Scientific Reports. 1-16.
  • Show author(s) (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. Biomedicines. 1-20.
  • Show author(s) (2019). The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. Frontiers in Endocrinology. 1-13.
  • Show author(s) (2019). Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. Stem Cells International. 1-16.
  • Show author(s) (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica. 1-16.
  • Show author(s) (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. bioRxiv.
  • Show author(s) (2019). Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. Stem Cells. 542-555.
  • Show author(s) (2019). Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 43-48.
  • Show author(s) (2018). Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. PLOS ONE. 1-15.
  • Show author(s) (2017). Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. Scientific Reports. 1-14.
  • Show author(s) (2016). Proteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls. Nephron. 70-80.
  • Show author(s) (2015). Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis. Proteomics. 3361-3369.
  • Show author(s) (2015). Distinct protein signature of hypertension-induced damage in the renal proteome of two-kidney-one-clip (2K1C) rat model. Journal of Hypertension. 126-135.
  • Show author(s) (2014). Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats. Nephrology, Dialysis and Transplantation. 11 pages.
  • Show author(s) (2014). In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR). Molecular & Cellular Proteomics. 3152-3163.
  • Show author(s) (2014). Carboxyl-ester lipase maturity-onset diabetes of the young disease protein biomarkers in secretin-stimulated duodenal juice. Journal of Proteome Research. 521-530.
  • Show author(s) (2013). Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM. Journal of Proteomics. 312-325.
Academic chapter/article/Conference paper
  • Show author(s) (2022). Neurogenesis in the Tumor Microenvironment. 11 pages.
Abstract
  • Show author(s) (2013). Proteomic analysis of outer and juxtamedullary cortex of non-clipped kidneys in 2K1C hypertensive rats. The FASEB Journal. 1 pages.

More information in national current research information system (CRIStin)

Fields of competence 
Cancer Biology
Cell biology
Human cell culture models
Mass Spectrometry
Stem Cell Research
Tumor microenvironment