Home
  • E-mailInari.Kursula@uib.no
  • Phone+47 55 58 68 46+47 458 48 818
  • Visitor Address
    Jonas Lies vei 91
  • Postal Address
    Postboks 7804
    5020 Bergen

We use a wide selection of structural biology and biochemical approaches with the aim to understand the molecular mechanism and evolution of the machinery driving apicomplexan parasite gliding motility. You can find more information on my research group, project, and methods we use from our group web pages (link above).

Academic article
  • 2020. A function of profilin in force generation during malaria parasite motility that is independent of actin binding. Journal of Cell Science. 1-12.
  • 2019. Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical giardia lamblia assemblage A and B isolates. Infection and Drug Resistance. 1221-1235.
  • 2019. Atomic view into plasmodium actin polymerization, ATP hydrolysis, and fragmentation. PLoS Biology.
  • 2018. The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity. Journal of Neurochemistry. 291-306.
  • 2018. Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases. EMBO Journal.
  • 2017. Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase. BMC Biochemistry. 1-14.
  • 2017. Rapid cadmium SAD phasing at the standard wavelength (1 Å). Acta Crystallographica Section D: Structural Biology. 581-590.
  • 2017. Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. Proceedings of the National Academy of Sciences of the United States of America. 10636-10641.
  • 2017. Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility. Journal of Biological Chemistry. 17857-17875.
  • 2017. Apicomplexan actin polymerization depends on nucleation. Scientific Reports.
  • 2017. A unique profilin-actin interface is important for malaria parasite motility. PLoS Pathogens.
  • 2017. A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress. Science. 522-528.
  • 2016. Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein. Journal of Cell Science. 1031-1045.
  • 2016. An apicomplexan actin-binding protein serves as a connector and lipid sensor to coordinate motility and invasion. Cell Host and Microbe. 731-743.
  • 2015. Two independently folding units of Plasmodium profilin suggest evolution via gene fusion. Cellular and Molecular Life Sciences (CMLS). 4193-4203.
  • 2015. Determinants of ligand binding and catalytic activity in the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase. Scientific Reports.

More information in national current research information system (CRIStin)

2018

  • Mukherjee B, Tessaro F, Vahokoski J, Kursula I, Marq JB, Scapozza L & Soldati-Favre D (2018) Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases. EMBO J 37: e98047.

2017

  • Pino P, Caldelari R, Mukherjee B, Vahokoski J, Klages N, Maco B, Collins CR, Blackman MJ, Kursula I, Heussler V, Brochet M & Soldati-Favre D (2017) A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress. Science 358: 522-528.

  • Kumpula EP, Pires IP, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J & Kursula I (2017) Apicomplexan actin polymerization depends on nucleation. Sci Rep 7: 12137.

  • Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I & Raunser S (2017) Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. Proc Natl Acad Sci 114: 10636-10641.

  • Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R & Holder AA (2017) Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility. J Biol Chem 292: 17857-17875.

  • Panneerselvam S, Kumpula EP, Kursula I, Burkhardt A & Meents A (2017) Rapid cadmium SAD phasing at the standard wavelength (1 Å). Acta Cryst D 73: 581-590.

  • Moreau C, Bhargav SP, Kumar H, Quadt KA, Piirainen H, Strauss L, Kehrer J, Streichfuss M, Spatz J, Wade R, Kursula I & Frischknecht F (2017) A unique profilin-actin interface is important for malaria parasite motility. PLoS Pathog 13: e1006412.

  • Muruganandam G, Raasakka A, Myllykoski M, Kursula I & Kursula P (2017) Structural similarities and functional differences point to evolutionary relationship between tRNA healing enzymes and the myelin enzyme CNPase. BMC Biochem 18: 7.

2016

  • Jacot D, Tosetti N, Pires I, Stock J, Graindorge A, Hung YF, Han H, Tewari R, Kursula I, Soldati-Favre D (2016) An apicomplexan actin-binding protein serves as a connector and lipid sensor to coordinate motility and invasion. Cell Host Microbe 20: 731-743.

  • Mueller C, Samoo A, Hammoudi PM, Klages N, Kallio JP, Kursula I & Soldati-Favre D (2016) Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein. J Cell Sci 129: 1031-1045.

2015

  • Raasakka A, Myllykoski M, Laulumaa S, Lehtimäki M, Haertlein M, Moulin M, Kursula I & Kursula P (2015) Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3-cyclic nucleotide 3'-phosphodiesterase. Sci Rep 5: 16520.
  • Bhargav SP, Vahokoski J, Kallio JP, Torda AE, Kursula P & Kursula I (2015) Two independently folding units of Plasmodium profilin suggest evolution via gene fusion. Cell Mol Life Sci 72: 4193-4203.
  • Kumpula EP & Kursula I (2015) Towards a molecular understanding of the apicomplexan actin motor – on a road to novel targets for malaria remedies? Acta Cryst F, 71: 500-513.

2014

  • Salamun J, Kallio JP, Daher W, Soldati-Favre D & Kursula I (2014) Structure of Toxoplasma gondii coronin – an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress. FASEB J, 28: 4729-4747.
  • Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Muñico Martinez S, Ignatev A, Lepper S, Frischknecht F, Sidén-Kiamos I, Sachse C & Kursula I (2014) Structural differences explain diverse functions of Plasmodium actins. PLoS Pathog, 10: e1004091.
  • Kallio JP & Kursula I (2014) Recombinant production, purification, and crystallization of the Toxoplasma gondii coronin WD40 domain. Acta Cryst F, 70: 517-521.
  • Ruskamo S, Yadav RP, Sharma S, Lehtimäki M, Laulumaa S, Aggarwal S, Simons M, Bürck J, Ulrich AS, Juffer AH, Kursula I & Kursula P (2014) Atomic-resolution view into structure-function relationships of human myelin peripheral membrane protein P2. Acta Cryst D, 70: 165-176.

2013

  • Muruganandam G, Bürck J, Ulrich AS, Kursula I & Kursula P (2013) Lipid membrane association of myelin proteins and peptide segments studied by oriented and synchrotron radiation circular dichroism spectroscopy. J Phys Chem B, 117: 14983-14993.
  • Vervaet N, Kallio JP, Meier S, Salmivaara E, Eberhardt M, Zhang S, Sun X, Wu Z, Kursula P & Kursula I (2013) Recombinant production, crystallization, and preliminary structural characterization of Schistosoma japonicum profilin. Acta Cryst F, 69: 1264-1267.
  • Wedderhoff I, Kursula I, Groves MR & Ortiz de Orué Lucana D (2013) Iron binding at specific sites within the octameric HbpS protects streptomycetes from iron-mediated oxidative stress. PLoS ONE, 8: e71579.
  • Myllykoski M, Raasakka A, Lehtimäki M, Han H, Kursula I & Kursula P (2013) Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a member of the 2H phosphoesterase family. J Mol Biol, 425: 4307-4322.

2012

  • Ruskamo S, Chukhlieb M, Vahokoski J, Bhargav SP, Liang F, Kursula I & Kursula P (2012) Juxtanodin is an intrinsically disordered F-actin binding protein. Sci Rep 2: 899.
  • Myllykoski M, Itoh K, Kangas SM, Heape AM, Kang SU, Lubec G, Kursula I & Kursula P (2012) Direct molecular interaction of the myelin enzyme 2’,3’-cyclic nucleotide 3’-phosphodiesterase with the calcium sensor calmodulin. J Neurochem 123: 515-524.
  • Ignatev A, Bhargav SP, Vahokoski J, Kursula P & Kursula I (2012) The lasso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain. PLoS ONE 7: e33586.

2011

  • Singh BK, Sattler JM, Chatterjee M, Huttu J, Schüler H & Kursula I (2011) Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite. J Biol Chem 286: 28256-28264.
  • Nilsson S, Moll K, Angeletti D, Albrecht L, Kursula I, Jiang N, Sun X, Berzins K, Wahlgren M & Chen Q (2011) Characterization of the Duffy-binding like domain of Plasmodium falciparum blood-stage antigen 332. Malaria Res Treat 2011: 671439.
  • Patel AK, Yadav RP, Majava V, Kursula I & Kursula P (2011) Structure of the pro-apoptotic protein kinase DAPK2, a member of the death-associated protein kinase family J Mol Biol 409: 369-383.

2010

  • Huttu J, Singh BK, Bhargav SP, Sattler JM, Schüler H & Kursula I (2010) Crystallization and preliminary structural characterization of the two actin depolymerization factors of the malaria parasite. Acta Cryst F 66: 583-587.
  • Majava V, Polverini E, Mazzini A, Nanekar R, Knoll W, Peters J, Natali F, Baumgärtel P, Kursula I & Kursula P (2010) Structural and functional characterization of human peripheral nervous system myelin protein P2. PLoS ONE 5: e10300.
  • Wigren E, Bourhis JM, Kursula I, Guy JE & Lindqvist Y (2010) Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of Factor V and Factor VIII. FEBS Lett 584: 878-882.

2008

  • Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K & Schüler H (2008) Structural basis for parasite‐specific functions of the divergent profilin of Plasmodium falciparum. Structure 16: 1638-1648.
  • Kursula P, Kursula I, Massimi M, Song YH, Downer, J, Stanley WA, Witke W & Wilmanns M (2008) High‐resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: formin homology 1 domain of mDia1 and the proline rich domain of VASP. J Mol Biol 375: 270‐290.

Molecular mechanisms of actin-based motility

Research groups