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Ian F Pryme's picture

Ian F Pryme

Emeritus
The Department of Biomedicine
  • E-mailian.pryme@uib.no
  • Visitor Address
    Jonas Lies vei 91
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2015). The ideal antipsychotic: Hybrid between typical haloperidol and the atypical clozapine antipsychotic. Bioanalysis & Biomedicine.
  • Show author(s) (2012). The biological significance of vitamin A in humans : A review of nutritional aspects and clinical considerations. ScienceJet. 13-19.
  • Show author(s) (2012). CUG binding protein 1 binds to a specific region within the human albumin 3 ' untranslated region. Biochemical and Biophysical Research Communications - BBRC. 539-543.
  • Show author(s) (2012). Albumin 3 ' untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells. Biotechnology Journal. 8 pages.
  • Show author(s) (2009). In thrombin stimulated human platelets Citalopram, Promethazine, Risperidone, and Ziprasidone, but not Diazepam, may exert their pharmacological effects also through intercalation in membrane phospholipids in a receptor-independent manner. Journal of chemical biology. 89-103.
  • Show author(s) (2008). Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane? Biochimica et Biophysica Acta - Biomembranes. 2165-2176.
  • Show author(s) (2008). Effects of psychotropic drugs on the thrombin-induced liberation of arachidonate in human platelets. Saudi Medical Journal. 1397-1407.
  • Show author(s) (2007). Vectors ancoding seven oikosin signal peptides transfected into CHO cells differ greatly in mediating Gaussia luciferase and human endostatin production although mRNA levels are largely unaffected. Gene Regulation and Systems Biology. 303-312.
  • Show author(s) (2007). The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide. Journal of Biotechnology. 705-715.
  • Show author(s) (2007). Reducing the availability of polyamines for a developing tumour. Biochemical Society Transactions. 340-342.
  • Show author(s) (2007). Oral Misteltoe lectins: A case for their use in cancer therapy. Cancer therapy. 287-300.
  • Show author(s) (2007). Improving mammalian cell factories: The selection of signal peptide has a major impact on recombinant protein synthesis and secretion an mammalian cells. Trends in Cell & Molecular Biology. 1-17.
  • Show author(s) (2004). A mistletoe lectin (ML-1)-containing diet reduces the viability of a murine non-Hodgkin lymphoma tumor. Cancer Detection and Prevention. 52-56.
  • Show author(s) (2003). In vivo studies on possible health consequences of genetically modified food and feed - with particular regard to ingredients consisting of genetically modified plant materials. Nutrition and Health. 1-8.
  • Show author(s) (2002). Sodium butyrate stimulates the synthesis of firefly luciferase in transfected CHO cells but levels of BiP chaperone are unaffected. Cell Biology International. 489-494.
  • Show author(s) (2002). Dietary mistletoe lectin supplementation and reduced growth of a murine non-Hodgkin lymphoma. Histology and Histopathology. 261-271.
  • Show author(s) (2001). Anti-cancer therapy : diversion of polyamines in the gut. European Journal of Gastroenterology and Hepathology. 1041-1046.
  • Show author(s) (1999). The growth of an established murine non-Hodgkin lymphoma tumour is limited by switching to a phytohaemagglutinin-containing diet. Cancer Letters. 87-91.
  • Show author(s) (1999). Growth of a murine non-Hodgkin lymphoma is stimulated by extraneous dietary polyamines. Zeitschrift für Gastroenterologie - German Journal of Gastroenterology. 656-657.
  • Show author(s) (1999). Competition between the signal sequence and a 3'UTR localisation signal during redirection of beta-globin mRNA to the endoplasmic reticulum: implications for biotechnology. Cytotechnology (Dordrecht). 37-47.
  • Show author(s) (1999). A combination of dietary protein depletion and PHA-induced gut growth reduce the mass of a murine non-Hodgkin lymphoma. Cancer Letters. 145-152.
  • Show author(s) (1998). The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth. Histology and Histopathology. 575-583.
  • Show author(s) (1998). Ribosomal proteins sustain morphology, function and phenotype in acute myeloid leukemia blasts. Leukemia Research. 329-339.
  • Show author(s) (1996). The effect of switching between phytohaemagglutinin-containing and a control diet on the growth and lipid content of a Krebs II lymphosarcoma tumour. Journal of experimental therapeutics and oncology. 273-277.
  • Show author(s) (1996). The compartmentalization of protein synthesis: importance of cytoskeleton and role in mRNA targeting. International Journal of Biochemistry and Cell Biology. 1089-1105.
  • Show author(s) (1996). Phytohaemagglutinin-induced gut hyperplasia and the growth of a mouse lymphosarcoma tumour. Journal of experimental therapeutics and oncology. 171-176.
  • Show author(s) (1996). Enrichment of specific mRNAs in cytoskeletal-bound polysomes and membrane bound polysomes in Chinese hamster ovary cells. Biochemical Society Transactions. 187S.
  • Show author(s) (1996). Dietary phytohaemagglutinin slows down the proliferation of a mouse plasmacytoma (MPC-11) tumour in Balb/c mice. Cancer Letters. 151-155.
  • Show author(s) (1996). Compartmentation of the protein synthetic machinery of CHO cells into free, cytoskeletal-bound and membrane-bound polysomes. Genetic Engineering and Biotechnology Monitor. 137-144.
  • Show author(s) (1996). Association of mRNAs and polyribosomes with the cytoskeleton: Potential roles in transport and compartmentalization of mRNAs. Cell Motility and the Cytoskeleton. 31-57.
  • Show author(s) (1995). The sequestration of mRNA in the cytoskeleton and other subcellular structures. Advances in Molecular and Cell Biology. 41-74.
  • Show author(s) (1995). The mRNAs for cyclin A, c-myc, and ribosomal proteins L4 and S6 are associated with cytoskeletal polysomes in HepG2 cells. Biochemical Journal. 193-196.
  • Show author(s) (1995). Switching between control and phytohaemagglutinin-containing diets affects growth of Krebs II ascites cells and produces differences in the levels of putrescine, spermidine and spermine. Cancer Letters. 233-237.
  • Show author(s) (1995). Effect of PHA on intestinal cell proliferation and tumor growth: role of polyamines. Interlec. 40.
  • Show author(s) (1995). Changes in the distribution of actin mRNA in different polysome fractions following stimulation of MPC-11 cells. Molecular and Cellular Biochemistry. 107-115.
  • Show author(s) (1994). The initial growth rate of Krebs II ascites cell tumours in mice is slowed down by the inclusion of phytohaemagglutinin in the diet. International Journal of Oncology. 1105-1107.
  • Show author(s) (1994). Phytohaemagglutinin in the diet induces growth of the gut and modifies some organ weights in mice. Medical science research. 101-103.
  • Show author(s) (1994). Free, cytoskeletal-bound and mambrane-bound polysomes isolated from MPC-11 cells differ in their complement of poly(A) binding proteins. Molecular and Cellular Biochemistry. 131-139.
  • Show author(s) (1994). Effect of phytohaemagglutinin on the growth of Krebs II tumour cells, body metabolism and internal organs of mice. International Journal of Oncology. 1369-1374.
  • Show author(s) (1994). Changes in distribution of actin mRNA in different polysome fractions following stimulation of MPC-11 cells. Molecular and Cellular Biochemistry. 107-115.
  • Show author(s) (1994). A diet containing the lectin phytohaemagglutinin (PHA) slows down the proliferation of Krebs II cell tumours in mice. Cancer Letters. 133-137.
  • Show author(s) (1993). The involvement of microfilaments in protein synthesis; effects of insulin. International journal of biochemistry. 853-864.
  • Show author(s) (1993). The effect of insulin on proteins associated with free, cytoskeletal-bound and membranes-bound polysome populations. Cell Biology International. 1065-1073.
  • Show author(s) (1992). The effects of insulin, cycloheximide and phalloidin on the content of actin and p35 in extracts prepared from the nuclear fraction of Krebs II ascites cells. Molecular and Cellular Biochemistry. 187-194.
  • Show author(s) (1992). Morphological changes in Krebs II ascites tumour cells induced by insulin are associated with differences in protein composition and altered amounts of free, cytoskeletal-bound and membrane-bound polysomes. Molecular and Cellular Biochemistry. 131-140.
  • Show author(s) (1992). Insulin. Signal transmission and short term effects on the cytoskeleton and protein synthesis. International journal of biochemistry. 183-191.
  • Show author(s) (1991). The mapping of three subfractions of endoplasmic reticulum membranes isolated from L-929 cells by the use of spin probes. Molecular and Cellular Biochemistry. 49-54.
  • Show author(s) (1991). The isolation of three distinct populations of polysomes from eukaryotic cells. Biochemical Society Transactions. 1108-1111.
  • Show author(s) (1991). The effect of phorbol esters on lipid microviscosity in various fractions of Krebs 2 endoplasmic reticulum membranes. Journal of Cellular Biochemistry. 260-265.
  • Show author(s) (1991). The characterization of free, cytoskeletal- and membrane-bound polysomes in Krebs 2 ascites and 3T3 cells. Molecular and Cellular Biochemistry. 183-193.
  • Show author(s) (1991). The activities of aminoacyl-tRNA synthetase phosphatase and 17 aminoacyl-tRNA synthetases MPC-11 and Krebs 2 ascites cells. Cancer Letters. 119-123.
  • Show author(s) (1991). Interaction between mRNA, ribosomes and the cytoskeleton. Biochemical Journal. 1-10.
  • Show author(s) (1991). Insulin induces changes in the subcellular distribution of actin and 5'-nucleotidase. Molecular and Cellular Biochemistry. 67-74.
  • Show author(s) (1991). Differences in the content of acitin-binding proteins in subcellular fractions prepared from Krebs 2 ascites cells. Biochemical Society Transactions. 1140-1141.
  • Show author(s) (1991). Differences in patterns of proteins isolated from polysomes in free, cytoskeletal-bound and membrane-bound fractions in MPC-11 cells incubated with insulin. Biochemical Society Transactions. 1138-1139.
  • Show author(s) (1991). Changes in amounts of polysomes in free, cytoskeletal-bound and membrane-bound populations in Krebs 2 ascites cells subjected to different growth conditions. Biochemical Society Transactions. 1136-1137.
  • Show author(s) (1981). Variation in microsomal subfractions obtained from normal animal tissues and transformed cells following cell disruption by nitrogen cavitation. Molecular and Cellular Biochemistry. 177-183.
  • Show author(s) (1981). Ultrastructure and polysome content of the microsomal subfractions of mouse plasmacytoma cells. Molecular and Cellular Biochemistry. 165-175.
  • Show author(s) (1980). The effect of "shearing" forces during ultracentrifugation on the membrane-bound polysomes associated with light rough microsomes of MPC-11 cells. Molecular Biology Reports. 105-110.
  • Show author(s) (1980). Correlation of the effect of feeding upon the cell cycle distribution profiles of MPC-11 cells with the relative apperance of (3H)-choline labeled material in microsomal subfractions and other cell fractions. Molecular and Cellular Biochemistry. 159-171.
  • Show author(s) (1980). Aspects of the role of the endoplasmic reticulum in protein synthesis. Subcellular biochemistry. 117-170.
  • Show author(s) (1978). The isolation of microsomal subfractions of mouse plasmacytoma cells: The effect of salt concentration during nitrogen cavitation. Analytical Biochemistry. 332-336.
  • Show author(s) (1978). Differences in the incorporation of (3H)-glucosamine into nascent polypeptide chains on free polysomes and two fractions of membrane-bound polysomes in mouse myeloma cells. Molecular Biology Reports. 223-228.
Report
  • Show author(s) (1995). Role of polyamines in cancer. In "Polyamines in Food: Consequences for food quality and human health". .
  • Show author(s) (1994). Institutt for samfunnsmedisinske fag. En evaluering av instituttet tre år etter sammenslåingen. .
Popular scientific lecture
  • Show author(s) (1997). Biologically active amines in food.
Academic lecture
  • Show author(s) (2004). Polyamines, diet and cancer.
  • Show author(s) (2004). Forskning på misteltein lektiner.
  • Show author(s) (2004). Beneficial effects of the antinutrional factors in human nutrition.
  • Show author(s) (2001). Exogenous polyamines and cancer.
  • Show author(s) (1998). The non-release of free polysomes from CHO cells using homogenisation buffer enriched in protein.
  • Show author(s) (1998). The mass of a murine non-Hodgkin lymphoma tumour is reduced by phytohaemagglutinin-induced gut hyperplasia and feeding a protein-depleted diet.
  • Show author(s) (1998). The extent of PHA-induced gut hyperplasia is reduced by a developing tumour.
  • Show author(s) (1998). The effect of butyric acid on luciferase production in transfected CHO cells.
  • Show author(s) (1998). Ribozyme-mediated knock-out of beta actin gene experssion.
  • Show author(s) (1998). Phytohaemagglutinin: effects on tumour growth.
  • Show author(s) (1998). Manipulation of tumour growth by polyamines.
  • Show author(s) (1998). Importance of polyamines for tumour development.
  • Show author(s) (1998). Dietary polyamines and growth of a murine non-Hodgkin lymphoma.
  • Show author(s) (1998). A protein-depleted diet augments the effect of PHA-induced gut hyperplasia on limiting the growth of a murine non-Hodgkin lymphoma.
  • Show author(s) (1997). Timimg of feeding mice a phytohaemagglutinin-containing diet and effect on tumour formation.
  • Show author(s) (1995). Inhibition of tumor growth by PHA.
  • Show author(s) (1995). Inclusion of the plant lectin PHA in the diet and its effect on development of murine tumors.
Non-fiction book
  • Show author(s) (2004). Beneficial (antiproliferative) effects of different substances. Wageningen Academic Publishers.
  • Show author(s) (1995). The Cytoskeleton: Structure and Assembly. JAI Press Inc.
  • Show author(s) (1993). Kunnskapens tre - 30 år på Årstadvollen. De prekliniske institutter, Universitetet i Bergen, 1963-1992. [Mangler utgivernavn].
Masters thesis
  • Show author(s) (2009). A Signal Peptide Library Approach as a Novel Tool to Improve Synthesis and Secretion of Recombinant Proteins.
  • Show author(s) (2007). Oikosin 1 signal peptide mutants - Effects on synthesis and secretion of Gaussia luciferase in transfected CHO cells.
  • Show author(s) (2005). Gaussia luciferase production in transfected CHO cells: Effects of signal peptides derived fram bulk-secreted proteins with or without specific amino acid substitutions.
Feature article
  • Show author(s) (1992). Cytoskeletons in the Fjords. Biochemist. 42-44.
Doctoral dissertation
  • Show author(s) (1981). Protein synthesis in plasmacytoma cells : the synthesis of immunoglobulin light chain and a subfractionation of membrane- bound polysomes.
Academic chapter/article/Conference paper
  • Show author(s) (2007). UTRech tm: Exploiting mRNA Targeting To Increase Protein Secetion From Mammalian Cells. 8 pages.
  • Show author(s) (2002). Exogenous polyamines : Stimulation of growth of a murine non-Hodgkin lymphoma and effects on polyamine content of the tumour and small intestine. 6 pages.
  • Show author(s) (2000). The extent of PHA-induced gut hyperplasia is reduced by a developing murine non-Hodgkin tumour. 5 pages.
  • Show author(s) (2000). Reduction in growth of a non-Hodgkin lymphoma tumour in mice fed a polyamine-poor phytohaemagglutinin-containing diet is reversed by addition of polyamines. 6 pages.
  • Show author(s) (2000). Feeding mice the plant lectins PHA and ML-1 decreases tumour mass and mitotic activity, increases lymphocyte infiltration and induces necrosis of a murine non-Hodgkin lymphoma.I. 6 pages.
  • Show author(s) (2000). Dietary phytohaemagglutinin reduces growth of a murine non-Hodgkin lymphoma. 5 pages.
  • Show author(s) (1999). Limiting the availability of polyamines for a developing tumour: An alternative approach to reducing tumour growth. 9 pages.
  • Show author(s) (1998). The plant lectins PHA and ML-1 suppress the growth of a lymphosarcoma tumour in mice. 6 pages.
  • Show author(s) (1998). The effects of PHA and mistletoe lectin binding to epithelium of rat and mouse gut. 5 pages.
  • Show author(s) (1998). The effect of PHA on the growth and polyamine content of Krebs II non-Hodgkin lymphoma tumour cells in mice. 7 pages.
  • Show author(s) (1998). Post-transcriptional control of recombinant gene expression: mRNA retargeting and regulation of expression. 3 pages.
  • Show author(s) (1998). Polyamines in PHA-induced growth of the gut: implications for tumour growth. 7 pages.
  • Show author(s) (1998). Mice fed a diet based on an oat variety with a low polyamine content developed smaller lymphosarcoma tumours than animals fed a standard pellet die. 5 pages.
  • Show author(s) (1996). The plant lectin PHA as a tool for reducing the progression of tumour growth. 6 pages.
  • Show author(s) (1996). The effect of delaying the inclusion of the plant lectin PHA in the diet on the growth of a subcutaneous Krebs II tumour. 5 pages.
  • Show author(s) (1996). Inclusion of the plant lectin phytohaemagglutinin in the diet and its effect on development of murine tumours. 7 pages.
  • Show author(s) (1991). Cytoskeleton: Its role in cellular function. 151 pages.
  • Show author(s) (1982). Differences among microsomal subfractions in normal and transformed cells obtained after cell disruption by nitrogen cavitation. 6 pages.
Other
  • Show author(s) (2001). The pattern of polyamines in a murine non-Hodgkin lymphoma tumor and small intestine is modulated by feeding PHA and exogenous polyamines. 46-50.
  • Show author(s) (2001). Feeding mice the plant lectins PHA and ML-1 decreases tumor mass and mitotic activity increases lymphocyte infiltration and induces necrosis of murine non-Hodgkin lymphoma. 48-53.
Abstract
  • Show author(s) (2004). The effect of a phorbol ester on the lipid peroxidation and microviscosity of three endoplasmic reticulum membrane fractions isolated from Krebs 11 ascites cells. Chemistry and Physics of Lipids. 32-32.
Poster
  • Show author(s) (2004). Lectins for health improvement.
Academic literature review
  • Show author(s) (2022). Drug treatment of insomnia: impact of zopiclone. Gazzetta Medica Italiana. 572-581.
  • Show author(s) (2021). Ketamine: Use in psychiatry, its pharmacology and treatment following intoxication. Minerva Psychiatry.
  • Show author(s) (2017). Neuroleptic malignant syndrome: An easily overlooked neurologic emergency. Neuropsychiatric Disease and Treatment. 161-175.
  • Show author(s) (2014). Lithium: A review of pharmacology, clinical uses, and toxicity. European Journal of Pharmacology. 464-473.
  • Show author(s) (2006). Suppression of growth of tumour cell lines in vitro and tumours in vivo by mistletoe lectins. Histology and Histopathology. 285-299.

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