Home
Ingvild Aukrust's picture

Ingvild Aukrust

Researcher
  • E-mailIngvild.Aukrust@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Journal articles
  • Holtan, Josephine Prener; Teigen, Knut; Aukrust, Ingvild; Bragadottir, Ragnheidur; Houge, Gunnar. 2019. Dominant ARL3-related retinitis pigmentosa. Ophthalmic Genetics. 40: 124-128. doi: 10.1080/13816810.2019.1586965
  • Berland, Siren; Toft-Bertelsen, Trine; Aukrust, Ingvild; Byska, Jan; Vaudel, Marc; Bindoff, Laurence; MacAulay, Nanna; Houge, Gunnar. 2018. A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance. Molecular Case Studies. 4.
  • Hamanaka, Kohei; Sugawara, Yuji; Shimoji, Takeyoshi; Nordtveit, Tone Irene; Kato, Mitsuhiro; Nakashima, Mitsuko; Saitsu, Hirotomo; Suzuki, Toshimitsu; Yamakawa, Kazuhiro; Aukrust, Ingvild; Houge, Gunnar; Mitsuhashi, Satomi; Takata, Atsushi; Iwama, Kazuhiro; Alkanaq, Ahmed; Fujita, Atsushi; Imagawa, Eri; Mizuguchi, Takeshi; Miyake, Noriko; Miyatake, Satoko; Matsumoto, Naomichi. 2018. De novo truncating variants in PHF21A cause intellectual disability and craniofacial anomalies. European Journal of Human Genetics. 27: 378-383. doi: 10.1038/s41431-018-0289-x
  • Kaci, Alba; Keindl, Magdalena; Solheim, Marie Holm; Njølstad, Pål Rasmus; Bjørkhaug, Lise; Aukrust, Ingvild. 2018. The E3 SUMO ligase PIASy is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1a. Scientific Reports. 8. doi: 10.1038/s41598-018-29448-w
  • Mc Tiernan, Nina; Støve, Svein Isungset; Aukrust, Ingvild; Mårli, Marita Torrissen; Myklebust, Line Merethe; Houge, Gunnar; Arnesen, Thomas. 2018. NAA10 dysfunction with normal NatA-complex activity in a girl with non-syndromic ID and a de novo NAA10 p.(V111G) variant - a case report. BMC Medical Genetics. 19:47: 1-9. doi: 10.1186/s12881-018-0559-z
  • Aukrust, Ingvild; Rosenberg, Linn Andersen; Ankerud, Mia Madeleine; Bertelsen, Vibeke; Hollås, Hanne; Saraste, Jaakko; Grindheim, Ann Kari; Vedeler, Anni. 2017. Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes. FEBS Open Bio. 7: 160-173. doi: 10.1002/2211-5463.12173
  • Johansson, Bente Berg; Fjeld, Karianne; Solheim, Marie Holm; Shirakawa, Jun; Zhang, Enming; Keindl, Magdalena; Hu, Jiang; Lindqvist, Andreas; Døskeland, Anne Marie Simonne; Mellgren, Gunnar; Flatmark, Torgeir; Njølstad, Pål Rasmus; Kulkarni, Rohit N.; Wierup, Nils; Aukrust, Ingvild; Bjørkhaug, Lise. 2017. Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Molecular and Cellular Endocrinology. 454: 146-157. doi: 10.1016/j.mce.2017.06.020
  • Johansson, Bente Berg; Irgens, Henrik Underthun; Molnes, Janne; Sztromwasser, Pawel Szymon; Aukrust, Ingvild; Juliusson, Petur Benedikt; Søvik, Oddmund; Levy, Shawn; Skrivarhaug, Torild; Joner, Geir; Molven, Anders; Johansson, Stefan; Njølstad, Pål Rasmus. 2017. Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry. Diabetologia. 60: 625-635. doi: 10.1007/s00125-016-4167-1
  • Moortgat, Stéphanie; Berland, Siren; Aukrust, Ingvild; Maystadt, Isabelle; Baker, Laura; Benoit, Valerie; Caro-Llopis, Alfonso; Cooper, Nicola S.; Debray, François-Guillaume; Faivre, Laurence; Gardeitchik, Thatjana; Haukanes, Bjørn Ivar; Houge, Gunnar; Kivuva, Emma; Martinez, Francisco; Mehta, Sarju G.; Nassogne, Marie-Cécile; Powell-Hamilton, Nina; Pfundt, Rolph; Rosello, Monica; Prescott, Trine; Vasudevan, Pradeep; van Loon, Barbara; Verellen-Dumoulin, Christine; Verloes, Alain; von der Lippe, Charlotte; Wakeling, Emma; Wilkie, Andrew O.M.; Wilson, Louise; Yuen, Amy; Low, Karen J.; Newbury-Ecob, Ruth A. 2017. HUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients. European Journal of Human Genetics. 26: 64-74. Published 2017-11-27. doi: 10.1038/s41431-017-0038-6
  • Najmi, Laeya Abdoli; Aukrust, Ingvild; Flannick, Jason; Molnes, Janne; Burtt, Noël; Molven, Anders; Groop, Leif; Altshuler, David; Johansson, Stefan; Bjørkhaug, Lise; Njølstad, Pål Rasmus. 2017. Functional investigations of HNF1A identify rare variants as risk factors for type 2 diabetes in the general population. Diabetes. 66: 335-346. doi: 10.2337/db16-0460
  • Pakdaman, Yasaman; Sanchez Guixe, Monica; Kleppe, Rune; Erdal, Sigrid; Bustad, Helene J.; Bjørkhaug, Lise; Haugarvoll, Kristoffer; Tzoulis, Charalampos; Heimdal, Ketil Riddervold; Knappskog, Per; Johansson, Stefan; Aukrust, Ingvild. 2017. In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins. Bioscience Reports. 37: 1-12. doi: 10.1042/BSR20170251
  • Storbeck, Markus; Eriksen, Beate Horsberg; Unger, Andreas; Holker, Irmgard; Aukrust, Ingvild; Martinez-Carrera, Lillian A.; Linke, Wolfgang A.; Ferbert, Andreas; Heller, Raoul; Vorgerd, Matthias; Houge, Gunnar; Wirth, Brunhilde. 2017. Phenotypic extremes of BICD2-opathies: From lethal, congenital muscular atrophy with arthrogryposis to asymptomatic with subclinical features. European Journal of Human Genetics. 25: 1040-1048. doi: 10.1038/ejhg.2017.98
  • Aukrust, Ingvild; Jansson, Ragnhild Wivestad; Bredrup, Cecilie; Rusaas, Hilde E.; Berland, Siren; Jørgensen, Agnete; Haug, Marte Gjøl; Rødahl, Eyvind; Houge, Gunnar; Knappskog, Per. 2016. The intronic ABCA4 c.5461-10T>C variant, frequently seen in patients with Stargardt disease, causes splice defects and reduced ABCA4 protein level. Acta Ophthalmologica. 95: 240-246. doi: 10.1111/aos.13273
  • Lek, M; Aggregation Consortium, Exome; Njølstad, Pål Rasmus; Najmi, Laeya Abdoli; Aukrust, Ingvild; Bjørkhaug, Lise. 2016. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 18: 285-291.
  • Rozenkova, Klara; Malikova, Jana; Nessa, Azizun; Dusatkova, Lenka; Bjørkhaug, Lise; Obermannova, Barbora; Dusatkova, Petra; Kytnarova, Jitka; Aukrust, Ingvild; Najmi, Laeya Abdoli; Rypackova, Blanka; Sumnik, Zdenek; Lebl, Jan; Njølstad, Pål Rasmus; Hussain, Khalid; Pruhova, Stepanka. 2015. High incidence of heterozygous ABCC8 and HNF1A mutations in Czech patients with congenital hyperinsulinism. Journal of Clinical Endocrinology and Metabolism. 100: E1540-E1549. doi: 10.1210/jc.2015-2763
  • Estrada, Karol; Aukrust, Ingvild; Bjørkhaug, Lise; Bjørkhaug, Lise; Burtt, Noël P.; Mercader, Josep P.; García-Ortiz, Humberto; Huerta-Chagoya, Alicia; Moreno-Macías, Hortensia; Walford, Geoffrey; Flannick, Jason; Williams, Amy L.; Gómez-Vázquez, Maria J.; Fernandez-Lopez, Juan C.; Martínez-Hernández, Angélica; Jiménez-Morales, Silvia; Centeno-Cruz, Federico; Mendoza-Caamal, Elvia; Revilla-Monsalve, Cristina; Islas-Andrade, Sergio; Córdova, Emilio J.; Soberón, Xavier; González-Villalpando, María E.; Henderson, Brian E.; Wilkens, Lynne R; Le Marchand, Loic; Arellano-Campos, Olimpia; Ordóñez-Sánchez, Maria L.; Rodríguez-Torres, Maribel; Rodríguez-Guillén, Rosario; Riba, Laura; Najmi, Laeya Abdoli; Jacobs, Susanne B.R.; Fennell, Timothy; Gabriel, Stacey; Fontanillas, Pierre; Hanis, Craig L; Lehman, Donna M.; Jenkinson, Christopher; Abboud, Hanna E.; Bell, Graeme I.; Cortes, Maria L.; Boehnke, Michael; González-Villalpando, Clicerio; Orozco, Lorena; Haiman, Christopher A.; Tusié-Luna, Teresa; Aguilar-Salinas, Carlos A.; Altshuler, David; Njølstad, Pål Rasmus; Florez, Jose C.; MacArthur, Daniel G. 2014. Association of a low-frequency variant in HNF1A with type 2 diabetes in a latino population the SIGMA Type 2 Diabetes Consortium. Journal of the American Medical Association (JAMA). 311: 2305-2314. doi: 10.1001/jama.2014.6511
  • Heimdal, Ketil Riddervold; Sanchez Guixe, Monica; Aukrust, Ingvild; Bollerslev, Jens; Bruland, Ove; Jablonski, Greg; ERICHSEN, ANNE KJERSTI; Gude, Einar; Koht, Jeanette; Erdal, Sigrid; Fiskerstrand, Torunn; Haukanes, Bjørn Ivar; Boman, Helge; Bjørkhaug, Lise; Tallaksen, Chantal; Knappskog, Per; Johansson, Stefan. 2014. STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity. Orphanet Journal of Rare Diseases. 9:146. doi: 10.1186/s13023-014-0146-0
  • Negahdar, Maria; Aukrust, Ingvild; Molnes, Janne; Solheim, Marie Holm; Johansson, Bente Berg; Sagen, Jørn V.; Dahl-Jørgensen, Knut; Kulkarni, Rohit Rajesh; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2014. GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Molecular and Cellular Endocrinology. 382: 55-65. doi: 10.1016/j.mce.2013.08.020
  • Aukrust, Ingvild; Bjørkhaug, Lise; Negahdar, Maria; Molnes, Janne; Johansson, Bente Berg; Müller, Yvonne; Haas, Wilhelm; Gygi, Steven P.; Søvik, Oddmund; Flatmark, Torgeir; Kulkarni, Rohit N; Njølstad, Pål Rasmus. 2013. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. Journal of Biological Chemistry. 288: 5951-5962. doi: 10.1074/jbc.M112.393769
  • Negahdar, Maria; Aukrust, Ingvild; Johansson, Bente Berg; Molnes, Janne; Molven, Anders; Matschinsky, Franz M.; Søvik, Oddmund; Kulkarni, Rohit N; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2012. GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822: 1705-1715. doi: 10.1016/j.bbadis.2012.07.005
  • Molnes, Janne; Teigen, Knut; Aukrust, Ingvild; Bjørkhaug, Lise; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus. 2011. Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity. The FEBS Journal. 278: 2372-2386. doi: 10.1111/j.1742-4658.2011.08160.x
  • Aukrust, Ingvild; Hollås, Hanne; Strand, Elin; Evensen, Lasse; Trave, Gilles Michel; Flatmark, Torgeir; Vedeler, Anni. 2007. The mRNA-binding site of annexin A2 resides in helices C-D of its domain IV. Journal of Molecular Biology. 368: 1367-1378. doi: 10.1016/j.jmb.2007.02.094
  • Aukrust, Ingvild; Evensen, Lasse; Hollås, Hanne; Berven, Frode; Atkinson, R. Andrew; Trave, Gilles Michel; Flatmark, Torgeir; Vedeler, Anni. 2006. Engineering, biophysical characterisation and binding properties of a soluble mutant form of annexin A2 domain IV that adopts a partially folded conformation. Journal of Molecular Biology. 363: 469-481. doi: 10.1016/j.jmb.2006.08.042
  • Hollås, Hanne; Aukrust, Ingvild; Grimmer, Stine; Strand, Elin; Flatmark, Torgeir; Vedeler, Anni. 2006. Annexin A2 recognises a specific region in the 3 '-UTR of its cognate messenger RNA. Biochimica et Biophysica Acta. Molecular Cell Research. 1763: 1325-1334. doi: 10.1016/j.bbamcr.2006.08.043
  • Lauvrak, Silje Anett Ugland; Hollås, Hanne; Døskeland, Anne Paulus; Aukrust, Ingvild; Flatmark, Torgeir; Vedeler, Anni. 2005. Ubiquitinated annexin A2 is enriched in the cytoskeleton fraction. FEBS Letters. 579: 203-206. doi: 10.1016/j.febslet.2004.11.076
Reports and theses
  • Aukrust, Ingvild. 2007. Annexin A2 as an mRNA-binding protein.
  • Aukrust, Ingvild. 2002. Studies on the binding of heparin, anxA2 mRNA and F-actin to heterotetrameric annexin A2 (anxA2^2 p11^2) and its recombinant forms. VIII, 150 bl.

More information in national current research information system (CRIStin)