Helge Wiig's picture

Helge Wiig

Professor, Professor
  • E-mailHelge.Wiig@uib.no
  • Phone+47 55 58 63 87+47 906 44 029
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen

Tissue microenvironment: interstitial fluid in skin, muscle and tumor

During the first years I worked with development of techniques for measurement of interstitial fluid pressure, primarily in skin and muscle. I showed that the servocontrolled micropipette technique could be used for measurement of interstitial fluid pressure (Pif), and also worked with other techniques for Pif measurements. As one of the first I measured Pif in tumors and found that these pressures were markedly elevated that has later been verified in numerous studies.

I also established techniques to measure compliance (stiffness, yielding in properties in tissues, of importance for edema prevention) and performed several studies addressing this topic. I have also contributed and am part of a team that has studied the mechanistic role of integrins in control of Pif.

Another focus of my research has been the interstitial fluid, i.e. the fluid bathing the cells of the interstitial matrix. This fluid is not readily accessible, and I have been working to establish methods for interstitial fluid isolation. Of major interest is isolation of such fluid in tumors, and I recently showed that exposing tumors to an increased G-force could result in isolation of such fluid.

Another area of interest is the effect of the extracellular matrix on distribution of extracellular proteins in the interstitial fluid (exclusion), and I have been able to quantify such effect. Specifically, I have been able to separate the steric and charge effect of exclusion, and also to relate this to tissue hydration. This phenomenon is of importance for plasma volume regulation.

Recently I have become interested in the role of the lymphatics in fluid volume regulation and also in relation to tumor metastasis. 


OD1FYS Human phyiology

BMED350, BMED902 - Sirkulasjonsfysiologi


FARM260 Molecular cell biology


ORCID: https://orcid.org/0000-0002-7740-8210

  • Indrebø, Marianne Muller; Berg, Ansgar; Holmstrøm, Henrik; Seem, Egil; Guthe, Hans Jørgen; Wiig, Helge; Norgård, Gunnar. 2019. Fluid accumulation in the staged Fontan procedure: the impact of colloid osmotic pressures. Interactive Cardiovascular and Thoracic Surgery. 28: 510-517. doi: 10.1093/icvts/ivy298
  • Wagner, Marek; Steinskog, Eli Sihn Samdal; Wiig, Helge. 2019. Blockade of Lymphangiogenesis Shapes Tumor-Promoting Adipose Tissue Inflammation. American Journal of Pathology. 189: 2102-2114. doi: 10.1016/j.ajpath.2019.06.010
  • Guthe, Hans Jørgen; Nedrebø, Torbjørn; Damås, Jan Kristian; Wiig, Helge; Berg, Ansgar. 2018. Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: An open, longitudinal, observational study. BMC Pediatrics. 18:82: 1-11. doi: 10.1186/s12887-018-1020-3
  • Huang, Li-Hao; Zinselmeyer, Bernd H.; Chang, Chih-Hao; Saunders, Brian T.; Elvington, Andrew; Baba, Osamu; Broekelmann, Thomas J.; Qi, Lina; Rueve, Joseph S.; Swartz, Melody A.; Kim, Brian S.; Mecham, Robert P.; Wiig, Helge; Thomas, Michael J.; Sorci-Thomas, Mary G.; Randolph, Gwendalyn J. 2018. Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis. Cell Metabolism. 29: 475-487.e7. doi: 10.1016/j.cmet.2018.10.006
  • Karlsen, Tine Veronica; Nikpey, Elham; Han, Jianhua; Reikvam, Tore; Rakova, Natalia; Castorena-Gonzalez, Jorge A.; Davis, Michael J.; Titze, Jens M.; Tenstad, Olav; Wiig, Helge. 2018. High-Salt Diet Causes Expansion of the Lymphatic Network and Increased Lymph Flow in Skin and Muscle of Rats. Arteriosclerosis, Thrombosis and Vascular Biology. 38: 2054-2064. doi: 10.1161/ATVBAHA.118.311149
  • Wiig, Helge. 2018. Regulation of Fluid Volume From the Outside A Role of Glycosaminoglycans in the Skin Interstitium? Circulation: Heart Failure. doi: 10.1161/CIRCHEARTFAILURE.118.005135
  • Øien, Alf Hartvig; Wiig, Helge. 2018. Modeling In Vivo Interstitial Hydration-Pressure Relationships in Skin and Skeletal Muscle. Biophysical Journal. 115: 924-935. doi: 10.1016/j.bpj.2018.07.025
  • Eigenmann, Miro Julian; Karlsen, Tine Veronica; Krippendorff, Ben-Fillippo; Tenstad, Olav; Fronton, Ludivine; Otteneder, Michael B.; Wiig, Helge. 2017. Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches. Journal of Physiology. 595: 7311-7330. doi: 10.1113/JP274819
  • Karlsen, Tine Veronica; Reikvam, Tore; Tofteberg, Anne; Nikpey, Elham; Skogstrand, Trude; Wagner, Marek; Tenstad, Olav; Wiig, Helge. 2017. Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration. Arteriosclerosis, Thrombosis and Vascular Biology. 37: 2128-2135. doi: 10.1161/ATVBAHA.117.309883
  • Wiig, Helge; Luft, FC; Titze, Jens M. 2017. The interstitium conducts extrarenal storage of sodium and represents a third compartment essential for extracellular volume and blood pressure homeostasis. Acta Physiologica. doi: 10.1111/apha.13006

More information in national current research information system (CRIStin)

  • 1986 PhD, University of Bergen: Bergen, Norway
  • 1974-1981, Medical Doctor (MD) University of Bergen: Bergen, Norway 
Fields of competence 

Research groups