- E-mailIngeborg.Winge@uib.no
- Phone+47 55 97 32 84+47 472 71 426
- Visitor AddressHaukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
- Postal AddressPostboks 78045020 Bergen
Cancer biomarkers in breast cancer
Coordinator in CCBIO905
- 2020. GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production. Science Advances. 1-19.
- 2018. Structure of the mouse acidic amino acid decarboxylase GADL1. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 65-73.
- 2015. Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. Neurochemistry International. 173-184.
- 2013. Functional properties of rare missense variants of human CDH13 found in adult attention deficit/hyperactivity disorder (ADHD) patients. PLOS ONE. 9 pages.
- 2010. Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2. Journal of Neurochemistry. 853-863.
- 2010. Attention-deficit/hyperactivity disorder symptoms in offspring of mothers with impaired serotonin production. Archives of General Psychiatry. 1033-1043.
- 2009. Functional Properties of Missense Variants of Human Tryptophan Hydroxylase 2. Human Mutation. 787-794.
- 2008. Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. Journal of Neurochemistry. 1648-1657.
- 2008. Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5 '-region are associated with bipolar affective disorder. Human Molecular Genetics. 87-97.
- 2008. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochemical Journal. 195-204.
- 2007. Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. Journal of Neurochemistry. 1648-1657.
- 2006. Characterization og wild-type and mutant forms of human trytopan hydroxylase 2. Journal of Neurochemistry. 10 pages.
- 2007. Common and rare variation in the gene for brain-expressed tryptophan hydroxylase 2 (TPH2) is associated with bipolar affective disorder in independent samples from Germany and Russia.
- 1998. The effect of butyric acid on luciferase production in transfected CHO cells.
- 2008. A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder. Molecular Psychiatry. 365-367.
- 2008. Human Tryptophan Hydroxylase 2; Regulatory properties and characterization of missense variants involved in neuropsychiatric disorders.
- 2010. PHARMACOLOGICAL CHAPERONES FOR THE AROMATIC AMINO ACID HYDROXYLASES. The Journal of Inherited Metabolic Disease (JIMD). S163-S163.
- 2010. FUNCTIONAL STUDIES OF DISEASE-RELATED VARIANTS IN HUMAN TRYPTOPHAN HYDROXYLASE 1 AND 2. The Journal of Inherited Metabolic Disease (JIMD). S165-S165.
- 2009. From synthesis to uptake - serotonergic genes in adult ADHD. European Neuropsychopharmacology. S186-S186.
- 2005. Effects of mutations in human tryptophan hydroxylases associated with altered monoaminergic neurotransmission. Journal of Neurochemistry.
- 2005. Biochemical characterization of mutant aromatic amino acid hydroxylases implicated in psychiatric disorders. American Journal of Medical Genetics.
- 2007. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding.
- 2005. Functional analysis of candidate genes and mutations involved in psychiatric disorders.
- 2005. Expression and molecular characterization of human tryptophan hydroxylases.
- 2010. Functional studies of candidate genes involved in ADHD. European Psychiatric Review. 44-46.
More information in national current research information system (CRIStin)
Key publications:
Winge I, McKinney JA, Ying M, D'Santos CS, Kleppe R, Knappskog PM, Haavik J.
Activation and stabilization of human tryptophan hydroxylase 2 by
phosphorylation and 14-3-3 binding. Biochem J. 2008 Feb 15;410(1):195-204. doi:
10.1042/BJ20071033. PMID: 17973628.
Winge I, Teigen K, Fossbakk A, Mahootchi E, Kleppe R, Sköldberg F, Kämpe O,
Haavik J. Mammalian CSAD and GADL1 have distinct biochemical properties and
patterns of brain expression. Neurochem Int. 2015 Nov;90:173-84. doi:
10.1016/j.neuint.2015.08.013. Epub 2015 Sep 1. PMID: 26327310.
Winge I, McKinney JA, Knappskog PM, Haavik J. Characterization of wild-type
and mutant forms of human tryptophan hydroxylase 2. J Neurochem. 2007
Mar;100(6):1648-57. doi: 10.1111/j.1471-4159.2006.04290.x. Epub 2006 Dec 23.
PMID: 17181551.
Mahootchi E, Cannon Homaei S, Kleppe R, Winge I, Hegvik TA, Megias-Perez R,
Totland C, Mogavero F, Baumann A, Glennon JC, Miletic H, Kursula P, Haavik J.
GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine
and carnosine production. Sci Adv. 2020 Jul 17;6(29):eabb3713. doi:
10.1126/sciadv.abb3713. PMID: 32733999; PMCID: PMC7367687.
Raasakka A, Mahootchi E, Winge I, Luan W, Kursula P, Haavik J. Structure of
the mouse acidic amino acid decarboxylase GADL1. Acta Crystallogr F Struct Biol
Commun. 2018 Jan 1;74(Pt 1):65-73. doi: 10.1107/S2053230X17017848. Epub 2018 Jan
1. PMID: 29372909; PMCID: PMC5947694.
McKinney JA, Turel B, Winge I, Knappskog PM, Haavik J. Functional properties
of missense variants of human tryptophan hydroxylase 2. Hum Mutat. 2009
May;30(5):787-94. doi: 10.1002/humu.20956. PMID: 19319927.