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Ingeborg Winge's picture

Ingeborg Winge

Senior Engineer, Senior engineer in CCBIO
  • E-mailIngeborg.Winge@uib.no
  • Phone+47 55 97 32 84+47 472 71 426
  • Visitor Address
    Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
  • Postal Address
    Postboks 7804
    5020 Bergen

Cancer biomarkers in breast cancer

Coordinator in CCBIO905

Academic article
  • Show author(s) 2020. GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production. Science Advances. 1-19.
  • Show author(s) 2018. Structure of the mouse acidic amino acid decarboxylase GADL1. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 65-73.
  • Show author(s) 2015. Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. Neurochemistry International. 173-184.
  • Show author(s) 2013. Functional properties of rare missense variants of human CDH13 found in adult attention deficit/hyperactivity disorder (ADHD) patients. PLOS ONE. 9 pages.
  • Show author(s) 2010. Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2. Journal of Neurochemistry. 853-863.
  • Show author(s) 2010. Attention-deficit/hyperactivity disorder symptoms in offspring of mothers with impaired serotonin production. Archives of General Psychiatry. 1033-1043.
  • Show author(s) 2009. Functional Properties of Missense Variants of Human Tryptophan Hydroxylase 2. Human Mutation. 787-794.
  • Show author(s) 2008. Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. Journal of Neurochemistry. 1648-1657.
  • Show author(s) 2008. Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5 '-region are associated with bipolar affective disorder. Human Molecular Genetics. 87-97.
  • Show author(s) 2008. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochemical Journal. 195-204.
  • Show author(s) 2007. Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. Journal of Neurochemistry. 1648-1657.
  • Show author(s) 2006. Characterization og wild-type and mutant forms of human trytopan hydroxylase 2. Journal of Neurochemistry. 10 pages.
Academic lecture
  • Show author(s) 2007. Common and rare variation in the gene for brain-expressed tryptophan hydroxylase 2 (TPH2) is associated with bipolar affective disorder in independent samples from Germany and Russia.
  • Show author(s) 1998. The effect of butyric acid on luciferase production in transfected CHO cells.
Reader opinion piece
  • Show author(s) 2008. A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder. Molecular Psychiatry. 365-367.
Doctoral dissertation
  • Show author(s) 2008. Human Tryptophan Hydroxylase 2; Regulatory properties and characterization of missense variants involved in neuropsychiatric disorders.
Abstract
  • Show author(s) 2010. PHARMACOLOGICAL CHAPERONES FOR THE AROMATIC AMINO ACID HYDROXYLASES. The Journal of Inherited Metabolic Disease (JIMD). S163-S163.
  • Show author(s) 2010. FUNCTIONAL STUDIES OF DISEASE-RELATED VARIANTS IN HUMAN TRYPTOPHAN HYDROXYLASE 1 AND 2. The Journal of Inherited Metabolic Disease (JIMD). S165-S165.
  • Show author(s) 2009. From synthesis to uptake - serotonergic genes in adult ADHD. European Neuropsychopharmacology. S186-S186.
  • Show author(s) 2005. Effects of mutations in human tryptophan hydroxylases associated with altered monoaminergic neurotransmission. Journal of Neurochemistry.
  • Show author(s) 2005. Biochemical characterization of mutant aromatic amino acid hydroxylases implicated in psychiatric disorders. American Journal of Medical Genetics.
Poster
  • Show author(s) 2007. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding.
  • Show author(s) 2005. Functional analysis of candidate genes and mutations involved in psychiatric disorders.
  • Show author(s) 2005. Expression and molecular characterization of human tryptophan hydroxylases.
Academic literature review
  • Show author(s) 2010. Functional studies of candidate genes involved in ADHD. European Psychiatric Review. 44-46.

More information in national current research information system (CRIStin)

Key publications:

Winge I, McKinney JA, Ying M, D'Santos CS, Kleppe R, Knappskog PM, Haavik J.
Activation and stabilization of human tryptophan hydroxylase 2 by
phosphorylation and 14-3-3 binding. Biochem J. 2008 Feb 15;410(1):195-204. doi:
10.1042/BJ20071033. PMID: 17973628.

Winge I, Teigen K, Fossbakk A, Mahootchi E, Kleppe R, Sköldberg F, Kämpe O,
Haavik J. Mammalian CSAD and GADL1 have distinct biochemical properties and
patterns of brain expression. Neurochem Int. 2015 Nov;90:173-84. doi:
10.1016/j.neuint.2015.08.013. Epub 2015 Sep 1. PMID: 26327310.

Winge I, McKinney JA, Knappskog PM, Haavik J. Characterization of wild-type
and mutant forms of human tryptophan hydroxylase 2. J Neurochem. 2007
Mar;100(6):1648-57. doi: 10.1111/j.1471-4159.2006.04290.x. Epub 2006 Dec 23.
PMID: 17181551.

Mahootchi E, Cannon Homaei S, Kleppe R, Winge I, Hegvik TA, Megias-Perez R,
Totland C, Mogavero F, Baumann A, Glennon JC, Miletic H, Kursula P, Haavik J.
GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine
and carnosine production. Sci Adv. 2020 Jul 17;6(29):eabb3713. doi:
10.1126/sciadv.abb3713. PMID: 32733999; PMCID: PMC7367687.

Raasakka A, Mahootchi E, Winge I, Luan W, Kursula P, Haavik J. Structure of
the mouse acidic amino acid decarboxylase GADL1. Acta Crystallogr F Struct Biol
Commun. 2018 Jan 1;74(Pt 1):65-73. doi: 10.1107/S2053230X17017848. Epub 2018 Jan
1. PMID: 29372909; PMCID: PMC5947694.

McKinney JA, Turel B, Winge I, Knappskog PM, Haavik J. Functional properties
of missense variants of human tryptophan hydroxylase 2. Hum Mutat. 2009
May;30(5):787-94. doi: 10.1002/humu.20956. PMID: 19319927.