- E-mailIngeborg.Winge@uib.no
- Phone+47 55 97 32 84
- Visitor AddressHaukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst5009 Bergen
- Postal AddressPostboks 78045020 Bergen
Cancer biomarkers in breast cancer
Coordinator in CCBIO905
Key publications:
Winge I, McKinney JA, Ying M, D'Santos CS, Kleppe R, Knappskog PM, Haavik J.
Activation and stabilization of human tryptophan hydroxylase 2 by
phosphorylation and 14-3-3 binding. Biochem J. 2008 Feb 15;410(1):195-204. doi:
10.1042/BJ20071033. PMID: 17973628.
Winge I, Teigen K, Fossbakk A, Mahootchi E, Kleppe R, Sköldberg F, Kämpe O,
Haavik J. Mammalian CSAD and GADL1 have distinct biochemical properties and
patterns of brain expression. Neurochem Int. 2015 Nov;90:173-84. doi:
10.1016/j.neuint.2015.08.013. Epub 2015 Sep 1. PMID: 26327310.
Winge I, McKinney JA, Knappskog PM, Haavik J. Characterization of wild-type
and mutant forms of human tryptophan hydroxylase 2. J Neurochem. 2007
Mar;100(6):1648-57. doi: 10.1111/j.1471-4159.2006.04290.x. Epub 2006 Dec 23.
PMID: 17181551.
Mahootchi E, Cannon Homaei S, Kleppe R, Winge I, Hegvik TA, Megias-Perez R,
Totland C, Mogavero F, Baumann A, Glennon JC, Miletic H, Kursula P, Haavik J.
GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine
and carnosine production. Sci Adv. 2020 Jul 17;6(29):eabb3713. doi:
10.1126/sciadv.abb3713. PMID: 32733999; PMCID: PMC7367687.
Raasakka A, Mahootchi E, Winge I, Luan W, Kursula P, Haavik J. Structure of
the mouse acidic amino acid decarboxylase GADL1. Acta Crystallogr F Struct Biol
Commun. 2018 Jan 1;74(Pt 1):65-73. doi: 10.1107/S2053230X17017848. Epub 2018 Jan
1. PMID: 29372909; PMCID: PMC5947694.
McKinney JA, Turel B, Winge I, Knappskog PM, Haavik J. Functional properties
of missense variants of human tryptophan hydroxylase 2. Hum Mutat. 2009
May;30(5):787-94. doi: 10.1002/humu.20956. PMID: 19319927.
- (2020). GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production. Science Advances. 1-19.
- (2018). Structure of the mouse acidic amino acid decarboxylase GADL1. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 65-73.
- (2015). Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. Neurochemistry International. 173-184.
- (2013). Functional properties of rare missense variants of human CDH13 found in adult attention deficit/hyperactivity disorder (ADHD) patients. PLOS ONE. 9 pages.
- (2010). PHARMACOLOGICAL CHAPERONES FOR THE AROMATIC AMINO ACID HYDROXYLASES. The Journal of Inherited Metabolic Disease (JIMD). S163-S163.
- (2010). Functional studies of candidate genes involved in ADHD. European Psychiatric Review. 44-46.
- (2010). FUNCTIONAL STUDIES OF DISEASE-RELATED VARIANTS IN HUMAN TRYPTOPHAN HYDROXYLASE 1 AND 2. The Journal of Inherited Metabolic Disease (JIMD). S165-S165.
- (2010). Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2. Journal of Neurochemistry. 853-863.
- (2010). Attention-deficit/hyperactivity disorder symptoms in offspring of mothers with impaired serotonin production. Archives of General Psychiatry. 1033-1043.
- (2009). From synthesis to uptake - serotonergic genes in adult ADHD. European Neuropsychopharmacology. S186-S186.
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